{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T23:57:40Z","timestamp":1793750260261,"version":"4.6.1"},"reference-count":159,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:00:00Z","timestamp":1689292800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>Animals have been widely utilized as surrogate models for humans in exposure testing, infectious disease experiments, and immunology studies. However, respiratory diseases affect both humans and animals. These disorders can spontaneously affect wild and domestic animals, impacting their quality and quantity of life. The origin of such responses can primarily be traced back to the pathogens deposited in the respiratory tract. There is a lack of understanding of the transport and deposition of respirable particulate matter (bio-aerosols or viruses) in either wild or domestic animals. Moreover, local dosimetry is more relevant than the total or regionally averaged doses in assessing exposure risks or therapeutic outcomes. An accurate prediction of the total and local dosimetry is the crucial first step to quantifying the dose-response relationship, which in turn necessitates detailed knowledge of animals\u2019 respiratory tract and flow\/aerosol dynamics within it. In this review, we examined the nasal anatomy and physiology (i.e., structure-function relationship) of different animals, including the dog, rat, rabbit, deer, rhombus monkey, cat, and other domestic and wild animals. Special attention was paid to the similarities and differences in the vestibular, respiratory, and olfactory regions among different species. The ventilation airflow and behaviors of inhaled aerosols were described as pertinent to the animals\u2019 mechanisms for ventilation modulation and olfaction enhancement. In particular, sniffing, a breathing maneuver that animals often practice enhancing olfaction, was examined in detail in different animals. Animal models used in COVID-19 research were discussed. The advances and challenges of using numerical modeling in place of animal studies were discussed. The application of this technique in animals is relevant for bidirectional improvements in animal and human health.<\/jats:p>","DOI":"10.3389\/fvets.2023.1172140","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T18:45:32Z","timestamp":1689360332000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Nasal anatomy and sniffing in respiration and olfaction of wild and domestic animals"],"prefix":"10.3389","volume":"10","author":[{"given":"Jinxiang","family":"Xi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuhua 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behavior: clues to vomeronasal system functions","volume-title":"Chemical signals in vertebrates 3","author":"Halpern","year":"1983"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.1002\/ar.23028","article-title":"Mapping the nasal airways: using histology to enhance CT-based three-dimensional reconstruction in nycticebus","volume":"297","author":"Deleon","year":"2014","journal-title":"Anat Rec"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/S0940-9602(11)80156-1","article-title":"Comparative anatomy of the vomeronasal cartilage in mammals: mink, cat, dog, pig, cow and horse","volume":"177","author":"Salazar","year":"1995","journal-title":"Anat Rec"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1002\/ar.1092150107","article-title":"A morphometric comparison of the nasopharyngeal airway of laboratory animals and humans","volume":"215","author":"Patra","year":"1986","journal-title":"Anat Rec"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1002\/1099-1263(200007\/08)20:4<273","article-title":"Allometric respiration\/body mass data for animals to be used for estimates of inhalation toxicity to young adult humans","volume":"20","author":"Bide","year":"2000","journal-title":"J Appl Toxicol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"2","DOI":"10.24072\/pcjournal.76","article-title":"The origin of the allometric scaling of lung ventilation in mammals","author":"No\u00ebl","year":"2022","journal-title":"Peer Commun J"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1038\/s41467-021-21405-y","article-title":"Sniffing speeds up chemical detection by controlling air-flows near sensors","volume":"12","author":"Spencer","year":"2021","journal-title":"Nat Commun"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1152\/jn.90981.2008","article-title":"Why sniff fast? The relationship between sniff frequency, odor discrimination, and receptor neuron activation in the rat","volume":"101","author":"Wesson","year":"2009","journal-title":"J Neurophysiol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1093\/chemse\/bjj016","article-title":"The sniff as a unit of olfactory processing","volume":"31","author":"Kepecs","year":"2006","journal-title":"Chem Senses"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"15577","DOI":"10.1523\/jneurosci.1464-12.2012","article-title":"Interplay between sniffing and odorant sorptive properties in the rat","volume":"32","author":"Rojas-L\u00edbano","year":"2012","journal-title":"J Neurosci"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1098\/rsif.2009.0490","article-title":"The fluid dynamics of canine olfaction: unique nasal airflow patterns as an explanation of macrosmia","volume":"7","author":"Craven","year":"2010","journal-title":"J R Soc Interface"},{"key":"ref21","doi-asserted-by":"crossref","DOI":"10.1017\/9780511801822","volume-title":"Animal physiology: adaptation and