{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T00:10:41Z","timestamp":1793837441916,"version":"4.6.1"},"reference-count":154,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T00:00:00Z","timestamp":1687132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32273082"],"award-info":[{"award-number":["32273082"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A20262"],"award-info":[{"award-number":["U21A20262"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>Mastitis is considered the costliest disease on dairy farms and also adversely affects animal welfare. As treatment (and to a lesser extent prevention) of mastitis rely heavily on antibiotics, there are increasing concerns in veterinary and human medicine regarding development of antimicrobial resistance. Furthermore, with genes conferring resistance being capable of transfer to heterologous strains, reducing resistance in strains of animal origin should have positive impacts on humans. This article briefly reviews potential roles of non-steroidal anti-inflammatory drugs (NSAIDs), herbal medicines, antimicrobial peptides (AMPs), bacteriophages and their lytic enzymes, vaccination and other emerging therapies for prevention and treatment of mastitis in dairy cows. Although many of these approaches currently lack proven therapeutic efficacy, at least some may gradually replace antibiotics, especially as drug-resistant bacteria are proliferating globally.<\/jats:p>","DOI":"10.3389\/fvets.2023.1160350","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T03:59:10Z","timestamp":1687147150000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":88,"title":["Alternatives to antibiotics for treatment of mastitis in dairy cows"],"prefix":"10.3389","volume":"10","author":[{"given":"Xiaoping","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingchun","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Kastelic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,6,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1080\/07315724.2018.1491016","article-title":"Cow\u2019s milk consumption and health: a health professional\u2019s guide","volume":"38","author":"Marangoni","year":"2019","journal-title":"J Am Coll Nutr"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"637152","DOI":"10.3389\/fimmu.2021.637152","article-title":"Bovine coronavirus immune milk against COVID-19","volume":"12","author":"Arenas","year":"2021","journal-title":"Front Immunol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1002\/jmv.1890380209","article-title":"Passive immunizations of suckling mice and infants with bovine colostrum containing antibodies to human rotavirus","volume":"38","author":"Ebina","year":"1992","journal-title":"J Med Virol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1533\/9781845697198.2.269","article-title":"10 - Bovine milk immunoglobulins against microbial human diseases","volume-title":"Dairy-Derived Ingredients","author":"Korhonen","year":"2009"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2416","DOI":"10.3168\/jds.2018-15135","article-title":"Antimicrobial resistance profiles of 5 common bovine mastitis pathogens in large Chinese dairy herds","volume":"102","author":"Cheng","year":"2019","journal-title":"J Dairy Sci"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"10381","DOI":"10.3168\/jds.2017-13023","article-title":"A 100-year review: mastitis detection, management, and prevention","volume":"100","author":"Ruegg","year":"2017","journal-title":"J Dairy Sci"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.3168\/jds.S0022-0302(58)91071-3","article-title":"Bovine mastitis: a review","volume":"41","author":"Plastridge","year":"1958","journal-title":"J Dairy Sci"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/s0749-0720(02)00071-3","article-title":"Establishing treatment protocols for clinical mastitis","volume":"19","author":"Roberson","year":"2003","journal-title":"Vet Clin North Am Food Anim Pract"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1017\/S1466252319000094","article-title":"Causes, types, etiological agents, prevalence, diagnosis, treatment, prevention, effects on human health and future aspects of bovine mastitis","volume":"21","author":"Ashraf","year":"2020","journal-title":"Anim Health Res Rev"},{"key":"ref10","first-page":"483","article-title":"War against mastitis: current concepts on controlling bovine mastitis pathogens","volume-title":"Science against microbial pathogens: Communicating current research and technological advances","author":"Bogni","year":"2011"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.vetmic.2014.06.011","article-title":"Further evidence for the existence of environmental and host-associated species of coagulase-negative staphylococci in dairy cattle","volume":"172","author":"De Visscher","year":"2014","journal-title":"Vet Microbiol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1093\/clinids\/15.1.77","article-title":"Antimicrobial resistance in Streptococcus pneumoniae: an overview","volume":"15","author":"Appelbaum","year":"1992","journal-title":"Clin Infect Dis"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"S122","DOI":"10.1038\/nm1145","article-title":"Antibacterial resistance worldwide: causes, challenges and responses","volume":"10","author":"Levy","year":"2004","journal-title":"Nat Med"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1056\/nejm199708143370701","article-title":"The effect of changes in the consumption of macrolide antibiotics on erythromycin resistance in group a streptococci in Finland","volume":"337","author":"Sepp\u00e4l\u00e4","year":"1997","journal-title":"N Engl J Med"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"4727","DOI":"10.3168\/jds.2020-19315","article-title":"Quantification of antimicrobial usage in adult cows and preweaned calves on 40 large Wisconsin dairy