{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T03:13:51Z","timestamp":1786590831084,"version":"build-2736575974"},"reference-count":75,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>The purpose of the present study was to investigate the effects of different levels of a Chinese herbal medicine formulation combined with JM113 (CHM-JM113) on growth performance, antioxidant capacity, organ index, and intestinal health of AA broilers. The AA broiler chicks were randomly allocated to 5 treatments as follows: a basic diet for the control group, the basic diet supplemented with 0.25% CHM-JM113, 0.5% CHM-JM113, 1% CHM-JM113 and 2% CHM-JM113 for the treatment group, respectively. The results showed that the addition of CHM-JM113 to the diet significantly reduced the mortality (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.01) and improved the European Broiler Index (EBI) (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05), whereas it had no significance on growth performance of AA broilers (<jats:italic>p<\/jats:italic>\u2009&amp;gt;\u20090.05). Comparing the control group, 0.5 and 1% CHM-JM113 group significantly improved the organ index of liver, spleen and bursa (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05). In terms of intestinal morphology and structure, the addition of different levels of CHM-JM113 increased VH and VH\/CD ratio, decreased CD in the small intestine compared to the control group, with 1 and 2% of the additive dose being more effective (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05). Chinese herbal medicine and probiotics as natural antioxidants also significantly increased the content of SOD in serum of 21-day-old broilers (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.01), and significantly decreased the content of MDA in serum (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.01). At 42\u2009days of age, the addition of 1 and 2% CHM-JM113 significantly increased the content of SOD (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.01) and significantly decreased the content of MDA in the organism (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.01), accompanied by a significant increase in T-AOC and CAT content. In the study of the effect of CHM-JM113 on intestinal immunity, compared with the control group, we found that 1% or 2% CHM-JM113 had a better effect on the expression of occludin and claudin-1 in the intestinal segments of broilers (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05). For the expression of GATA-3, 0.5% CHM-JM113 may have a better effect (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05). CHM-JM113 may be used as an antibiotic alternative in broiler production.<\/jats:p>","DOI":"10.3389\/fvets.2024.1388173","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T04:27:06Z","timestamp":1715747226000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Effects of different addition levels of CHM-JM113 on growth performance, antioxidant capacity, organ index, and intestinal health of AA broilers"],"prefix":"10.3389","volume":"11","author":[{"given":"Guanhua","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runyu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixuan","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongchen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tenghe","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"539","DOI":"10.3390\/antibiotics10050539","article-title":"Pollution 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