{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:26:00Z","timestamp":1782962760429,"version":"3.54.5"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:00:00Z","timestamp":1712188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>Ameloblastoma in dogs most often has a highly conserved acanthomatous cell morphology and is recognized as canine acanthomatous ameloblastoma (CAA) while conventional ameloblastoma (CA) makes up a smaller yet morphologically diverse group of epithelial odontogenic tumors. In humans, a rare desmoplastic histological subtype has distinctive clinical, radiological, and microscopic features. Desmoplastic ameloblastoma (DA) has not previously been described in dogs, although it has been rarely referenced in the veterinary literature. This is the first thorough description of a case series of DA in dogs and describes clinical presentation, diagnostic imaging findings, histopathological features for diagnosis, and treatment outcome. Clinically, DA most often presents as a mass or swelling in the rostral mandible or maxilla of middle age to older dogs. On diagnostic imaging, the lesion has a radiolucent or mixed pattern with well-defined borders and variable loculation. As a solid, fibrous tumor with obscured odontogenic epithelium, DA is challenging to diagnose histologically and can mimic several other oral tumors, both benign and malignant. As an ameloblastoma, the biological behavior of DA is locally destructive yet benign and prognosis is favorable following surgical excision.<\/jats:p>","DOI":"10.3389\/fvets.2024.1362237","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T05:09:01Z","timestamp":1712207341000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Desmoplastic histological subtype of ameloblastoma in 16 dogs"],"prefix":"10.3389","volume":"11","author":[{"given":"Kristina","family":"Feigin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1177\/030098587901600206","article-title":"The nomenclature of periodontal epulides in dogs","volume":"16","author":"Dubielzig","year":"1979","journal-title":"Vet Pathol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1177\/030098588201900602","article-title":"Ameloblastoma and keratinizing ameloblastoma in dogs","volume":"19","author":"Dubielzig","year":"1982","journal-title":"Vet Pathol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/S0021-9975(08)80304-0","article-title":"The histopathological features of canine keratinizing ameloblastoma","volume":"109","author":"Gardner","year":"1993","journal-title":"J Comp Pathol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1177\/0898756417734312","article-title":"Clinical characterization of canine acanthomatous ameloblastoma (CAA) in 263 dogs and the influence of postsurgical histopathological margin on local recurrence","volume":"34","author":"Goldschmidt","year":"2017","journal-title":"J Vet Dent."},{"key":"B5","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1177\/0898756420969869","article-title":"Biological behavior of canine acanthomatous ameloblastoma assessed with computed tomography and histopathology: a comparative study","volume":"37","author":"Goldschmidt","year":"2020","journal-title":"J Vet Dent."},{"key":"B6","doi-asserted-by":"publisher","first-page":"17792","DOI":"10.1038\/s41598-021-97430-0","article-title":"Comparative transcriptional profiling of canine acanthomatous ameloblastoma and homology with human ameloblastoma","volume":"11","author":"Peralta","year":"2021","journal-title":"Sci Rep."},{"key":"B7","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1177\/0898756420924847","article-title":"Presentation, diagnostic imaging, and clinical outcome of conventional ameloblastoma in dogs","volume":"37","author":"Tjepkema","year":"2020","journal-title":"J Vet Dent."},{"key":"B8","first-page":"215","author":"El-Naggar","year":"2017","journal-title":"WHO Classification of Head and Neck Tumours"},{"key":"B9","doi-asserted-by":"publisher","first-page":"495","DOI":"10.2460\/javma.238.4.495","article-title":"Clinicopathologic characterization of odontogenic tumors and fibrous hyperplasia in dogs: 152 cases","volume":"15","author":"Fiani","year":"2011","journal-title":"J Am Vet Med Assoc."},{"key":"B10","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/j.oraloncology.2009.01.016","article-title":"Desmoplastic ameloblastoma\u2013A review","volume":"45","author":"Sun","year":"2009","journal-title":"Oral Oncol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"e246","DOI":"10.4317\/medoral.24152","article-title":"Retrospective analysis of desmoplastic ameloblastoma: clinical review","volume":"26","author":"Sharma","year":"2021","journal-title":"Med Oral Patol Oral Cir Bucal."