{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T06:23:14Z","timestamp":1785046994185,"version":"3.55.0"},"reference-count":149,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>Infectious bursal disease (IBD) is one of the dangerous diseases of poultry that affects the bursa of Fabricius, which is an important organ of the bird\u2019s immune system. IBD virus is resistant to many drugs, making its control difficult. Vaccination of IBD is in practice for a long time worldwide to control IBD, but secondary issues like vaccine failure and lower efficacy lead to their reduced use in the field. Multiple medicines are currently used, but the phytochemicals have emerged as promising agents for controlling IBD. The drugs to be developed should possess direct antiviral properties by targeting viral entry mechanisms, enhancing the host immune response, and inhibiting viral protein synthesis. Phytochemicals have potential to contribute to food security by minimizing the possibility of disease outbreaks and ensuring that consumers worldwide obtain healthy poultry products. It has been now claimed that direct and indirect activities of phytochemicals can be effective in the control of IBDV. Although available evidence suggest that the phytochemicals can contribute in controlling occurrence IBDV, there is a definite need of focused studies to gain more insight and develop rational strategies for their practical use. This review highlights the disease caused by IBDV, inhibition of viral replication, boosting the immune system, disruption of viral membrane, and important phytochemicals showing antiviral activities against IBDV.<\/jats:p>","DOI":"10.3389\/fvets.2024.1421668","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T18:17:44Z","timestamp":1718129864000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Phytochemicals: a promising approach to control infectious bursal disease"],"prefix":"10.3389","volume":"11","author":[{"given":"Ifrah","family":"Tahir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah F.","family":"Alsayeqh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,6,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1093\/af\/vfac069","article-title":"Smallholder poultry production in the context of increasing global food prices: roles in poverty reduction and food security","volume":"13","author":"Birhanu","year":"2023","journal-title":"Anim Front"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"57","DOI":"10.47278\/journal.abr\/2024.012","article-title":"Unraveling the combinational approach for the antibacterial efficacy against infectious pathogens using the herbal extracts of the leaves of Dodonaea viscosa and fruits of Rubus fruticosus","volume":"16","author":"Rashid","year":"2024","journal-title":"Agrobiol Rec"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"75","DOI":"10.47278\/journal.ijab\/2022.011","article-title":"Antifungal activity of essential oils extracted from different plants against Penicillium digitatum causing green mold of citrus","volume":"11","author":"Bangulzai","year":"2022","journal-title":"Int J Agric Biosci"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"644","DOI":"10.3390\/ani12050644","article-title":"Poultry production and sustainability in developing countries under the COVID-19 crisis: lessons learned","volume":"12","author":"Attia","year":"2022","journal-title":"Animals"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"583","DOI":"10.9775\/kvfd.2021.25907","article-title":"In vitro and in vivo anticoccidial effects of butyric acid and its impact on blood and serum chemistry of broiler chickens","volume":"27","author":"Zurisha","year":"2021","journal-title":"Kafkas Univ Vet Fak Derg"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"84","DOI":"10.47278\/journal.ijab\/2022.012","article-title":"Effectiveness of Calotropis procera (Ait. 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