{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:33:39Z","timestamp":1781714019279,"version":"3.54.5"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The prevalence of lipid metabolism disorders, including obesity, increases with age in cats and humans. Obesity is a condition characterized by systemic low-grade inflammation and oxidative stress caused by excessive visceral fat accumulation. Resveratrol (RSV), a natural plant polyphenol, modulates the expression of anti-inflammatory factors. This study aimed to investigate the effects of resveratrol supplementation on lipid metabolism in both healthy and obese cats and assess its potential as a dietary supplement for improving lipid metabolism disorders in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Plasma metabolite and hormone concentrations, and enzyme activities were measured in healthy, obese, and overweight cats supplemented with RSV for 4 weeks. RVS was supplemented at 1 mg\/kg body weight\/day (low dose) and 5 mg\/kg\/day (high dose) in capsules for 4 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Body weight, body condition score, BUN, and insulin concentrations did not change in obese or overweight cats with RSV supplementation for 4 weeks. Plasma triglyceride, free fatty acids, and serum amyloid A (SAA) concentrations and lactate dehydrogenase (LDH) activities decreased, and adiponectin concentrations increased markedly in obese and overweight cats after RSV supplementation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Decreased plasma SAA concentrations and LDH activities and increased plasma adiponectin concentrations in obese and overweight cats seem to be induced by the improvement in liver function and the anti-inflammatory effect of RSV. Moreover, RSV supplementation may be useful in treating lipid metabolism disorders, including obesity, in cats.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fvets.2025.1565367","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T13:10:11Z","timestamp":1744809011000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of resveratrol supplementation on lipid metabolism in healthy and obese cats"],"prefix":"10.3389","volume":"12","author":[{"given":"Jung Eun","family":"Yun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Rok","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Joong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoo","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiro","family":"Arai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,16]]},"reference":[{"key":"B1","first-page":"177","article-title":"Prevalence and risk factor for obesity in adult dogs from private US veterinary practices","volume":"4","author":"Lund","year":"2006","journal-title":"Int Appl Res Vetmed."},{"key":"B2","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.jcpa.2017.03.006","article-title":"Obesity and associated comorbidities in people and companion animals. 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