{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:42:50Z","timestamp":1791852170062,"version":"4.3.4"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Yeast peptides have garnered attention as valuable nutritional modifiers due to their potential health benefits. However, the precise mechanisms underlying their effects remain elusive. This study aims to explore the potential of yeast peptides, when added to diets, to mitigate lipopolysaccharide (LPS)-induced intestinal damage and microbiota alterations in rabbits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 160 35-day-old Hyla line rabbits (0.96\u2009\u00b1\u20090.06\u2009kg) were randomly assigned to 4 groups. These groups constituted a 2\u2009\u00d7\u20092 factorial arrangement: basal diet (CON), 100\u2009mg\/kg yeast peptide diet (YP), LPS challenge + basal diet (LPS), LPS challenge +100\u2009mg\/kg yeast peptide diet (L-YP). The experiment spanned 35\u2009days, encompassing a 7-day pre-feeding period and a 28-day formal trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results indicated that yeast peptides mitigated the intestinal barrier damage induced by LPS, as evidenced by a significant reduction in serum Diamine oxidase and D-lactic acid levels in rabbits in the L-YP group compared to the LPS group (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05). Furthermore, in the jejunum, the L-YP group exhibited a significantly higher villus height compared to the LPS group (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05). In comparison to the LPS group, the L-YP rabbits significantly upregulated the expression of <jats:italic>Claudin-1<\/jats:italic>, <jats:italic>Occludin-1<\/jats:italic> and <jats:italic>ZO-1<\/jats:italic> in the jejunum (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05). Compared with the CON group, the YP group significantly reduced the levels of rabbit jejunal inflammatory cytokines (TNF-\u03b1, IL-1\u03b2 and IL-6) and decreased the relative mRNA expression of jejunal signaling pathway-associated inflammatory factors such as <jats:italic>TLR4<\/jats:italic>, <jats:italic>MyD88<\/jats:italic>, <jats:italic>NF-\u03baB<\/jats:italic> and <jats:italic>IL-1\u03b2<\/jats:italic> (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05). Additionally, notable changes in the hindgut also included the concentration of short-chain fatty acids (SCFA) of the YP group was significantly higher than that of the CON group (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05). 16S RNA sequencing revealed a substantial impact of yeast peptides on the composition of the cecal microbiota. Correlation analyses indicated potential associations of specific gut microbiota with jejunal inflammatory factors, tight junction proteins, and SCFA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, yeast peptides have shown promise in mitigating LPS-induced intestinal barrier damage in rabbits through their anti-inflammatory effects, modulation of the gut microbiota, and maintenance of intestinal tight junctions.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fvets.2024.1393434","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T05:03:50Z","timestamp":1719378230000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Yeast peptides alleviate lipopolysaccharide-induced intestinal barrier damage in rabbits involving Toll-like receptor signaling pathway modulation and gut microbiota regulation"],"prefix":"10.3389","volume":"11","author":[{"given":"Jiaqi","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiao","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongfeng","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilin","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saijuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baojiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,6,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/jpn.12058","article-title":"Morphological and functional events associated to weaning in rabbits","volume":"98","author":"Bivolarski","year":"2014","journal-title":"J Anim Physiol Anim Nutr"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1242\/dmm.013284","article-title":"A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide","volume":"6","author":"Williams","year":"2013","journal-title":"Dis Model Mech"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.3892\/ijmm.2014.1965","article-title":"Amelioration of hypoxia and LPS-induced intestinal epithelial barrier dysfunction by emodin through the suppression of the NF-\u03baB and HIF-1\u03b1 signaling pathways","volume":"34","author":"Lei","year":"2014","journal-title":"Int J Mol Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s12986-016-0089-7","article-title":"The role of I-FABP as a biomarker of intestinal barrier dysfunction driven by gut microbiota changes in obesity","volume":"13","author":"Lau","year":"2016","journal-title":"Nutr Metab"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"113532","DOI":"10.1016\/j.ecoenv.2022.113532","article-title":"Long-term hexavalent chromium exposure disturbs the gut microbial homeostasis of chickens","volume":"237","author":"Li","year":"2022","journal-title":"Ecotoxicol Environ Saf"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1017\/S002966512100197X","article-title":"Inflammatory bowel disease and the gut