{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:35:51Z","timestamp":1789594551900,"version":"build-2803163510"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>Oxidative damage resulting from weaning stress significantly impacts the growth performance and health status of piglets. Taurine, a dietary antioxidant with diverse functions, was investigated in this study for its protective role against weaning stress-induced oxidative damage and its underlying mechanism. Forty 28-day-old male castrated weaned piglets were randomly assigned to four groups. The control group received the basal diet, while the experimental groups were fed the basal diet supplemented with 0.1, 0.2%, or 0.3% taurine over a 28-day period. <jats:italic>In vitro<\/jats:italic>, H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> was utilized to induce oxidative damage to the jejunal mucosa of piglets via IPEC-J2 cells. The results demonstrated that taurine supplementation reduced the incidence of diarrhea in piglets compared to that in the control group (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05); the addition of 0.2 and 0.3% taurine led to increased average daily gain and improved feed conversion efficiency in weaned piglets, showing a linear dose-response correlation (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05). Taurine supplementation at 0.2 and 0.3% enhanced the activities of serum CAT and GSH-Px while decreasing the levels of serum NO, XOD, GSSG, and MDA (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05). Moreover, it significantly elevated the levels of GSS, Trx, POD, complex I, mt-nd5, and mt-nd6, enhancing superoxide anion scavenging capacity and the hydroxyl-free scavenging rate in the livers of weaned piglets while reducing NO levels in the liver (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05). Additionally, 0.2 and 0.3% taurine supplementation decreased serum IL-6 levels and elevated the concentrations of IgA, IgG, and IL-10 in weaned piglets (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05). The levels of occludin, claudin, and ZO-1 in the jejunum mucosa of weaned piglets increased with 0.2 and 0.3% taurine supplementation (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05). In IPEC-J2 cells, pretreatment with 25\u2009mM taurine for 24\u2009h enhanced the activities of SOD and CAT; reduced the MDA content; upregulated the mRNA expression of various genes, including <jats:italic>ZO-1<\/jats:italic>, occludin, claudin-1, <jats:italic>Nrf2<\/jats:italic>, and <jats:italic>HO-1<\/jats:italic>; and reversed the oxidative damage induced by H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> exposure (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05). Overall, the findings suggest that the inclusion of 2 and 3% taurine in the diet can enhance growth performance, reduce diarrhea rates, ameliorate oxidative stress and inflammation, and promote intestinal barrier function in weaned piglets.<\/jats:p>","DOI":"10.3389\/fvets.2024.1436282","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T10:33:47Z","timestamp":1723026827000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Effects of taurine on the growth performance, diarrhea, oxidative stress and intestinal barrier function of weanling piglets"],"prefix":"10.3389","volume":"11","author":[{"given":"Miao","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zichen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghua","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"100115","DOI":"10.1016\/j.animal.2020.100115","article-title":"Short communication: preweaning socialization and environmental enrichment affect short-term performance after regrouping in commercially reared pigs","volume":"15","author":"Ko","year":"2021","journal-title":"Animal"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2280","DOI":"10.2527\/jas.2013-7388","article-title":"Management strategies to improve the performance of low birth weight pigs to weaning and their long-term consequences","volume":"92","author":"Douglas","year":"2014","journal-title":"J Anim Sci"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2585","DOI":"10.3390\/ani12192585","article-title":"Review on preventive measures to reduce post-weaning diarrhoea in piglets","volume":"12","author":"Canibe","year":"2022","journal-title":"Animals"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"944390","DOI":"10.3389\/fnut.2022.944390","article-title":"Research on the mechanism of HRP relieving IPEC-J2 cells immunological stress based on transcriptome sequencing analysis","volume":"9","author":"Li","year":"2022","journal-title":"Front Nutr"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/s43018-024-00738-9","article-title":"The pleiotropic functions of reactive oxygen species in cancer","volume":"5","author":"Wu","year":"2024","journal-title":"Nat Cancer"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1002\/fsn3.3784","article-title":"Reactive oxygen species in biological systems: pathways, associated diseases, and potential inhibitors-a review","volume":"12","author":"Rauf","year":"2024","journal-title":"Food Sci Nutr"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.aninu.2023.09.002","article-title":"Targeting mitochondria with antioxidant nutrients for the prevention and treatment of postweaning diarrhea in piglets","volume":"15","author":"Qiao","year":"2023","journal-title":"Anim Nutr"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"966","DOI":"10.3390\/antiox11050966","article-title":"Polyphenols