{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:25:34Z","timestamp":1791228334962,"version":"4.1.0"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>A 7-month-old male Central American tapir with a history of recurrent respiratory diseases and repeated prolonged administration of amoxicillin with clavulanic acid presented with lethargy, severe hyperalgesia, and interscapular ulcerating vesicular lesions with serosanguineous content, as well as dorsal skin peeling, oral ulcers, and thoracic limb, abdominal, and submandibular pustules with surrounding erythema and alopecia. The histopathological analysis and clinical manifestations were compatible with erythema multiforme, which was treated with daily wound cleaning and silver sulfadiazine cream application, as well as oral prednisolone for 15\u2009days, with five daily tapering doses, achieving clinical improvement and an adequate cure of the disease. Vesicular dermatitis syndrome of tapirs is a disease complex including erythema multiforme, a condition rarely diagnosed, since the analyses required for a definitive diagnosis are almost never performed; therefore, it is important to carry out the necessary tests that allow the differentiation of the dermatopathies included in this complex of vesicular skin diseases.<\/jats:p>","DOI":"10.3389\/fvets.2023.1162819","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T05:46:01Z","timestamp":1684302361000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Erythema multiforme in a Central American tapir (Tapirus bairdii) calf, clinical case report"],"prefix":"10.3389","volume":"10","author":[{"given":"Luana","family":"Hern\u00e1ndez Wolters","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Striedinger Cardona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,17]]},"reference":[{"key":"ref1","article-title":"Vesicular skin disease of tapirs.","volume-title":"American Association of Zoo Veterinarians Conference","author":"Finnegan","year":"1993"},{"key":"ref2","volume-title":"Fowler\u2019s zoo and wild animal medicine","author":"Miller","year":"2012"},{"key":"ref3","volume-title":"Tapir Veterinary Manual","author":"Quse","year":"2014"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1638\/04-077.1","article-title":"Erythema MULTIFORME in a spotted hyena (CROCUTA CROCUTA)","volume":"36","author":"Hanley","year":"2005","journal-title":"J Zoo Wildl Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1177\/1040638711403429","article-title":"Canine parvovirus-2b\u2013associated erythema multiforme in a litter of English setter dogs","volume":"23","author":"Woldemeskel","year":"2011","journal-title":"J Vet Diagn Investig"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.cvex.2013.05.001","article-title":"Erythema Multiforme in a ferret (Mustela putorius furo)","volume":"16","author":"Fisher","year":"2013","journal-title":"Vet Clin North Am Exot Anim Pract"},{"key":"ref7","first-page":"2","article-title":"Use of human immunoglobulin for treatment of severe erythema multiforme in a cat","volume-title":"JAVMA","author":"Byrne","year":"2002"},{"key":"ref8","volume-title":"Caracteriza\u00e7\u00e3o de Desordens Imunomediadas na Medicina Veterin\u00e1ria: Eritema Multiforme e Necr\u00f3lise Epid\u00e9rmica T\u00f3xica","author":"Michaelsen","year":"2011"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"406\u2013e64","DOI":"10.1111\/vde.12142","article-title":"Erythema multiforme, Stevens\u2013Johnson syndrome and toxic epidermal necrolysis: a comparative review","volume":"25","author":"Yager","year":"2014","journal-title":"Vet Dermatol"},{"key":"ref10","volume-title":"Muller & Kirk\u2019s Small Animal Dermatology","author":"Scott","year":"2001"},{"key":"ref11","doi-asserted-by":"crossref","DOI":"10.1002\/9780470752487","volume-title":"Skin Diseases of the Dog and Cat: Clinical and Histopathologic Diagnosis","author":"Gross","year":"2005"},{"key":"ref12","volume-title":"Pathology of Wildlife and Zoo Animals","author":"Terio","year":"2018"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"133","DOI":"10.4102\/jsava.v62i3.1611","article-title":"Erythema multiforme in two horses","volume":"62","author":"Marshall","year":"1991","journal-title":"J S Afr Vet Assoc"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"133","DOI":"10.5326\/JAAHA-MS-6896","article-title":"Erythema Multiforme major in a dog treated with intravenous human immunoglobulin and immunosuppressive therapy","volume":"56","author":"Ramos","year":"2020","journal-title":"J Am Anim Hosp Assoc"}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2023.1162819\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T05:46:09Z","timestamp":1684302369000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2023.1162819\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,17]]},"references-count":14,"alternative-id":["10.3389\/fvets.2023.1162819"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2023.1162819","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,17]]},"article-number":"1162819"}}