{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:17:35Z","timestamp":1790083055594,"version":"4.0.1"},"reference-count":86,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T00:00:00Z","timestamp":1660262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014434","name":"Narodowa Agencja Wymiany Akademickiej","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014434","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>\n                    Endometrium type I (COL1) and III (COL3) collagen accumulation, periglandular fibrosis and mare infertility characterize endometrosis. Metalloproteinase-2 (MMP-2), MMP-9 and tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) are involved in collagen turnover. Since epigenetic changes may control fibroproliferative diseases, we hypothesized that epigenetic mechanisms could modulate equine endometrosis. Epigenetic changes can be reversed and therefore extremely promising for therapeutic use. Methylation pattern analysis of a particular gene zone is used to detect epigenetic changes. DNA methylation commonly mediates gene repression. Thus, this study aimed to evaluate if the transcription of some genes involved in equine endometrosis was altered with endometrial fibrosis, and if the observed changes were epigenetically modulated, through DNA methylation analysis. Endometrial biopsies collected from cyclic mares were histologically classified (Kenney and Doig category I,\n                    <jats:italic>n<\/jats:italic>\n                    = 6; category IIA,\n                    <jats:italic>n<\/jats:italic>\n                    = 6; category IIB,\n                    <jats:italic>n<\/jats:italic>\n                    = 6 and category III,\n                    <jats:italic>n<\/jats:italic>\n                    = 6). Transcription of\n                    <jats:italic>COL1A1, COL1A2, COL3A1, MMP2, MMP9, TIMP1<\/jats:italic>\n                    , and\n                    <jats:italic>TIMP2<\/jats:italic>\n                    genes and DNA methylation pattern by pyrosequencing of\n                    <jats:italic>COL1A1, MMP2, MMP9, TIMP1<\/jats:italic>\n                    genes were evaluated. Both\n                    <jats:italic>MMP2<\/jats:italic>\n                    and\n                    <jats:italic>MMP9<\/jats:italic>\n                    transcripts decreased with fibrosis, when compared with healthy endometrium (category I) (\n                    <jats:italic>P<\/jats:italic>\n                    &amp;lt; 0.05).\n                    <jats:italic>TIMP1<\/jats:italic>\n                    transcripts were higher in category III, when compared to category I endometrium (\n                    <jats:italic>P<\/jats:italic>\n                    &amp;lt; 0.05). No differences were found for\n                    <jats:italic>COL1A1, COL1A2, COL3A1<\/jats:italic>\n                    and\n                    <jats:italic>TIMP2<\/jats:italic>\n                    transcripts between endometrial categories. There were higher methylation levels of (i)\n                    <jats:italic>COL1A1<\/jats:italic>\n                    in category IIB (\n                    <jats:italic>P<\/jats:italic>\n                    &amp;lt; 0.05) and III (\n                    <jats:italic>P<\/jats:italic>\n                    &amp;lt; 0.01), when compared to category I; (ii)\n                    <jats:italic>MMP2<\/jats:italic>\n                    in category III, when compared to category I (\n                    <jats:italic>P<\/jats:italic>\n                    &amp;lt; 0.001) and IIA (\n                    <jats:italic>P<\/jats:italic>\n                    &amp;lt; 0.05); and (iii)\n                    <jats:italic>MMP9<\/jats:italic>\n                    in category III, when compared to category I and IIA (\n                    <jats:italic>P<\/jats:italic>\n                    &amp;lt; 0.05). No differences in\n                    <jats:italic>TIMP1<\/jats:italic>\n                    methylation levels were observed between endometrial categories. The hypermethylation of\n                    <jats:italic>MMP2<\/jats:italic>\n                    and\n                    <jats:italic>MMP9<\/jats:italic>\n                    , but not of\n                    <jats:italic>COL1A1<\/jats:italic>\n                    genes, occurred simultaneously with a decrease in their mRNA levels, with endometrial fibrosis, suggesting that this hypermethylation is responsible for repressing their transcription. Our results show that endometrosis is epigenetically modulated by anti-fibrotic genes (\n                    <jats:italic>MMP2<\/jats:italic>\n                    and\n                    <jats:italic>MMP9<\/jats:italic>\n                    ) inhibition, rather than fibrotic genes activation and therefore, might be promising targets for therapeutic use.