{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:40:42Z","timestamp":1792712442031,"version":"4.5.0"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>A female giant panda presented with a large, hard mass on the right cheek, which was investigated at the Dujiangyan Base of the China Conservation and Research Center for the Giant Panda with computed tomography (CT) scans and biopsy of the oral mass, as well as venous blood sampling. Hematological tests revealed elevated levels of the tumor marker CA724, along with infectious disease, anemia, hepatic damage, and renal failure. Imaging studies identified a soft tissue mass in the right cheek area. Macroscopic pathological changes, histopathological features, and immunohistochemical analysis were consistent with a low-grade malignant fibrosarcoma within the oral cavity, indicating malignant potential. This case represents the first report of an oral tumor in a giant panda, providing valuable data for future clinical diagnoses of neoplasms in this species.<\/jats:p>","DOI":"10.3389\/fvets.2024.1500679","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T06:33:47Z","timestamp":1738650827000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case report: A study on the pathological diagnosis of oral fibrosarcoma in a giant panda"],"prefix":"10.3389","volume":"11","author":[{"given":"Zongliang","family":"Xiong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiwu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linhua","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengdong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengli","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,2,4]]},"reference":[{"key":"B1","first-page":"24","article-title":"Haemangiosarcoma of the conjunctiva of a giant panda","volume":"138","author":"Lopez","year":"1996","journal-title":"Vet Rec."},{"key":"B2","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1638\/04-098.1","article-title":"Cutaneous hemangioma in a giant panda (Ailuropoda melanoleuca)","volume":"37","author":"Mauroo","year":"2006","journal-title":"J Zoo Wildl Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"e1348","DOI":"10.1002\/vms3.1348","article-title":"Single-cell mRNA sequencing of giant panda (Ailuropoda melanoleuca) seminoma reveals the cellular and molecular characteristics of tumour cells","volume":"10","author":"Yijiao","year":"2024","journal-title":"Vet Med Sci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1002\/ame2.12269","article-title":"A rare case of giant panda cancer: pancreatic ductal adenocarcinoma","volume":"5","author":"Wang","year":"2022","journal-title":"Animal Model Exp Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1186\/s12917-018-1630-x","article-title":"A case of giant panda ovarian cancer diagnosis and histopathology","volume":"14","author":"Gao","year":"2018","journal-title":"BMC Vet Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"554","DOI":"10.5455\/javar.2023.j709","article-title":"Characteristics of canine oral tumors: Insights into prevalence, types, lesion distribution","volume":"10","author":"Satthathum","year":"2023","journal-title":"J Adv Vet Anim Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1111\/vco.12017","article-title":"Canine oral fibrosarcomas: a retrospective analysis of 65 cases (1998-2010)","volume":"13","author":"Gardner","year":"2015","journal-title":"Vet Comp Oncol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1111\/jsap.13082","article-title":"Spontaneous oral tumours in 18 rabbits (2005-2015)","volume":"62","author":"Miwa","year":"2021","journal-title":"J Small Anim Pract."},{"key":"B9","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1002\/1097-0142(19890815)64:4<925::AID-CNCR2820640427>3.0.CO;2-T","article-title":"Soft tissue fibrosarcoma. 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