{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:00:28Z","timestamp":1792706428745,"version":"4.5.0"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T00:00:00Z","timestamp":1689638400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Dog owners have gradually changed their approach, paying more attention to the nutrition and health of their animals. Various pet foods with different ingredients and nutritional characteristics are available on the market. The present study aimed to evaluate the administration of three diets, namely, two grain-free (GF1 and GF2) and one grain-based (CB), with different sources of carbohydrates that can influence the glycemic and insulin postprandial responses in healthy dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials<\/jats:title><jats:p>Fifteen healthy dogs were dived in three groups and alternatively fed each diet for 50 days. Blood samples were collected at beginning of each feeding period. Glycemia and insulin were measured before and after 120, 240 and 360 minutes diet administration to evaluate postprandial responses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>GF2 diet showed the highest level of albumin and mean insulin concentration (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001). Furthermore, the GF1 diet caused the smallest (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001) glucose and insulin area under the curve (AUC) and the lowest (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05) glucose nadir. Otherwise, GF1 showed the highest (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.01) insulin time to peak. The GF2 diet showed the highest level of albumin while reporting the lowest amount of fructosamine (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05). The diet GF2 registered the highest (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001) level of insulin zenith. The cereal-based (CB) diet reported the highest amount of fructosamine (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05). The CB diet had the highest levels of glucose and the highest (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001) glucose and insulin mean concentrations. Diet CB reported the lowest (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001) insulin nadir.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Diets with different carbohydrate sources and chemical compositions could modulate the glycemic response in healthy dogs. Bearing in mind that glycemic\/insulin postprandial responses influence energy availability and that different dogs have specific lifestyles, it may be preferable to also consider these aspects when choosing a maintenance diet for animals<\/jats:p><\/jats:sec>","DOI":"10.3389\/fvets.2023.1201611","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T09:36:25Z","timestamp":1689672985000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of diet on postprandial glycemic and insulin responses in healthy dogs"],"prefix":"10.3389","volume":"10","author":[{"given":"Alessandro","family":"Vastolo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Gizzarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Ruggiero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Chiara","family":"Alterisio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Calabr\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Ferrara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica 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expression","volume":"257","author":"Briens","year":"2021","journal-title":"Comp Biochem Physiol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1111\/j.1439-0396.2007.00794.x","article-title":"Effects of six carbohydrate sources on dog diet digestibility and postprandial glucose and insulin response","volume":"92","author":"Carciofi","year":"2008","journal-title":"J Anim Physiol Anim Nutr"},{"key":"ref6","article-title":"The effects of carnohydrate-free diets containing different levels of protein on reproduction in the bitch","volume-title":"Nutrition of the dog and cat","author":"Kienzle","year":"1989"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1080\/1828051X.2019.1596758","article-title":"Carbohydrate digestion and predicted glycemic index of bakery\/confectionary ex-food intended for pig nutrition, Italian","volume":"18","author":"Ottoboni","year":"2019","journal-title":"J Anim 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supplement in obese dogs","volume":"11","author":"Mitsuhashi","year":"2013","journal-title":"Intern J Appl Res Vet Med"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.2460\/javma.245.11.1241","article-title":"Awareness and evaluation of natural pet food products in the United States","volume":"245","author":"Carter","year":"2014","journal-title":"JAVMA"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.ijbiomac.2022.12.002","article-title":"Resistant starch from sweet potatoes: recent advancements and applications in the food sector","volume":"225","author":"Bodjrenou","year":"2023","journal-title":"Int J Biol Macromol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/jpn.13806","article-title":"Evaluation of postprandial glycemic response in rats (Wistar) fed with different starch sources","volume":"107","author":"Boaventura","year":"2023","journal-title":"J Anim Physiol Anim Nutr"},{"key":"ref24","first-page":"S91","article-title":"Glycaemic index of foods","volume":"46","author":"Truswell","year":"1992","journal-title":"Eur J Clin Nutr"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1111\/jpn.12275","article-title":"Effect of an extruded pea or rice diet on postprandial insulin and cardiovascular responses in dogs","volume":"99","author":"Adolphe","year":"2015","journal-title":"J Anim Physiol Anim Nutr"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1002\/1521-379X(200206)54:6<217::AID-STAR217>3.0.CO;2-R","article-title":"Pea starch: composition structure and properties-a review","volume":"54","author":"Ratnayake","year":"2002","journal-title":"Starch\/St\u00e4rke"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1080\/00071668.2022.2079398","article-title":"Dietary amylose and amylopectin ratio changes starch digestion and intestinal microbiota diversity in goslings","volume":"63","author":"Yang Icon","year":"2022","journal-title":"Br Poult Sci"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.anifeedsci.2012.03.006","article-title":"In vitro starch digestion and predicted glycemic index of cereal grains commonly utilized in pig nutrition","volume":"174","author":"Giuberti","year":"2012","journal-title":"Anim Feed Sci Technol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1590\/0103-8478cr20150763","article-title":"Starch and fibre intake and glucose postprandial response of dogs","volume":"46","author":"Monti","year":"2016","journal-title":"Ci\u00eancia Rural"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"3099","DOI":"10.3390\/nu5083099","article-title":"Alternative dietary Fiber sources in companion animal nutrition","volume":"5","author":"de 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