{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T11:42:21Z","timestamp":1793187741771,"version":"4.5.0"},"reference-count":100,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T00:00:00Z","timestamp":1678320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p><jats:italic>Salmonella enterica<\/jats:italic> is an important zoonotic pathogen that is frequently identified in dairy farming systems. An increase in antibiotic resistance has led to inadequate results of treatments, with impacts on animal and human health. Here, the phenotypic and genotypic susceptibility patterns of <jats:italic>Salmonella<\/jats:italic> isolates from dairy cattle and dairy farm environments were evaluated and compared. A collection of 75 <jats:italic>S. enterica<\/jats:italic> isolates were evaluated, and their phenotypic susceptibility was determined. For genotypic characterization, the whole genomes of the isolates were sequenced, and geno-serotypes, sequence types (STs) and core-genome-sequence types were determined using the EnteroBase pipeline. To characterize antibiotic resistance genes and gene mutations, tools from the Center for Genomic Epidemiology were used. <jats:italic>Salmonella<\/jats:italic> Dublin (SDu), <jats:italic>S<\/jats:italic>. Typhimurium (STy), <jats:italic>S<\/jats:italic>. Anatum (SAn), <jats:italic>S<\/jats:italic>. Newport (SNe), <jats:italic>S<\/jats:italic>. Agona (Sag), <jats:italic>S<\/jats:italic>. Montevideo (SMo) and IIIb 61:i:z53 were included in the collection. A single sequence type was detected per serovar. Phenotypic non-susceptibility to streptomycin and tetracycline was very frequent in the collection, and high non-susceptibility to ciprofloxacin was also observed. Multidrug resistance (MDR) was observed in 42 isolates (56.0%), with SAn and STy presenting higher MDR than the other serovars, showing non-susceptibility to up to 6 groups of antibiotics. Genomic analysis revealed the presence of 21 genes associated with antimicrobial resistance (AMR) in <jats:italic>Salmonella<\/jats:italic> isolates. More than 60% of the isolates carried some gene associated with resistance to aminoglycosides and tetracyclines. Only one gene associated with beta-lactam resistance was found, in seven isolates. Two different mutations were identified, <jats:italic>parC_T57S<\/jats:italic> and acrB_R717Q, which confer resistance to quinolones and azithromycin, respectively. The accuracy of predicting antimicrobial resistance phenotypes based on AMR genotypes was 83.7%. The genomic approach does not replace the phenotypic assay but offers valuable information for the survey of circulating antimicrobial resistance. This work represents one of the first studies evaluating phenotypic and genotypic AMR in <jats:italic>Salmonella<\/jats:italic> from dairy cattle in South America.<\/jats:p>","DOI":"10.3389\/fvets.2023.1055432","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T05:45:00Z","timestamp":1678340700000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Phenotypic and genotypic survey of antibiotic resistance in Salmonella enterica isolates from dairy farms in Uruguay"],"prefix":"10.3389","volume":"10","author":[{"given":"Mar\u00eda 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