{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:01:47Z","timestamp":1779894107542,"version":"3.53.1"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Brucellosis is endemic in bison and elk in Yellowstone National Park and surrounding areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comparative study was conducted using data from naive (<jats:italic>n<\/jats:italic>\u202f=\u202f82 and 67, respectively) and <jats:italic>Brucella abortus<\/jats:italic> strain RB51 (RB51) vaccinated (n-99 and 29, respectively) bison and elk experimentally challenged with virulent <jats:italic>B. abortus<\/jats:italic> strain during pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of abortion, fetal infection, uterine or mammary infection, or infection in maternal tissues after experimental challenge was greater (<jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.05) in na\u00efve and vaccinated bison when compared to similar groups in elk. Vaccinated bison had lower (<jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.002) abortion rates and recovery of <jats:italic>Brucella<\/jats:italic> from fetal or uterine\/mammary tissues when compared to na\u00efve bison. Vaccinated elk had reduced (<jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.01) rates of maternal infection, but rates of abortion and fetal or uterine\/mammary infection did not differ (<jats:italic>p<\/jats:italic>\u202f&amp;gt;\u202f0.05) from na\u00efve elk. Na\u00efve and vaccinated bison had greater (<jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.05) <jats:italic>Brucella<\/jats:italic> colonization in placentomes, and parotid and supramammary lymphatic tissues when compared to elk. In elk or bison that aborted, mean colonization in placentome tissues were typically more than 5 logs higher than in animals that did not abort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The results of our study suggest differences in disease pathogenesis between these two wildlife reservoirs of <jats:italic>B. abortus<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fvets.2024.1519453","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T06:15:48Z","timestamp":1736921748000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of bison and elk susceptibility to experimental challenge with Brucella abortus strain 2308"],"prefix":"10.3389","volume":"11","author":[{"given":"S. C.","family":"Olsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. M.","family":"Boggiatto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. J.","family":"Putz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,15]]},"reference":[{"key":"ref1","first-page":"745","article-title":"Bang's disease in Bison and elk in the Yellowstone National Park and on the National Bison Range","volume":"86","author":"Tunnicliff","year":"1935","journal-title":"J Am Vet Med Assoc"},{"key":"ref2","first-page":"105","article-title":"Abortion disease","volume-title":"Agriculture USDo","author":"Mohler","year":"1917"},{"key":"ref3","article-title":"Brucellosis-Feedground-habitat program: an integrated management approach to brucellosis in elk in Wyoming","volume-title":"Brucellosis in elk and Bison in the greater Yellowstone area","author":"Clause","year":"2002"},{"key":"ref4","article-title":"Brucellosis in the greater Yellowstone area","volume-title":"Science 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