{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:32:41Z","timestamp":1790083961488,"version":"4.0.1"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["20242BAB20313"],"award-info":[{"award-number":["20242BAB20313"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["JXSNKYJCRC202307"],"award-info":[{"award-number":["JXSNKYJCRC202307"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["JXSNKYJCRC202217"],"award-info":[{"award-number":["JXSNKYJCRC202217"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Jiangxi Province possesses abundant genetic resources of local pig breeds, whose effective conservation is essential for maintaining biodiversity and sustainable utilization. <jats:italic>Streptococcus suis<\/jats:italic> is an important zoonotic pathogen that continuously threatens swine production systems and public health globally. This study aimed to investigate the epidemiological characteristics of <jats:italic>S. suis<\/jats:italic> among local pig breeds in Jiangxi Province.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An investigation was conducted on the prevalence and antimicrobial resistance profiles of <jats:italic>S. suis<\/jats:italic> in six local pig breeds from Jiangxi Province, including Gandong black pig, Hang pig, Ganxi two-end-black pig, Dongxiang spotted pig, Yushan black pig, and Binhu black pig.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 340 porcine nasal swabs were collected from six local pig breeds. 208 <jats:italic>S. suis<\/jats:italic> strains were isolated from 187 samples, with an overall isolation rate of 55.0%. The positive isolation rates of the six local breeds were 58.0, 80.0, 71.7, 51.7, 13.3, and 60.0%, respectively. Antimicrobial susceptibility testing revealed that &amp;gt;98% of isolates were susceptible to carbapenems (meropenem and imipenem), followed by doxycycline (71.6%), ceftiofur (65.9%), spectinomycin (64.4%), and amoxicillin (55.8%). High resistance rates were observed for tilmicosin (96.6%), sulfadiazine (92.8%), colistin (89.9%), apramycin (88.9%), chlortetracycline (87.5%), tiamulin (83.2%), and kanamycin (79.8%). 100% of isolates exhibited multidrug resistance, with significant variations in resistance patterns among breeds. Genotypic analysis identified <jats:italic>ermB<\/jats:italic> (macrolides), <jats:italic>tetL<\/jats:italic> (tetracyclines), and <jats:italic>Sul2<\/jats:italic> (sulfonamides) as the predominant resistance determinants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Multidrug-resistant <jats:italic>S. suis<\/jats:italic> strains have become widespread among local pig breeds. This study could provide evidence-based guidance for developing effective prevention and control strategies against <jats:italic>S. suis<\/jats:italic> infections and protecting valuable genetic resources of indigenous pig breeds.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fvets.2025.1582461","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T04:10:17Z","timestamp":1754280617000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Prevalence and antimicrobial resistance of Streptococcus suis isolated from local pig breeds in Jiangxi Province, China"],"prefix":"10.3389","volume":"12","author":[{"given":"Mei-Fang","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Long","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan-Yong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Zhen","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Wei","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Chun","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Lin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Yuan","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1186\/s12864-021-07476-7","article-title":"Identifying 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