{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:39:54Z","timestamp":1783946394754,"version":"3.55.0"},"reference-count":83,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Hypocalcemia and magnesium disturbances are linked to vasoplegia, cardiac arrhythmias, gastrointestinal ileus, and coagulopathies. In human critical care patients, these imbalances are associated with higher mortality and longer hospital stay. Little is known about such associations in companion animals. Our study assessed the prevalence of ionized calcium (iCa) and ionized magnesium (iMg) disturbances in dogs and cats with septic peritonitis at presentation, and their association with administration of antiarrhythmics, vasopressors, prokinetics, and plasma, hospitalization duration and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records of patients with septic peritonitis from January 2018 to December 2023 were reviewed. Inclusion criteria were confirmed septic peritonitis and blood gas analysis with ionized calcium and magnesium values at admission. Data collected included signalment, diagnosis and cause, calcium and magnesium levels, administration of vasopressors, antiarrhythmics, prokinetics, and plasma, length of hospitalization, and survival. Comparisons were made using Chi-square, Fisher exact test, and ANOVA. Correlations were assessed with the Spearman coefficient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty-one dogs and 17 cats were included. Hypocalcemia (iCa\u202f&amp;lt;\u202f1.25\u202fmmol\/L in dogs; &amp;lt;1.10\u202fmmol\/L in cats) was diagnosed in 51.7% of dogs and 23.5% of cats. Hypomagnesemia (iMg\u202f&amp;lt;\u202f0.43\u202fmmol\/L in dogs; &amp;lt;0.47\u202fmmol\/L in cats) was found in 13.5% of dogs and 0% of cats, and hypermagnesemia (iMg\u202f&amp;gt;\u202f0.6\u202fmmol\/L in dogs; &amp;gt;0.7\u202fmmol\/L in cats) in 15.4% of dogs and 60% of cats. Hypocalcemia and hypermagnesemia were significantly more common in dogs and cats, respectively. Ionized hypocalcemia was associated with plasma administration in dogs (<jats:italic>p<\/jats:italic>\u202f=\u202f0.038). No significant correlation was found between iCa and iMg disturbances and length of hospitalization in dogs (respectively <jats:italic>p<\/jats:italic>\u202f=\u202f0.62 and <jats:italic>p<\/jats:italic>\u202f=\u202f0.62) or cats (respectively <jats:italic>p<\/jats:italic>\u202f=\u202f0.62 and <jats:italic>p<\/jats:italic>\u202f=\u202f0.27). The survival rate was 50%, with no association between iCa and iMg derangements and survival in dogs (<jats:italic>p<\/jats:italic>\u202f=\u202f0.30 and <jats:italic>p<\/jats:italic>\u202f=\u202f0.38 respectively), nor in cats (<jats:italic>p<\/jats:italic>\u202f=\u202f0.29 and <jats:italic>p<\/jats:italic>\u202f=\u202f0.29 respectively). A significant difference was observed in the mean iMg values between survivors (0.49\u202f\u00b1\u202f0.09\u202fmmol\/L) and non-survivors (0.55\u202f\u00b1\u202f0.11\u202fmmol\/L) in dogs (<jats:italic>p<\/jats:italic>\u202f=\u202f0.042).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>In this population with septic peritonitis, about half of the dogs and a quarter of the cats had ionized hypocalcemia. Hypo- and hypermagnesemia were rare in dogs, while hypermagnesemia was common in cats and hypomagnesemia was not seen in cats. Dogs and cats with hypocalcemia were more likely to receive plasma. Mean iMg values were lower in survived dogs than dogs that did not survive.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fvets.2025.1550701","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T14:02:28Z","timestamp":1747404148000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Ionized calcium and ionized magnesium disturbances in dogs and cats with septic peritonitis"],"prefix":"10.3389","volume":"12","author":[{"given":"Chiara","family":"Debie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Giberto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Noel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Paepe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kris","family":"Gommeren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/S0272-6386(01)80116-5","article-title":"Hypocalcemia: a pervasive metabolic abnormality in the critically ill","volume":"37","author":"Zivin","year":"2001","journal-title":"Am J Kidney Dis"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/0002-9343(88)90415-9","article-title":"Prevalence and clinical implications of hypocalcemia in acutely III patients in a medical intensive care