{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:37:20Z","timestamp":1777559840703,"version":"3.51.4"},"reference-count":79,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Dogs are definitive hosts of <jats:italic>Echinococcus granulosus<\/jats:italic>, with the small intestine being the only site of parasitic infections. However, the immunomodulatory processes that occur during interactions between <jats:italic>E. granulosus<\/jats:italic> and its definitive host remain unclear. Therefore, this study aimed to evaluate gene transcription patterns in canine small intestinal epithelial cells (CIECs) following stimulation by <jats:italic>E. granulosus<\/jats:italic> protoscoleces (PSCs). Particularly, this study investigated the roles of pattern recognition receptors (PRRs), involved in recognizing pathogen-associated molecular patterns (PAMPs) and mediating the host innate immune response to the tapeworm <jats:italic>E. granulosus<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>RNA sequencing (RNA-seq) was used to examine gene transcription patterns in CIECs following stimulation with PSCs for 12 and 24\u202fh. The potential roles of differentially expressed (DE) genes were inferred through Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>RNA-seq analysis identified 78,206,492\u201390,548,214 clean reads in 12 RNA samples. This included six samples stimulated with PSCs for 12\u202fh (PSC1_12h\u2013PSC3_12h) and 24\u202fh (PSC1_24h\u2013PSC3_24h) and six corresponding control samples (PBS1_12h\u2013PBS3_12h and PBS1_24h\u2013PBS3_24h). In the PSC_12h vs. PBS_12h and PSC_24h vs. PBS_24h groups, 3,520 (2,359 upregulated and 1,161 downregulated) and 3,287 (1765 upregulated and 1,522 downregulated) DEgenes were identified, respectively. The expression of 45 PRRs genes was upregulated in the PSC_12h and PSC_24h groups compared to those in the control groups, including 4 Toll-like receptors (TLRs), 4C-type lectin receptors (CLRs), 3 NOD-like receptors (NLRs), 17\u202fG protein-coupled receptors (GPCRs), 4 scavenger receptors (SRs), and 13 leucine-rich repeat-containing proteins (LRRCs). GO enrichment and KEGG analyses revealed that these DEgenes were mainly involved in the regulation of host immune response processes and molecules. These included antigen processing and presentation, Th17, PI3K-Akt, Th1, and Th2 cell differentiation, neutrophil extracellular trap formation, NOD- and Toll-like receptors, TNF, intestinal immune network for IgA production and IL-17 signaling pathway. Furthermore, the identified DEgenes were involved in the regulation of signaling molecules and interaction (e.g., cell adhesion molecules and ECM-receptor interaction).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These preliminary findings provide novel perspectives on the host innate immune response to <jats:italic>E. granulosus<\/jats:italic> PSC stimulation, with a focus on the involvement of <jats:italic>E. granulosus<\/jats:italic>-specific PRRs in host defense mechanisms against infection.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fvets.2024.1503995","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T07:09:14Z","timestamp":1732864154000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["RNA sequencing reveals dynamic expression of genes related to innate immune responses in canine small intestinal epithelial cells induced by Echinococcus granulosus 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disease","author":"Thompson","year":"1986"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1128\/CMR.17.1.107-135.2004","article-title":"Biological, epidemiological, and clinical aspects of echinococcosis, a zoonosis of increasing concern","volume":"17","author":"Eckert","year":"2004","journal-title":"Clin Microbiol Rev"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.29261\/pakvetj\/2023.094","article-title":"Molecular characterization and phylogenetic analysis of canine parvovirus isolates in Palestine","volume":"43","author":"Sameh","year":"2023","journal-title":"Pak Vet J"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.29261\/pakvetj\/2022.009","article-title":"Molecular prevalence with associated risk factors and haemato-serum electrolyte analysis of E. coli O157:H7 in canine pups with diarrhoea","author":"Asfand","year":"2022","journal-title":"Pak Vet 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Vectors"},{"key":"ref21","first-page":"52","article-title":"The isolation and identification of primary canine intestinal epithelial cells","volume":"54","author":"Zhao","year":"2022","journal-title":"Anim. 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Helminthol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"925","DOI":"10.3390\/pathogens10080925","article-title":"Trichuris muris model: role in understanding intestinal immune response, inflammation and host defense","volume":"10","author":"Yousefi","year":"2021","journal-title":"Pathogens"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"e0139769","DOI":"10.1371\/journal.pone.0139769","article-title":"Toll-like receptor family polymorphisms are associated with primary renal diseases but not with renal outcomes following kidney transplantation","volume":"10","author":"Dessing","year":"2015","journal-title":"PLoS 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Dis"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/sj.gene.6364096","article-title":"Toll-like receptor 6 gene (TLR6): single-nucleotide polymorphism frequencies and preliminary association with the diagnosis of asthma","volume":"5","author":"Tantisira","year":"2004","journal-title":"Gene Immun"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"3977","DOI":"10.4049\/jimmunol.171.8.3977","article-title":"Expression and function of toll-like receptors in eosinophils: activation by toll-like receptor 7 ligand","volume":"171","author":"Nagase","year":"2003","journal-title":"J Immunol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"4531","DOI":"10.4049\/jimmunol.168.9.4531","article-title":"Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides","volume":"168","author":"Hornung","year":"2002","journal-title":"J