\n                  <\/jats:p>","DOI":"10.3389\/fvets.2022.970003","type":"journal-article","created":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T03:14:51Z","timestamp":1660274091000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Metallopeptidades 2 and 9 genes epigenetically modulate equine endometrial fibrosis"],"prefix":"10.3389","volume":"9","author":[{"given":"Joana","family":"Alpoim-Moreira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Pimenta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Bliebernicht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosa","family":"Rebord\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Castelo-Branco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Sz\u00f3stek-Mioduchowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz J.","family":"Skarzynski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gra\u00e7a","family":"Ferreira-Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"547","DOI":"10.2478\/pjvs-2014-0083","article-title":"Endometrosis-significance for horse reproduction, pathogenesis, diagnosis, and proposed therapeutic methods","volume":"17","author":"Buczkowska","year":"2014","journal-title":"Pol J Vet Sci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"625","DOI":"10.3390\/ani10040625","article-title":"The healthy and diseased equine endometrium: a review of morphological features and molecular analyses","volume":"10","author":"Sch\u00f6niger","year":"2020","journal-title":"Animals."},{"key":"B3","first-page":"241","article-title":"Cyclic and pathologic changes of the mare endometrium as detected by biopsy, with a note on early embryonic death","volume":"172","author":"Kenney","year":"1978","journal-title":"J Am Vet Med Assoc."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1095\/biolreprod65.5.1311","article-title":"Developmental biology of uterine glands","volume":"65","author":"Gray","year":"2001","journal-title":"Biol Reprod."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.14670\/HH-20.1105","article-title":"Matrix metalloproteinase 2 (MMP-2) and tissue transglutaminase (TG 2) are expressed in periglandular fibrosis in horse mares with endometrosis","volume":"20","author":"Walter","year":"2005","journal-title":"Histol Histopathol."},{"key":"B6","first-page":"140","article-title":"\u201cInflammation and repair of tissue\u201d. In: Slauson DO, Cooper BJ, editors","volume-title":"Mechanisms of Disease: A Textbook of Comparative General Pathology, 3rd Edition.","author":"Bochsler","year":"2002"},{"key":"B7","volume-title":"Caracteriza\u00e7\u00e3o histoqu","author":"Masseno","year":"2009"},{"key":"B8","volume-title":"Histochemical and immunohistochemical characterization of fibrotic changes in mares endometrosis","author":"Costa","year":"2015"},{"key":"B9","doi-asserted-by":"publisher","first-page":"599","DOI":"10.4236\/abb.2013.44078","article-title":"Collagen types in relation to expression of estradiol and progesterone receptors in equine endometrial fibrosis","volume":"4","author":"Lunelli","year":"2013","journal-title":"Adv Biosci Biotechnol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.matbio.2007.07.001","article-title":"Control of matrix metalloproteinase catalytic activity","volume":"26","author":"Ra","year":"2007","journal-title":"Matrix Biol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"171","DOI":"10.4142\/jvs.2012.13.2.171","article-title":"The role of inflammation and matrix metalloproteinases in equine endometriosis","volume":"13","author":"Aresu","year":"2012","journal-title":"J Vet Sci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.jevs.2018.05.182","article-title":"Gene expression of Mmp-1, Mmp-2 And TNF-\u03b1 in the endometrium of mares with different degrees of fibrosis","volume":"66","author":"Centeno","year":"2018","journal-title":"J Equine Vet Sci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1186\/s12917-019-2215-z","article-title":"Different expression of Defensin-B gene in the endometrium of mares of different age during the breeding season","volume":"15","author":"Crociati","year":"2019","journal-title":"BMC Vet Res."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1038\/s41598-020-58109-0","article-title":"Matrix metallopeptidase expression and modulation by transforming growth factor-\u03b21 in equine endometrosis","volume":"10","author":"Sz\u00f3stek-Mioduchowska","year":"2020","journal-title":"Sci Rep."},{"key":"B15","doi-asserted-by":"publisher","first-page":"222","DOI":"10.3109\/10409238.2013.770819","article-title":"Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): the next decade","volume":"48","author":"Vandooren","year":"2013","journal-title":"Crit Rev Biochem Mol Biol."