{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:15:26Z","timestamp":1790154926230,"version":"4.0.1"},"reference-count":73,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Spontaneous abortion (SA) in cattle refers to pregnancy loss occurring between days 42 and 260 of gestation. SA is costly, inefficient, and often leads to premature culling of cows.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study aimed to identify loci associated with SA in primiparous Holstein cows by conducting a genome-wide association analysis of cows bred via artificial insemination (AI; 679 controls and 69 cases that aborted) or that were embryo transfer (ET) recipients (236 controls and 41 cases) from a single dairy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In AI-bred cows, 86 loci (413 single nucleotide polymorphisms or SNPs) and 168 positional candidate genes were associated (FDR &amp;lt;0.05) with SA, while in ET recipients, 4 loci (10 SNPs) and 16 positional candidate genes were associated (FDR &amp;lt;0.05) with SA. No SA-associated loci were shared between AI-bred or ET recipient cows, but nine associated loci (FDR &amp;lt;0.05) in AI-bred cows were shared with AI-bred heifers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      The difference in loci associated with AI-bred and ET recipient cattle may be due to differences in mechanisms associated with the maintenance of pregnancy between\n                      <jats:italic>in vivo<\/jats:italic>\n                      and\n                      <jats:italic>in vitro<\/jats:italic>\n                      derived embryos, or a larger sample size may be needed to identify additional shared loci. Identifying loci associated with SA in AI-bred and ET recipient cows provides an opportunity to enhance selection for reproductive efficiency in Holstein cattle.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fvets.2025.1599401","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T06:28:42Z","timestamp":1748586522000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Loci associated with spontaneous abortion in primiparous Holstein cattle"],"prefix":"10.3389","volume":"12","author":[{"given":"Emaly M.","family":"Suarez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria C.","family":"Kelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer N.","family":"Kiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly M.","family":"Davenport","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda M.","family":"Murdoch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison L.","family":"Herrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly L.","family":"Neibergs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1016\/S0093-691X(01)00644-6","article-title":"Use of pregnancy specific proteins and progesterone assays to monitor pregnancy and determine the timing, frequencies and sources of embryonic mortality in ruminants","volume":"56","author":"Humblot","year":"2001","journal-title":"Theriogenology."},{"key":"B2","doi-asserted-by":"publisher","first-page":"722","DOI":"10.2527\/jas.2012-5368","article-title":"Pregnancy establishment and maintenance in cattle1","volume":"91","author":"Atkins","year":"2013","journal-title":"J Anim Sci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"954","DOI":"10.3390\/genes10120954","article-title":"Genomic analysis of spontaneous abortion in holstein heifers and primiparous cows","volume":"10","author":"Oliver","year":"2019","journal-title":"Genes"},{"key":"B4","doi-asserted-by":"publisher","first-page":"106458","DOI":"10.1016\/j.anireprosci.2020.106458","article-title":"Effect of abortion on milk production, health, and reproductive performance of holstein dairy cattle","volume":"217","author":"Keshavarzi","year":"2020","journal-title":"Anim Reprod Sci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"3754","DOI":"10.3168\/jds.2018-15602","article-title":"Symposium review: mechanisms of disruption of fertility by infectious diseases of the reproductive tract","volume":"102","author":"Gilbert","year":"2019","journal-title":"J Dairy Sci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-021-92525-0","article-title":"Genes and pathways associated with pregnancy loss in dairy cattle","volume":"11","author":"Sigdel","year":"2021","journal-title":"Sci Reports"},{"key":"B7","doi-asserted-by":"publisher","first-page":"3869","DOI":"10.3168\/jds.2008-1405","article-title":"Milk production change following clinical mastitis and reproductive