{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T19:12:30Z","timestamp":1785265950747,"version":"3.55.0"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>In adult horses, the development and evaluation of enteral electrolyte solutions containing sodium acetate for correcting hyperchloremic metabolic acidosis are still lacking, although these electrolyte and acid\u2013base imbalances are commonly observed. The objective of this study was to evaluate the alkalinizing effect of two enteral electrolyte solutions containing different concentrations of acetate, administered via nasogastric tube in continuous flow, in adult horses with experimental hyperchloremic metabolic acidosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six mares aged between 3 and 10\u2009years were used in a 6\u00d72 crossover design, with each animal receiving both treatments. The horses were subjected to a protocol to induce hyperchloremic metabolic acidosis. They then received one of two treatments: HighAcetate (81.4\u2009mmol\/L) and LowAcetate (22.7\u2009mmol\/L) at an infusion rate of 15\u2009mL\/kg\/h for 12\u2009h. Plasma, serum, and urinary biochemical assessments; hematocrit; urinary volume, pH, and specific gravity; and blood gas analysis were measured at the following time points: T-12\u2009h (beginning of the 12-h fast), T0h (end of fasting and beginning of the acidosis induction phase), every 2\u2009h during the hyperchloremic metabolic acidosis induction phase (T<jats:sub>i<\/jats:sub>2h and T<jats:sub>i<\/jats:sub>4h), every 2\u2009h during the 12-h enteral hydration phase (T<jats:sub>t<\/jats:sub>2h, T<jats:sub>t<\/jats:sub>4h, Tt6h, T<jats:sub>t<\/jats:sub>8h, T<jats:sub>t<\/jats:sub>10h, and T<jats:sub>t<\/jats:sub>12h), with one sample taken at T24h (24\u2009h after the start of acidosis induction) and another at T36h (36\u2009h after the start of acidosis induction). Data were analyzed using descriptive statistics and analysis of variance based on a factorial design of repeated measures, with Tukey\u2019s <jats:italic>post-hoc<\/jats:italic> test or the Kruskal-Wallis test with Dunn\u2019s <jats:italic>post-hoc<\/jats:italic> test for non-parametric tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the end of the induction phase, the animals developed moderate to severe hyperchloremic metabolic acidosis. The HighAcetate solution effectively corrected electrolyte and acid\u2013base imbalances before the end of the treatment phase (Tt12h), while the LowAcetate solution was not effective in correcting those changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The HighAcetate (81.4 mmol\/L) solution is deemed an effective and safe alternative for the treatment of hyperchloremic metabolic acidosis in horses.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fvets.2024.1376578","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T05:11:38Z","timestamp":1726031498000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Treatment of experimental hyperchloremic metabolic acidosis in horses with enteral electrolyte solution containing sodium acetate"],"prefix":"10.3389","volume":"11","author":[{"given":"Lorena Chaves","family":"Monteiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio Monteiro","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Ancelmo Nunes","family":"Ermita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio Jos\u00e9 Printes Gomes","family":"J\u00fanior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe Sperandio","family":"Mattos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Campos","family":"Mansur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayara Oliveira","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel 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