{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T15:00:09Z","timestamp":1763046009975,"version":"3.45.0"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>Clinical signs due to distant bony metastasis from a malignant pheochromocytoma are rare in dogs, with the majority of reported cases presenting as single-limb lameness. This case report describes a 6-year-old neutered male mixed-breed dog presenting with multiple limb lameness and joint swelling that occurred over 3\u202fweeks. Computed tomography revealed a mass in the right adrenal gland with extensive intrathoracic, intra-abdominal, and skeletal metastases. Because of the poor prognosis, the dog was humanely euthanized. A postmortem examination revealed a primary neoplasm of the right adrenal gland with metastases affecting the contralateral adrenal gland, kidneys, lungs, liver, and bones of the appendicular and axial skeletons. Immunohistochemistry confirmed a metastatic neuroendocrine carcinoma of the right adrenal gland, consistent with a pheochromocytoma. This case is a unique presentation of polyostotic metastases from a pheochromocytoma and emphasizes the importance of including this tumor in the differential diagnosis of dogs presenting with symptoms identical to those of polyarthritis.<\/jats:p>","DOI":"10.3389\/fvets.2025.1585969","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T14:55:45Z","timestamp":1763045745000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Osteolytic metastases from a pheochromocytoma presenting as multiple limb lameness and joint swelling in a dog: a case report"],"prefix":"10.3389","volume":"12","author":[{"given":"Madeleine","family":"Swindell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy A.","family":"Bolton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassandra M.","family":"Powers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ladislav","family":"Novotny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Jarvis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/B978-1-4557-4456-5.00013-4","article-title":"Pheochromocytoma and multiple endocrine neoplasia","volume-title":"Canine and feline endocrinology. 4th edition","author":"Reusch","year":"2015"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1111\/j.1939-1676.1997.tb00464.x","article-title":"Pheochromocytomas in dogs: 61 cases (1984-1995)","volume":"11","author":"Barthez","year":"1997","journal-title":"J Vet Intern Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1111\/j.1939-1676.1994.tb03222.x","article-title":"Pheochromocytoma in 50 dogs","volume":"8","author":"Gilson","year":"1994","journal-title":"J Vet Intern Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.jcpa.2022.01.006","article-title":"Metastatic canine phaeochromocytoma with unusual manifestation","volume":"192","author":"Gregor","year":"2022","journal-title":"J Comp Pathol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1111\/j.1740-8261.2011.01828.x","article-title":"Imaging diagnosis\u2014metastatic adrenal pheochromocytoma in a dog","volume":"52","author":"Spall","year":"2011","journal-title":"Vet Radiol Ultrasound"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1111\/j.1939-165X.2009.00117.x","article-title":"What is your diagnosis? 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