performance compared among J5 vaccinated and control dairy cattle","volume":"91","author":"Wilson","year":"2008","journal-title":"J Dairy Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"412","DOI":"10.3389\/fgene.2019.00412","article-title":"A large-scale genome-wide association study in U","volume":"10","author":"Jiang","year":"2019","journal-title":"Front Genet"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e0264029","DOI":"10.1371\/journal.pone.0264029","article-title":"Factors affecting calving to conception interval (days open) in dairy cows located at Dessie and Kombolcha towns, Ethiopia","volume":"17","author":"Temesgen","year":"2022","journal-title":"PLoS ONE"},{"key":"B10","doi-asserted-by":"publisher","first-page":"671","DOI":"10.3390\/ani12060671","article-title":"Calving ease risk factors and subsequent survival, fertility and milk production in Italian holstein cows","volume":"12","author":"Probo","year":"2022","journal-title":"Animals"},{"key":"B11","unstructured":"Bowie, MD\n          CDCB\n          In Genetic Trend: Cow Conception Rate for Holstein\n          \n          2024"},{"key":"B12","unstructured":"Bowie, MD\n          CDCB\n          In Genetic Trend: Heifer Conception Rate for Holstein.\n          \n          2024"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.3390\/genes15121498","article-title":"Genomic regions associated with spontaneous abortion in Holstein heifers","volume":"15","author":"Suarez","year":"2024","journal-title":"Genes."},{"key":"B14","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/B978-0-12-374407-4.00117-5","article-title":"Dairy farm management systems | dry lot dairy cow breeds","volume":"2011","author":"Hutjens","year":"2011","journal-title":"Encyclop Dairy Sci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.ajhg.2015.11.020","article-title":"Genotype imputation with millions of reference samples","volume":"98","author":"Browning","year":"2016","journal-title":"Am J Human Genet."},{"key":"B16","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/ng.548","article-title":"Variance component model to account for sample structure in genome-wide association studies","volume":"42","author":"Kang","year":"2010","journal-title":"Nat Genet."},{"key":"B17","doi-asserted-by":"publisher","first-page":"e112559","DOI":"10.1371\/journal.pone.0112559","article-title":"Genome-wide and gene-based association studies of anxiety disorders in European and African American samples","volume":"9","author":"Otowa","year":"2014","journal-title":"PLoS ONE"},{"key":"B18","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/B978-0-12-397025-1.00323-7","article-title":"False discovery rate control","volume":"1","author":"Genovese","year":"2015","journal-title":"Elsevier eBooks."},{"key":"B19","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/S0168-9525(01)02550-1","article-title":"Linkage disequilibrium and the mapping of complex human traits","volume":"18","author":"Weiss","year":"2002","journal-title":"Trends in Genetics."},{"key":"B20","doi-asserted-by":"publisher","first-page":"767","DOI":"10.3390\/genes11070767","article-title":"Identification of loci and pathways associated with Heifer conception rate in U.S. Holsteins","volume":"11","author":"Galliou","year":"2020","journal-title":"Genes"},{"key":"B21","doi-asserted-by":"publisher","first-page":"2225","DOI":"10.1126\/science.1069424","article-title":"The structure of haplotype blocks in the human genome","volume":"296","author":"Gabriel","year":"2002","journal-title":"Science."},{"key":"B22","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1093\/gigascience\/giaa021","article-title":"De Novo assembly of the cattle reference genome with single-molecule sequencing","volume":"9","author":"Rosen","year":"2020","journal-title":"GigaScience"},{"key":"B23","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1093\/ije\/31.3.669","article-title":"Relative risk for genetic associations: the case-parent triad as a variant of case-cohort design","volume":"31","author":"Ahsan","year":"2002","journal-title":"Int J Epidemiol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"4414","DOI":"10.3168\/jds.2007-0980","article-title":"Efficient methods to compute genomic predictions","volume":"91","author":"VanRaden","year":"2008","journal-title":"J Dairy Sci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"S8","DOI":"10.1016\/j.aquaculture.2013.02.017","article-title":"Implementation and accuracy of genomic selection","volume":"421","author":"Taylor","year":"2014","journal-title":"Aquaculture"},{"key":"B26","doi-asserted-by":"publisher","first-page":"2540","DOI":"10.1093\/bioinformatics\/bts474","article-title":"Estimation of pleiotropy between complex diseases using single-nucleotide polymorphism-derived genomic relationships and restricted maximum likelihood","volume":"28","author":"Lee","year":"2012","journal-title":"Bioinformatics."