sourced from Ilex latifolia Thunb. relieve intestinal injury via modulating ferroptosis in weanling piglets under oxidative stress","volume":"11","author":"Xu","year":"2022","journal-title":"Antioxidants"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"737522","DOI":"10.1016\/j.aquaculture.2021.737522","article-title":"Dietary Taraxacum mongolicum polysaccharide ameliorates the growth, immune response, and antioxidant status in association with NF-\u03baB, Nrf2 and TOR in Jian carp (Cyprinus carpio var. Jian)","volume":"547","author":"Yu","year":"2022","journal-title":"Aquaculture"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"740637","DOI":"10.1016\/j.aquaculture.2024.740637","article-title":"The major role of glucocorticoid receptor (GR) in astaxanthin alleviates immune stress in Channa argus lymphocyte","volume":"584","author":"Niu","year":"2024","journal-title":"Aquaculture"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3390\/nu14010107","article-title":"Astaxanthin as a novel mitochondrial regulator: a new aspect of carotenoids, beyond antioxidants","volume":"14","author":"Nishida","year":"2021","journal-title":"Nutrients"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.aninu.2023.03.006","article-title":"Research progress on anti-stress nutrition strategies in swine","volume":"13","author":"Wang","year":"2023","journal-title":"Anim Nutr"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.3390\/antiox10121876","article-title":"Taurine as a natural antioxidant: from direct antioxidant effects to protective action in various toxicological models","volume":"10","author":"Surai","year":"2021","journal-title":"Antioxidants"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"606","DOI":"10.4103\/1673-5374.380820","article-title":"Taurine: a promising nutraceutic in the prevention of retinal degeneration","volume":"19","author":"Garc\u00eda-Ayuso","year":"2024","journal-title":"Neural Regen Res"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"134","DOI":"10.7570\/jomes21088","article-title":"Beneficial effects of taurine on metabolic parameters in animals and humans","volume":"31","author":"Bae","year":"2022","journal-title":"J Obes Metab Syndr"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1093\/jas\/skaa311","article-title":"Dietary taurine supplementation attenuates lipopolysaccharide-induced inflammatory responses and oxidative stress of broiler chickens at an early age","volume":"98","author":"Han","year":"2020","journal-title":"J Anim Sci"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"4912141","DOI":"10.1155\/2023\/4912141","article-title":"Effects of apple polyphenols and taurine on growth performance, tissue morphology, and lipid and glucose metabolism in rice field eel (Monopterus albus) fed high oxidized fish oil","volume":"2023","author":"Wu","year":"2023","journal-title":"Aquac Nutr"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.aninu.2022.06.014","article-title":"Effects of daidzein on antioxidant capacity in weaned pigs and IPEC-J2 cells","volume":"11","author":"Li","year":"2022","journal-title":"Anim Nutr"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"100486","DOI":"10.1016\/j.xinn.2023.100486","article-title":"Obese Ningxiang pig-derived microbiota rewires carnitine metabolism to promote muscle fatty acid deposition in lean DLY pigs","volume":"4","author":"Yin","year":"2023","journal-title":"Innovation"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.aninu.2023.12.004","article-title":"Diarrhea induced by insufficient fat absorption in weaned piglets: causes and nutrition regulation","volume":"16","author":"Li","year":"2024","journal-title":"Anim Nutr"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.aninu.2024.03.005","article-title":"Tryptophan metabolism and piglet diarrhea: where we stand and the challenges ahead","volume":"17","author":"Zhao","year":"2024","journal-title":"Anim Nutr"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.3390\/antiox12071342","article-title":"Exploring the benefits of probiotics in gut inflammation and diarrhea-from an antioxidant perspective","volume":"12","author":"Li","year":"2023","journal-title":"Antioxidants"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.3390\/antiox12101852","article-title":"Dietary taurine improves growth performance and intestine health via the GSH\/GSSG antioxidant system and Nrf2\/ARE signaling pathway in weaned piglets","volume":"12","author":"Wang","year":"2023","journal-title":"Antioxidants"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1259133","DOI":"10.3389\/fmicb.2023.1259133","article-title":"Dietary taurine effect on intestinal barrier function, colonic microbiota and metabolites in weanling piglets induced by LPS","volume":"14","author":"Zhao","year":"2023","journal-title":"Front Microbiol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"493","DOI":"10.3390\/ani14030493","article-title":"Lactobacillus johnsonii improves intestinal barrier function and reduces post-weaning diarrhea in piglets: involvement of the endocannabinoid system","volume":"14","author":"Yin","year":"2024","journal-title":"Animals"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"100818","DOI":"10.1016\/j.animal.2023.100818","article-title":"Influence of body lesion severity on oxidative status and gut microbiota of weaned pigs","volume":"17","author":"Correa","year":"2023","journal-title":"Animal"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.3390\/antiox11112215","article-title":"Development