farms using dose-based and mass-based metrics","volume":"104","author":"de Campos","year":"2021","journal-title":"J Dairy Sci"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3168\/jds.S0022-0302(79)83213-0","article-title":"Economic losses from and the national research program on mastitis in the United States","volume":"62","author":"Blosser","year":"1979","journal-title":"J Dairy Sci"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"4476","DOI":"10.3168\/jds.2010-4123","article-title":"The cost and management of different types of clinical mastitis in dairy cows estimated by dynamic programming","volume":"94","author":"Cha","year":"2011","journal-title":"J Dairy Sci"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1017\/S0022029907002932","article-title":"Costs of mastitis: facts and perception","volume":"75","author":"Huijps","year":"2008","journal-title":"J Dairy Res"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.prevetmed.2015.11.006","article-title":"The cost of clinical mastitis in the first 30 days of lactation: an economic modeling tool","volume":"122","author":"Rollin","year":"2015","journal-title":"Prev Vet Med"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/rda.13032","article-title":"Mastitis treatment\u2014 reduction in antibiotic usage in dairy cows","volume":"52","author":"Kr\u00f6mker","year":"2017","journal-title":"Reprod Dom Anim"},{"key":"ref21","volume-title":"Global Action Plan On Antimicrobial Resistance","year":"2015"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s11259-018-9730-4","article-title":"Antibiotic susceptibility of Staphylococcus aureus isolated from subclinical bovine mastitis cases and in vitro efficacy of bacteriophage","volume":"42","author":"Varela-Ortiz","year":"2018","journal-title":"Vet Res Commun"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.3390\/antibiotics10111418","article-title":"Susceptibility to nisin, bactofencin, pediocin and reuterin of multidrug resistant Staphylococcus aureus, Streptococcus dysgalactiae and Streptococcus uberis causing bovine mastitis","volume":"10","author":"Bennett","year":"2021","journal-title":"Antibiotics (Basel)"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1007\/s10989-021-10243-7","article-title":"Linear and branched forms of short antimicrobial peptide-irk inhibit growth of multi drug resistant Staphylococcus aureus isolates from mastitic cow milk","volume":"27","author":"Gogoi","year":"2021","journal-title":"Int J Pept Res Ther"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1007\/s10989-021-10355-0","article-title":"Wasp venom peptide (polybia mp-1) shows antimicrobial activity against multi drug resistant bacteria isolated from mastitic cow milk","volume":"28","author":"Shah","year":"2022","journal-title":"Int J Pept Res Ther"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1186\/s12917-022-03501-3","article-title":"Isolation and evaluation of the efficacy of bacteriophages against multidrug-resistant (MDR), methicillin-resistant (MRSA) and biofilm-producing strains of Staphylococcus aureus recovered from bovine mastitis","volume":"18","author":"Mohammadian","year":"2022","journal-title":"BMC Vet Res"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.3390\/ani12131680","article-title":"Prevalence, antimicrobial resistance, and characterization of Staphylococcus aureus isolated from subclinical bovine mastitis in East Coast Malaysia","volume":"12","author":"Saeed","year":"2022","journal-title":"Animals (Basel)."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.5433\/1679-0359.2022v43n3p1355","article-title":"Queiroz RBde. Antimicrobial resistance profile of Staphylococcus spp. isolates in cattle herds from Western Amazon","volume":"43","author":"Dias","year":"2022","journal-title":"Semin Cienc Agrar"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"e178109","DOI":"10.11606\/issn.1678-4456.bjvras.2021.178109","article-title":"Antimicrobial susceptibility profile of Streptococcus agalactiae strains isolated from bovine mastitis","volume":"58","author":"da Costa","year":"2021","journal-title":"Braz J Vet Res Anim Sci"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"644","DOI":"10.3390\/antibiotics10060644","article-title":"Genotyping and antimicrobial susceptibility profiling of Streptococcus uberis isolated from a clinical bovine mastitis outbreak in a dairy farm","volume":"10","author":"Monistero","year":"2021","journal-title":"Antibiotics (Basel)"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"520","DOI":"10.22456\/1679-9216.101045","article-title":"Bovine mastitis caused by multidrug-resistant Nocardia farcinica","volume":"48","author":"Pereira de Oliveira","year":"2020","journal-title":"Acta Sci Vet"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"6317","DOI":"10.1016\/j.sjbs.2021.06.099","article-title":"Virulence determinants and antimicrobial resistance of E. coli isolated from bovine clinical mastitis in some selected dairy farms of Bangladesh. Saudi","volume":"28","author":"Bag","year":"2021","journal-title":"J Biol Sci"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"402","DOI":"10.54203\/scil.2021.wvj52","article-title":"Antibiotic resistance profile of Escherichia coli isolated from bovine subclinical mastitis of dairy farms in Algeria from 2017 to 2019","volume":"11","author":"Ghallache","year":"2021","journal-title":"World\u2019s Vet J"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"690377","DOI":"10.3389\/fcimb.2021.690377","article-title":"Bacteriophage cocktails protect dairy cows against mastitis caused by drug resistant Escherichia coli infection","volume":"11","author":"Guo","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"2471","DOI":"10.1007\/s10989-021-10266-0","article-title":"Synthetic antimicrobial peptide polybia mp-1 (mastoparan) inhibits growth of antibiotic resistant