environment","author":"Schmidt-Nielsen","year":"1997"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1152\/jappl.1962.17.2.249","article-title":"Mechanical aspects of panting in dogs","volume":"17","author":"Crawford","year":"1962","journal-title":"J Appl Physiol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/nn1819","article-title":"Mechanisms of scent-tracking in humans","volume":"10","author":"Porter","year":"2007","journal-title":"Nat Neurosci"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1016\/j.neuron.2011.08.030","article-title":"All in a sniff: olfaction as a model for active 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Biol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"ENEURO.0129-17.2017","DOI":"10.1523\/eneuro.0129-17.2017","article-title":"Prenatal and early postnatal odorant exposure heightens odor-evoked mitral cell responses in the mouse olfactory bulb","volume":"4","author":"Liu","year":"2017","journal-title":"eNeuro"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.tins.2009.06.001","article-title":"From the top down: flexible reading of a fragmented odor map","volume":"32","author":"Restrepo","year":"2009","journal-title":"Trends Neurosci"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/s0034-5687(96)02520-0","article-title":"Breath timing, volume and drive to breathe in conscious rats: comparative aspects","volume":"107","author":"Walker","year":"1997","journal-title":"Respir Physiol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1093\/chemse\/bjn029","article-title":"Sniffing 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Senses"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"105392","DOI":"10.1016\/j.tvjl.2019.105392","article-title":"Use of computational fluid dynamics to compare upper airway pressures and airflow resistance in brachycephalic, mesocephalic, and dolichocephalic dogs","volume":"253","author":"Fern\u00e1ndez-Parra","year":"2019","journal-title":"Vet J"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1115\/1.3148202","article-title":"Development and verification of a high-fidelity computational fluid dynamics model of canine nasal airflow","author":"Craven","year":"2009","journal-title":"J Biomech Eng"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1111\/vru.12531","article-title":"Quantification of nasal airflow resistance in English bulldogs using computed tomography and computational fluid dynamics","volume":"58","author":"Hostnik","year":"2017","journal-title":"Vet Radiol Ultrasound"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"107243","DOI":"10.1016\/j.cmpb.2022.107243","article-title":"In-silico decongested trial effects on the impaired breathing function of a bulldog suffering from severe brachycephalic obstructive airway syndrome","volume":"228","author":"Khoa","year":"2023","journal-title":"Comput Methods Prog Biomed"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"104398","DOI":"10.1016\/j.compbiomed.2021.104398","article-title":"Computational fluid dynamics comparison of impaired breathing function in French bulldogs with nostril stenosis and an examination of the efficacy of rhinoplasty","volume":"134","author":"Khoa","year":"2021","journal-title":"Comput Biol Med"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1093\/chemse\/bjs039","article-title":"A computational study of odorant transport and deposition in the canine nasal cavity: implications for olfaction","volume":"37","author":"Lawson","year":"2012","journal-title":"Chem Senses"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1242\/jeb.180.1.247","article-title":"Behaviour of dogs during olfactory tracking","volume":"180","author":"Thesen","year":"1993","journal-title":"J Exp Biol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1111\/j.1939-1676.2010.0513.x","article-title":"Tidal breathing flow-volume loop analysis for the diagnosis and staging of tracheal collapse in dogs","volume":"24","author":"Pardali","year":"2010","journal-title":"J Vet Intern Med"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1520\/JFS2002118","article-title":"Reliability of bloodhounds in criminal investigations","volume":"48","author":"Harvey","year":"2003","journal-title":"J Forensic Sci"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s10071-021-01473-9","article-title":"Sex differences in the behavioral responses of dogs exposed to human chemosignals of fear and happiness","volume":"24","author":"D\u2019Aniello","year":"2021","journal-title":"Anim Cogn"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"4103","DOI":"10.1038\/s41598-019-40721-4","article-title":"Dogs demonstrate the existence of an epileptic seizure odour in humans","volume":"9","author":"Catala","year":"2019","journal-title":"Sci Rep"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.semerg.2013.06.002","article-title":"Narcolepsy and odor: preliminary report","volume":"39","author":"Dominguez-Ortega","year":"2013","journal-title":"Semergen"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.jcjd.2019.04.020","article-title":"An idiographic investigation of diabetic alert dogs\u2019 ability to learn from a small sample of breath samples from people with type 1 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considerations for the experimental training and evaluation of cancer odour detection dogs: lessons learnt from a double-blind, controlled trial of prostate cancer detection","volume":"14","author":"Elliker","year":"2014","journal-title":"BMC