{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:13:01Z","timestamp":1793945581465,"version":"4.8.0"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","award":["FOOD66310019"],"award-info":[{"award-number":["FOOD66310019"]}],"id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p><jats:italic>Clinostomum<\/jats:italic>spp. is a fish-borne pathogen and a digenetic trematode with a global range. Despite its zoonotic relevance, the pathogenic impact of the parasite in Thai aquaculture is currently unclear. The present study deals with the pathogenic changes that fluke causes in their host,<jats:italic>Trichopodus pectoralis<\/jats:italic>, and the molecular confirmation of the<jats:italic>Clinostomum piscidium<\/jats:italic>by targeting 18\u2009s rDNA and ITS gene. The metacercariae of<jats:italic>C. piscidium<\/jats:italic>were discovered in the body cavity of infected fish. The gross pathological examination revealed a few white migratory tracks on the surface of the liver and spleen. The migratory track showed histologically as a primary hemorrhage and necrosis of hepatic cells surrounded by a layer of macrophages and epithelioid cells, inflammatory cells, and eosinophilic granular cells in the cytoplasm of liver cells and close to the epithelial cells of the intestine. Also, the migratory track in the spleen appeared as a marked decrease of Red Blood Cell (RBC) count and changes in the necrotic tissue. Infection with this metacercaria produced hepatic tissue injury, which disrupted hepatic metabolism and decreased body weight in the fish hosts. The findings of the study suggest that the pathological effect of<jats:italic>C. piscidium<\/jats:italic>on farm<jats:italic>T. pectoralis<\/jats:italic>can cause significant economic loss by stunting fish development and predisposing fish to opportunistic pathogens in the environment. Hence, the treatment and control of<jats:italic>C. piscidium<\/jats:italic>infections are crucial for the viability of the aquaculture sector since this parasite has been found to cause pathological damage to the vital organs of fish.<\/jats:p>","DOI":"10.3389\/fvets.2023.1177218","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T04:46:25Z","timestamp":1683002785000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Pathological effects due to metacercariae of Clinostomum piscidium migration in snakeskin gourami (Trichopodus pectoralis) in Thailand"],"prefix":"10.3389","volume":"10","author":[{"given":"Sk Injamamul","family":"Islam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Channarong","family":"Rodkhum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyanan","family":"Taweethavonsawat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1111\/j.1469-7998.1910.tb06972.x","article-title":"The Asiatic fishes of: the family Anabantidne","volume":"79","author":"Eegan","year":"2009","journal-title":"J Zool"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s10228-013-0334-2","article-title":"Growth and morphological development of laboratory-reared larval and juvenile giant gourami Osphronemus goramy (Perciformes: Osphronemidae)","volume":"60","author":"Morioka","year":"2013","journal-title":"Ichthyol Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"223","DOI":"10.56808\/2985-1130.2564","article-title":"Prevalence and histopathology of Trichogaster pectoralis Harbouring Metacercaria of Clinostomum piscidium (Southwell and Prashad, 1918) in Central Thailand","volume":"44","author":"Tansatit","year":"2014","journal-title":"Thai J Vet Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1017\/S0022149X00034209","article-title":"On the life history, growth and development from the metacercarial stage to adulthood, of Clinostomum tilapiae Ukoli, 1966","volume":"40","author":"Ukoli","year":"1966","journal-title":"J Helminthol"},{"key":"ref5","first-page":"382","article-title":"Clinostomum trematode from human eye","volume":"30","author":"Tiewchaloern","year":"1999","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"ref6","first-page":"99","article-title":"A new record of Clinostomum philippinensis (Valasquez, 1959) in Trichogaster microlepis (Gunther, 1861) from bung Borapet, Nakhon Sawan, Thailand","volume":"37","author":"Yooyen","year":"2006","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"ref7","first-page":"001","article-title":"Redescription and histopathology of two species of Myxozoans infecting gills of fingerlings of Indian major carps","volume":"11","author":"Ahmad","year":"2017","journal-title":"J Fish"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1007\/s12639-018-1035-6","article-title":"Prevalence, site and tissue preference of myxozoan parasites infecting gills of cultured fingerlings of Indian major carps in district Fatehgarh sahib, Punjab (India)","volume":"42","author":"Ahmad","year":"2018","journal-title":"J Parasit Dis"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"6537","DOI":"10.1111\/are.15524","article-title":"Morphological, histopathological and molecular characterization of Myxobolus szekelyianus n. sp. 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