Pseudomonas aeruginosa isolates from mastitic cow milk","volume":"27","author":"Shah","year":"2021","journal-title":"Int J Pept Res Ther"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.vetmic.2017.11.021","article-title":"Monitoring of antimicrobial susceptibility of udder pathogens recovered from cases of clinical mastitis in dairy cows across Europe: vet path results","volume":"213","author":"de Jong","year":"2018","journal-title":"Vet Microbiol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"4441","DOI":"10.3168\/jds.2010-4046","article-title":"The selective treatment of clinical mastitis based on on-farm culture results: I. effects on antibiotic use, milk withholding time, and short-term clinical and bacteriological outcomes","volume":"94","author":"Lago","year":"2011","journal-title":"J Dairy Sci"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"453","DOI":"10.3168\/jds.S0022-0302(94)76973-3","article-title":"Efficacy of two therapy regimens for treatment of experimentally induced Escherichia coli mastitis in cows","volume":"77","author":"Py\u00f6r\u00e4l\u00e4","year":"1994","journal-title":"J Dairy Sci"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1161\/ATVBAHA.110.207449","article-title":"Prostaglandins and inflammation","volume":"31","author":"Ricciotti","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/rheumatology\/35.suppl_1.1","article-title":"Introduction: mechanism of action of NSAIDs","volume":"35","author":"Vane","year":"1996","journal-title":"Br J Rheumatol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.3390\/ani10101832","article-title":"Outcomes from experimental testing of nonsteroidal anti-inflammatory drug (NSAID) administration during the transition period of dairy cows","volume":"10","author":"Trimboli","year":"2020","journal-title":"Animals (Basel)."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"697","DOI":"10.2460\/javma.232.5.697","article-title":"Extralabel use of nonsteroidal anti-inflammatory drugs in cattle","volume":"232","author":"Smith","year":"2008","journal-title":"J Am Vet Med Assoc"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"282","DOI":"10.3390\/ani11020282","article-title":"Non-steroidal anti-inflammatory drugs: pharmacokinetics and mitigation of procedural-pain in cattle","volume":"11","author":"Wagner","year":"2021","journal-title":"Animals (Basel)."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1071\/an16028","article-title":"Effects of a single injection of flunixin meglumine or carprofen postpartum on haematological parameters, productive performance and fertility of dairy cattle","volume":"58","author":"Giammarco","year":"2018","journal-title":"Anim Prod Sci"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"834","DOI":"10.3390\/antiox10060834","article-title":"Flunixin meglumine reduces milk isoprostane concentrations in Holstein dairy cattle suffering from acute coliform mastitis","volume":"10","author":"Walker","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"4939","DOI":"10.3168\/jds.2011-5064","article-title":"The effects of experimentally induced Escherichia coli mastitis and flunixin meglumine administration on activity measures, feed intake, and milk parameters","volume":"95","author":"Yeiser","year":"2012","journal-title":"J Dairy Sci"},{"key":"ref47","first-page":"1196","article-title":"Evaluation of the effects of treating dairy cows with meloxicam at calving on retained fetal membranes risk","volume":"55","author":"Newby","year":"2014","journal-title":"Can Vet J"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"e0209236","DOI":"10.1371\/journal.pone.0209236","article-title":"Evaluating the impact of meloxicam oral suspension administered at parturition on subsequent production, health, and culling in dairy cows: a randomized clinical field trial","volume":"13","author":"Shock","year":"2018","journal-title":"PLoS One"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.3168\/jds.2012-5855","article-title":"The effect of meloxicam on pain sensitivity, rumination time, and clinical signs in dairy cows with endotoxin-induced clinical mastitis","volume":"96","author":"Fitzpatrick","year":"2013","journal-title":"J Dairy Sci"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"3387","DOI":"10.3168\/jds.2017-12869","article-title":"Addition of meloxicam to the treatment of bovine clinical mastitis results in a net economic benefit to the dairy farmer","volume":"101","author":"van Soest","year":"2018","journal-title":"J Dairy Sci"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"182","DOI":"10.12968\/live.2017.22.4.182","article-title":"The importance of non-steroidal anti-inflammatory drugs (NSAIDs) in mastitis therapeutics","volume":"22","author":"Breen","year":"2017","journal-title":"Livestock"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"2624","DOI":"10.3168\/jds.2019-17504","article-title":"Efficacy of ketoprofen for treatment of spontaneous, culture-negative, mild cases of clinical mastitis: a randomized, controlled superiority trial","volume":"103","author":"Latosinski","year":"2020","journal-title":"J Dairy Sci"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"11321","DOI":"10.3168\/jds.2018-15034","article-title":"Ketoprofen affects the mammary immune response in dairy cows in vivo and in vitro","volume":"101","author":"Dan","year":"2018","journal-title":"J Dairy Sci"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1017\/S0022029917000863","article-title":"Effects of chronic mastitis and its treatment with ketoprofen on the milk ejection curve","volume":"85","author":"Zecconi","year":"2018","journal-title":"J Dairy Res"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/0034-5288(94)90197-x","article-title":"Anti-inflammatory ketoprofen in the treatment of field cases of bovine mastitis","volume":"56","author":"Shpigel","year":"1994","journal-title":"Res