Urol"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"027001","DOI":"10.1088\/1752-7155\/9\/2\/027001","article-title":"Study of the art: canine olfaction used for cancer detection on the basis of breath odour perspectives and limitations","volume":"9","author":"Jezierski","year":"2015","journal-title":"J Breath Res"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1177\/1534735408319058","article-title":"Human ovarian carcinomas detected by specific odor","volume":"7","author":"Horvath","year":"2008","journal-title":"Integr Cancer Ther"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1089\/acm.2006.6408","article-title":"The use of canines in the detection of human cancers","volume":"14","author":"Gordon","year":"2008","journal-title":"J Altern Complement Med"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1016\/s0140-6736(89)92257-5","article-title":"Sniffer dogs in the melanoma clinic?","volume":"1","author":"Williams","year":"1989","journal-title":"Lancet"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"902151","DOI":"10.3389\/fvets.2022.902151","article-title":"Using canine olfaction to detect bovine respiratory disease: a pilot study","volume":"9","author":"Juge","year":"2022","journal-title":"Front Vet Sci."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"00345","DOI":"10.3389\/fvets.2018.00345","article-title":"Canine olfactory thresholds to amyl acetate in a biomedical detection scenario","volume":"5","author":"Concha","year":"2019","journal-title":"Front Vet Sci."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"597","DOI":"10.3389\/fvets.2020.00597","article-title":"Selecting dogs for explosives detection: behavioral characteristics","volume":"7","author":"Lazarowski","year":"2020","journal-title":"Front Vet Sci"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/S0378-4274(02)00412-5","article-title":"Risk assessment dosimetry model for inhaled particulate matter: II. Laboratory surrogates (rat)","volume":"138","author":"Martonen","year":"2003","journal-title":"Toxicol Lett"},{"key":"ref66","first-page":"83","article-title":"Comparative morphometry of the nasal cavity in rats and mice","volume":"135","author":"Gross","year":"1982","journal-title":"J Anat"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1002\/ar.1092000208","article-title":"Anatomy of the nasal-pharyngeal airway of experimental animals","volume":"200","author":"Schreider","year":"1981","journal-title":"Anat Rec"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1080\/089583798197772","article-title":"Computational fluid dynamics simulations of inspiratory airflow in the human nose and nasopharynx","volume":"10","author":"Subramaniam","year":"1998","journal-title":"Inhal Toxicol"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1093\/toxsci\/kfl112","article-title":"Use of a pharmacokinetic-driven computational fluid dynamics model to predict nasal extraction of hydrogen sulfide in rats and humans","volume":"94","author":"Schroeter","year":"2006","journal-title":"Toxicol Sci"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.jaerosci.2011.08.008","article-title":"Computational fluid dynamics simulations of submicrometer and micrometer particle deposition in the nasal passages of a Sprague\u2013Dawley rat","volume":"43","author":"Schroeter","year":"2012","journal-title":"J Aerosol Sci"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1093\/toxsci\/kfj072","article-title":"Incorporation of tissue reaction kinetics in a computational fluid dynamics model for nasal extraction of inhaled hydrogen sulfide in rats","volume":"90","author":"Schroeter","year":"2006","journal-title":"Toxicol Sci"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1093\/toxsci\/kfs168","article-title":"Comparative computational modeling of airflows and vapor dosimetry in the respiratory tracts of rat, monkey, and human","volume":"128","author":"Corley","year":"2012","journal-title":"Toxicol Sci"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.3109\/08958370902882713","article-title":"Deposition of inhaled nanoparticles in the rat nasal passages: dose to the olfactory region","volume":"21","author":"Garcia","year":"2009","journal-title":"Inhal Toxicol"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"831","DOI":"10.3109\/08958379609034267","article-title":"Incorporation of nasal-lining mass-transfer resistance into a CFD model for prediction of ozone dosimetry in the upper respiratory tract","volume":"8","author":"Cohen Hubal","year":"1996","journal-title":"Inhal Toxicol"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1006\/taap.1996.8076","article-title":"Comparison of inhaled formaldehyde dosimetry predictions with DNA-protein cross-link measurements in the rat nasal passages","volume":"143","author":"Cohen Hubal","year":"1997","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/taap.1997.8350","article-title":"Computer simulation of inspiratory nasal airflow and inhaled gas uptake in a rhesus monkey","volume":"150","author":"Kepler","year":"1998","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1093\/toxsci\/64.1.100","article-title":"Dosimetry modeling of inhaled formaldehyde: comparisons of local flux predictions in the rat, monkey, and human nasal passages","volume":"64","author":"Kimbell","year":"2001","journal-title":"Toxicol Sci"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1006\/taap.1993.1152","article-title":"Application of computational fluid dynamics to regional dosimetry of inhaled chemicals in the upper respiratory tract of the 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