of intestinal injury and restoration of weaned piglets under chronic immune stress","volume":"11","author":"Yu","year":"2022","journal-title":"Antioxidants"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1012207","DOI":"10.3389\/fnut.2022.1012207","article-title":"Tannic acid attenuates intestinal oxidative damage by improving antioxidant capacity and intestinal barrier in weaned piglets and IPEC-J2 cells","volume":"9","author":"Wang","year":"2022","journal-title":"Front Nutr"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s40104-020-00463-0","article-title":"Protective effects of taurine against muscle damage induced by diquat in 35 days weaned piglets","volume":"11","author":"Wen","year":"2020","journal-title":"J Anim Sci Biotechnol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"124280","DOI":"10.1016\/j.envpol.2024.124280","article-title":"Exploring Cr(VI)-induced blood-brain barrier injury and neurotoxicity in zebrafish and snakehead fish, and inhibiting toxic effects of astaxanthin","volume":"355","author":"Li","year":"2024","journal-title":"Environ Pollut"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"103559","DOI":"10.1016\/j.rsma.2024.103559","article-title":"Long-term exposure of zebrafish (Danio rerio) to Cr(VI): reproductive toxicity and neurotoxicity","volume":"74","author":"Zhao","year":"2024","journal-title":"Reg Stud Mar Sci"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"109925","DOI":"10.1016\/j.cbpc.2024.109925","article-title":"Review: mechanism of herbivores synergistically metabolizing toxic plants through liver and intestinal microbiota","volume":"281","author":"Tan","year":"2024","journal-title":"Comp Biochem Physiol C"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"190","DOI":"10.3390\/ani14020190","article-title":"Remodeling of hepatic glucose metabolism in response to early weaning in piglets","volume":"14","author":"Yu","year":"2024","journal-title":"Animals"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"324","DOI":"10.3390\/antiox13030324","article-title":"Silybin alleviated hepatic injury by regulating redox balance, inflammatory response, and mitochondrial function in weaned piglets under paraquat-induced oxidative stress","volume":"13","author":"Cai","year":"2024","journal-title":"Antioxidants"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"2679","DOI":"10.3390\/ani11092679","article-title":"Early weaning affects liver antioxidant function in piglets","volume":"11","author":"Yu","year":"2021","journal-title":"Animals"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.toxicon.2022.06.003","article-title":"Taurine attenuates AFB1-induced liver injury by alleviating oxidative stress and regulating mitochondria-mediated apoptosis","volume":"215","author":"Wu","year":"2022","journal-title":"Toxicon"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.3390\/antiox10111690","article-title":"The protective effect of taurine on oxidized fish-oil-induced liver oxidative stress and intestinal barrier-function impairment in juvenile Ictalurus punctatus","volume":"10","author":"Shi","year":"2021","journal-title":"Antioxidants"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s40104-019-0379-9","article-title":"Putrescine mitigates intestinal atrophy through suppressing inflammatory response in weanling piglets","volume":"10","author":"Liu","year":"2019","journal-title":"J Anim Sci Biotechnol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1042778","DOI":"10.3389\/fimmu.2022.1042778","article-title":"Weaning stress and intestinal health of piglets: a review","volume":"13","author":"Tang","year":"2022","journal-title":"Front Immunol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"402","DOI":"10.3390\/ani11020402","article-title":"Using nutritional strategies to shape the gastro-intestinal tracts of suckling and weaned piglets","volume":"11","author":"Huting","year":"2021","journal-title":"Animals"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"2323220","DOI":"10.1080\/19490976.2024.2323220","article-title":"IgA-mediated control of host-microbial interaction during weaning reaction influences gut inflammation","volume":"16","author":"Tang","year":"2024","journal-title":"Gut Microbes"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"skae007","DOI":"10.1093\/jas\/skae007","article-title":"Effect of Saccharomyces cerevisiae postbiotics and essential oil on growth performance and intestinal health of weanling pigs during K88 ETEC infection","volume":"102","author":"Yan","year":"2024","journal-title":"J Anim Sci"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.3390\/nu12092847","article-title":"The anti-inflammatory effect of taurine on cardiovascular disease","volume":"12","author":"Qaradakhi","year":"2020","journal-title":"Nutrients"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"e28400","DOI":"10.1016\/j.heliyon.2024.e28400","article-title":"Alleviation of taurine on liver injury of type 2 diabetic rats by improving antioxidant and anti-inflammatory capacity","volume":"10","author":"Ouyang","year":"2024","journal-title":"Heliyon"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"111028","DOI":"10.1016\/j.intimp.2023.111028","article-title":"Taurine reduction of injury from neutrophil infiltration ameliorates Streptococcus uberis-induced mastitis","volume":"124","author":"Li","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"114705","DOI":"10.1016\/j.ecoenv.2023.114705","article-title":"Dietary