{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:22:09Z","timestamp":1780399329454,"version":"3.54.1"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T00:00:00Z","timestamp":1678060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>Following the discovery of <jats:italic>Eimeria kongi<\/jats:italic>, we investigated the pathogenicity, immunogenicity, endogenous development and drug sensitivity of this coccidian. Coccidia-free rabbits were inoculated with 1 \u00d7 10<jats:sup>2<\/jats:sup> to 5 \u00d7 10<jats:sup>4<\/jats:sup> sporulated oocysts of <jats:italic>E. kongi<\/jats:italic> before challenge 14 days post inoculation. <jats:italic>E. kongi<\/jats:italic> was moderately pathogenic and induced good immunity against re-infection. All inoculated doses results in reduced food intake and body weight gain, and an inoculation oocyst dose of 1 \u00d7 10<jats:sup>3<\/jats:sup> or higher caused various degrees of diarrhea. Except for one death of the highest dose group, all rabbits recovered 12 days post inoculation. An inoculation dose of 1 \u00d7 10<jats:sup>3<\/jats:sup> or 1 \u00d7 10<jats:sup>4<\/jats:sup> oocysts conferred the most effective protection from re-infection, which reduced oocyst output by approximately 99% and maintained body weight gain. Four generations of schizogony were observed, and the endogenous development mainly occurred in the jejunum and ileum of rabbits. <jats:italic>E. kongi<\/jats:italic> was most sensitive to sulfachloropyrazine sodium, followed by decoquinate; it is resistant to diclazuril. Both decoquinate and sulfachloropyrazine sodium may be effective in the control of <jats:italic>E. kongi<\/jats:italic> infection.<\/jats:p>","DOI":"10.3389\/fvets.2023.1134193","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T06:25:56Z","timestamp":1678083956000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Study on the pathogenicity, immunogenicity, endogenous development and drug sensitivity of Eimeria kongi"],"prefix":"10.3389","volume":"10","author":[{"given":"Sufang","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubo","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihui","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Suo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.vetpar.2018.04.010","article-title":"A review of Eimeria infections in horses and other equids","volume":"256","author":"Dubey","year":"2018","journal-title":"Vet Parasitol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.cvfa.2019.12.006","article-title":"Ruminant coccidiosis","volume":"36","author":"Dvm","year":"2020","journal-title":"Vet Clin North Am Food Anim Pract."},{"key":"B3","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1080\/03079457409353827","article-title":"The specific characters of the Eimeria, with special reference to the coccidia of the fowl","volume":"3","author":"Joyner","year":"1974","journal-title":"Avian Pathol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1111\/j.1439-0450.2005.00894.x","article-title":"Eimeriosis in cattle: current understanding","volume":"52","author":"Daugschies","year":"2005","journal-title":"J Vet Med B Infect Dis Vet Public Health."},{"key":"B5","article-title":"\u201cEimeria species and strains of rabbits,\u201d","author":"Coudert","year":"1995"},{"key":"B6","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.vetpar.2012.11.013","article-title":"et al. 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