{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T06:35:05Z","timestamp":1784010905963,"version":"3.55.0"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T00:00:00Z","timestamp":1691020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>A 2-year-old male entire Cane Corso was presented for investigations into a 1-week history of ambulatory paraparesis and pelvic limb ataxia gradually deteriorating. Magnetic resonance imaging (MRI) revealed intraventricular space-occupying lesions affecting the fourth ventricle and lateral apertures and intradural-extramedullary space-occupying lesions at the level of C7 vertebra, L4-L5, and L7-S1 intervertebral disk spaces. Due to poor quality of life, the patient was euthanized. A post-mortem examination revealed partially encapsulated, multifocally infiltrative, and moderately cellular neoplastic masses. The histological description was similar for all masses. The cells appeared cuboidal with round central nuclei and a moderate amount of eosinophilic cytoplasm and were arranged almost exclusively in single-layered papilliform patterns supported by a fibrovascular stroma. Mitoses were rarely observed (1\/2.37 mm<jats:sup>2<\/jats:sup>). The primary neoplasm was morphologically most consistent with a choroid plexus papilloma despite drop metastases. This is the first report of a histologically confirmed primary ventricular choroid plexus papilloma causing disseminated MRI-apparent intraventricular and spinal drop metastases.<\/jats:p>","DOI":"10.3389\/fvets.2023.1223729","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T22:10:35Z","timestamp":1691100635000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical, magnetic resonance imaging, and histological description of a choroid plexus papilloma with disseminated intraventricular and spinal cerebrospinal fluid drop metastases in a young adult dog: a case report"],"prefix":"10.3389","volume":"10","author":[{"given":"Guillaume Marc","family":"Albertini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Malbon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Staudacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Stabile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,8,3]]},"reference":[{"key":"B1","volume-title":"Veterinary Neuroanatomy and Clinical Neurology","author":"De Lahunta","year":"2015"},{"key":"B2","doi-asserted-by":"publisher","first-page":"S52","DOI":"10.1111\/j.1740-8261.2010.01785.x","article-title":"Magnetic resonance imaging features of canine intracranial neoplasia","volume":"52","author":"Wisner","year":"2011","journal-title":"Vet Radiol Ultras"},{"key":"B3","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/j.1939-1676.2006.tb02913.x","article-title":"canine intracranial primary neoplasia: 173 Cases (1986-2003)","volume":"20","author":"Snyder","year":"2006","journal-title":"J Vet Intern Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1111\/j.1939-1676.2008.0170.x","article-title":"Choroid plexus tumors in 56 dogs (1985-2007)","volume":"22","author":"Westworth","year":"2008","journal-title":"J Vet Intern Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.3389\/fonc.2019.01151","article-title":"Canine primary intracranial cancer: a clinic pathologic and comparative review of glioma, meningioma, and choroid plexus tumors","volume":"9","author":"Miller","year":"2019","journal-title":"Front Oncol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1177\/0300985817754124","article-title":"Glomeruloid microvascular proliferation, desmoplasia, and high proliferative index as potential indicators of high-grade canine choroid plexus tumors","volume":"55","author":"Muscatello","year":"2018","journal-title":"Vet Pathol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1177\/0300985815620844","article-title":"E-cadherin, N-cadherin expression and histologic characterization of canine choroid plexus tumors","volume":"53","author":"Reginato","year":"2016","journal-title":"Vet Pathol."},{"key":"B8","first-page":"142","article-title":"Veterinary Neuropathology, Essentials of Theory and Practice","author":"Vandevelde","year":"2012"},{"key":"B9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1177\/030098588902600109","article-title":"A histologic and immune cytochemical study of choroid plexus tumors of the dog","volume":"26","author":"Ribas","year":"1989","journal-title":"Vet. Pathol."},{"key":"B10","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1201\/9781315121055","volume-title":"Diagnostic MRI in Dogs and Cats","author":"Mai","year":"2018"},{"key":"B11","doi-asserted-by":"publisher","first-page":"650320","DOI":"10.3389\/fvets.2021.650320","article-title":"Cerebrospinal Fluid Drop Metastases of Canine Glioma: Magnetic Resonance Imaging Classification","volume":"8","author":"Bentley","year":"2021","journal-title":"Front Vet Sci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"E32","DOI":"10.1111\/vru.12474","article-title":"Imaging diagnosis \u2014antemortem detection of oligodendroglioma \u201ccerebrospinal fluid drop metastases\u201d in a dog by serial magnetic resonance imaging","volume":"59","author":"Vigeral","year":"2018","journal-title":"Vet Radiol Ultrasound."