{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:29:22Z","timestamp":1787027362844,"version":"build-2736575974"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>This case report describes a novel example of an extranodal null-type lymphoma in the myocardium of a middle-aged English bulldog who presented with signs of right heart failure. An echocardiogram found, in addition to the pericardial effusion, thickened right and left ventricular free walls and the interventricular septum. The right ventricular free wall myocardium had multinodular lesions, suspicious for infiltrative disease. The owner elected humane euthanasia, and permission for necropsy was obtained. Multifocal left and right ventricular nodules and an incidental aortic root mass were detected, the latter of which was later confirmed as a chemodectoma. Microscopically, the myocardial nodules were sheets of round cells consistent with a high-grade lymphoma. Neoplastic cells were not immunoreactive to CD3 (T-cell) or CD20 and CD79a (B-cell), Mum-1 (plasma cell), CD117 (mast cell), or CD18 (histiocyte). These findings are consistent with a high-grade, null-cell-type lymphoma.<\/jats:p>","DOI":"10.3389\/fvets.2024.1256442","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T23:43:51Z","timestamp":1707263031000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["A case report: Null-cell cardiac lymphoma in an English bulldog"],"prefix":"10.3389","volume":"11","author":[{"given":"Liza S.","family":"K\u00f6ster","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Newkirk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Krawec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,2,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1111\/vco.12167","article-title":"A descriptive review of cardiac tumours in dogs and cats","volume":"15","author":"Treggiari","year":"2017","journal-title":"Vet Comp Oncol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.2460\/javma.2005.227.1449","article-title":"Cardiac lymphoma and pericardial effusion in dogs: 12 cases (1994-2004)","volume":"227","author":"MacGregor","year":"2005","journal-title":"J Am Vet Med Assoc"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.2460\/javma.235.12.1456","article-title":"Echocardiographic and clinicopathologic characterization of pericardial effusion in dogs: 107 cases (1985-2006)","volume":"235","author":"MacDonald","year":"2009","journal-title":"J Am Vet Med Assoc"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1111\/jvim.12253","article-title":"Diagnostic yield of cytologic analysis of pericardial effusion in dogs","volume":"28","author":"Cagle","year":"2014","journal-title":"J Vet Intern Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.jtho.2015.11.009","article-title":"The 2015 WHO classification of tumors of the heart and pericardium","volume":"11","author":"Burke","year":"2016","journal-title":"J Thorac Oncol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1111\/j.1476-4431.2011.00626.x","article-title":"Abdominal and thoracic focused assessment with sonography for trauma, triage, and monitoring in small animals","volume":"21","author":"Lisciandro","year":"2011","journal-title":"J Vet Emerg Crit Care"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1111\/j.1939-1676.1993.tb01015.x","article-title":"Recommendations for standards in transthoracic two-dimensional echocardiography in the dog and cat. 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