{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:07:25Z","timestamp":1777673245331,"version":"3.51.4"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Neonatal infectious arthritis (NIA) is a bacterial disease of lambs in the first month of life. NIA is associated with poor animal welfare, economic losses, and prophylactic antibiotic use. Farmers report problems with NIA despite following current guidance on prevention. The aim of this study was to estimate NIA UK incidence, describe current management practices for NIA control, and farm management risk factors associated with NIA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross-sectional, online questionnaire of UK sheep farmers was carried out between June and October 2020. Descriptive statistics, and univariable and multivariable risk factor analysis was undertaken.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 322 respondents, 64% reported joint ill cases in the 2020 lambing period. The median within flock incidence was 1.4% (IQR 0.8\u20132.6%; 95% CI, 1.2\u20131.6). Seventeen percent of farmers estimated their current treatment efficacy for NIA was less than 50%. Eleven percent of farmers used prophylactic or metaphylactic antibiotics in all lambs to prevent NIA occurrence. Across all flocks, risk factor associated with NIA occurrence was the number of ewes lambed (301\u2013600; OR, 3.9; 95% CI 1.9\u20138.0. &amp;gt;600; OR, 13.7; 95% CI, 5.4\u201334.4). In outdoor lambing flocks, increased risk of joint ill was associated with the number of ewes lambed (&amp;gt;600 ewes; OR, 34.7; 95% CI, 6.6\u2013182.7), not providing outdoor shelter to lambing ewes (OR, 3.0; 95% CI, 1.2\u20137.8), and not cleaning ear tags (OR, 5.7; 95% CI, 1.5\u201321.4). Using antibiotics as a preventative measure was associated with a reduced risk of joint ill (OR, 0.1; 95% CI, 0.01\u20130.4). In indoor lambing flocks, increased risk of joint ill was associated with upland flocks (OR, 3.0; 95% CI, 1.3\u20136.8), number of lambs born alive (501\u20131,000; OR, 4.1; 95% CI, 1.6\u201310.7. &amp;gt;1,000; OR, 14.0; 95% CI, 4.0\u201348.9), and not washing hands (OR, 3.6; 95% CI, 1.2\u201310.6).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NIA was reported in indoor and outdoor lambing flocks. A pattern of risk factors associated with increasing intensity of lambing was observed. Prophylactic antibiotic use was associated with a reduced risk of NIA in outdoor flocks, however, NIA still occurred in flocks where this was practiced. More veterinary involvement is advised in the diagnosis, treatment protocols, and prevention of NIA.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fvets.2024.1489751","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T06:42:46Z","timestamp":1734936166000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["A cross-sectional survey of farmer reported prevalence and farm management practices associated with neonatal infectious arthritis (\u201cjoint ill\u201d) in lambs, on UK sheep farms"],"prefix":"10.3389","volume":"11","author":[{"given":"L. P.","family":"Jackson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. M.","family":"Higgins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. S.","family":"Duncan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,12,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1136\/inpract.13.5.204","article-title":"Arthritis in lambs and sheep","volume":"13","author":"Angus","year":"1991","journal-title":"In Pract"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/s1090-0233(98)80132-9","article-title":"Bacteria isolated from arthritic and omphalatic lesions in lambs in England and Wales","volume":"156","author":"Watkins","year":"1998","journal-title":"Vet J"},{"key":"ref3","first-page":"1207","author":"Blakemore","year":"1939"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1136\/vr.102781","article-title":"Characteristics of sheep flocks affected by Streptococcus dysgalactiae arthritis","volume":"176","author":"Rutherford","year":"2015","journal-title":"Vet Rec"},{"key":"ref5","volume-title":"Piecing together the chain of infection for","author":"Smistad","year":"2022"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.smallrumres.2008.06.001","article-title":"Digestive pathway of infection in Streptococcus dysgalactiae polyarthritis in lambs","volume":"78","author":"Lacasta","year":"2008","journal-title":"Small Rumin Res"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1002\/path.1700520105","article-title":"Studies on suppurative polyarthritis (joint-ill) in lambs","volume":"52","author":"Blakemore","year":"1941","journal-title":"J Pathol Bacteriol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"298","DOI":"10.12968\/live.2014.19.5.298","article-title":"Joint ill in lambs","volume":"19","author":"Hovers","year":"2014","journal-title":"Livestock"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1136\/inp.k5370","article-title":"Responsible use of antibiotics on sheep farms: application at farm level","volume":"41","author":"Lovatt","year":"2019","journal-title":"In Pract"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.smallrumres.2019.06.008","article-title":"Effects of Streptococcus dysgalactiae polyarthritis on lamb growth and mortality and risk factors for disease","volume":"177","author":"Ridler","year":"2019","journal-title":"Small Rumin Res"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12917-016-0832-3","article-title":"Clinical, diagnostic and pathologic features of presumptive cases of Chlamydia pecorum-associated arthritis in Australian sheep flocks","volume":"12","author":"Walker","year":"2016","journal-title":"BMC Vet Res"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s13028-020-00561-z","article-title":"Flock-level risk factors for outbreaks of infectious arthritis in lambs, Norway 2018","volume":"62","author":"Smistad","year":"2020","journal-title":"Acta Vet Scand"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"43","DOI":"10.20506\/rst.17.1.1096","article-title":"Immunoglobulin diversity, B-cell and antibody repertoire development in large farm animals","volume":"17","author":"Butler","year":"1998","journal-title":"Revue scientifique et technique (International Office of Epizootics)"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.smallrumres.2013.11.006","article-title":"Passive immunity in lambs: serum lactoferrin concentrations as a predictor of IgG concentration and its relation to health status from birth to 12 weeks of life","volume":"116","author":"Gokce","year":"2014","journal-title":"Small Rumin Res"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/s0167-5877(02)00235-0","article-title":"Factors related to the risk of neonatal mortality, birth-weight and serum immunoglobulin concentration in lambs in the UK","volume":"57","author":"Christley","year":"2003","journal-title":"Prev Vet Med"},{"key":"ref16","year":"2023"},{"key":"ref17","year":"2024"},{"key":"ref18","year":"2024"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.vetmic.2009.08.012","article-title":"Erysipelothrix rhusiopathiae","volume":"140","author":"Wang","year":"2010","journal-title":"Vet Microbiol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/bf02214910","article-title":"Tick-borne fever: a review","volume":"6","author":"Woldehiwet","year":"1983","journal-title":"Vet Res Commun"},{"key":"ref21","volume-title":"Veterinary antibiotic resistance and sales surveillance report (UK-VARSS 2022)","year":"2023"},{"key":"ref22","doi-asserted-by":"crossref","DOI":"10.1201\/b18182","volume-title":"Sheep medicine","author":"Scott","year":"2015"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"109221","DOI":"10.1016\/j.vetmic.2021.109221","article-title":"Molecular detection and genotype characterization of Streptococcus dysgalactiae from sheep flocks with outbreaks of infectious arthritis","volume":"262","author":"Smistad","year":"2021","journal-title":"Vet Microbiol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/0007-1935(85)90142-3","article-title":"Observations on watery mouth in newborn lambs","volume":"141","author":"Collins","year":"1985","journal-title":"Br Vet J"},{"key":"ref25","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511974175","volume-title":"Multivariate analysis: A practical guide for clinicians and public health researchers","author":"Katz","year":"2011"},{"key":"ref26","year":"2021"}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2024.1489751\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T06:42:50Z","timestamp":1734936170000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2024.1489751\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,23]]},"references-count":26,"alternative-id":["10.3389\/fvets.2024.1489751"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2024.1489751","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,23]]},"article-number":"1489751"}}