},{"key":"B13","doi-asserted-by":"crossref","first-page":"757","DOI":"10.3171\/jns.1998.88.4.0757","article-title":"Diffuse cranio spinal seeding from a benign fourth ventricle choroid plexus papilloma Case report","volume":"88","author":"Leblanc","year":"1998","journal-title":"J. Neurosurg"},{"key":"B14","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.surneu.2005.09.023","article-title":"Variations of disseminated choroid plexus papilloma: 2 case reports and a review of the literature","volume":"66","author":"McCall","year":"2006","journal-title":"Surg Neurol."},{"key":"B15","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/jsap.12087","article-title":"A sacro-caudal spinal cord choroid plexus papilloma in a shar-pei dog","volume":"54","author":"Giannuzzi","year":"2013","journal-title":"Journal of Small Animal Practice."},{"key":"B16","doi-asserted-by":"crossref","DOI":"10.1177\/20551169211048464","article-title":"Spinal ectopic choroid plexus papilloma in a cat","volume":"7","author":"Tabanez","year":"2021","journal-title":"Journal of Feline Medicine and Surgery Open Reports"},{"key":"B17","doi-asserted-by":"publisher","first-page":"37","DOI":"10.5326\/JAAHA-MS-6982","article-title":"Long-term outcome after surgical resection of a spinal choroid plexus tumor in a dog","volume":"57","author":"Saitoh","year":"2021","journal-title":"JAAHA."},{"key":"B18","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0303-8467(98)00033-X","article-title":"Pathology of choroid plexus papillomas: a review","volume":"100","author":"Gaudio","year":"1998","journal-title":"Clin Neurol Neurosurg."},{"key":"B19","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1556\/avet.57.2009.3.5","article-title":"First report of the simultaneous occurrence of choroid plexus papilloma and meningioma in a dog","volume":"57","author":"Espino","year":"2009","journal-title":"Acta Vet Hung."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1111\/vsu.13859","article-title":"Use of a telovelar approach for complete resection of a choroid plexus tumor in a dog","volume":"51","author":"Antonakakis","year":"2022","journal-title":"Vet Surg."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/759054","article-title":"Canine choroid plexus tumor with intracranial dissemination presenting as multiple cystic lesions","volume":"2013","author":"Oura","year":"2013","journal-title":"Case Rep Veter Med."},{"key":"B22","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1177\/030098587100800110","article-title":"Choroid plexus papilloma in a dog","volume":"8","author":"Kurtz","year":"1971","journal-title":"Vet Path."},{"key":"B23","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1292\/jvms.15-0330","article-title":"Choroid plexus papilloma in a dog surviving for 15 months after diagnosis with symptomatic therapy","volume":"78","author":"Itoh","year":"2016","journal-title":"J Vet Med Sci."},{"key":"B24","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/j.1748-5827.1985.tb02186.x","article-title":"Two cases of paradoxical vestibular syndrome in rough collies","volume":"26","author":"Skerritt","year":"1985","journal-title":"J Small Anim Prac."},{"key":"B25","first-page":"38","article-title":"Cerebrospinal fluid overproduction and hydrocephalus associated with choroid plexus papilloma","volume":"40","author":"Eisenrerg","year":"1974","journal-title":"J Neurosurg."},{"key":"B26","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1159\/000120250","article-title":"Etiology of ventriculomegaly in choroid plexus papilloma","volume":"12","author":"Rekate","year":"1985","journal-title":"Pediatric Neurosurg"},{"key":"B27","doi-asserted-by":"publisher","first-page":"265","DOI":"10.5326\/JAAHA-MS-6479","article-title":"Magnetic resonance imaging and clinical findings associated with choroid plexus spinal cord \u201cdrop\u201d metastases","volume":"53","author":"Yeamans","year":"2017","journal-title":"J Am Anim Hosp Assoc."}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2023.1223729\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T12:08:47Z","timestamp":1702901327000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2023.1223729\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,3]]},"references-count":27,"alternative-id":["10.3389\/fvets.2023.1223729"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2023.1223729","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,3]]},"article-number":"1223729"}}