{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T02:35:59Z","timestamp":1769740559749,"version":"3.49.0"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Aberrant lymphoma phenotypes are frequently found in dogs, but the clinical implications are sparse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty-seven dogs with aberrant lymphoma diagnosed using flow cytometry between 2017 and 2023 were analyzed. Major paraneoplastic syndromes, prognostic factors, and clinical features of lymphoma were compared to their immunophenotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty-seven dogs had aberrant immunophenotypes, with MHCII- (48%) and CD3+\/CD21+ (44%) being the most commonly identified aberrancies. In B-cell lymphoma, the most frequent aberrancies were MHC II- (53%), CD3+\/CD21+ (41%), CD34+ (24%), and CD79a- (24%). Meanwhile, in T-cell lymphoma, CD3+\/CD21+ (63%), CD4-\/CD8-(50%), CD5- (50%), and CD45- (50%) were the most common. The platelet\u2013neutrophil ratio was significantly higher in the CD3+\/CD21+ group than in the other groups, where either one or both markers were not expressed (55.23\u2009\u00b1\u200939.64; 18.72\u2009\u00b1\u200914.95, respectively;<jats:italic>p<\/jats:italic>\u2009=\u20090.001). Serum albumin concentration was significantly lower in the MHCII-group (2.59\u2009g\/dL, 95% CI 2.31\u20132.87) than in the MHCII+ group (3.06\u2009g\/dL, 95% CI 2.88\u20133.23;<jats:italic>p<\/jats:italic>\u2009=\u20090.009). CD34 expression showed significant correlations with cranial mediastinal mass, WHO clinical substage, and fever (<jats:italic>p<\/jats:italic>\u2009=\u20090.028,<jats:italic>p<\/jats:italic>\u2009=\u20090.041, and<jats:italic>p<\/jats:italic>\u2009=\u20090.047, respectively). MHCII expression was correlated with adverse reactions to chemotherapy, cranial mediastinal masses, and fever (<jats:italic>p<\/jats:italic>\u2009=\u20090.009,<jats:italic>p<\/jats:italic>\u2009=\u20090.023, and<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001, respectively). No statistically significant differences in the survival period were observed for any of the phenotypic aberrancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Aberrant lymphomas are common in dogs. Some clinical prognostic factors that significantly correlate with aberrant immunophenotypes have been identified and can be applied clinically.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fvets.2023.1254458","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T04:33:21Z","timestamp":1697430801000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparative analysis of the aberrant immunophenotype and clinical characteristics in dogs with lymphoma: a study of 27 cases"],"prefix":"10.3389","volume":"10","author":[{"given":"Hyeona","family":"Bae","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Ki","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DoHyeon","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,10,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.2460\/javma.1994.205.12.1722","article-title":"Prognostic factors for treatment of malignant lymphoma in dogs","volume":"205","author":"Teske","year":"1994","journal-title":"J Am Vet Med Assoc"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.vetimm.2017.07.008","article-title":"Specific immunotypes of canine T cell lymphoma are associated with different 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