Immunol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1159\/000535523","article-title":"TLR10: an intriguing toll-like receptor with many unanswered questions","volume":"16","author":"Rodrigues","year":"2024","journal-title":"J Innate Immun"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"219","DOI":"10.18502\/ijpa.v16i2.6271","article-title":"Dysregulation of ovine toll-like receptors 2 and 4 expression by hydatid cyst-derived antigens","volume":"16","author":"Soleymani","year":"2021","journal-title":"Iran J Parasitol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/s41423-019-0314-1","article-title":"Glycomolecules in Echinococcus granulosus cyst fluid inhibit TLR4-mediated inflammatory responses via c-Raf","volume":"17","author":"Hou","year":"2020","journal-title":"Cell Mol Immunol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.molimm.2017.12.007","article-title":"Expression profiles of genes involved in TLRs and NLRs signaling pathways of water buffaloes infected with Fasciola gigantica","volume":"94","author":"Zhang","year":"2018","journal-title":"Mol Immunol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1093\/glycob\/cwg005","article-title":"A novel GlcNAcalpha1-HPO3-6Gal(1-1) ceramide antigen and alkylated inositol-phosphoglycerolipids expressed by the liver fluke Fasciola hepatica","volume":"13","author":"Wuhrer","year":"2003","journal-title":"Glycobiology"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1080\/07853890701576172","article-title":"Nod-like receptors in innate immunity and inflammatory diseases","volume":"39","author":"Carneiro","year":"2007","journal-title":"Ann Med"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1002\/ana.24070","article-title":"NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage","volume":"75","author":"Ma","year":"2014","journal-title":"Ann Neurol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"e96703","DOI":"10.1371\/journal.pone.0096703","article-title":"Serum amyloid a induces NLRP-3-mediated IL-1\u03b2 secretion in neutrophils","volume":"9","author":"Migita","year":"2014","journal-title":"PLoS One"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s11882-010-0109-z","article-title":"Inflammasome and IL-1beta-mediated disorders","volume":"10","author":"Hoffman","year":"2010","journal-title":"Curr Allergy Asthma Rep"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"20459","DOI":"10.1073\/pnas.1010337107","article-title":"Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses","volume":"107","author":"Ritter","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"39316","DOI":"10.18632\/oncotarget.10044","article-title":"Activation of NLRP3 inflammasomes in mouse hepatic stellate cells during Schistosoma","volume":"7","author":"Meng","year":"2016","journal-title":"J Inf Oncotarget"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s13071-018-3223-8","article-title":"NLRP3 inflammasome activation from Kupffer cells is involved in liver fibrosis of Schistosoma japonicum-infected mice via NF-\u03baB","volume":"12","author":"Zhang","year":"2019","journal-title":"Parasit Vectors"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"109254","DOI":"10.1016\/j.vetpar.2020.109254","article-title":"Pyroptosis executioner gasdermin D contributes to host defense and promotes Th 1 immune response during Neospora caninum infection","volume":"286","author":"Wang","year":"2020","journal-title":"Vet 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fertilization","volume":"46","author":"Abe","year":"2017","journal-title":"Immunity"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.fsi.2022.09.041","article-title":"Involvement and characterization of NLRCs and pyroptosis-related genes in Nile tilapia (Oreochromis niloticus) immune response","volume":"130","author":"Li","year":"2022","journal-title":"Fish Shellfish Immunol"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1186\/s13071-019-3441-8","article-title":"Transcriptional profiling of innate immune responses in sheep PBMCs induced by Haemonchus contortus soluble extracts","volume":"12","author":"Wang","year":"2019","journal-title":"Parasit Vectors"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.4049\/jimmunol.163.4.1973","article-title":"APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory 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XCIV. Adhesion G protein-coupled receptors","volume":"67","author":"Hamann","year":"2015","journal-title":"Pharmacol Rev"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"38250","DOI":"10.1038\/srep38250","article-title":"Increased EMR2 expression on neutrophils correlates with disease severity and predicts overall mortality in cirrhotic patients","volume":"6","author":"Huang","year":"2016","journal-title":"Sci Rep"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"4425","DOI":"10.1128\/IAI.66.9.4425-4430.1998","article-title":"An essential role for interleukin-5 and eosinophils in helminth-induced airway hyperresponsiveness","volume":"66","author":"Hall","year":"1998","journal-title":"Infect Immun"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/0167-5699(94)90021-3","article-title":"Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells","volume":"15","author":"Zurawski","year":"1994","journal-title":"Immunol Today"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1146\/annurev.iy.07.040189.001045","article-title":"TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties","volume":"7","author":"Mosmann","year":"1989","journal-title":"Annu Rev Immunol"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.cytogfr.2012.04.001","article-title":"Plasticity and cross-talk of interleukin 6-type cytokines","volume":"23","author":"Garbers","year":"2012","journal-title":"Cytokine Growth Factor Rev"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.canlet.2016.01.004","article-title":"The role of IL-11 in immunity and cancer","volume":"373","author":"Xu","year":"2016","journal-title":"Cancer 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