setting","volume":"84","author":"Desai","year":"1988","journal-title":"Am J Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"36","DOI":"10.7326\/0003-4819-107-1-36","article-title":"The multifactorial basis for hypocalcemia during Sepsis: studies of the parathyroid hormone-vitamin D Axis","volume":"107","author":"Zaloga","year":"1987","journal-title":"Ann Intern Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1016\/S0196-0644(05)81466-0","article-title":"Ionized hypocalcemia during prolonged cardiac arrest and closed-chest CPR in a canine model","volume":"20","author":"Cairns","year":"1991","journal-title":"Ann Emerg Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/B978-1-4377-0654-3.00013-5","article-title":"Disorders of Calcium: Hypercalcemia and Hypocalcemia","volume-title":"Fluid, electrolyte, and acid-base disorders in small animal practice, Fourth Edition","author":"Schenck","year":"2012"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1016\/j.cvsm.2013.07.008","article-title":"Hypocalcemia of critical illness in dogs and cats","volume":"43","author":"Holowaychuk","year":"2013","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1097\/00003246-199008000-00012","article-title":"Pharmacodynamic response to ionized calcium during acute sepsis","volume":"18","author":"Steinhorn","year":"1990","journal-title":"Crit Care Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1097\/00003246-199009000-00004","article-title":"Hypermagnesemia and hypocalcemia as predictors of high mortality in critically ill pediatric patients","volume":"18","author":"Broner","year":"1990","journal-title":"Crit Care Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1111\/j.1939-1676.2009.0280.x","article-title":"Ionized hypocalcemia in critically ill dogs","volume":"23","author":"Holowaychuk","year":"2009","journal-title":"J Vet Intern Med"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1111\/j.1476-4431.2010.00553.x","article-title":"Retrospective study: incidence of ionized hypocalcemia in septic dogs and its association with morbidity and mortality: 58 cases (2006\u20132007)","volume":"20","author":"Luschini","year":"2010","journal-title":"J Vet Emerg Crit Care"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"187","DOI":"10.2460\/ajvr.24.07.0187","article-title":"Calcium and magnesium abnormalities in puppies with parvoviral enteritis","volume":"86","author":"Mouton","year":"2025","journal-title":"Am J Vet Res"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"897","DOI":"10.2460\/javma.2004.225.897","article-title":"Underlying cause, pathophysiologic abnormalities, and response to treatment in cats with septic peritonitis: 51 cases (1990\u20132001)","volume":"225","author":"Costello","year":"2004","journal-title":"J Am Vet Med Assoc"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1111\/j.1476-4431.2010.00562.x","article-title":"Retrospective study: ionized calcium concentrations in cats with septic peritonitis: 55 cases (1990\u20132008)","volume":"20","author":"Kellett-Gregory","year":"2010","journal-title":"J Vet Emerg Crit Care"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1093\/bja\/79.3.363","article-title":"Effects of magnesium sulphate on the cardiovascular system, coronary circulation and myocardial metabolism in anaesthetized dogs","volume":"79","author":"Nakaigawa","year":"1997","journal-title":"Br J Anaesth"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1111\/j.1939-1676.1999.tb01467.x","article-title":"Hemodynamic and electrocardiographic effects of magnesium sulfate in healthy dogs","volume":"13","author":"Nakayama","year":"1999","journal-title":"J Vet Intern Med"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0033-0620(93)90008-2","article-title":"Magnesium and cardiovascular disease","volume":"35","author":"Arsenian","year":"1993","journal-title":"Prog Cardiovasc Dis"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1177\/0885066604271539","article-title":"Magnesium deficiency in critical illness","volume":"20","author":"Tong","year":"2005","journal-title":"J Intensive Care Med"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/0002-9149(94)90362-X","article-title":"The associations of levels of serum potassium and magnesium with ventricular premature complexes (the Framingham heart study)","volume":"74","author":"Tsuji","year":"1994","journal-title":"Am J Cardiol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1097\/00005792-196901000-00003","article-title":"Experimental human magnesium depletion","volume":"48","author":"Shils","year":"1969","journal-title":"Medicine (Baltimore)"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1001\/archinte.1985.00360090162024","article-title":"Magnesium depletion as a cause of refractory potassium repletion","volume":"145","author":"Whang","year":"1985","journal-title":"Arch Intern Med"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1111\/j.1365-2265.1976.tb01947.x","article-title":"Functional hypoparathyroidism and parathyroid hormone end-organ resistance in human magnesium 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ill patients","volume":"31","author":"Escuela","year":"2005","journal-title":"Intensive Care Med"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"S256","DOI":"10.1097\/00003246-199304001-00246","article-title":"Ionized magnesium values un critically ill patients - a novel ion selective electrode for determining free extracellular magnesium concentrations","volume":"21","author":"Salem","year":"1993","journal-title":"Crit Care Med"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1111\/j.1476-4431.1994.tb00111.x","article-title":"Abnormalities of serum magnesium in critically III dogs: incidence and implications","volume":"4","author":"Martin","year":"1994","journal-title":"J Vet Emerg Crit Care"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"e301","DOI":"10.1002\/vetr.301","article-title":"Investigation of hypomagnesaemia prevalence and underlying aetiology in a hospitalised cohort of dogs with ionised hypocalcaemia","volume":"189","author":"Woods","year":"2021","journal-title":"Vet Rec"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/j.1467-2995.2006.00300.x","article-title":"The effects of surgery and anesthesia on blood magnesium and calcium concentrations in canine and feline patients","volume":"34","author":"Brainard","year":"2007","journal-title":"Vet Anaesth Analg"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"251","DOI":"10.3109\/00365519609088645","article-title":"Relationship between ionized and total magnesium in serum","volume":"56","author":"K\u00fclpmann","year":"1996","journal-title":"Scand J Clin Lab Invest"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.2460\/javma.1998.212.09.1398","article-title":"Ionized and total magnesium concentrations in blood from dogs with naturally acquired parvoviral enteritis","volume":"212","author":"Mann","year":"1998","journal-title":"J Am Vet Med 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diagnosis","volume":"33","author":"Ragetly","year":"2011","journal-title":"Compend Contin Educ Vet"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"462","DOI":"10.2460\/javma.2003.223.462","article-title":"Pneumoperitoneum in dogs and cats: 39 cases (1983\u20132002)","volume":"223","author":"Saunders","year":"2003","journal-title":"J Am Vet Med Assoc"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/B978-0-323-76469-8.00066-6","article-title":"Calcium disorders","volume-title":"Small animal critical care medicine, Third Edition","author":"Felipe de Brito Galvao","year":"2023"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"734","DOI":"10.35248\/2329-9096.24.12.734","article-title":"Hypocalcemia and acute traumatic coagulation disease","volume":"12","author":"Zou","year":"2024","journal-title":"Int J Phys Med Rehabil"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"130","DOI":"10.15406\/emij.2017.05.00130","article-title":"Hypocalcemia in the critically ill: a mini-review","volume":"5","author":"Naafs","year":"2017","journal-title":"Endocrinol Int J"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1111\/vec.12673","article-title":"The effect of fasting on gastrointestinal motility in healthy dogs as assessed by sonography","volume":"27","author":"Sanderson","year":"2017","journal-title":"J Vet Emerg Crit Care"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1111\/vec.12092","article-title":"Positive impact of an emergency department protocol on time to antimicrobial administration in dogs with septic peritonitis","volume":"23","author":"Abelson","year":"2013","journal-title":"J Vet Emerg Crit Care"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1111\/j.1532-950X.2014.12258.x","article-title":"Closed suction drainage for treatment of septic peritonitis of confirmed gastrointestinal origin in 20 dogs","volume":"43","author":"Adams","year":"2014","journal-title":"Vet Surg"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1111\/jsap.13346","article-title":"Outcome following surgery to treat septic peritonitis in 95 cats in the United