{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:36:52Z","timestamp":1753893412880,"version":"3.41.2"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2024-00337663"],"award-info":[{"award-number":["RS-2024-00337663"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>An 8-year-old neutered male Miniature Poodle, weighing 6.7 kg, was presented with lethargy, anorexia, and single seizure episode. Neurological examination revealed bilaterally absent menace reflexes and an obtunded mental status. Magnetic resonance imaging showed a papilliform shaped mass measuring 1.2 \u00d7 1.4 \u00d7 1.3 cm in size, with a volume of 1.17 cm<jats:sup>3<\/jats:sup> in the third ventricle. 3,4-dihydroxy-6-[<jats:sup>18<\/jats:sup>F] fluoro-l-phenylalanine (<jats:sup>18<\/jats:sup>F-FDOPA) positron emission tomography\/computed tomography (PET\/CT) was performed 53 days after presentation, revealing a hypermetabolic region in the intraventricular mass with mean and maximal standardized uptake values (SUV<jats:sub>mean<\/jats:sub> and SUV<jats:sub>max<\/jats:sub>) of 1.2 and 1.42, respectively, and a tumor to normal tissue (T\/N) ratio of 1.33. The mass lesion measured 1.3 \u00d7 1.4 \u00d7 1.2 cm in size, with a volume of 1.09 cm<jats:sup>3<\/jats:sup> on contrast-enhanced CT images. The metabolic tumor volume (MTV) was 1.184 <jats:inline-formula><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:msubsup><mml:mrow><mml:mtext>cm<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mo>.<\/mml:mo><\/mml:mrow><mml:mrow><mml:mn>3<\/mml:mn><\/mml:mrow><\/mml:msubsup><\/mml:math><\/jats:inline-formula> No evidence of brain parenchymal metastases was observed. Therefore, the dog was tentatively diagnosed with a brain tumor, which was suspected to be a choroid plexus papilloma (CPP) and chemotherapy with prednisolone and cyclophosphamide was initiated. As worsening clinical signs were observed, a second <jats:sup>18<\/jats:sup>F-FDOPA PET\/CT scan was performed on day 183. The SUV<jats:sub>mean<\/jats:sub>, SUV<jats:sub>max<\/jats:sub>, and T\/N ratio of the lesion were 1.49, 1.85, and 1.62, respectively. The mass lesion measured 1.0 \u00d7 1.0 \u00d7 1.3 cm in size, with a volume of 0.68 cm<jats:sup>3<\/jats:sup> on contrast-enhanced CT images, whereas the MTV was increased to 2.217 cm<jats:sup>3<\/jats:sup>. The dog died 186 days after the presentation. To the best of our knowledge, this is the first report describing the <jats:sup>18<\/jats:sup>F-FDOPA PET\/CT findings in a dog with an intraventricular brain tumor suspected of having CPP. In the present case, although the lesion size decreased on CT contrast imaging, an increase in the MTV was observed on follow-up <jats:sup>18<\/jats:sup>F-FDOPA PET\/CT after chemotherapy. Thus, an increase in MTV post-chemotherapy combined with the worsening clinical signs and limited survival period in dogs correlates with poor prognosis, as previously reported in a human study. This case offers significant diagnostic insights into canine intraventricular tumors within the field of veterinary medicine.<\/jats:p>","DOI":"10.3389\/fvets.2025.1477063","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T10:45:24Z","timestamp":1742985924000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: 18F-FDOPA PET in the clinical management of a dog with an intraventricular tumor suspected to be choroid plexus 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