{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:05:58Z","timestamp":1793120758723,"version":"4.5.0"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>The high-altitude, low-oxygen environment of the Qinghai-Tibet Plateau poses significant challenges for the introduction of superior livestock breeds. However, local plateau species have adapted to thrive and reproduce under these harsh conditions. Understanding the molecular mechanisms behind plateau animals\u2019 adaptation to low-oxygen environments is essential for breeding livestock suited to high-altitude regions. Tibetan pigs, which have undergone long-term natural selection and artificial breeding, have developed the ability to survive and reproduce in hypoxic environments. In this study, we conducted whole-genome resequencing of 30 Tibetan pigs from high-altitude regions and 30 Diannan small-ear pigs from low-altitude areas, to identify candidate genes that support Tibetan pigs\u2019 adaptation to hypoxic conditions through selection signal analysis. Additionally, we performed transcriptome sequencing on five tissues (heart, liver, spleen, lung, and bone marrow) from both Tibetan pigs and Diannan small-ear pigs to identify genes with significant differential expression between the two breeds. We then integrated the genomic and transcriptomic data by examining the expression of candidate genes identified in selection signal analysis across different tissues. The selection signal analysis identified 10 genes\u2014<jats:italic>HES<\/jats:italic>4, <jats:italic>ANGPT<\/jats:italic>1, <jats:italic>HIF3<\/jats:italic>A, <jats:italic>SPHK<\/jats:italic>2, <jats:italic>PCK<\/jats:italic>2, <jats:italic>RCN<\/jats:italic>3, <jats:italic>HIGD2<\/jats:italic>A, <jats:italic>DNM<\/jats:italic>2, <jats:italic>IRF<\/jats:italic>9, and <jats:italic>SRF<\/jats:italic>\u2014that were under positive selection in the Tibetan pig population and are associated with hypoxia adaptation. When combined with transcriptome data, we found that five of these genes\u2014<jats:italic>HIF3<\/jats:italic>A, <jats:italic>RCN<\/jats:italic>3, <jats:italic>HIGD2<\/jats:italic>A, <jats:italic>PCK<\/jats:italic>2, and <jats:italic>IRF<\/jats:italic>9\u2014exhibited differential expression. Through an integrated approach of selection signal and transcriptome analysis, we identified five key functional genes that contribute to the adaptation of Tibetan pigs to hypoxic environments. These findings offer new insights into the adaptability of plateau animals.<\/jats:p>","DOI":"10.3389\/fvets.2024.1486258","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T05:10:42Z","timestamp":1729487442000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Screening of functional genes for hypoxia adaptation in Tibetan pigs by combined genome resequencing and transcriptome 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