microbiota","volume":"80","author":"Wu","year":"2021","journal-title":"Proc Nutr Soc"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.jnutbio.2015.09.020","article-title":"Butyrate suppresses murine mast cell proliferation and cytokine production through inhibiting histone deacetylase","volume":"27","author":"Zhang","year":"2016","journal-title":"J Nutr Biochem"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.tifs.2021.10.008","article-title":"Bioactive peptides from yeast: a comparative review on production methods, bioactivity, structure-function relationship, and stability","volume":"118","author":"Mirzaei","year":"2021","journal-title":"Trends Food Sci Technol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"2654","DOI":"10.1007\/s11694-019-00186-5","article-title":"Antioxidant activity and protective effects of Saccharomyces cerevisiae peptide fractions against H2O2-induced oxidative stress in Caco-2 cells","volume":"13","author":"Mirzaei","year":"2019","journal-title":"J Food Meas Charact"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"851184","DOI":"10.3389\/fvets.2022.851184","article-title":"Effects of Saccharomyces cerevisiae cultures on performance and immune performance of dairy cows during heat stress","volume":"9","author":"Dewei","year":"2022","journal-title":"Front Vet Sci"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"798","DOI":"10.3382\/ps\/pew379","article-title":"Effects of antimicrobial peptides on growth performance and small intestinal function in broilers under chronic heat stress","volume":"96","author":"Hu","year":"2017","journal-title":"Poult Sci"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/s41573-019-0058-8","article-title":"Antimicrobial host defence peptides: functions and clinical potential","volume":"19","author":"Mookherjee","year":"2020","journal-title":"Nat Rev Drug Discov"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"5064","DOI":"10.2527\/jas2017.1494","article-title":"Dietary supplemented antimicrobial peptide microcin J25 improves the growth performance, apparent total tract digestibility, fecal microbiota, and intestinal barrier function of weaned pigs","volume":"95","author":"Yu","year":"2017","journal-title":"J Anim Sci"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.intimp.2015.01.017","article-title":"Antimicrobial peptide cathelicidin-BF prevents intestinal barrier dysfunction in a mouse model of endotoxemia","volume":"25","author":"Song","year":"2015","journal-title":"Int Immunopharmacol"},{"key":"ref15","volume-title":"Nutrient requirements of rabbits","year":"1977"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"2472","DOI":"10.3390\/microorganisms11102472","article-title":"Yeast peptides improve the intestinal barrier function and alleviate weaning stress by changing the intestinal microflora structure of weaned lambs","volume":"11","author":"Li","year":"2023","journal-title":"Microorganisms"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.jevs.2017.02.009","article-title":"Alterations in intestinal permeability: the role of the \u201cleaky gut\u201d in health and disease","volume":"52","author":"Stewart","year":"2017","journal-title":"J Equine Vet"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s11739-023-03374-w","article-title":"Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review","volume":"19","author":"Di Vincenzo","year":"2023","journal-title":"Intern Emerg Med"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1136\/gut.2005.085373","article-title":"Alterations in intestinal permeability","volume":"55","author":"Arrieta","year":"2006","journal-title":"Gut"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"skab296","DOI":"10.1093\/jas\/skab296","article-title":"Bisdemethoxycurcumin attenuates lipopolysaccharide-induced intestinal damage through improving barrier integrity, suppressing inflammation, and modulating gut microbiota in broilers","volume":"99","author":"Zhang","year":"2021","journal-title":"J Anim Sci"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s40104-023-00835-2","article-title":"Yeast hydrolysate attenuates lipopolysaccharide-induced inflammatory responses and intestinal barrier damage in weaned piglets","volume":"14","author":"Fu","year":"2023","journal-title":"J Animal Sci Biotechnol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/s00018-012-1070-x","article-title":"Regulation of intestinal epithelial permeability by tight junctions","volume":"70","author":"Suzuki","year":"2013","journal-title":"Cell Mol Life Sci"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"14176","DOI":"10.1038\/s41598-019-50511-7","article-title":"Antimicrobial peptide, cLF36, affects performance and intestinal morphology, microflora, junctional proteins, and immune cells in broilers challenged with E. coli","volume":"9","author":"Daneshmand","year":"2019","journal-title":"Sci Rep"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"25679","DOI":"10.1038\/srep25679","article-title":"High therapeutic efficacy of Cathelicidin-WA against postweaning diarrhea via inhibiting inflammation and enhancing epithelial barrier in the intestine","volume":"6","author":"Yi","year":"2016","journal-title":"Sci Rep"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"242","DOI":"10.3389\/fcimb.2018.00242","article-title":"Protective ability of biogenic antimicrobial peptide microcin J25 against enterotoxigenic Escherichia