{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T14:21:06Z","timestamp":1754144466380,"version":"3.41.2"},"reference-count":10,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Orthotopic rat liver transplantation (OLT) is widely used in basic research; normal liver anatomy and structures are attributable to its success, but its deformities are complicated by a negative OLT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>For tolerance induction, we used OLT from Lewis to Brown Norway (BN) rats as a chronic rejection model and encountered two anatomical deformities in the recipient livers. The outcomes of OLT were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 47 liver transplantations, the accessory liver lobe occurred in four cases, and bifurcations of liver outflow occurred in five cases in BN rats. For the accessory liver lobe, we discontinued OLT in one patient with a large accessory liver lobe. Two rats died from pneumothorax upon separation, and one case succeeded with a small lobe. For two vein outflow orifices of the liver, we succeeded in OLT due to its reconstruction in one case; however, the recipient died 1\u202fweek later in one case, after one small orifice was sutured. We failed in three cases due to thrombosis following OLT. Among the 38 rats with normal liver anatomy, only four failed to survive the LT. There were significant differences in OLT success (<jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The recipient\u2019s liver abnormal anatomical structure has a negative impact on OLT, suggesting that pretransplant comprehensive screening is important and that clinicians are cautious in clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fvets.2025.1593434","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T15:34:27Z","timestamp":1752593667000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The impact of anatomical recipient liver abnormalities on rat liver transplantation"],"prefix":"10.3389","volume":"12","author":[{"given":"Yongfeng","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenzhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoyong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaotang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1002\/hep.23595","article-title":"Themes of liver transplantation","volume":"51","author":"Starzl","year":"2010","journal-title":"Hepatology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1097\/00007890-197312000-00019","article-title":"A technique for orthotopic liver transplantation in the rat","volume":"16","author":"Lee","year":"1973","journal-title":"Transplantation"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1097\/00007890-197907000-00011","article-title":"Orthotopic liver transplantation in the rat. Technique using cuff for portal vein anastomosis and biliary drainage","volume":"28","author":"Kamada","year":"1979","journal-title":"Transplantation"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1002\/micr.1920140812","article-title":"Protocol for the technique of orthotopic liver transplantation in the rat","volume":"14","author":"Kobayashi","year":"1993","journal-title":"Microsurgery"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"956","DOI":"10.6002\/ect.2020.0364","article-title":"Revisiting orthotopic rat liver transplant","volume":"19","author":"Zhao","year":"2021","journal-title":"Exp Clin Transplant"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1001\/archsurg.1925.01120170071007","article-title":"Accessory lobes of the lever: an accessory hepatic lobe springing from the surface of the gallbladder","volume":"11","author":"Cullen","year":"1925","journal-title":"Arch Surg"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/S0002-9378(16)39845-3","article-title":"Umbilical accessory liver","volume":"52","author":"Nora","year":"1946","journal-title":"Am J Obstet Gynecol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"2248.e1","DOI":"10.1016\/j.ajem.2020.05.069","article-title":"Morgagni hernia and accessory liver lobe torsion in an adult","volume":"38","author":"Ufuk","year":"2020","journal-title":"Am J Emerg Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.jhep.2015.07.040","article-title":"EASL clinical practice guidelines: vascular diseases of the liver","volume":"64","year":"2016","journal-title":"J Hepatol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s00261-020-02440-7","article-title":"Post-operative imaging anatomy in liver transplantation","volume":"46","author":"Chupetlovska","year":"","journal-title":"Abdom Radiol"}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2025.1593434\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T15:34:27Z","timestamp":1752593667000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2025.1593434\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,15]]},"references-count":10,"alternative-id":["10.3389\/fvets.2025.1593434"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2025.1593434","relation":{},"ISSN":["2297-1769"],"issn-type":[{"type":"electronic","value":"2297-1769"}],"subject":[],"published":{"date-parts":[[2025,7,15]]},"article-number":"1593434"}}