{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T01:35:43Z","timestamp":1788658543284,"version":"build-2803163510"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>In this study, the effect of hazelnut skin dietary supplementation on antioxidant status and cytokine profile was evaluated in growing lambs. A total of 22 male lambs at the age of 2\u2009months, balanced for their initial live weight (15.33\u2009\u00b1\u2009SD 1.79\u2009kg), were selected and allocated into two experimental groups: the control group (CON) receiving a maize-barley-based concentrated diet, and the hazelnut group (HS) receiving supplementation with hazelnut skin (150\u2009g\/kg on the dry matter) as a maize substitute for the concentrate diet. The experiment lasted for 56\u2009days. Peripheral blood was collected at 7, 35, and 56\u2009days of the experiment. The free radical scavenging activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay, the total antioxidant capacity assay (TAC), the reactive oxygen species (ROS), and reactive nitrogen species (RNS) were determined in plasma. The secretion of IL-1\u03b2, IL-6, and IL-10 cytokines was also determined by ELISA. The DPPH was affected by the interaction between feeding strategy and time of sampling (<jats:italic>p<\/jats:italic>\u2009=\u20090.039) with a higher level of DPPH at 7\u2009days in the HS group than the CON group. The time of sampling affected the levels of plasma TAC (<jats:italic>p<\/jats:italic>\u2009=\u20090.016), while the ROS\/RNS levels showed a higher value in the HS group (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001), on average. The antioxidant\/oxidant index, which combines the TAC and the ROS\/RNS levels, was not affected by the inclusion of hazelnut skin in the diet (<jats:italic>p<\/jats:italic>\u2009=\u20090.394). The cytokine profile showed a lower IL-6 secretion at both 35 and 56\u2009days than at 7\u2009days, on average. Furthermore, the feeding treatment affected the IL-1\u03b2 level, showing a lower level in the HS group than in the CON group on average. Lambs from the HS group had higher IL-10 plasma levels than the CON group at 7\u2009days of the experiment. The present data highlight an antioxidant effect and a modulatory role in the cytokine profile of HS supplementation in growing lambs.<\/jats:p>","DOI":"10.3389\/fvets.2024.1340141","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T04:39:09Z","timestamp":1706762349000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Role of hazelnut skin supplementation on plasma antioxidant status and cytokine profile in growing lambs"],"prefix":"10.3389","volume":"11","author":[{"given":"Maria Giovanna","family":"Ciliberti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Santillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Caroprese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"della 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