},{"key":"B27","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1093\/med\/9780199398348.003.0011","article-title":"Genome-wide association study for female fertility in nordic red cattle","volume":"16","author":"H\u00f6glund","year":"2015","journal-title":"BMC Genet"},{"key":"B28","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1186\/1471-2164-12-408","article-title":"Genome-wide association analysis of thirty one production, health, reproduction and body conformation traits in contemporary U.S. Holstein cows","volume":"12","author":"Cole","year":"2011","journal-title":"BMC Genom"},{"key":"B29","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/1471-2156-14-49","article-title":"Discovery of single nucleotide polymorphisms in candidate genes associated with fertility and production traits in Holstein cattle","volume":"14","author":"Cochran","year":"2013","journal-title":"BMC Genet"},{"key":"B30","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1111\/age.12420","article-title":"Use of single nucleotide polymorphisms in candidate genes associated with daughter pregnancy rate for prediction of genetic merit for reproduction in Holstein Cows","volume":"47","author":"Ortega","year":"2016","journal-title":"Anim Genet."},{"key":"B31","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s12864-019-6203-2","article-title":"Identification of loci associated with conception rate in primiparous Holstein cows","volume":"20","author":"Kiser","year":"2019","journal-title":"BMC Genom"},{"key":"B32","doi-asserted-by":"publisher","first-page":"E1749","DOI":"10.1073\/pnas.1721191115","article-title":"Uterine influences on conceptus development in fertility-classified animals","volume":"115","author":"Moraes","year":"2018","journal-title":"Proc Nat Acad Sci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1093\/biolre\/ioad123","article-title":"Single-cell insights into development of the bovine placenta","volume":"110","author":"Davenport","year":"2024","journal-title":"Biol Reprod."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2023\/8497453","article-title":"Genomic regions and candidate genes associated with milk production traits in Holstein and its crossbred cattle: a review","volume":"2023","author":"Bekele","year":"2023","journal-title":"Int J Genomics."},{"key":"B35","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0093-691X(96)00338-X","article-title":"In vitro produced and cloned embryos: effects on pregnancy, parturition and offspring","volume":"47","author":"Kruip","year":"1997","journal-title":"Theriogenology."},{"key":"B36","first-page":"47","article-title":"In-vitro production of cattle embryos: problems with pregnancies and parturition","volume-title":"Hum Reprod.","author":"Hasler","year":"2000"},{"key":"B37","doi-asserted-by":"publisher","first-page":"281","DOI":"10.4141\/cjas2013-113","article-title":"Estimation of genetic parameters of fertility traits in chinese holstein cattle","volume":"94","author":"Guo","year":"2014","journal-title":"Can J Anim Sci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"333","DOI":"10.4025\/actascianimsci.v38i3.31377","article-title":"Genetic analysis of fertility traits of Holstein dairy cattle in warm and temperate climate","volume":"38","author":"Rahbar","year":"2016","journal-title":"Acta Scientiarum Animal Sci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.3390\/ani12121485","article-title":"Estimation of genetic parameters for female fertility traits in the polish holstein-friesian population","volume":"12","author":"Otwinowska-Mindur","year":"2022","journal-title":"Animals"},{"key":"B40","doi-asserted-by":"publisher","first-page":"5073","DOI":"10.3168\/jds.2007-0223","article-title":"Factors affecting conception rates following artificial insemination or embryo transfer in lactating Holstein cows","volume":"90","author":"Demetrio","year":"2007","journal-title":"J Dairy Sci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1016\/j.theriogenology.2005.05.055","article-title":"Comparison of artificial insemination versus embryo transfer in lactating dairy cows","volume":"65","author":"Sartori","year":"2006","journal-title":"Theriogenology."