Vet Sci"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1111\/jvp.12057","article-title":"Treatment for bovine Escherichia coli mastitis\u2014an evidence-based approach","volume":"36","author":"Suojala","year":"2013","journal-title":"J Vet Pharmacol Ther"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1111\/j.1365-2885.1991.tb00830.x","article-title":"Pharmacodynamics and pharmacokinetics of carprofen, a non-steroidal anti-inflammatory drug, in healthy cows and cows with Escherichia coli endotoxin-induced mastitis","volume":"14","author":"Lohuis","year":"1991","journal-title":"J Vet Pharmacol Ther"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"2361","DOI":"10.3168\/jds.S0022-0302(05)72914-3","article-title":"Effect of carprofen treatment following experimentally induced Escherichia coli mastitis in primiparous cows","volume":"88","author":"Vangroenweghe","year":"2005","journal-title":"J Dairy Sci"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"105691","DOI":"10.1016\/j.micpath.2022.105691","article-title":"Drug repurposing strategy: an emerging approach to identify potential therapeutics for treatment of bovine mastitis","volume":"171","author":"Muzammil","year":"2022","journal-title":"Microb Pathog"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"189","DOI":"10.3390\/antibiotics10020189","article-title":"Veterinary treatment approach and antibiotic usage for clinical mastitis in Danish dairy herds","volume":"10","author":"Wilm","year":"2021","journal-title":"Antibiotics (Basel)"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.rvsc.2020.04.025","article-title":"Use of plant extracts and essential oils in the control of bovine mastitis","volume":"131","author":"Lopes","year":"2020","journal-title":"Res Vet Sci"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"382","DOI":"10.5897\/AJMR10.776","article-title":"The effect of red ginger (zingiber officinale roscoe) extract on the growth of mastitis causing bacterial isolates","volume":"5","author":"Poeloengan","year":"2011","journal-title":"Afr J Microbiol Res"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"e6461","DOI":"10.7717\/peerj.6461","article-title":"Effects of stigmata maydis on the methicillin resistant Staphylococus aureus biofilm formation","volume":"7","author":"Shang","year":"2019","journal-title":"Peer J"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1590\/S0102-09352011000500026","article-title":"Activity of essential oils from spices against Staphylococcus spp. isolated from bovine mastitis","volume":"63","author":"Dal Pozzo","year":"2011","journal-title":"Arq Bras Med Vet Zootec"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1080\/10495398.2018.1451752","article-title":"In vitro antibacterial evaluation of Terminalia chebula as an alternative of antibiotics against bovine subclinical mastitis","volume":"30","author":"Kher","year":"2019","journal-title":"Anim Biotechnol"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.jep.2017.04.025","article-title":"Taraxacum mongolicum extract induced endoplasmic reticulum stress associated-apoptosis in triple-negative breast cancer cells","volume":"206","author":"Li","year":"2017","journal-title":"J Ethnopharmacol"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"113595","DOI":"10.1016\/j.jep.2020.113595","article-title":"Taraxacum mongolicum protects against Staphylococcus aureus-infected mastitis by exerting anti-inflammatory role via TLR2-NF-\u03baB\/MAPKs pathways in mice","volume":"268","author":"Ge","year":"2021","journal-title":"J Ethnopharmacol"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"7977433","DOI":"10.1155\/2022\/7977433","article-title":"Vitexin mitigates Staphylococcus aureus-induced mastitis via regulation of ROS\/ER stress\/NF-\u03baB\/MAPK pathway","volume":"2022","author":"Chen","year":"2022","journal-title":"Oxidative Med Cell Longev"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.intimp.2015.07.012","article-title":"Baicalein attenuates inflammatory responses by suppressing TLR4 mediated NF-\u03baB and MAPK signaling pathways in LPS-induced mastitis in mice","volume":"28","author":"He","year":"2015","journal-title":"Int Immunopharmacol"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.intimp.2016.08.032","article-title":"Baicalin attenuates lipopolysaccharide induced inflammation and apoptosis of cow mammary epithelial cells by regulating NF-\u03baB and HSP72","volume":"40","author":"Yang","year":"2016","journal-title":"Int Immunopharmacol"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.intimp.2016.11.036","article-title":"Mangiferin inhibits mastitis induced by LPS via suppressing NF-\u0138B and NLRP3 signaling pathways","volume":"43","author":"Qu","year":"2017","journal-title":"Int Immunopharmacol"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/aps.2016.123","article-title":"Polydatin ameliorates Staphylococcus aureus-induced mastitis in mice via inhibiting TLR2-mediated activation of the p 38 MAPK\/NF-\u03baB pathway","volume":"38","author":"Jiang","year":"2017","journal-title":"Acta Pharmacol Sin"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1007\/s10753-014-9885-2","article-title":"Geniposide plays an anti-inflammatory role via regulating TLR4 and downstream signaling pathways in lipopolysaccharide-induced mastitis in mice","volume":"37","author":"Song","year":"2014","journal-title":"Inflammation"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"56","DOI":"10.26873\/SVR-790-2019","article-title":"Effect of supplementation of aromatic plants oils on immunity, udder health and milk production of friesian cows","author":"Salem","year":"2019","journal-title":"SVR [Internet]"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"115448","DOI":"10.1016\/j.anifeedsci.2022.115448","article-title":"Fermented Chinese herbal