{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:43:39Z","timestamp":1791593019525,"version":"4.3.4"},"reference-count":79,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>The management of osteoarthritis (OA) in dogs is typically multimodal, including weight management, activity adjustment, joint supplements, and medical treatments when needed. This study evaluated the efficacy of a joint supplement containing eggshell membrane, krill meal with omega-3 fatty acids, <jats:italic>Haematococcus pluvialis<\/jats:italic> as a source of astaxanthin, hyaluronic acid and a <jats:italic>Boswellia Serrata<\/jats:italic> extract, in dogs with OA, in a multicenter, randomized, placebo-controlled trial. Fifty-two dogs with confirmed OA were given the test supplement or a placebo, for 90\u202fdays. Owners regularly completed two validated questionnaires for osteoarthritis (CBPI and LOAD) and rated their dog\u2019s discomfort every 15 to 30\u202fdays. Monthly evaluations by investigators included assessments of the dog\u2019s posture, gait, joint pain upon palpation and range of motion (from 1-normal to 4-severe or severely impacted) to determine a clinical score. Statistical analyses included both within-group and between-group comparisons. Of the 52 dogs enrolled, 46 completed the study, with 22 receiving the supplement and 24 receiving the placebo. All main parameters significantly improved over time in the supplement group (CBPI pain severity, CBPI pain interference, LOAD, discomfort, clinical score). In the placebo group, only the CBPI pain interference and LOAD improved. However, there was a statistically significant difference between groups for the CBPI pain interference (<jats:italic>p<\/jats:italic>\u202f=\u202f0.009). Therefore, this study demonstrates that the test supplement can improve the mobility and quality of life of osteoarthritic dogs.<\/jats:p>","DOI":"10.3389\/fvets.2025.1561793","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T05:24:00Z","timestamp":1748841840000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of a joint supplement containing eggshell membrane among other ingredients to improve the mobility of dogs with osteoarthritis: a multicenter double-blind randomized placebo-controlled study"],"prefix":"10.3389","volume":"12","author":[{"given":"Guillaume R.","family":"Ragetly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c2ngela","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciprian A.","family":"Ober","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Boiocchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line S.","family":"Nicolas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"830098","DOI":"10.3389\/fvets.2022.830098","article-title":"Proposed Canadian Consensus Guidelines on Osteoarthritis Treatment based on OA-COAST Stages 1\u20134","volume":"9","author":"Mosley","year":"2022","journal-title":"Front Vet Sci"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s12917-021-02775-3","article-title":"Prevalence of commonly diagnosed disorders in UK dogs under primary veterinary care: results and applications","volume":"17","author":"O\u2019Neill","year":"2021","journal-title":"BMC Vet Res"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1140417","DOI":"10.3389\/fvets.2023.1140417","article-title":"Lifetime prevalence of owner-reported medical conditions in the 25 most common dog breeds in the dog aging project pack","volume":"10","author":"Forsyth","year":"2023","journal-title":"Front Vet Sci"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"339","DOI":"10.3415\/VCOT-08-08-0069","article-title":"A review of osteoarthritis and obesity: current understanding of the relationship and benefit of obesity treatment and prevention in the dog","volume":"22","author":"Marshall","year":"2009","journal-title":"Vet Comp Orthop Traumatol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"5641","DOI":"10.1038\/s41598-018-23940-z","article-title":"Prevalence, duration and risk factors for appendicular osteoarthritis in a UK dog population under primary veterinary care","volume":"8","author":"Anderson","year":"2018","journal-title":"Sci Rep"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"220","DOI":"10.3389\/fvets.2020.00220","article-title":"Risk factors for canine osteoarthritis and its predisposing arthropathies: a systematic review","volume":"7","author":"Anderson","year":"2020","journal-title":"Front Vet Sci"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1275964","DOI":"10.3389\/fvets.2023.1275964","article-title":"Body weight, gonadectomy, and other risk factors for diagnosis of osteoarthritis in companion dogs","volume":"10","author":"Graves","year":"2023","journal-title":"Front Vet Sci"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"2827","DOI":"10.1038\/s41598-024-52324-9","article-title":"Prevalence of radiographic appendicular osteoarthritis and associated clinical signs in young dogs","volume":"14","author":"Enomoto","year":"2024","journal-title":"Sci Rep"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"106132","DOI":"10.1016\/j.tvjl.2024.106132","article-title":"Prevalence of osteoarthritis in the shoulder, elbow, hip and stifle joints of dogs older than 8 years","volume":"305","author":"Roitner","year":"2024","journal-title":"Vet J"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1186\/s12917-020-02647-2","article-title":"Clinical and diagnostic imaging findings in police working dogs referred for hip osteoarthritis","volume":"16","author":"Alves","year":"2020","journal-title":"BMC Vet Res"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1137888","DOI":"10.3389\/fvets.2023.1137888","article-title":"COAST Development Group\u2019s international consensus guidelines for the treatment of canine osteoarthritis","volume":"10","author":"Cachon","year":"2023","journal-title":"Front Vet Sci"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"105198","DOI":"10.1016\/j.prevetmed.2020.105198","article-title":"Could it be osteoarthritis? 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