{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:13:37Z","timestamp":1790194417491,"version":"4.1.0"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>To comprehensively provide insight into goose fatty liver formation, we performed an integrative analysis of the liver transcriptome, lipidome, and amino acid metabolome, as well as peripheral adipose tissue transcriptome analysis using samples collected from the overfed geese and normally fed geese. Transcriptome analysis showed that liver metabolism pathways were mainly enriched in glucolipid metabolism, amino acid metabolism, inflammation response, and cell cycle; peripheral adipose tissue and the liver cooperatively regulated liver lipid accumulation during overfeeding. Liver lipidome patterns obviously changed after overfeeding, and 157 different lipids were yielded. In the liver amino acid metabolome, the level of Lys increased after overfeeding. In summary, this is the first study describing goose fatty liver formation from an integrative analysis of transcriptome, lipidome, and amino acid metabolome, which will provide a whole new dimension to understanding the mechanism of goose fatty liver formation.<\/jats:p>","DOI":"10.3389\/fvets.2024.1122904","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T04:26:37Z","timestamp":1706502397000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Multi-omics reveals goose fatty liver formation from metabolic reprogramming"],"prefix":"10.3389","volume":"11","author":[{"given":"Rongxue","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqiang","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunchun","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouhai","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hehe","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenqiang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengyong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,1,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"eaaw5473","DOI":"10.1126\/science.aaw5473","article-title":"Metabolic reprogramming and cancer progression","volume":"368","author":"Faubert","year":"2020","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2839","DOI":"10.1002\/jcp.25998","article-title":"Involvement of the Warburg effect in non-tumor diseases processes","volume":"233","author":"Chen","year":"2018","journal-title":"J Cell Physiol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/nrgastro.2014.25","article-title":"Metabolic make-up of NASH: from fat and sugar to amino acids","volume":"11","author":"Sookoian","year":"2014","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1097\/mco.0000000000000346","article-title":"Update on lipid species and paediatric nonalcoholic fatty liver disease","volume":"20","author":"Mann","year":"2017","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1038\/s41575-021-00502-9","article-title":"Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests","volume":"18","author":"Masoodi","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"3083","DOI":"10.1038\/ncomms4083","article-title":"Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease","volume":"5","author":"Mardinoglu","year":"2014","journal-title":"Nat Commun"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1016\/j.cell.2018.09.055","article-title":"Microbially produced imidazole propionate impairs insulin signaling through mTORC1","volume":"175","author":"Koh","year":"2018","journal-title":"Cell"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1080\/00071668.2020.1812527","article-title":"Research progress into the physiological changes in metabolic pathways in waterfowl with hepatic steatosis","volume":"62","author":"Wei","year":"2020","journal-title":"Br Poult Sci"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"581699","DOI":"10.3389\/fphys.2020.581699","article-title":"A serum metabolic profiling analysis during the formation of fatty liver in Landes geese via GC-TOF\/MS","volume":"11","author":"Gong","year":"2020","journal-title":"Front Physiol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"110938","DOI":"10.1016\/j.cbpa.2021.110938","article-title":"Utilizing comparative models in biomedical research","volume":"256","author":"Little","year":"2021","journal-title":"Comp Biochem Physiol A"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"753","DOI":"10.3382\/ps\/pey432","article-title":"Influence of the corn form in the diet and length of fasting before slaughter on the performance of overfed mule ducks","volume":"98","author":"Arroyo","year":"2019","journal-title":"Poult Sci"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s13059-015-0652-y","article-title":"The goose genome sequence leads to insights into the evolution of waterfowl and susceptibility to fatty liver","volume":"16","author":"Lu","year":"2015","journal-title":"Genome Biol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"31763","DOI":"10.1038\/srep31763","article-title":"Prosteatotic and protective components in a unique model of fatty liver: gut microbiota and suppressed complement system","volume":"6","author":"Liu","year":"2016","journal-title":"Sci Rep"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1902996","DOI":"10.1002\/advs.201902996","article-title":"Switching from fatty acid oxidation to glycolysis improves the outcome of acute-on-chronic liver failure","volume":"7","author":"Yu","year":"2020","journal-title":"Adv Sci"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/s1095-6433(00)00190-2","article-title":"Metabolism in two breeds of geese with moderate or large overfeeding induced liver-steatosis","volume":"126","author":"Davail","year":"2000","journal-title":"Comp Biochem Physiol A"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.cbpb.2016.01.006","article-title":"Identification of protective components that prevent the exacerbation of goose fatty liver: characterization, expression and regulation of adiponectin receptors","author":"Geng","year":"2016","journal-title":"Comp Biochem Physiol B"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"101729","DOI":"10.1016\/j.psj.2022.101729","article-title":"Study on the effect of different types of sugar on lipid deposition in goose fatty liver","volume":"101","author":"Wei","year":"2022","journal-title":"Poult