preparation: impacts on milk production, nutrient digestibility, blood biochemistry, and antioxidant capacity of late-lactation cows under heat stress","volume":"292","author":"Zhao","year":"2022","journal-title":"Anim Feed Sci Technol"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.3390\/ani11041039","article-title":"The use of Chinese skullcap (Scutellaria baicalensis) and its extracts for sustainable animal production","volume":"11","author":"Yin","year":"2021","journal-title":"Animals (Basel)"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"586","DOI":"10.3390\/molecules14020586","article-title":"Antimicrobial activity of five herbal extracts against multi drug resistant (MDR) strains of bacteria and fungus of clinical origin","volume":"14","author":"Khan","year":"2009","journal-title":"Molecules"},{"key":"ref78","first-page":"228","article-title":"Antimicrobial activity of lemongrass (Cymbopogon citratus) oil against microbes of environmental, clinical and food origin","volume":"1","author":"Singh","year":"2011","journal-title":"Int Res J Pharm Pharmacol"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"434","DOI":"10.4172\/2153-2435.1000434","article-title":"Emergence of herbal antimicrobial drug resistance in clinical bacterial isolates","volume":"6","author":"Vadhana","year":"2015","journal-title":"Pharm Anal Acta"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"106314","DOI":"10.1016\/j.phrs.2022.106314","article-title":"The path towards FDA approval: a challenging journey for traditional Chinese medicine","volume":"182","author":"You","year":"2022","journal-title":"Pharmacol Res"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.cub.2015.11.017","article-title":"Antimicrobial peptides","volume":"26","author":"Zhang","year":"2016","journal-title":"Curr Biol"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"101229","DOI":"10.1016\/j.nantod.2021.101229","article-title":"Design, optimization, and nanotechnology of antimicrobial peptides: from exploration to applications","volume":"39","author":"Tan","year":"2021","journal-title":"Nano Today"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"3185","DOI":"10.3168\/jds.S0022-0302(92)78083-7","article-title":"Evaluation of a nisin-based germicidal formulation on teat skin of live cows","volume":"75","author":"Sears","year":"1992","journal-title":"J Dairy Sci"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"3980","DOI":"10.3168\/jds.2007-0153","article-title":"Efficacy of nisin in treatment of clinical mastitis in lactating dairy cows","volume":"90","author":"Cao","year":"2007","journal-title":"J Dairy Sci"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"3131","DOI":"10.1128\/AAC.00629-07","article-title":"Therapeutic effect of nisin Z on subclinical mastitis in lactating cows","volume":"51","author":"Wu","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"11956","DOI":"10.1016\/S0021-9258(17)32666-2","article-title":"Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides","volume":"269","author":"Simmaco","year":"1994","journal-title":"J Biol Chem"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1002\/psc.1148","article-title":"Esculentin 1-21: a linear antimicrobial peptide from frog skin with inhibitory effect on bovine mastitis-causing bacteria","volume":"15","author":"Islas-Rodr\u00ecguez","year":"2009","journal-title":"J Pept Sci"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"775","DOI":"10.3168\/jds.2009-2729","article-title":"The spatial expression pattern of antimicrobial peptides across the healthy bovine udder","volume":"93","author":"Tetens","year":"2010","journal-title":"J Dairy Sci"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"990","DOI":"10.14202\/vetworld.2017.990-998","article-title":"\u03b2-defensins: an innate defense for bovine mastitis","volume":"10","author":"Gurao","year":"2017","journal-title":"Vet World"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.rvsc.2008.12.005","article-title":"Expression of tracheal antimicrobial peptide in bovine mammary epithelial cells","volume":"87","author":"L\u00f3pez-Meza","year":"2009","journal-title":"Res Vet Sci"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"700930","DOI":"10.3389\/fvets.2021.700930","article-title":"Directed expression of tracheal antimicrobial peptide as a treatment for bovine-associated Staphylococcus aureus-induced mastitis in mice","volume":"8","author":"Zhang","year":"2021","journal-title":"Front Vet Sci"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1038\/nature04051","article-title":"Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus","volume":"437","author":"Mygind","year":"2005","journal-title":"Nature"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"6255","DOI":"10.1007\/s00253-015-6394-7","article-title":"In vitro and in vivo characterization of a new recombinant antimicrobial peptide, MP1102, against methicillin-resistant Staphylococcus aureus","volume":"99","author":"Zhang","year":"2015","journal-title":"Appl Microbiol Biotechnol"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"44459","DOI":"10.1021\/acsami.0c12226","article-title":"Targeted and intracellular antibacterial activity against S. agalactiae of the chimeric peptides based on pheromone and cell-penetrating peptides","volume":"12","author":"Li","year":"2020","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.4155\/fmc-2019-0167","article-title":"Antimicrobial peptides with protease stability: progress and perspective","volume":"11","author":"Shao","year":"2019","journal-title":"Future Med Chem"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3390\/antibiotics4010018","article-title":"Mechanisms of antimicrobial peptide resistance in gram-negative bacteria","volume":"4","author":"Band","year":"2015","journal-title":"Antibiotics (Basel)."