},{"key":"B16","doi-asserted-by":"crossref","DOI":"10.5772\/intechopen.70265","article-title":"Overview of MMP biology and gene associations in human diseases","volume-title":"The Role of Matrix Metalloproteinase in Human Body Pathologies","author":"Djuric","year":"2017"},{"key":"B17","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1242\/dmm.012062","article-title":"Diverse functions of matrix metalloproteinases during fibrosis","volume":"7","author":"Giannandrea","year":"2014","journal-title":"Dis Model Mech."},{"key":"B18","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/j.jhep.2007.02.003","article-title":"Expression of MMPs and TIMPs in liver fibrosis - a systematic review with special emphasis on anti-fibrotic strategies","volume":"46","author":"Hemmann","year":"2007","journal-title":"J Hepatol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s13069-015-0035-8","article-title":"Epigenetics and the overhealing wound: the role of DNA methylation in fibrosis","volume":"8","author":"Neary","year":"2015","journal-title":"Fibrogenesis Tissue Repair."},{"key":"B20","doi-asserted-by":"publisher","first-page":"463","DOI":"10.2217\/epi-2016-0150","article-title":"Epigenetic factors as drivers of fibrosis in systemic sclerosis","volume":"9","author":"Bergmann","year":"2017","journal-title":"Epigenomics."},{"key":"B21","doi-asserted-by":"publisher","first-page":"546","DOI":"10.3390\/ijms23010546","article-title":"Epigenetic mechanisms in parenchymal lung diseases: bystanders or therapeutic targets?","volume":"23","author":"Avci","year":"2022","journal-title":"Int J Mol Sci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1038\/s41419-021-04365-5","article-title":"The histone methyltransferase DOT1L is a new epigenetic regulator of pulmonary fibrosis","volume":"13","author":"Yang","year":"2022","journal-title":"Cell Death Dis."},{"key":"B23","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s40139-018-0155-0","article-title":"Hagood JS. Epigenetic regulation of myofibroblast phenotypes in fibrosis","volume":"6","author":"Duong","year":"2018","journal-title":"Curr Pathobiol Rep."},{"key":"B24","unstructured":"Epigenetic influence and disease6\n            SimmonsD\n          Nat Educ12008"},{"key":"B25","doi-asserted-by":"publisher","first-page":"4632","DOI":"10.1200\/JCO.2004.07.151","article-title":"Singal, R. DNA methylation and cancer","volume":"22","author":"Das","year":"2004","journal-title":"J Clin Oncol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1126\/science.1063127","article-title":"Translating the histone code","volume":"293","author":"Jenuwein","year":"2001","journal-title":"Science."},{"key":"B27","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/S1043-2760(00)00248-4","article-title":"DNA methylation and silencing of gene expression","volume":"11","author":"Newell-Price","year":"2000","journal-title":"Trends Endocrinol Metab."},{"key":"B28","doi-asserted-by":"publisher","first-page":"3157","DOI":"10.1128\/MCB.22.9.3157-3173.2002","article-title":"Molecular mechanisms of gene silencing mediated by DNA methylation","volume":"22","author":"Curradi","year":"2002","journal-title":"Mol Cell Biol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"553","DOI":"10.2217\/epi.13.43","article-title":"DNA methylation and differentiation: silencing, upregulation and modulation of gene expression","volume":"5","author":"Ehrlich","year":"2013","journal-title":"Epigenomics."},{"key":"B30","doi-asserted-by":"publisher","first-page":"5361","DOI":"10.1038\/sj.onc.1205609","article-title":"DNA methylation and chromatin - unraveling the tangled web","volume":"21","author":"Robertson","year":"2002","journal-title":"Oncogene."},{"key":"B31","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1038\/nrg3230","article-title":"Functions of DNA methylation: islands, start sites, gene bodies and beyond","volume":"13","author":"Jones","year":"2012","journal-title":"Nat Rev Genet."},{"key":"B32","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1097\/BOR.0000000000000128","article-title":"Epigenetics in rheumatoid arthritis","volume":"27","author":"Klein","year":"2015","journal-title":"Curr Opin Rheumatol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.gde.2005.08.002","article-title":"DNA methylation and histone modifications: teaming up to silence genes","volume":"15","author":"Fuks","year":"2005","journal-title":"Curr Opin Genet Dev."