Sci"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1097\/mco.0000000000000558","article-title":"Sarcopenic obesity in fatty liver","volume":"22","author":"Merli","year":"2019","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.3390\/ijms19072034","article-title":"New aspects of lipotoxicity in nonalcoholic steatohepatitis","volume":"19","author":"Mendez-Sanchez","year":"2018","journal-title":"Int J Mol Sci"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"2807","DOI":"10.1038\/s41598-021-82208-1","article-title":"High-fructose feeding does not induce steatosis or non-alcoholic fatty liver disease in pigs","volume":"11","author":"Schmidt","year":"2021","journal-title":"Sci Rep"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1186\/s12864-019-5765-3","article-title":"Transcriptomic analysis between normal and high-intake feeding geese provides insight into adipose deposition and susceptibility to fatty liver in migratory birds","volume":"20","author":"Wang","year":"2019","journal-title":"BMC Genomics"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/S0022-2275(20)30465-X","article-title":"Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs","volume":"43","author":"Matsuzaka","year":"2002","journal-title":"J Lipid Res"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.bbrc.2008.01.075","article-title":"Mouse Elovl-6 promoter is an SREBP target","volume":"368","author":"Kumadaki","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"45358","DOI":"10.1074\/jbc.M108413200","article-title":"Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins","volume":"276","author":"Moon","year":"2001","journal-title":"J Biol Chem"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.nutres.2020.12.022","article-title":"Dietary supplementation with myo-inositol reduces high-fructose diet-induced hepatic ChREBP binding and acetylation of histones H3 and H4 on the Elovl6 gene in rats","volume":"88","author":"Hibi","year":"2021","journal-title":"Nutr Res"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/s41419-018-0330-6","article-title":"Downregulation of SREBP inhibits tumor growth and initiation by altering cellular metabolism in colon cancer","volume":"9","author":"Wen","year":"2018","journal-title":"Cell Death Dis"},{"key":"ref27","article-title":"Study on the role of cholesterol trafficking genes related to steroid hormones synthesis in goose follicles","author":"Xia","year":"2010"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1016\/j.jcmgh.2022.02.018","article-title":"Coordinated cross-talk between the Myc and Mlx networks in liver regeneration and neoplasia","volume":"13","author":"Wang","year":"2022","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1038\/s41586-021-03422-5","article-title":"AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity","volume":"592","author":"Maiani","year":"2021","journal-title":"Nature"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.cmet.2006.03.007","article-title":"The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis","volume":"3","author":"Li","year":"2006","journal-title":"Cell Metab"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1021\/pr050364w","article-title":"High performance liquid chromatography-mass spectrometry for metabonomics: potential biomarkers for acute deterioration of liver function in chronic hepatitis B","volume":"5","author":"Yang","year":"2006","journal-title":"J Proteome Res"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1186\/s12951-022-01540-4","article-title":"Lipidomic identification of urinary extracellular vesicles for non-alcoholic steatohepatitis diagnosis","volume":"20","author":"Zhu","year":"2022","journal-title":"J Nanobiotechnol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.4103\/1673-5374.274331","article-title":"Autophagy and inflammation in ischemic stroke","volume":"15","author":"Mo","year":"2020","journal-title":"Neural Regen Res"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.cell.2016.05.051","article-title":"Autophagy, inflammation, and immunity: a troika governing cancer and its treatment","volume":"166","author":"Zhong","year":"2016","journal-title":"Cell"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"783498","DOI":"10.3389\/fphys.2021.783498","article-title":"Metabolic profiling analysis of liver in Landes geese during the formation of fatty liver via GC-TOF\/MS","volume":"12","author":"Yu","year":"2022","journal-title":"Front Physiol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.cmet.2007.01.001","article-title":"The GCN2 eIF2 alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid","volume":"5","author":"Guo","year":"2007","journal-title":"Cell Metab"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s12986-017-0215-1","article-title":"Branched-chain amino acid supplementation restores reduced insulinotropic activity of a low-protein diet through the vagus nerve in rats","volume":"14","author":"Horiuchi","year":"2017","journal-title":"Nutr Metab"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1557S","DOI":"10.1093\/jn\/135.6.1557S","article-title":"Branched-chain corrected amino acid metabolism: implications for establishing safe intakes","volume":"135","author":"Hutson","year":"2005","journal-title":"J Nutr"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.molmet.2016.04.006","article-title":"Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export","volume":"5","author":"White","year":"2016","journal-title":"Mol Metab"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.3389\/fphys.2019.01607","article-title":"Chronic adipose tissue inflammation linking obesity to insulin resistance and type 2 diabetes","volume":"10","author":"Zatterale","year":"2020","journal-title":"Front Physiol"}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2024.1122904\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T04:26:40Z","timestamp":1706502400000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2024.1122904\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,29]]},"references-count":40,"alternative-id":["10.3389\/fvets.2024.1122904"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2024.1122904","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,29]]},"article-number":"1122904"}}