},{"key":"ref97","doi-asserted-by":"publisher","first-page":"e00209","DOI":"10.1128\/mBio.00209-20","article-title":"Targeting hidden pathogens: cell-penetrating enzybiotics eradicate intracellular drug-resistant Staphylococcus aureus","volume":"11","author":"R\u00f6hrig","year":"2020","journal-title":"MBio"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.chom.2019.01.014","article-title":"Phage therapy: a renewed approach to combat antibiotic-resistant bacteria","volume":"25","author":"Kortright","year":"2019","journal-title":"Cell Host Microbe"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"fuaa041","DOI":"10.1093\/femsre\/fuaa041","article-title":"Bacteriophages as drivers of bacterial virulence and their potential for biotechnological exploitation","volume":"45","author":"Schroven","year":"2021","journal-title":"FEMS Microbiol Rev"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s11259-018-9736-y","article-title":"Isolation and characterization of two lytic bacteriophages against Staphylococcus aureus from India: newer therapeutic agents against bovine mastitis","volume":"42","author":"Ganaie","year":"2018","journal-title":"Vet Res Commun"},{"key":"ref101","doi-asserted-by":"publisher","first-page":"620","DOI":"10.3390\/v14030620","article-title":"Efficacy assessment of phage therapy in treating Staphylococcus aureus-induced mastitis in mice","volume":"14","author":"Teng","year":"2022","journal-title":"Viruses"},{"key":"ref102","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3390\/biology7010008","article-title":"Bacteriophage \u03a6SA012 has a broad host range against Staphylococcus aureus and effective lytic capacity in a mouse mastitis model","volume":"7","author":"Iwano","year":"2018","journal-title":"Biology (Basel)"},{"key":"ref103","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1007\/s00705-013-1667-x","article-title":"Characterization and genome sequencing of a novel bacteriophage infecting Streptococcus agalactiae with high similarity to a phage from Streptococcus pyogenes","volume":"158","author":"Bai","year":"2013","journal-title":"Arch Virol"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"6845","DOI":"10.1038\/s41598-018-24896-w","article-title":"Genomic analysis and immune response in a murine mastitis model of vB_EcoM-UFV13, a potential biocontrol agent for use in dairy cows","volume":"8","author":"da Silva","year":"2018","journal-title":"Sci Rep"},{"key":"ref105","doi-asserted-by":"publisher","first-page":"689770","DOI":"10.3389\/fcimb.2021.689770","article-title":"Phage vB_PaeS-PAJD-1 rescues murine mastitis infected with multidrug-resistant Pseudomonas aeruginosa","volume":"11","author":"Wang","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"ref106","doi-asserted-by":"publisher","first-page":"943279","DOI":"10.3389\/fmicb.2022.943279","article-title":"Biological and genomic characteristics of two bacteriophages isolated from sewage, using one multidrug-resistant and one non-multidrug-resistant strain of Klebsiella pneumoniae","volume":"13","author":"Liang","year":"2022","journal-title":"Front Microbiol"},{"key":"ref107","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s12917-020-02738-0","article-title":"Bacteriophages isolated from dairy farm mitigated Klebsiella pneumoniae-induced inflammation in bovine mammary epithelial cells cultured in vitro","volume":"17","author":"Shi","year":"2021","journal-title":"BMC Vet Res"},{"key":"ref108","doi-asserted-by":"publisher","first-page":"3474","DOI":"10.3168\/jds.2020-19094","article-title":"Bacteriophage has beneficial effects in a murine model of Klebsiella pneumoniae mastitis","volume":"104","author":"Zhao","year":"2021","journal-title":"J Dairy Sci"},{"key":"ref109","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.tim.2018.10.008","article-title":"Phage therapy: going temperate?","volume":"27","author":"Monteiro","year":"2019","journal-title":"Trends Microbiol"},{"key":"ref110","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-030-26736-0_3","article-title":"Bacterial resistance to phage and its impact on clinical therapy","volume-title":"Phage Therapy: A Practical Approach","author":"McCallin","year":"2019"},{"key":"ref111","doi-asserted-by":"publisher","first-page":"94","DOI":"10.3390\/microorganisms7040094","article-title":"Efficiency of single phage suspensions and phage cocktail in the inactivation of Escherichia coli and Salmonella Typhimurium: an in vitro preliminary study","volume":"7","author":"Costa","year":"2019","journal-title":"Microorganisms."},{"key":"ref112","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1016\/j.resmic.2011.06.010","article-title":"Use of newly isolated phages for control of Pseudomonas aeruginosa PAO1 and ATCC 10145 biofilms","volume":"162","author":"Pires","year":"2011","journal-title":"Res Microbiol"},{"key":"ref113","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1089\/sur.2018.184","article-title":"Bacteriophages: a therapy concept against multi-drug-resistant bacteria","volume":"19","author":"Rohde","year":"2018","journal-title":"Surg Infect"},{"key":"ref114","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1093\/femsre\/fuaa017","article-title":"Current challenges and future opportunities of phage therapy","volume":"44","author":"Pires","year":"2020","journal-title":"FEMS Microbiol Rev"},{"key":"ref115","doi-asserted-by":"publisher","first-page":"3019","DOI":"10.3168\/jds.2008-1744","article-title":"Prevalence of bacteriophages infecting Staphylococcus aureus in dairy samples and their potential as biocontrol agents","volume":"92","author":"Garc\u00eda","year":"2009","journal-title":"J Dairy Sci"},{"key":"ref116","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3390\/antibiotics7010017","article-title":"Potential for bacteriophage endolysins to supplement or replace antibiotics in food production and clinical care","volume":"7","author":"Love","year":"2018","journal-title":"Antibiotics (Basel)"},{"key":"ref117","doi-asserted-by":"publisher","first-page":"621","DOI":"10.3390\/antibiotics9090621","article-title":"Characterization of the bacteriophage-derived endolysins PlySs2 and PlySs9 with in vitro lytic activity against bovine mastitis Streptococcus uberis","volume":"9","author":"Vander Elst","year":"2020","journal-title":"Antibiotics (Basel)."