},{"key":"B34","doi-asserted-by":"publisher","first-page":"2042","DOI":"10.1056\/NEJMra023075","article-title":"Gene silencing in cancer in association with promoter hypermethylation","volume":"349","author":"Herman","year":"2003","journal-title":"N Engl J Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/ng1990","article-title":"Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome","volume":"39","author":"Weber","year":"2007","journal-title":"Nat Genet."},{"key":"B36","doi-asserted-by":"publisher","first-page":"3498","DOI":"10.1093\/nar\/gkv153","article-title":"A diverse epigenetic landscape at human exons with implication for expression","volume":"43","author":"Singer","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1016\/j.bbagrm.2013.08.001","article-title":"Intragenic DNA methylation in transcriptional regulation, normal differentiation and cancer","volume":"1829","author":"Kulis","year":"2013","journal-title":"Biochim Biophys Acta."},{"key":"B38","first-page":"723","article-title":"Equine endometrial biopsy","volume-title":"Current Therapy in Theriogenology.","author":"Kenney","year":"1986"},{"key":"B39","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.theriogenology.2018.02.001","article-title":"Constituents of neutrophil extracellular traps induce in vitro collagen formation in mareendometrium","volume":"113","author":"Rebord\u00e3o","year":"2018","journal-title":"Theriogenology."},{"key":"B40","doi-asserted-by":"publisher","first-page":"e115","DOI":"10.1093\/nar\/gks596","article-title":"Primer3\u2013new capabilities and interfaces","volume":"40","author":"Untergasser","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"112","DOI":"10.2144\/04371RR03","article-title":"Validation of housekeeping genes for normalizing RNA expression in real-time PCR","volume":"37","author":"Dheda","year":"2004","journal-title":"Biotechniques."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1089\/cmb.2005.12.1047","article-title":"Comprehensive algorithm for quantitative real-time polymerase chain reaction","volume":"12","author":"Zhao","year":"2005","journal-title":"J Comput Biol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1093\/bioinformatics\/18.11.1427","article-title":"MethPrimer: designing primers for methylation PCRs","volume":"18","author":"Li","year":"2002","journal-title":"Bioinformatics."},{"key":"B44","doi-asserted-by":"publisher","first-page":"933","DOI":"10.18632\/aging.100951","article-title":"MMP-9 overexpression is associated with intragenic hypermethylation of MMP9 gene in melanoma","volume":"8","author":"Falzone","year":"2016","journal-title":"Aging."},{"key":"B45","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/S1470-2045(13)70110-4","article-title":"Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study","volume":"14","author":"Castelo-Branco","year":"2013","journal-title":"Lancet Oncol."},{"key":"B46","first-page":"D108","article-title":"TRANSFAC and its module TRANSCompel: transcriptional gene regulation in eukaryotes","volume-title":"Nucleic Acids Res","author":"Matys","year":"2006"},{"key":"B47","first-page":"S1","article-title":"AliBaba2: context specific identification of transcription factor binding sites","volume":"2","author":"Grabe","year":"2002","journal-title":"In Silico Biol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1002\/art.21948","article-title":"Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts","volume":"54","author":"Wang","year":"2006","journal-title":"Arthritis Rheum."},{"key":"B49","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1038\/nm.2135","article-title":"Methylation determines fibroblast activation and fibrogenesis in the kidney","volume":"16","author":"Bechtel","year":"2010","journal-title":"Nat Med."},{"key":"B50","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.2353\/ajpath.2010.100446","article-title":"Hypermethylation of PTGER2 confers prostaglandin E2 resistance in fibrotic fibroblasts from humans and mice","volume":"177","author":"Huang","year":"2010","journal-title":"Am J Pathol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1136\/annrheumdis-2012-203194","article-title":"The Wnt antagonists DKK1 and SFRP1 are downregulated by promoter hypermethylation in systemic sclerosis","volume":"73","author":"Dees","year":"2014","journal-title":"Ann Rheum Dis."},{"key":"B52","doi-asserted-by":"publisher","first-page":"5797","DOI":"10.1038\/ncomms6797","article-title":"Simultaneous downregulation of KLF5 and Fli1 is a key feature underlying systemic sclerosis","volume":"5","author":"Noda","year":"2014","journal-title":"Nat Commun."},{"key":"B53","doi-asserted-by":"publisher","first-page":"2176","DOI":"10.1093\/hmg\/ddt614","article-title":"Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype","volume":"23","author":"Watson","year":"2014","journal-title":"Hum Mol Genet."