Kingdom","volume":"62","author":"Anderson","year":"2021","journal-title":"J Small Anim Pract"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1111\/vec.12234","article-title":"Plasma lactate concentrations in septic peritonitis: a retrospective study of 83 dogs (2007\u20132012)","volume":"25","author":"Cortellini","year":"2015","journal-title":"J Vet Emerg Crit Care"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1111\/j.1476-4431.2012.00819.x","article-title":"The use of canine-specific albumin in dogs with septic peritonitis","volume":"22","author":"Craft","year":"2012","journal-title":"J Vet Emerg Crit Care"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1111\/jsap.12151","article-title":"Septic peritonitis from pyloric and non-pyloric gastrointestinal perforation: prognostic factors in 44 dogs and 11 cats","volume":"54","author":"Dayer","year":"2013","journal-title":"J Small Anim Pract"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1111\/vec.12273","article-title":"Impact of appropriate empirical antimicrobial therapy on outcome of dogs with septic peritonitis","volume":"25","author":"Dickinson","year":"2015","journal-title":"J Vet Emerg Crit 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Rec"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1053\/jvet.2002.31043","article-title":"Open peritoneal drainage versus primary closure for the treatment of septic peritonitis in dogs and cats: 42 cases (1993\u20131999)","volume":"31","author":"Staatz","year":"2002","journal-title":"Vet Surg"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1111\/vec.13052","article-title":"Prognostic indicators at presentation for canine parvoviral enteritis: 322 cases (2001-2018)","volume":"31","author":"Chalifoux","year":"2021","journal-title":"J Vet Emerg Crit Care"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.34067\/KID.0002592021","article-title":"Increased mortality associated with Hypermagnesemia in severe COVID-19 illness","volume":"2","author":"Stevens","year":"2021","journal-title":"Kidney"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.jss.2015.12.036","article-title":"Hypocalcemia in trauma patients receiving massive transfusion","volume":"202","author":"Giancarelli","year":"2016","journal-title":"J Surg Res"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.jcrc.2004.02.011","article-title":"Serum levels of calcium and albumin in survivors versus nonsurvivors after critical injury","volume":"19","author":"Ward","year":"2004","journal-title":"J Crit Care"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1097\/01.CCM.0000171840.01892.36","article-title":"Early hypocalcemia in severe trauma","volume":"33","author":"Vivien","year":"2005","journal-title":"Crit Care Med"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1111\/j.1476-4431.1993.tb00108.x","article-title":"Magnesium in the 1990\u2019s: implications for veterinary critical care","volume":"3","author":"Martin","year":"1993","journal-title":"J Vet Emerg Crit Care"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1093\/ajh\/4.2.113","article-title":"Effect of saline infusion on urinary calcium excretion in essential hypertension","volume":"4","author":"Nakamura","year":"1991","journal-title":"Am J Hypertens"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/B978-0-323-76469-8.00211-2","volume-title":"Small animal critical care medicine, Third Edition","author":"Wolf","year":"2023"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/B978-1-4377-0654-3.00015-9","article-title":"Disorders of magnesium: magnesium deficit and excess","volume-title":"Fluid, electrolyte, and acid-base disorders in small animal practice, Fourth Edition","author":"Bateman","year":"2012"},{"key":"ref68","first-page":"137","article-title":"Evaluation of ionized and total serum magnesium concentrations in hyperthyroid cats","volume":"70","author":"Gilroy","year":"2006","journal-title":"Can J Vet Res"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"656","DOI":"10.2460\/ajvr.2005.66.656","article-title":"Assessment of the effect of dilution of blood samples with sodium heparin on blood gas, electrolyte, and lactate measurements in dogs","volume":"66","author":"Hopper","year":"2005","journal-title":"Am J Vet Res"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"e72","DOI":"10.1136\/vr.105900","article-title":"Effect of pH and storage conditions on measured ionised calcium concentration in dogs and cats","volume":"187","author":"Mazaki-Tovi","year":"2020","journal-title":"Vet 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