},{"key":"ref118","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3389\/fmicb.2020.00007","article-title":"Phage lytic protein Lys RODI prevents staphylococcal mastitis in mice","volume":"11","author":"Guti\u00e9rrez","year":"2020","journal-title":"Front Microbiol"},{"key":"ref119","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1007\/s00134-017-4878-x","article-title":"Antimicrobial resistance in the next 30 years, humankind, bugs and drugs: a visionary approach","volume":"43","author":"Bassetti","year":"2017","journal-title":"Intensive Care Med"},{"key":"ref120","doi-asserted-by":"publisher","first-page":"e00012","DOI":"10.1128\/MMBR.00012-19","article-title":"Pharmacologically aware phage therapy: pharmacodynamic and pharmacokinetic obstacles to phage antibacterial action in animal and human bodies","volume":"83","author":"D\u0105browska","year":"2019","journal-title":"Microbiol Mol Biol Rev"},{"key":"ref121","doi-asserted-by":"publisher","first-page":"376","DOI":"10.3389\/fcimb.2018.00376","article-title":"Bacteriophage therapy: clinical trials and regulatory hurdles","volume":"8","author":"Furfaro","year":"2018","journal-title":"Front Cell Infect Microbiol"},{"key":"ref122","doi-asserted-by":"publisher","first-page":"769","DOI":"10.2217\/fmb.13.47","article-title":"Phage cocktails and the future of phage therapy","volume":"8","author":"Chan","year":"2013","journal-title":"Future Microbiol"},{"key":"ref123","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3390\/v10020064","article-title":"The Magistral phage","volume":"10","author":"Pirnay","year":"2018","journal-title":"Viruses"},{"key":"ref124","doi-asserted-by":"publisher","first-page":"10427","DOI":"10.3168\/jds.2021-20434","article-title":"Invited review: a critical appraisal of mastitis vaccines for dairy cows","volume":"104","author":"Rainard","year":"2021","journal-title":"J Dairy Sci"},{"key":"ref125","first-page":"301","article-title":"Prevention of clinical coliform mastitis in dairy cows by a mutant Escherichia coli vaccine","volume":"53","author":"Gonz\u00e1lez","year":"1989","journal-title":"Can J Vet Res"},{"key":"ref126","doi-asserted-by":"publisher","first-page":"4282","DOI":"10.3168\/jds.2007-0160","article-title":"Comparison of J5 vaccinates and controls for incidence, etiologic agent, clinical severity, and survival in the herd following naturally occurring cases of clinical mastitis","volume":"90","author":"Wilson","year":"2007","journal-title":"J Dairy Sci"},{"key":"ref127","doi-asserted-by":"publisher","first-page":"e0166621","DOI":"10.1371\/journal.pone.0166621","article-title":"Characterization of a vraG mutant in a genetically stable Staphylococcus aureus small-colony variant and preliminary assessment for use as a live-attenuated vaccine against intrammamary infections","volume":"11","author":"C\u00f4t\u00e9-Gravel","year":"2016","journal-title":"PLoS One"},{"key":"ref128","unstructured":"VidlundJessica J.\n          2022"},{"key":"ref129","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.vetimm.2010.03.010","article-title":"Evaluation of some Staphylococcus aureus iron-regulated proteins as vaccine targets","volume":"15","author":"Ster","year":"2010","journal-title":"Vet Immunol Immunopathol"},{"key":"ref130","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.3390\/microorganisms9071497","article-title":"The role of Streptococcus spp. in bovine mastitis","volume":"9","author":"Kabelitz","year":"2021","journal-title":"Microorganisms"},{"key":"ref131","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1111\/tbed.12704","article-title":"An update on environmental mastitis: challenging perceptions","volume":"65","author":"Klaas","year":"2018","journal-title":"Transbound Emerg Dis"},{"key":"ref132","doi-asserted-by":"publisher","first-page":"10290","DOI":"10.3168\/jds.2018-14840","article-title":"Study of the efficacy of a Streptococcus uberis mastitis vaccine against an experimental intramammary infection with a heterologous strain in dairy cows","volume":"101","author":"Collado","year":"2018","journal-title":"J Dairy Sci"},{"key":"ref133","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1016\/s0264-410x(96)00307-6","article-title":"Further studies on the efficacy of a live vaccine against mastitis caused by Streptococcus uberis","volume":"15","author":"Finch","year":"1997","journal-title":"Vaccine"},{"key":"ref134","doi-asserted-by":"publisher","first-page":"105809","DOI":"10.1016\/j.micpath.2022.105809","article-title":"Research progress on the association between mastitis and gastrointestinal microbes in dairy cows and the effect of probiotics","volume":"173","author":"Luo","year":"2022","journal-title":"Microb Pathog"},{"key":"ref135","doi-asserted-by":"publisher","first-page":"e13764","DOI":"10.1111\/asj.13764","article-title":"Prevention of mastitis in multiparous dairy cows with a previous history of mastitis by oral feeding with probiotic Bacillus subtilis","volume":"93","author":"Urakawa","year":"2022","journal-title":"Anim Sci J"},{"key":"ref136","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s13568-020-0953-8","article-title":"Impact of yeast and lactic acid bacteria on mastitis and milk microbiota composition of dairy cows","volume":"10","author":"Gao","year":"2020","journal-title":"AMB Express"},{"key":"ref137","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1128\/AEM.03323-12","article-title":"Inhibition of Staphylococcus aureus invasion into bovine mammary epithelial cells by contact with live Lactobacillus casei","volume":"79","author":"Bouchard","year":"2013","journal-title":"Appl Environ Microbiol"},{"key":"ref138","doi-asserted-by":"publisher","first-page":"985","DOI":"10.3920\/BM2018.0010","article-title":"Lactobacillus casei BL23 modulates the innate immune response in Staphylococcus aureus-stimulated bovine mammary epithelial cells","volume":"9","author":"Souza","year":"2018","journal-title":"Benef Microbes"},{"key":"ref139","doi-asserted-by":"publisher","first-page":"584436","DOI":"10.3389\/fvets.2020.584436","article-title":"Efficacy of a Lactobacillus-based teat spray on udder health in lactating dairy cows","volume":"7","author":"Alawneh","year":"2020","journal-title":"Front Vet Sci."