{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:21:18Z","timestamp":1780392078902,"version":"3.54.1"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T00:00:00Z","timestamp":1721260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities of China","doi-asserted-by":"publisher","award":["31920240104"],"award-info":[{"award-number":["31920240104"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>Intestinal microbiota community is an important factor affecting the nutritional and health status of poultry, and its balance is crucial for improving the overall health of poultry. The study aimed to investigate the effect of dietary supplementation with <jats:italic>Glycyrrhiza uralensis<\/jats:italic> extract (GUE), <jats:italic>Lactobacillus acidophilus<\/jats:italic> (Lac) and their combination (GL) on growth performance and intestinal health in broilers in an 84-day feeding experiment. Supplementary 0.1% GUE and 4.5\u00d710<jats:sup>7<\/jats:sup> CFU\/g Lac significantly increased average daily gain (ADG), and GL (0.1% GUE and 4.5\u00d710<jats:sup>7<\/jats:sup> CFU\/g Lac) increased ADG and average daily feed intake (ADFI), and decreased feed conversion rate (FCR) in broilers aged 29 to 84 d and 1 to 84 d. Dietary GUE, Lac and GL increased the superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activity and decreased Malondialdehyde (MDA) content in the jejunum mucosa of broilers, and increased secretory IgA (sIgA) content in broilers at 84 d. Moreover, GUE, Lac and GL increased cecal microbial richness and diversity, and modulated microbial community composition. Both GUE and Lac reduced the harmful bacteria <jats:italic>Epsilonbacteraeota<\/jats:italic>, <jats:italic>Helicobacter<\/jats:italic>, and <jats:italic>H. pullorum<\/jats:italic> at 28 d and <jats:italic>Proteobacteria<\/jats:italic>, <jats:italic>Escherichia<\/jats:italic>, and <jats:italic>E. coli<\/jats:italic> at 84 d, while Lac and GL increased beneficial bacteria <jats:italic>Lactobacillus<\/jats:italic> and <jats:italic>L. gallinarum<\/jats:italic> at 28 d. Compared with individual supplementation, GL markedly increased the SOD activity and the sIgA content, and reduced <jats:italic>Helicobacter<\/jats:italic> and <jats:italic>Helicobacter pullorum<\/jats:italic>. In conclusion, GUE and <jats:italic>Lactobacillus acidophilus<\/jats:italic> as feed additives benefit growth performance and intestinal health, and their combined use shows an even more positive effect in broilers.<\/jats:p>","DOI":"10.3389\/fvets.2024.1436807","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T05:11:55Z","timestamp":1721279515000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of supplementation with Glycyrrhiza uralensis extract and Lactobacillus acidophilus on growth performance and intestinal health in broiler chickens"],"prefix":"10.3389","volume":"11","author":[{"given":"Ximei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotian","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaibing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingpai","family":"Zha Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxiong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"101905","DOI":"10.1016\/j.psj.2022.101905","article-title":"Polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis improve growth performance of broilers by enhancing intestinal health and modulating gut microbiota","volume":"101","author":"Qiao","year":"2022","journal-title":"Poult Sci"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1146\/annurev-animal-022114-111123","article-title":"The role of direct-fed Microbials in conventional livestock production","volume":"4","author":"Buntyn","year":"2016","journal-title":"Annu Rev Anim Biosci"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.3382\/ps.2013-03818","article-title":"Supplemental effect of probioticBacillus subtilis B2A on productivity, organ weight, intestinalSalmonella microflora, and breast meat quality of growing broiler chicks","volume":"93","author":"Park","year":"2014","journal-title":"Poult Sci"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s40793-022-00418-0","article-title":"Root-associated microbiota: the multifaceted hubs associated with environmental factors, growth status and accumulation of secondary metabolites","volume":"17","author":"Chen","year":"2022","journal-title":"Environ Microbiome"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1111\/pbi.13868","article-title":"Multi-omics profiling reveals comprehensive microbe-plant-metabolite regulation patterns for medicinal plant Glycyrrhiza uralensis Fisch","volume":"20","author":"Zhong","year":"2022","journal-title":"Plant Biotechnol J"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"8838290","DOI":"10.1155\/2020\/8838290","article-title":"Spectrum-effect relationships of flavonoids in Glycyrrhiza uralensis Fisch","volume":"2020","author":"Li","year":"2020","journal-title":"J Anal Methods Chem"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1080\/13880209.2016.1225775","article-title":"The anti-inflammatory activity of licorice, a widely used Chinese herb","volume":"55","author":"Yang","year":"2016","journal-title":"Pharm Biol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"100927","DOI":"10.1016\/j.psj.2020.12.025","article-title":"Effects of Glycyrrhiza polysaccharide in diet on growth performance, serum antioxidant capacity, and biochemistry of broilers","volume":"100","author":"Zhang","year":"2021","journal-title":"Poult Sci"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.jep.2013.02.017","article-title":"Glycyrrhizic acid as the antiviral component of Glycyrrhiza uralensis Fisch. 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