{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:28:13Z","timestamp":1789504093610,"version":"build-2803163510"},"reference-count":87,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Trichinellosis is a helminthic disease caused by<jats:italic>Trichinella spiralis via<\/jats:italic>the ingestion of raw or undercooked meat of infected animals. Current estimates indicate that 11 million humans have trichinellosis, worldwide. The effective use of anti-trichinella medications is limited by side effects and resistance which highlight the critical need for safe and effective drugs, particularly those derived from medicinal plants. Therefore, in the present study, we aimed to evaluate the efficacy of the ethanolic extract of<jats:italic>Artemisia annua<\/jats:italic>(<jats:italic>A. annua<\/jats:italic>) in treatment of experimentally induced trichinellosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Trichinellosis was induced experimentally in male 6\u20138 weeks BALB\/c mice. BALB\/c mice were divided into four groups, 10 mice each. One group was left uninfected and untreated, whereas three groups were infected with<jats:italic>T. spiralis. One<\/jats:italic>infected group of mice was left untreated (negative control) while the remaining two infected groups received either 300 mg\/kg of the ethanolic extract of<jats:italic>A. annua<\/jats:italic>or 50 mg\/kg of albendazole (positive control). All treatments started from the third day post-infection (dpi) for 3 successive days. All animals were sacrificed on the 7th dpi for evaluation of treatment efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our findings showed that<jats:italic>A. annua<\/jats:italic>treatment reduced the<jats:italic>T. spiralis<\/jats:italic>adult-worm count in the intestine of infected animals. Moreover, treatment with<jats:italic>A. annua<\/jats:italic>restored the normal intestinal architecture, reduced edema, alleviated inflammation as demonstrated by reduced inflammatory infiltrate and expression of TGF-\u03b2 in intestinal tissues of<jats:italic>A. annua<\/jats:italic>-treated animals compared to infected untreated animals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings show that<jats:italic>A. annua<\/jats:italic>extract is effective in treating experimentally induced trichinellosis which highlight the therapeutic potential of<jats:italic>A. annua<\/jats:italic>for intestinal trichinellosis.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fvets.2022.970327","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T05:49:21Z","timestamp":1661233761000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["A potential herbal therapeutic for trichinellosis"],"prefix":"10.3389","volume":"9","author":[{"given":"Asmaa M.","family":"El-kady","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman A. 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