},{"key":"ref140","doi-asserted-by":"publisher","first-page":"e2281","DOI":"10.1002\/rmv.2281","article-title":"Mesenchymal stem cells and their derived exosomes to combat Covid-19","volume":"32","author":"Yousefi Dehbidi","year":"2022","journal-title":"Rev Med Virol"},{"key":"ref141","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s13567-019-0643-1","article-title":"Bovine fetal mesenchymal stem cells exert antiproliferative effect against mastitis causing pathogen Staphylococcus aureus","volume":"50","author":"Cahuascanco","year":"2019","journal-title":"Vet Res"},{"key":"ref142","doi-asserted-by":"publisher","first-page":"2843","DOI":"10.1038\/s41598-020-59724-7","article-title":"Safety and efficacy of a mesenchymal stem cell intramammary therapy in dairy cows with experimentally induced Staphylococcus aureus clinical mastitis","volume":"10","author":"Peralta","year":"2020","journal-title":"Sci Rep"},{"key":"ref143","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.theriogenology.2022.05.001","article-title":"Allogenic umbilical cord blood-mesenchymal stem cells are more effective than antibiotics in alleviating subclinical mastitis in dairy cows","volume":"187","author":"Ghai","year":"2022","journal-title":"Theriogenology"},{"key":"ref144","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.3390\/molecules26072047","article-title":"Liposomes as antibiotic delivery dystems: a promising nanotechnological strategy against antimicrobial resistance","volume":"26","author":"Ferreira","year":"2021","journal-title":"Molecules"},{"key":"ref145","doi-asserted-by":"publisher","first-page":"524","DOI":"10.3390\/pharmaceutics11100524","article-title":"Enhanced treatment effects of tilmicosin against Staphylococcus aureus cow mastitis by self-assembly sodium alginate-chitosan nanogel","volume":"11","author":"Zhou","year":"2019","journal-title":"Pharmaceutics"},{"key":"ref146","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1186\/s12917-021-02842-9","article-title":"Antimicrobial and antibiofilm potentials of cinnamon oil and silver nanoparticles against Streptococcus agalactiae isolated from bovine mastitis: new avenues for countering resistance","volume":"17","author":"Abd El-Aziz","year":"2021","journal-title":"BMC Vet Res"},{"key":"ref147","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1007\/s12010-021-03748-w","article-title":"Novel polyherbal nanocolloids to control bovine mastitis","volume":"194","author":"Ranjani","year":"2022","journal-title":"Appl Biochem Biotechnol"},{"key":"ref148","doi-asserted-by":"publisher","first-page":"108","DOI":"10.2174\/1574891x113089990012","article-title":"Antimicrobial photodynamic therapy to kill gram-negative bacteria","volume":"8","author":"Sperandio","year":"2013","journal-title":"Recent Pat Antiinfect Drug Discov"},{"key":"ref149","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1039\/b311900a","article-title":"Photodynamic therapy: a new antimicrobial approach to infectious disease?","volume":"3","author":"Hamblin","year":"2004","journal-title":"Photochem Photobiol Sci"},{"key":"ref150","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.pdpdt.2017.12.009","article-title":"Use of photodynamic therapy in the treatment of bovine subclinical mastitis","volume":"21","author":"Moreira","year":"2018","journal-title":"Photodiagn Photodyn Ther"},{"key":"ref151","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.1007\/s10103-022-03506-2","article-title":"Use of photodynamic therapy and photobiomodulation as alternatives for microbial control on clinical and subclinical mastitis in sheep","volume":"37","author":"Silva","year":"2022","journal-title":"Lasers Med Sci"},{"key":"ref152","doi-asserted-by":"publisher","first-page":"102318","DOI":"10.1016\/j.pdpdt.2021.102318","article-title":"Application of photodynamic therapy in immune-related diseases","volume":"34","author":"Yang","year":"2021","journal-title":"Photodiagn Photodyn Ther"},{"key":"ref153","doi-asserted-by":"publisher","first-page":"e0199195","DOI":"10.1371\/journal.pone.0199195","article-title":"Assessment of acoustic pulse therapy (APT), a non-antibiotic treatment for dairy cows with clinical and subclinical mastitis","volume":"13","author":"Leitner","year":"2018","journal-title":"PLoS One"},{"key":"ref154","doi-asserted-by":"publisher","first-page":"256","DOI":"10.3390\/dairy2020022","article-title":"New treatment option for clinical and subclinical mastitis in dairy cows using acoustic pulse technology (APT)","volume":"2","author":"Leitner","year":"2021","journal-title":"Dairy"}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2023.1160350\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T03:59:19Z","timestamp":1687147159000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2023.1160350\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,19]]},"references-count":154,"alternative-id":["10.3389\/fvets.2023.1160350"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2023.1160350","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,19]]},"article-number":"1160350"}}