{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:49:00Z","timestamp":1792018140704,"version":"4.4.0"},"reference-count":71,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>\n                    Bovine respiratory disease (BRD) is a leading cause of disease in feedlot and stocker calves with\n                    <jats:italic>Mannheimia haemolytica<\/jats:italic>\n                    (\n                    <jats:italic>MH<\/jats:italic>\n                    ) as one of the most common etiologies. One of the most effective means of controlling BRD is through metaphylaxis, which involves administering antimicrobials to all animals at high risk of developing BRD. However, increasing prevalence of multidrug resistant (MDR)\n                    <jats:italic>MH<\/jats:italic>\n                    may reduce efficacy of metaphylaxis due to decreased susceptibility to drugs used for metaphylaxis. Primarily, this study aimed to determine the effect of tulathromycin metaphylaxis and subsequent BRD treatment on antimicrobial resistance (AMR) in\n                    <jats:italic>MH<\/jats:italic>\n                    isolated from stocker calves. Secondary objectives included evaluating the effect of metaphylaxis and treatment for BRD on animal health and comparing the genetic relationship of\n                    <jats:italic>MH<\/jats:italic>\n                    isolated. Crossbred beef heifers (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009331, mean weight\u2009=\u2009232, SD\u2009=\u200917.8\u2009kg) at high risk for BRD were randomly assigned to receive tulathromycin metaphylaxis (META,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009167) or not (NO META,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009164). Nasopharyngeal swabs were collected for\n                    <jats:italic>MH<\/jats:italic>\n                    isolation, antimicrobial susceptibility testing and whole genome sequencing at arrival and 3 (WK3) and 10 (WK10) weeks later. Mixed-effects logistic regression was used to identify risk factors for isolation of\n                    <jats:italic>MH<\/jats:italic>\n                    and MDR\n                    <jats:italic>MH<\/jats:italic>\n                    (resistant to \u22653 antimicrobial drug classes) at 3 and 10\u2009weeks, BRD morbidity, and crude mortality. Animals in the META group had higher odds of isolation of MDR\n                    <jats:italic>MH<\/jats:italic>\n                    at 3\u2009weeks [OR (95% CI)\u2009=\u200913.08 (5\u201330.9),\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&amp;lt;\u20090.0001] and 10\u2009weeks [OR (95% CI)\u2009=\u20095.92 (1.34\u201326.14),\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.019] after arrival. There was no difference in risk of isolation of any\n                    <jats:italic>MH<\/jats:italic>\n                    (resistant or susceptible) between META and NO META groups at all timepoints. Animals in the NO META group had 3 times higher odds of being treated for BRD [WK3: OR (95% CI)\u2009=\u20093.07 (1.70\u20135.52),\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0002; WK10: OR (95% CI)\u2009=\u20092.76 (1.59\u20134.80),\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0002]. Antimicrobial resistance genes found within isolates were associated with integrative conjugative element (ICE) genes. Tulathromycin metaphylaxis increased risk of isolation of MDR\n                    <jats:italic>MH<\/jats:italic>\n                    and in this population, the increase in MDR\n                    <jats:italic>MH<\/jats:italic>\n                    appeared to be associated with ICE containing antimicrobial resistance genes for multiple antimicrobial classes. This may have important implications for future efficacy of antimicrobials for control and treatment of BRD.\n                  <\/jats:p>","DOI":"10.3389\/fvets.2023.1256997","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T05:35:56Z","timestamp":1700804156000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Tulathromycin metaphylaxis increases nasopharyngeal isolation of multidrug resistant Mannheimia haemolytica in stocker heifers"],"prefix":"10.3389","volume":"10","author":[{"given":"William B.","family":"Crosby","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandi B.","family":"Karisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lari M.","family":"Hiott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee J.","family":"Pinnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Pittman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan G.","family":"Frye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlene R.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Dustin","family":"Loy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B.","family":"Epperson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"John","family":"Blanton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah F.","family":"Capik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Morley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia R.","family":"Woolums","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/S0749-0720(15)30302-9","article-title":"Economic impact associated with respiratory disease in beef cattle","volume":"13","author":"Griffin","year":"1997","journal-title":"Vet Clin North Am"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.cvfa.2010.04.004","article-title":"Bacterial pathogens of the bovine respiratory disease complex","volume":"26","author":"Griffin","year":"2010","journal-title":"Vet Clin North Am"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.cvfa.2010.04.001","article-title":"Pathogenesis and pathology of bovine pneumonia","volume":"26","author":"Panciera","year":"2010","journal-title":"Vet Clin North Am"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1128\/JCM.02485-13","article-title":"Pathogens of bovine respiratory disease in north American feedlots conferring multidrug resistance via integrative conjugative elements","volume":"52","author":"Klima","year":"2","journal-title":"J Clin Microbiol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1177\/104063870902100405","article-title":"Bayesian estimation of the performance of using clinical observations and harvest lung lesions for diagnosing bovine respiratory disease in post-weaned beef calves","volume":"21","author":"White","year":"2009","journal-title":"J Vet Diagnostic Investig"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.cvfa.2015.05.008","article-title":"Use of antimicrobial metaphylaxis for the control of bovine respiratory disease in high-risk cattle","volume":"31","author":"Ives","year":"2015","journal-title":"Vet Clin North Am"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"ftx083","DOI":"10.1093\/femspd\/ftx083","article-title":"Do antimicrobial mass medications work? 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language and environment for statistical computing","year":"2020"},{"key":"ref32","volume-title":"pheatmap: Pretty Heatmaps","author":"Kolde","year":"2019"},{"key":"ref33","volume-title":"DNeasy","year":"2020"},{"key":"ref34","volume-title":"Nextera XT DNA Library Prep Kit Reference Guide (15031942)","year":"2023"},{"key":"ref35","first-page":"587","article-title":"A5-miseq: an updated pipeline to assemble microbial genomes from Illumina MiSeq data","volume-title":"Bioinformatics","author":"Coil","year":"2015"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"e42304","DOI":"10.1371\/journal.pone.0042304","article-title":"An integrated pipeline for de novo assembly of microbial genomes","volume":"7","author":"Tritt","year":"2012","journal-title":"PLoS One"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence 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annotation pipeline reach with protein family model curation","volume":"49","author":"Li","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"D851","DOI":"10.1093\/nar\/gkx1068","article-title":"RefSeq: an update on prokaryotic genome annotation and curation","volume":"46","author":"Haft","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"D744","DOI":"10.1093\/nar\/gkac1047","article-title":"MEGARes and AMR++, v3.0: an updated comprehensive database of antimicrobial resistance determinants and an improved software pipeline for classification using high-throughput sequencing","volume":"51","author":"Bonin","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2105-10-421","article-title":"BLAST+: Architecture and applications","volume":"10","author":"Camacho","year":"2009","journal-title":"BMC 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J"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1017\/S1466252314000176","article-title":"Review of BRD pathogenesis: the old and the new","volume":"15","author":"Mosier","year":"2015","journal-title":"Anim Health Res Rev"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1017\/S1466252309990193","article-title":"Update on bacterial pathogenesis in BRD","volume":"10","author":"Confer","year":"2009","journal-title":"Anim Health Res Rev"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.tvjl.2013.07.024","article-title":"Bovine viral diarrhoea: pathogenesis and diagnosis","volume":"199","author":"Lanyon","year":"2014","journal-title":"Vet J"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"595","DOI":"10.2460\/javma.2005.226.595","article-title":"Prevalence, outcome, and health consequences associated with persistent infection with bovine viral diarrhea virus in feedlot 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