{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:50:05Z","timestamp":1792799405764,"version":"4.5.0"},"reference-count":78,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>\n                    The objective of this study was to examine the effects of dietary Chinese herbal medicine (CHM) consisting of\n                    <jats:italic>Astragalus membranaceus (Fisch.) Bunge<\/jats:italic>\n                    (AMT) and\n                    <jats:italic>Codonopsis pilosula (Franch.) Nannf<\/jats:italic>\n                    (CPO) extracts on growth performance, antioxidant capacity, immune status, and intestinal health of broiler chickens. Two groups were formed, each consisting of six replicates of 12 one-day-old healthy male 817 white feather broilers. Broilers were fed either a basal diet (CON group) or a basal diet supplemented with 500\u2009mg\/kg CHM. The trial lasted 50\u2009days. The results showed that CHM supplementation resulted in enhanced feed efficiency and antioxidant capacity in both the serum and liver, while it reduced uric acid and endotoxin levels, as well as diamine oxidase activity (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&amp;lt;\u20090.05). Additionally, CHM treatment increased the height of jejunum villi and upregulated\n                    <jats:italic>Claudin-1<\/jats:italic>\n                    expression in the jejunal mucosa accompanied by an increase in the mRNA levels of interleukin-6 (IL-6), interferon-\u03b3 (IFN-\u03b3), interferon-\u03b2 (IFN-\u03b2), tumor necrosis factor-\u03b1 (TNF-\u03b1), and anti-inflammatory cytokine interleukin-10 (IL-10) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&amp;lt;\u20090.05). The presence of dietary CHM caused an increase in the proportions of\n                    <jats:italic>Bacteroidetes<\/jats:italic>\n                    and unclassified\n                    <jats:italic>Bacteroidales<\/jats:italic>\n                    but led to a decrease in those of\n                    <jats:italic>Firmicutes<\/jats:italic>\n                    and\n                    <jats:italic>Alistipes<\/jats:italic>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&amp;lt;\u20090.05). The composition of the jejunal mucosa microbiota was correlated with the feed conversion ratio, serum metabolites, and gene expression based on Spearman correlation analysis. The findings indicated that the consumption of dietary CHM improved the utilization of feed, increased the mRNA expression of pro-inflammatory cytokines in the jejunal mucosa, and decreased the endotoxin level and activities of diamine oxidase and lactate dehydrogenase in the serum, which could potentially be linked to changes in the gut microbiota of broiler chickens.\n                  <\/jats:p>","DOI":"10.3389\/fvets.2023.1302801","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T10:17:03Z","timestamp":1701944223000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["Effects of dietary Astragalus membranaceus and Codonopsis pilosula extracts on growth performance, antioxidant capacity, immune status, and intestinal health in broilers"],"prefix":"10.3389","volume":"10","author":[{"given":"Shun","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gengsheng","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinpeng","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,12,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.3382\/ps\/pew336","article-title":"Effects 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