taurine supplementation counteracts deoxynivalenol-induced liver injury via alleviating oxidative stress, mitochondrial dysfunction, apoptosis, and inflammation in piglets","volume":"253","author":"Ji","year":"2023","journal-title":"Ecotoxicol Environ Saf"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1002\/cphy.c180011","article-title":"Physiology of electrolyte transport in the gut: implications for disease","volume":"9","author":"Rao","year":"2019","journal-title":"Compr Physiol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"132","DOI":"10.3390\/metabo13010132","article-title":"Comparison of the pig breeds in the small intestinal morphology and digestive functions at different ages","volume":"13","author":"Cheng","year":"2023","journal-title":"Metabolites"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"103621","DOI":"10.1016\/j.psj.2024.103621","article-title":"Molecular and metabolic responses to immune stress in the jejunum of broiler chickens: transcriptomic and metabolomic analysis","volume":"103","author":"Hu","year":"2024","journal-title":"Poult Sci"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"119711","DOI":"10.1016\/j.bbamcr.2024.119711","article-title":"Regulation of oxidative stress in the intestine of piglets after enterotoxigenic Escherichia coli (ETEC) infection","volume":"1871","author":"Jin","year":"2024","journal-title":"Biochim Biophys Acta"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.biochi.2020.09.007","article-title":"Jejunum: the understudied meeting place of dietary lipids and the microbiota","volume":"178","author":"Lema","year":"2020","journal-title":"Biochimie"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"155712","DOI":"10.1016\/j.metabol.2023.155712","article-title":"Upper small intestine microbiome in obesity and related metabolic disorders: a new field of investigation","volume":"150","author":"Steinbach","year":"2024","journal-title":"Metabolism"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1115552","DOI":"10.3389\/fimmu.2023.1115552","article-title":"Multifaceted involvements of Paneth cells in various diseases within intestine and systemically","volume":"14","author":"Cui","year":"2023","journal-title":"Front Immunol"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"8836","DOI":"10.3390\/ijms24108836","article-title":"Intestinal enteroendocrine cells: present and future druggable targets","volume":"24","author":"Atanga","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1093\/jas\/skac318","article-title":"Regional epithelial cell diversity in the small intestine of pigs","volume":"101","author":"Wiarda","year":"2023","journal-title":"J Anim Sci"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"e16427","DOI":"10.15252\/emmm.202216427","article-title":"Paneth cells as the cornerstones of intestinal and organismal health: a primer","volume":"15","author":"Wallaeys","year":"2023","journal-title":"EMBO Mol Med"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s12272-021-01327-5","article-title":"The role of mucosal barriers in human gut health","volume":"44","author":"Seo","year":"2021","journal-title":"Arch Pharm Res"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"4140","DOI":"10.1039\/d3cc06288k","article-title":"Superoxide dismutase nanozymes: current status and future perspectives on brain disease treatment and diagnosis","volume":"60","author":"Chen","year":"2024","journal-title":"Chem Commun"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"103134","DOI":"10.1016\/j.redox.2024.103134","article-title":"Biomarkers of NRF2 signalling: current status and future challenges","volume":"72","author":"Morgenstern","year":"2024","journal-title":"Redox Biol"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s00726-024-03384-8","article-title":"An insight into role of amino acids as antioxidants via NRF2 activation","volume":"56","author":"Egbujor","year":"2024","journal-title":"Amino Acids"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1159\/000485762","article-title":"Taurine protects mouse spermatocytes from ionizing radiation-induced damage through activation of Nrf2\/HO-1 signaling","volume":"44","author":"Yang","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.3390\/antiox12061217","article-title":"Cytoprotective role of heme oxygenase-1 in cancer chemoresistance: focus on antioxidant, antiapoptotic, and pro-autophagy properties","volume":"12","author":"Wang","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1002\/fsn3.3203","article-title":"Taurine alleviates oxidative stress in porcine mammary epithelial cells by stimulating the Nrf2-MAPK signaling pathway","volume":"11","author":"Xu","year":"2023","journal-title":"Food Sci Nutr"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s11130-022-00980-5","article-title":"Taurine treatment alleviates intestinal mucositis induced by 5-fluorouracil in mice","volume":"77","author":"Wang","year":"2022","journal-title":"Plant Foods Hum Nutr"}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2024.1436282\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T10:33:50Z","timestamp":1723026830000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2024.1436282\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,7]]},"references-count":64,"alternative-id":["10.3389\/fvets.2024.1436282"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2024.1436282","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,7]]},"article-number":"1436282"}}