coli-induced intestinal epithelial dysfunction and inflammatory responses IPEC-J2 cells","volume":"8","author":"Yu","year":"2018","journal-title":"Front Cell Infect Microbiol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.4049\/jimmunol.1601221","article-title":"Cathelicidin-WA improves intestinal epithelial barrier function and enhances host defense against enterohemorrhagic Escherichia coli O157:H7 infection","volume":"198","author":"Yi","year":"2017","journal-title":"J Immunol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3389\/fvets.2015.00057","article-title":"Regulation of the intestinal barrier function by host defense peptides","volume":"2","author":"Robinson","year":"2015","journal-title":"Front Vet Sci"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.3389\/fimmu.2018.01302","article-title":"The clinical significance and potential role of C-reactive protein in chronic inflammatory and neurodegenerative diseases","volume":"9","author":"Luan","year":"2018","journal-title":"Front Immunol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.jaci.2009.05.038","article-title":"Intestinal barrier function: molecular regulation and disease pathogenesis","volume":"124","author":"Groschwitz","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.bcp.2016.01.009","article-title":"Porcine lactoferrin-derived peptide LFP-20 protects intestinal barrier by maintaining tight junction complex and modulating inflammatory response","volume":"104","author":"Zong","year":"2016","journal-title":"Biochem Pharmacol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1016\/j.kint.2019.11.024","article-title":"Lipopolysaccharide induces filtrate leakage from renal tubular lumina into the interstitial space via a proximal tubular Toll-like receptor 4\u2013dependent pathway and limits sensitivity to fluid therapy in mice","volume":"97","author":"Nakano","year":"2020","journal-title":"Kidney Int"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"e66","DOI":"10.1038\/emm.2013.97","article-title":"Recognition of lipopolysaccharide pattern by TLR4 complexes","volume":"45","author":"Park","year":"2013","journal-title":"Exp Mol Med"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/82_2010_103","article-title":"NF-\u03baB and mucosal homeostasis","volume":"349","author":"Eckmann","year":"2011","journal-title":"Curr Top Microbiol Immunol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1038\/cr.2010.175","article-title":"NF-\u03baB in the regulation of epithelial homeostasis and inflammation","volume":"21","author":"Wullaert","year":"2011","journal-title":"Cell Res"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1189\/jlb.0412178","article-title":"Induction of the human cathelicidin LL-37 as a novel treatment against bacterial infections","volume":"92","author":"Van Der Does","year":"2012","journal-title":"J Leukoc Biol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.biotechadv.2012.12.009","article-title":"Gut microbiota, host health, and polysaccharides","volume":"31","author":"Xu","year":"2013","journal-title":"Biotechnol Adv"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1194\/jlr.R036012","article-title":"The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism","volume":"54","author":"Den Besten","year":"2013","journal-title":"J Lipid Res"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/nm.3444","article-title":"Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis","volume":"20","author":"Trompette","year":"2014","journal-title":"Nat Med"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"80313","DOI":"10.18632\/oncotarget.13450","article-title":"Dietary grape seed proanthocyanidins (GSPs) improve weaned intestinal microbiota and mucosal barrier using a piglet model","volume":"7","author":"Han","year":"2016","journal-title":"Oncotarget"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.metabol.2017.01.007","article-title":"Gut microbiota interactions with the immunomodulatory role of vitamin D in normal individuals","volume":"69","author":"Luthold","year":"2017","journal-title":"Metabolism"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1111\/obr.12784","article-title":"Microbes: possible link between modern lifestyle transition and the rise of metabolic syndrome","volume":"20","author":"Moossavi","year":"2019","journal-title":"Obes Rev"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"e338","DOI":"10.1038\/emm.2017.20","article-title":"Roles of intestinal epithelial cells in the maintenance of gut homeostasis","volume":"49","author":"Okumura","year":"2017","journal-title":"Exp Mol Med"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"120","DOI":"10.3389\/fmicb.2020.00120","article-title":"Distinct types of gut microbiota dysbiosis in hospitalized gastroenterological patients are disease non-related and characterized with the predominance of either enterobacteriaceae or enterococcus","volume":"11","author":"Mahnic","year":"2020","journal-title":"Front Microbiol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"3461","DOI":"10.3892\/etm.2019.7943","article-title":"Dysbiosis of gram-negative gut microbiota and the associated serum lipopolysaccharide exacerbates inflammation in type-2 diabetic patients with chronic kidney disease","volume":"18","author":"Salguero","year":"2019","journal-title":"Exp Ther