},{"key":"B54","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s00281-015-0504-6","article-title":"Epigenetics and systemic sclerosis","volume":"37","author":"Altorok","year":"2015","journal-title":"Semin Immunopathol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.1172\/JCI122462","article-title":"TGF-\u03b2-induced epigenetic deregulation of SOCS3 facilitates STAT3 signaling to promote fibrosis","volume":"130","author":"Dees","year":"2020","journal-title":"J Clin Invest."},{"key":"B56","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1111\/rda.13515","article-title":"Collagens and DNA methyltransferases in mare endometrosis","volume":"46","author":"Alpoim-Moreira","year":"2019","journal-title":"Reprod Domest Anim."},{"key":"B57","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1007\/s11926-007-0008-z","article-title":"New developments in fibroblast and myofibroblast biology: implications for fibrosis and scleroderma","volume":"9","author":"Abraham","year":"2007","journal-title":"Curr Rheumatol Rep."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1038\/nm.2807","article-title":"Mechanisms of fibrosis: therapeutic translation for fibrotic disease","volume":"18","author":"Wynn","year":"2012","journal-title":"Nat Med."},{"key":"B59","volume-title":"Involvement of Hormones, Cytokines and Angiogenic Factors on Mare Oviduct Physiological Function and Fibrosis","author":"Bravo","year":"2018"},{"key":"B60","doi-asserted-by":"publisher","first-page":"631","DOI":"10.3389\/fvets.2020.00631","article-title":"Collagen and eosinophils in jenny's endometrium: do they differ with endometrial classification?","volume":"7","author":"Mir\u00f3","year":"2020","journal-title":"Front Vet Sci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.theriogenology.2018.10.005","article-title":"Effect of transforming growth factor -\u03b21 on \u03b1-smooth muscle actin and collagen expression in equine endometrial fibroblasts","volume":"124","author":"Sz\u00f3stek-Mioduchowska","year":"2019","journal-title":"Theriogenology."},{"key":"B62","unstructured":"GumbsJA\n          University of Liverpool, Liverpool, United KingdomTGF-\u03b2 Mediated Synthesis of Degradation-Resistant Collagen (I) Homotrimer in Musculoskeletal Cells2019"},{"key":"B63","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/nrg3185","article-title":"Insights into the regulation of protein abundance from proteomic and transcriptomic analyses","volume":"13","author":"Vogel","year":"2012","journal-title":"Nat Rev Genet."},{"key":"B64","doi-asserted-by":"publisher","first-page":"107","DOI":"10.2174\/1871529X14666140505122510","article-title":"Transcriptional control of collagen I gene expression","volume":"14","author":"Roche","year":"2014","journal-title":"Cardiovasc Hematol Disord Drug Targets."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1002\/cncr.10355","article-title":"Presence of active gelatinases in endometrial carcinoma and correlation of matrix metalloproteinase expression with increasing tumor grade and invasion","volume":"94","author":"Di Nezza","year":"2002","journal-title":"Cancer."},{"key":"B66","first-page":"215","article-title":"Matrix metalloproteinases involvement in pathologic conditions","volume":"51","author":"Am\u0103linei","year":"2010","journal-title":"Rom J Morphol Embryol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"141485","DOI":"10.1155\/2015\/141485","article-title":"Immunomodulatory role of adipose-derived stem cells on equine endometriosis","volume":"2015","author":"Falomo","year":"2015","journal-title":"Biomed Res Int."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.2353\/ajpath.2010.100011","article-title":"Epigenetic repression of matrix metalloproteinases in myofibroblastic hepatic stellate cells through histone deacetylases 4: implication in tissue fibrosis","volume":"177","author":"Qin","year":"2010","journal-title":"Am J Pathol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"345","DOI":"10.3892\/mmr_00000106","article-title":"Extracellular matrix metabolism-related gene expression in bile duct-ligated rats","volume":"2","author":"Sugihara","year":"2009","journal-title":"Mol Med Rep."},{"key":"B70","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.reprotox.2015.08.001","article-title":"Strain-specific induction of endometrial periglandular fibrosis in mice exposed during adulthood to the endocrine disrupting chemical bisphenol A","volume":"58","author":"Kendziorski","year":"2015","journal-title":"Reprod Toxicol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"e52332","DOI":"10.1371\/journal.pone.0052332","article-title":"IL-13 promotes collagen accumulation in Crohn's disease fibrosis by down-regulation of fibroblast MMP synthesis: a role for innate lymphoid cells?","volume":"7","author":"Bailey","year":"2012","journal-title":"PLoS ONE."