{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:25:56Z","timestamp":1775694356315,"version":"3.50.1"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to describe the therapeutic outcomes of dogs with locally advanced salivary gland carcinomas (SGC) following stereotactic body radiation therapy (SBRT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single institution retrospective study was conducted of client-owned dogs with macroscopic SGC treated with SBRT. Patient signalment, clinical characteristics, and treatment parameters were recorded. Clinical benefit was determined based on follow-up physical examination and medical history. Progression-free interval (PFI), median survival time (MST), and disease-specific survival (DSS) were calculated using Kaplan\u2013Meier analysis. Acute and late toxicity were recorded according to Veterinary Radiation Therapy Oncology Group (VRTOG) criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six patients were included in the study. Tumor origins were mandibular (<jats:italic>n<\/jats:italic>\u2009=\u20093), parotid (<jats:italic>n<\/jats:italic>\u2009=\u20092), and zygomatic (<jats:italic>n<\/jats:italic>\u2009=\u20091) salivary glands. The SBRT prescription was 10\u2009Gy \u00d7 3 daily or every other day. All patients (100%) experienced clinical benefit from treatment at a median time of 34 days (range 28\u2013214). No local or regional nodal failure was reported following SBRT. Progressive pulmonary metastatic disease was documented in three dogs (50%). The median PFI was 260 days (range 43\u20131,014) and the MST was 397 days (range 185\u20131,014). Median DSS was 636 days (range 185\u20131,014). Four dogs (66.6%) died of confirmed or suspected metastatic SGC. The reported acute side effects included grade 2 mucositis (<jats:italic>n<\/jats:italic>\u2009=\u20091) and vision loss (<jats:italic>n<\/jats:italic>\u2009=\u20091). No late side effects were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study suggests that SBRT may provide durable local control for invasive SGC in dogs. Further investigation in a larger cohort of patients is warranted. The incidence of reported acute and late toxicity was low.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fvets.2023.1202265","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T11:44:39Z","timestamp":1687866279000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Canine salivary gland carcinoma treated with stereotactic body radiation therapy: a retrospective case series"],"prefix":"10.3389","volume":"10","author":[{"given":"Patricia","family":"Gualtieri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiffany","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Del","family":"Leary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan E.","family":"Lana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan M.","family":"LaRue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary-Keara","family":"Boss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,6,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.2460\/javma.1991.198.03.465","article-title":"Salivary gland disease in dogs and cats: 245 cases (1985\u20131988)","volume":"198","author":"Spangler","year":"1991","journal-title":"J Am Vet Med Assoc"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1002\/vms3.228","article-title":"Salivary neoplasia in dogs and cats: 1996\u20132017","volume":"6","author":"Cray","year":"2020","journal-title":"Vet Med Sci"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1177\/1040638720932169","article-title":"A retrospective study of salivary gland diseases in 179 dogs (2010\u20132018)","volume":"32","author":"Lieske","year":"2020","journal-title":"J Vet Diagn Investig"},{"key":"ref4","first-page":"448","article-title":"Salivary gland neoplasia","volume-title":"Withrow & MacEwen\u2019s small animal clinical oncology","author":"Boston","year":"2020"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1002\/hed.24484","article-title":"Adjuvant radiotherapy versus concurrent chemoradiotherapy for the management of high-risk salivary gland carcinomas","volume":"38","author":"Mifsud","year":"2016","journal-title":"Head Neck"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"S52","DOI":"10.1016\/j.ijrobp.2007.04.079","article-title":"Postoperative and primary radiotherapy for salivary gland carcinomas: indications, techniques, and results","volume":"69","author":"Terhaard","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1111\/vsu.13928","article-title":"Outcomes and clinical features associated with surgically excised canine salivary gland carcinoma: a multi-institutional, retrospective, veterinary Society of Surgical Oncology study","volume":"52","author":"Bush","year":"2023","journal-title":"Vet Surg"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.ijrobp.2004.03.018","article-title":"The role of radiotherapy in the treatment of malignant salivary gland tumors","volume":"61","author":"Terhaard","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1016\/j.ijrobp.2006.06.050","article-title":"Long-term outcome of patients treated by radiation therapy alone for salivary gland carcinomas","volume":"66","author":"Chen","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"268","DOI":"10.3389\/fonc.2014.00268","article-title":"IMRT with stereotactic body radiotherapy boost for high risk malignant salivary gland malignancies: a case series","volume":"4","author":"Karam","year":"2014","journal-title":"Front Oncol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1111\/odi.13755","article-title":"Metastatic salivary gland carcinoma: a role for stereotactic body radiation therapy? 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