{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T19:12:58Z","timestamp":1785784378951,"version":"3.56.0"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T00:00:00Z","timestamp":1692057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>The primary purpose of this research is to determine the effect of Amino-Zn (AZn), <jats:italic>Yucca schidigera<\/jats:italic> extract (YE), and \u03b2-mannanase enzyme supplementation on growth performance, nutrient digestibility, fecal gas emission, and immune response in pigs. A total of 180 crossbred pigs (6.57\u2009\u00b1\u20091\u2009kg) were randomly assigned to one of three dietary treatments: CON-corn soybean meal (basal diet); TRT1-CON +1,000\u2009ppm AZn\u2009+\u20090.07% yucca extract (YE)\u2009+\u20090.05% \u03b2-mannanase; and TRT2-CON +2,000\u2009ppm AZn\u2009+\u20090.07% YE+ 0.05% \u03b2-mannanase for 22\u2009weeks. Each treatment had 12 replicates with 5 pigs per pen. Pigs fed a diet supplemented with AZn, YE, and \u03b2-mannanase linearly increased (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05) BW and average daily gain at weeks 6, 12, 17, and 18. In contrast, the gain-to-feed ratio showed a linear increase (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05) from weeks 6 to 17 and the overall trial period. Moreover, the inclusion of experimental diets linearly decreased (<jats:italic>p<\/jats:italic>\u2009&amp;gt;\u20090.05) noxious gas emissions such as ammonia, hydrogen sulfide, acetic acid, carbon dioxide, and methyl mercaptans. The dietary inclusion of AZn, YE, and \u03b2-mannanase significantly increased the serological immune responses to <jats:italic>Mycoplasma hyopneumoniae<\/jats:italic> (MH) and foot-and-mouth disease virus (FMDV-O type) at the end of week 6 and porcine circovirus-2 (PCV-2) at week 19. Based on this result, we infer that the combination of AZn, YE, and \u03b2-mannanase supplement would serve as a novel in-feed additive to enhance growth performance and act as a boosting agent and immune stimulatory to increase the efficacy of swine vaccinations.<\/jats:p>","DOI":"10.3389\/fvets.2023.1095877","type":"journal-article","created":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T04:22:38Z","timestamp":1692246158000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Enhancement of protective vaccine-induced antibody titer to swine diseases and growth performance by Amino-Zn, yucca extract, and \u03b2-mannanase feed additive in wean-finishing pigs"],"prefix":"10.3389","volume":"10","author":[{"given":"Vetriselvi","family":"Sampath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungbo","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Ryol","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam-Hun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Ho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,8,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/jpn.13544","article-title":"Effect of low-nutrient-density diet with probiotic mixture (Bacillus subtilis ms1, B. licheniformis SF5-1, and Saccharomyces 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