},{"key":"B12","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/0030-4220(87)90257-X","article-title":"A histopathologic study of 116 ameloblastomas with special reference to the desmoplastic variant","volume":"63","author":"Waldron","year":"1987","journal-title":"Oral Surg Oral Med Oral Pathol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/0278-2391(84)90423-3","article-title":"Ameloblastomas with pronounced stromal desmoplasia","volume":"42","author":"Eversole","year":"1984","journal-title":"J Oral Maxillofac Surg."},{"key":"B14","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/S0901-5027(05)80761-1","article-title":"The desmo- and osteoplastic ameloblastoma. Histologic variant or clinicopathologic entity? Case reports","volume":"21","author":"Philipsen","year":"1992","journal-title":"Int J Oral Maxillofac Surg."},{"key":"B15","doi-asserted-by":"publisher","first-page":"338","DOI":"10.4103\/jomfp.JOMFP_136_19","article-title":"Stromal desmoplasia as a possible prognostic indicator in different grades of oral squamous cell carcinoma","volume":"23","author":"Zainab","year":"2019","journal-title":"J Oral Maxillofac Pathol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1292\/jvms.17-0178","article-title":"Desmoplastic tricholemmoma in a dog","volume":"79","author":"Kok","year":"2017","journal-title":"J Vet Med Sci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.5146\/tjpath.2017.01410","article-title":"The World Health Organization classification of odontogenic lesions: a summary of the changes of the 2017 (4th) edition","volume":"34","author":"Soluk-Tekke\u015fin","year":"2018","journal-title":"Turk Patoloji Derg."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1097\/PAS.0b013e31817a8a58","article-title":"Sclerosing odontogenic carcinoma: a previously unreported variant of a locally aggressive odontogenic neoplasm without apparent metastatic potential","volume":"32","author":"Koutlas","year":"2008","journal-title":"Am J Surg Pathol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"e76","DOI":"10.4317\/medoral.18006","article-title":"Histopathology of ameloblastoma of the jaws; some critical observations based on a 40 years single institution experience","volume":"17","author":"Hertog","year":"2012","journal-title":"Med Oral Patol Oral Cirugia Bucal."},{"key":"B20","doi-asserted-by":"publisher","first-page":"e126","DOI":"10.1016\/j.oooo.2014.07.008","article-title":"Cone beam computed tomography signs of desmoplastic ameloblastoma: review of 7 cases","volume":"118","author":"Luo","year":"2014","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1007\/s11282-019-00385-2","article-title":"Desmoplastic ameloblastoma of the jaw: CT and MR imaging findings","volume":"36","author":"Baba","year":"2020","journal-title":"Oral Radiol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"e27734","DOI":"10.7759\/cureus.27734","article-title":"Ameloblastoma: an updated narrative review of an enigmatic tumor","volume":"14","author":"Ghai","year":"2022","journal-title":"Cureus."},{"key":"B23","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1016\/j.ijom.2021.11.017","article-title":"Prediction of ameloblastoma recurrence using random forest-a machine learning algorithm","volume":"51","author":"Wang","year":"2022","journal-title":"Int J Oral Maxillofac Surg."},{"key":"B24","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1111\/j.1600-0560.1996.tb01472.x","article-title":"Intermediate- and low-molecular-weight keratin detection with the monoclonal antibody MNF116. An immunohistochemical study on 232 paraffin-embedded cutaneous lesions","volume":"23","author":"Prieto","year":"1996","journal-title":"J Cutan Pathol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/vru.12101","article-title":"Computed tomographic characteristics of odontogenic neoplasms in dogs","volume":"55","author":"Amory","year":"2014","journal-title":"Vet Radiol Ultrasound."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.2460\/ajvr.73.7.1057","article-title":"Prevalence and types of tooth resorption in dogs with oral tumors","volume":"73","author":"Nemec","year":"2012","journal-title":"Am J Vet Res."},{"key":"B27","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1177\/08987564231187080","article-title":"Non-invasive and locally invasive hypercellular peripheral odontogenic fibroma in 20 dogs","volume":"41","author":"Kim","year":"2024","journal-title":"J Vet Dent."},{"key":"B28","doi-asserted-by":"publisher","first-page":"830258","DOI":"10.3389\/fvets.2022.830258","article-title":"Surgical margins for ameloblastoma in dogs: a review with an emphasis on the future","volume":"9","author":"Goldschmidt","year":"2022","journal-title":"Front Vet Sci."}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2024.1362237\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T05:09:03Z","timestamp":1712207343000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2024.1362237\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,4]]},"references-count":28,"alternative-id":["10.3389\/fvets.2024.1362237"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2024.1362237","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,4]]},"article-number":"1362237"}}