},{"key":"B72","doi-asserted-by":"publisher","first-page":"R71","DOI":"10.1186\/ar1454","article-title":"Elevated matrix metalloproteinase-9 in patients with systemic sclerosis","volume":"7","author":"Kim","year":"2005","journal-title":"Arthritis Res Ther."},{"key":"B73","doi-asserted-by":"publisher","first-page":"2199","DOI":"10.1016\/j.rmed.2007.04.019","article-title":"Bronchoalveolar matrix metalloproteinase 9 relates to restrictive lung function impairment in systemic sclerosis","volume":"101","author":"Andersen","year":"2007","journal-title":"Respir Med."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1183\/09031936.00024711","article-title":"Metalloproteinases in idiopathic pulmonary fibrosis","volume":"38","author":"Dancer","year":"2011","journal-title":"Eur Respir J."},{"key":"B75","doi-asserted-by":"publisher","first-page":"727451","DOI":"10.3389\/fphys.2021.727451","article-title":"Marshall JS. Distinct metalloproteinase expression and functions in systemic sclerosis and fibrosis: what we know and the potential for intervention","volume":"12","author":"Leong","year":"2021","journal-title":"Front Physiol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1002\/jcp.20948","article-title":"Regulation of matrix metalloproteinase gene expression","volume":"211","author":"Yan","year":"2007","journal-title":"J Cell Physiol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1165\/ajrcmb.24.5.4192","article-title":"Selective induction of tissue inhibitor of metalloproteinase-1 in bleomycin-induced pulmonary fibrosis","volume":"24","author":"Madtes","year":"2001","journal-title":"Am J Respir Cell Mol Biol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1161\/CIRCULATIONAHA.104.516963","article-title":"Increased cardiac expression of tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 is related to cardiac fibrosis and dysfunction in the chronic pressure-overloaded human heart","volume":"112","author":"Heymans","year":"2005","journal-title":"Circulation."},{"key":"B79","doi-asserted-by":"publisher","first-page":"243","DOI":"10.3892\/mmr.2011.425","article-title":"Unbalanced MMP\/TIMP-1 expression during the development of experimental pulmonary fibrosis with acute paraquat poisoning","volume":"4","author":"Wang","year":"2011","journal-title":"Mol Med Rep."},{"key":"B80","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1042\/bse0370033","article-title":"Regulation of the initiation of eukaryotic transcription","volume":"37","author":"Gill","year":"2001","journal-title":"Essays Biochem."},{"key":"B81","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1093\/bioinformatics\/18.2.333","article-title":"Detection of known transcription regulatory elements using species-tailored searches","volume":"18","author":"Messeguer","year":"2002","journal-title":"Bioinformatics."},{"key":"B82","doi-asserted-by":"publisher","first-page":"3651","DOI":"10.1093\/nar\/gkg605","article-title":"Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN","volume":"31","author":"Farr\u00e9","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"B83","doi-asserted-by":"publisher","first-page":"39574","DOI":"10.1074\/jbc.M405805200","article-title":"Transcriptional regulation of the human beta-1, 4-galactosyltransferase V gene in cancer cells: essential role of transcription factor Sp1","volume":"279","author":"Sato","year":"2004","journal-title":"J Biol Chem."},{"key":"B84","doi-asserted-by":"publisher","first-page":"13575","DOI":"10.1038\/s41598-017-14148-8","article-title":"Localization of TFPI-2 in the nucleus modulates MMP-2 gene expression in breast cancer cells","volume":"7","author":"Wang","year":"2017","journal-title":"Sci Rep."},{"key":"B85","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1042\/bj20020707","article-title":"A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers","volume":"369","author":"Bergman","year":"2003","journal-title":"Biochem J"},{"key":"B86","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1165\/rcmb.2015-0020TR","article-title":"Matrix metalloproteinases as therapeutic targets for idiopathic pulmonary fibrosis","volume":"53","author":"Craig","year":"2015","journal-title":"Am J Respir Cell Mol Biol."}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2022.970003\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T03:15:10Z","timestamp":1660274110000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2022.970003\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,12]]},"references-count":86,"alternative-id":["10.3389\/fvets.2022.970003"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2022.970003","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,12]]},"article-number":"970003"}}