{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:36:14Z","timestamp":1753893374808,"version":"3.41.2"},"reference-count":73,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>The inner ear is an often overlooked system in elasmobranchs with few documented reports of disease or other abnormalities in the literature. Similar to terrestrial vertebrates, it is located in the cranium, and there are multiple components to the ear of elasmobranchs including a pair of membranous labyrinths each with three semicircular canals and four chambers or end organs (the saccule, the lagena, the utricle and the macula neglecta) making up the endolymphatic system (ELS). There is species variability among the inner ear anatomy of elasmobranchs, and this may play a role in disease development, progression, and treatment outcomes. Also similar to terrestrial vertebrates, this system plays a key role in hearing, acceleration, and orientation. When affected, clinical signs may include localized areas of swelling or stoma development along the dorsal midline of the head at the endolymphatic pores, atypical swimming behaviors consistent with vestibular disease (spiraling\/spinning or barrel rolling, or tilting to one side), and anorexia. Less frequently, the eyes may also be affected and present with exophthalmia, hyphema, and\/or panophthalmitis. Herein are case series from five institutions representing a variety of elasmobranch species affected with ELS disease with discussion of anatomy, clinical presentation, diagnostics, etiology, treatment, and outcomes. Endolymphatic disease may be clinically underdiagnosed in elasmobranchs and mistaken for other diseases such as superficial subcutaneous or subdermal abscesses, focal dermatitis, or neuropathies presumed to not be associated with the inner ear system. In addition, disease may be occult for a long period of time prior to overt manifestation of signs or chronic with waxing and waning clinical signs, likely because of anatomy and resultant treatment challenges. Awareness and additional research may help to promote timely identification, improve diagnostic and treatment options, and help to optimize individual animal welfare.<\/jats:p>","DOI":"10.3389\/fvets.2024.1463428","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T13:50:34Z","timestamp":1741614634000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case report: Endolymphatic system disease in elasmobranchs: clinical presentation, diagnosis, and treatment strategies"],"prefix":"10.3389","volume":"11","author":[{"given":"Whitney","family":"Greene","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuno","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bethany","family":"Doescher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Rojo-Solis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"David","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Faustino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Reese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"De Voe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ed","family":"Latson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Mylniczenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,10]]},"reference":[{"article-title":"Fusarium solani infection in the eye, brain, otic capsule and endolymphatic tubes in captive port Jackson sharks (Heterodontus portusjacksoni)","year":"2002","author":"Pereira","key":"ref1"},{"article-title":"Twenty years later: a new case of endolymphatic tube infection, internal otitis and meningitis caused by Fusarium Solani in a port Jackson shark (Heterodontus 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Aquat Anim Health"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1097\/00003086-199205000-00037","article-title":"In vitro and in vivo evaluation of antibiotic diffusion from antibiotic-impregnated polymethylmethacrylate beads","volume":"278","author":"Adams","year":"1992","journal-title":"Clin Orthop Relat Res"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1053\/jvet.2000.7535","article-title":"In vitro elution of gentamicin, amikacin, and ceftiofur from polymethylmethacrylate and hydroxyapatite cement","volume":"29","author":"Ethell","year":"2000","journal-title":"Vet Surg"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"239","DOI":"10.5216\/cab.v11i1.1753","article-title":"Betahistine dihydrochloride in canine peripheral vestibular syndrome-case report","volume":"11","author":"Brum","year":"2010","journal-title":"Cienc Anim Bras"},{"key":"ref52","doi-asserted-by":"crossref","DOI":"10.1002\/9781119220190.ch30","article-title":"Chapter 30: Zoological applications of laser therapy","volume-title":"Laser therapy in veterinary medicine: Photobiomodulation","author":"Dadone","year":"2017"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.ejphar.2005.09.017","article-title":"Dose-and duration-dependent effects of betahistine dihydrochloride treatment on histamine turnover in the cat","volume":"523","author":"Tighilet","year":"2005","journal-title":"Eur J Pharmacol"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/S0378-5955(97)00085-3","article-title":"Total ablation of cochlear haircells by perilymphatic perfusion with water","volume":"110","author":"Harrison","year":"1997","journal-title":"Hear Res"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1002\/lsm.20800","article-title":"Penetration of CO2 laser into the otic capsule using a hand-held, flexible-fiber delivery system","volume":"41","author":"Majdani","year":"2009","journal-title":"Lasers Surg Med"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1117\/12.766919","article-title":"Laser ablation of otic capsule tissue","volume":"6854","author":"McCaughey","year":"2008","journal-title":"Proc SPIE Int Soc Opt Eng"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1177\/0091270011414575","article-title":"Meclizine metabolism and pharmacokinetics: formulation on its absorption","volume":"52","author":"Wang","year":"2012","journal-title":"J Clin Pharmacol"},{"key":"ref58","first-page":"975","article-title":"Elasmobranchs","volume-title":"Pathology of wildlife and zoo animals","author":"Steadman","year":"2018"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"856","DOI":"10.2307\/1445969","article-title":"The biological significance of the variation in crystalline morph and habit of otoconia in elasmobranchs","volume":"1989","author":"Mulligan","year":"1989","journal-title":"Copeia"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s42523-022-00187-8","article-title":"Microbiome differences between wild and aquarium whitespotted eagle rays (Aetobatus narinari)","volume":"4","author":"Clavere-Graciette","year":"2022","journal-title":"Anim Microbiome"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"1190030","DOI":"10.3389\/fmars.2023.1151119","article-title":"Unveiling microbiome signature in inner body fluids: comparison between wild and aquarium small-spotted catshark (Scyliorhinus canicula)","volume":"10","author":"Mu\u00f1oz-Baquero","year":"2023","journal-title":"Front Mar Sci"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"990","DOI":"10.3390\/pharmaceutics13070990","article-title":"Pharmacokinetics and bioavailability of Carprofen in rainbow trout (Oncorhynchus mykiss) 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