{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:26:52Z","timestamp":1790062012073,"version":"4.0.1"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>Extended-spectrum \u03b2-lactamase (ESBL)-producing <jats:italic>Escherichia coli<\/jats:italic> (ESBL-EC) is regarded as one of the most important priority pathogens within the One Health interface. However, few studies have investigated the occurrence of ESBL-EC in giant pandas, along with their antibiotic-resistant characteristics and horizontal gene transfer abilities. In this study, we successfully identified 12 ESBL-EC strains (8.33%, 12\/144) out of 144 <jats:italic>E. coli<\/jats:italic> strains which isolated from giant pandas. We further detected antibiotic resistance genes (ARGs), virulence-associated genes (VAGs) and mobile genetic elements (MGEs) among the 12 ESBL-EC strains, and the results showed that 13 ARGs and 11 VAGs were detected, of which <jats:italic>bla<\/jats:italic><jats:sub>CTX-M<\/jats:sub> (100.00%, 12\/12, with 5 variants observed) and <jats:italic>papA<\/jats:italic> (83.33%, 10\/12) were the most prevalent, respectively. And <jats:italic>ISEcp1<\/jats:italic> (66.67%, 8\/12) and <jats:italic>IS26<\/jats:italic> (66.67%, 8\/12) were the predominant MGEs. Furthermore, horizontal gene transfer ability analysis of the 12 ESBL-EC showed that all <jats:italic>bla<\/jats:italic><jats:sub>CTX-M<\/jats:sub> genes could be transferred by conjugative plasmids, indicating high horizontal gene transfer ability. In addition, ARGs of <jats:italic>rmtB<\/jats:italic> and <jats:italic>sul2<\/jats:italic>, VAGs of <jats:italic>papA<\/jats:italic>, <jats:italic>fimC<\/jats:italic> and <jats:italic>ompT<\/jats:italic>, MGEs of <jats:italic>ISEcp1<\/jats:italic> and <jats:italic>IS26<\/jats:italic> were all found to be co-transferred with <jats:italic>bla<\/jats:italic><jats:sub>CTX-M<\/jats:sub>. Phylogenetic analysis clustered these ESBL-EC strains into group B2 (75.00%, 9\/12), D (16.67%, 2\/12), and B1 (8.33%, 1\/12), and 10 sequence types (STs) were identified among 12 ESBL-EC (including ST48, ST127, ST206, ST354, ST648, ST1706, and four new STs). Our present study showed that ESBL-EC strains from captive giant pandas are reservoirs of ARGs, VAGs and MGEs that can co-transfer with <jats:italic>bla<\/jats:italic><jats:sub>CTX-M<\/jats:sub> via plasmids. Transmissible ESBL-EC strains with high diversity of resistance and virulence elements are a potential threat to humans, animals and surrounding environment.<\/jats:p>","DOI":"10.3389\/fvets.2024.1394814","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T12:28:40Z","timestamp":1721996920000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Antibiotic-resistant characteristics and horizontal gene transfer ability analysis of extended-spectrum \u03b2-lactamase-producing Escherichia coli isolated from giant pandas"],"prefix":"10.3389","volume":"11","author":[{"given":"Haifeng","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siping","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengdong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaqiu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangneng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qigui","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijun","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"940600","DOI":"10.3389\/fmicb.2022.940600","article-title":"World 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