{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T21:44:04Z","timestamp":1773956644292,"version":"3.50.1"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>This study evaluated the physiological uptake range of <jats:sup>18<\/jats:sup>F-fluoro-2-deoxy-D-glucose (<jats:sup>18<\/jats:sup>F-FDG) in the normal ovaries of seven dogs using positron emission tomography\/computed tomography (PET\/CT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>The dogs were subjected to general anesthesia and were positioned in ventral recumbency for PET\/CT scans. The dosage of <jats:sup>18<\/jats:sup>F-FDG ranged from 0.14 to 0.17\u2009mCi\/kg and was administered intravenously followed by 0.9% NaCl flushing; PET\/CT images of each dog were obtained precisely 60\u2009min after the injection of <jats:sup>18<\/jats:sup>F-FDG. The regions of interest were drawn manually, and standardized uptake values (SUV) were calculated to evaluate the <jats:sup>18<\/jats:sup>F-FDG uptake in each ovary. The maximum and mean SUVs (SUV max and SUV mean) for all the ovaries of the dogs were then computed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The range of SUV max and SUV mean of the normal ovaries of the dogs were 1.28\u20131.62 and 1.07\u20131.31 (mean\u2009\u00b1\u2009standard deviation), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first study to investigate the normal <jats:sup>18<\/jats:sup>F-FDG uptake baseline data of normal canine ovaries using PET\/CT scans. These data will help clinicians in identifying malignant tumors before anatomical changes in the ovary through PET\/CT scans.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fvets.2024.1343695","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T04:17:40Z","timestamp":1706847460000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["An evaluation of the physiological uptake range of 18F-fluoro-2-deoxy-D-glucose in normal ovaries of seven dogs using positron emission tomography\/computed 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