Med"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1080\/1828051X.2022.2104177","article-title":"Dietary effects of enzymolytic soybean meal inclusion on antioxidant capacity, intestinal morphology and caecal microbiota of rex rabbits","volume":"21","author":"Kong","year":"2022","journal-title":"Ital J Anim Sci"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.physbeh.2017.02.027","article-title":"Diet-driven microbiota dysbiosis is associated with vagal remodeling and obesity","volume":"173","author":"Sen","year":"2017","journal-title":"Physiol Behav"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"e9085","DOI":"10.1371\/journal.pone.0009085","article-title":"Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults","volume":"5","author":"Larsen","year":"2010","journal-title":"PLoS One"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s13567-016-0355-8","article-title":"Influence of orally fed a select mixture of Bacillus probiotics on intestinal T-cell migration in weaned MUC4 resistant pigs following Escherichia coli challenge","volume":"47","author":"Yang","year":"2016","journal-title":"Vet Res"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"858192","DOI":"10.3389\/fmicb.2022.858192","article-title":"A novel bacterium, Butyricimonas virosa, preventing HFD-induced diabetes and metabolic disorders in mice via GLP-1 receptor","volume":"13","author":"Lee","year":"2022","journal-title":"Front Microbiol"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"3462","DOI":"10.3390\/ani12243462","article-title":"Effects of the antimicrobial peptide mastoparan X on the performance, permeability and microbiota populations of broiler chickens","volume":"12","author":"Zhu","year":"2022","journal-title":"Animals"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"3681","DOI":"10.1039\/C9FO02556A","article-title":"The prophylactic effects of different lactobacilli on collagen-induced arthritis in rats","volume":"11","author":"Fan","year":"2020","journal-title":"Food Funct"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"104344","DOI":"10.1016\/j.micpath.2020.104344","article-title":"The critical role of Faecalibacterium prausnitzii in human health: An overview","volume":"149","author":"Leylabadlo","year":"2020","journal-title":"Microb Pathog"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"e0221055","DOI":"10.1371\/journal.pone.0221055","article-title":"Faecalibacterium diversity in dairy cow milk","volume":"14","author":"Savin","year":"2019","journal-title":"PLoS One"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"614","DOI":"10.3343\/alm.2016.36.6.614","article-title":"A case of Flavobacterium ceti meningitis","volume":"36","author":"Park","year":"2016","journal-title":"Ann Lab Med"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1996","DOI":"10.3390\/microorganisms9091996","article-title":"Effects of mixing volatile fatty acids as carbon sources on Rhodospirillum rubrum carbon metabolism and redox balance mechanisms","volume":"9","author":"Cabecas Segura","year":"2021","journal-title":"Microorganisms"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"6160","DOI":"10.1038\/s41467-023-41817-2","article-title":"Repressed Blautia-acetate immunological axis underlies breast cancer progression promoted by chronic stress","volume":"14","author":"Ye","year":"2023","journal-title":"Nat Commun"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"27509","DOI":"10.1073\/pnas.1921223117","article-title":"Bifidobacterium alters the gut microbiota and modulates the functional metabolism of T regulatory cells in the context of immune checkpoint blockade","volume":"117","author":"Sun","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"7728","DOI":"10.1039\/D0FO02939D","article-title":"Exercise training combined with Bifidobacterium longum OLP-01 treatment regulates insulin resistance and physical performance in db\/db mice","volume":"12","author":"Hsu","year":"2021","journal-title":"Food Funct"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"906","DOI":"10.3389\/fimmu.2020.00906","article-title":"The genus Alistipes: gut bacteria with emerging implications to inflammation, cancer, and mental health","volume":"11","author":"Parker","year":"2020","journal-title":"Front Immunol"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.kint.2018.11.012","article-title":"Targeting gut microbiota with a complex mix of dietary fibers improves metabolic diseases","volume":"95","author":"Cani","year":"2019","journal-title":"Kidney Int"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"E4485","DOI":"10.1073\/pnas.1415174111","article-title":"Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity","volume":"111","author":"Leclercq","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2020.1848158","article-title":"Gut Bacteroides species in health and disease","volume":"13","author":"Zafar","year":"2021","journal-title":"Gut Microbes"}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2024.1393434\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T05:03:55Z","timestamp":1719378235000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2024.1393434\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,26]]},"references-count":62,"alternative-id":["10.3389\/fvets.2024.1393434"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2024.1393434","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,26]]},"article-number":"1393434"}}