{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:57:49Z","timestamp":1787169469451,"version":"build-2736575974"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>The aim of the study was to compare the effect of three substances with ecbolic activity, Oxytocin, Prostaglandin F2\u03b1 (PGF2\u03b1) and Scopolamine, on the uterine involution process in dairy cows and on the resumption of ovarian activity. Eighty bovine were randomly divided in four groups: GROUP C: 20 cows treated, within 24\u2009h of calving, with 5\u2009mL\/head of saline solution; GROUP PG: 20 cows treated, within 24\u2009h of calving, with 150\u2009\u03bcg\/head of d-cloprostenol; GROUP OX: 20 cows treated, within 24\u2009h of calving, with 50\u2009IU\/head of oxytocin acetate; GROUP S: 20 cows treated, within 24\u2009h of calving, with 40\u2009mg\/q Scopolamine Butylbromide. Each cow was subjected to blood samples to evaluate the Hydroxyproline (HYP) levels, at T0, within 24\u2009h after calving, and T7, T14, T28, 7, 14, and 28\u2009days after calving, respectively. At T14 and T28, an ultrasound examination was performed to measure the diameter of ex-pregnant horn. In all cows, the reproductive indices (days to first service and number of artificial insemination for conception) were evaluated. In all groups, the HYP concentrations have been rising from T0 to T28, with the maximum levels obtained at T28 in the groups PG and S. As regard the diameter of uterine horn, the comparison among the groups showed significant differences only at T28, with lower values in the group PG and S. In group S and PG, the days to first service were less than other groups. Treatment with Scopolamine and PGF2\u03b1 resulted in better outcomes, evidenced clinically by more efficient uterine involution and faster ovarian recovery.<\/jats:p>","DOI":"10.3389\/fvets.2024.1405746","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T01:00:12Z","timestamp":1714611612000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Oxytocin, prostaglandin F2\u03b1, and scopolamine for uterine involution of dairy cows"],"prefix":"10.3389","volume":"11","author":[{"given":"Alice","family":"Carbonari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Burgio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenza","family":"Frattina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmondo","family":"Ceci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Sciannamblo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Cicirelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Rizzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,5,2]]},"reference":[{"key":"ref1","first-page":"1","volume-title":"Veterinary reproduction and obstetrics","author":"Noakes","year":"2018"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.cvfa.2004.06.008","article-title":"The postpartum uterus","volume":"20","author":"Sheldon","year":"2004","journal-title":"Vet Clin North Am"},{"key":"ref3","first-page":"38","article-title":"Uterine involution in cattle","volume-title":"The veterinary annual","author":"Kaidi","year":"1991"},{"key":"ref4","first-page":"126","article-title":"Effects of retained placenta on the fertility in treated dairy cows","volume":"17","author":"Gunay","year":"2011","journal-title":"Bulg J Agric Sci"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1016\/j.theriogenology.2005.08.021","article-title":"Defining postpartum uterine disease in cattle","volume":"65","author":"Sheldon","year":"2006","journal-title":"Theriogenology"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"2223","DOI":"10.3168\/jds.S0022-0302(02)74302-6","article-title":"Defining and diagnosing postpartum clinical endometritis and its impact on reproductive performance in dairy cows","volume":"85","author":"LeBlanc","year":"2002","journal-title":"J Dairy Sci"},{"key":"ref7","first-page":"940","article-title":"Studies into postpartal uterus motility of cattle. 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