},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv400","article-title":"The cumulative effect of assisted reproduction procedures on placental development and epigenetic perturbations in a mouse model","author":"de Waal","year":"2015","journal-title":"Human Mol Genet"},{"key":"B43","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/978-3-319-62414-3_3","article-title":"The importance of the periconception period: immediate effects in cattle breeding and in assisted reproduction such as artificial insemination and embryo transfer","volume":"1014","author":"Van Eetvelde","year":"2017","journal-title":"Adv Exp Med Biol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1038\/s41590-022-01343-7","article-title":"Nuclear corepressors NCOR1\/NCOR2 regulate B cell development, maintain genomic integrity and prevent transformation","volume":"23","author":"Lee","year":"2022","journal-title":"Nat Immunol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1471-2156-15-8","article-title":"Validation of associations for female fertility traits in nordic holstein, nordic red and jersey dairy cattle","volume":"15","author":"H\u00f6glund","year":"2014","journal-title":"BMC Genet"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-022-23743-3","article-title":"Early life nutrition affects the molecular ontogeny of testicular development in the young bull calf","volume":"13","author":"Coen","year":"2023","journal-title":"Sci Reports"},{"key":"B47","unstructured":"Gene\n          \n          2004"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12894-016-0171-5","article-title":"Clinical significance of CDH13 promoter methylation as a biomarker for bladder cancer: a meta-analysis","volume":"16","author":"Chen","year":"2016","journal-title":"BMC Urol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"3567","DOI":"10.1007\/s00429-017-1418-y","article-title":"Protective role of cadherin 13 in interneuron development","volume":"222","author":"Killen","year":"2017","journal-title":"Brain Struct Funct."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.3390\/genes12091356","article-title":"A common CDH13 variant is associated with low agreeableness and neural responses to working memory tasks in ADHD","volume":"12","author":"Ziegler","year":"2021","journal-title":"Genes."},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122664","article-title":"Association of CDH13 genotypes\/haplotypes with circulating adiponectin levels, metabolic syndrome, and related metabolic phenotypes: the role of the suppression effect","author":"Teng","year":"2015","journal-title":"PLoS ONE"},{"key":"B52","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1097\/PGP.0000000000000884","article-title":"Placental T-cadherin correlates with trophoblastic invasion anomalies: placenta percreta and fetal growth restriction","volume":"42","author":"Biyik","year":"2022","journal-title":"Int J Gynecol Patho."},{"key":"B53","doi-asserted-by":"publisher","first-page":"a018713","DOI":"10.1101\/cshperspect.a018713","article-title":"Erasers of histone acetylation: the histone deacetylase enzymes","volume":"6","author":"Seto","year":"2014","journal-title":"Cold Spring Harb Perspect Biol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"2290521","DOI":"10.1080\/10495398.2023.2290521","article-title":"Genome-wide selection signatures address trait specific candidate genes in cattle indigenous to arid regions of india","volume":"35","author":"Sukhija","year":"2023","journal-title":"Animal Biotechnol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"10875","DOI":"10.3390\/ijms231810875","article-title":"Role of RBMS3 novel potential regulator of the EMT phenomenon in physiological and pathological processes","volume":"23","author":"G\u00f3rnicki","year":"2022","journal-title":"Int J Mol Sci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s13041-017-0324-9","article-title":"The DLGAP family: neuronal expression, function and role in brain disorders","volume":"10","author":"Rasmussen","year":"2017","journal-title":"Mol Brain"},{"key":"B57","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s40364-019-0165-z","article-title":"DLGAP1 directs megakaryocytic growth and differentiation in an mpl dependent manner in hematopoietic cells","volume":"7","author":"Kwiatkowski","year":"2019","journal-title":"Biomarker Res"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1111\/mmi.14675","article-title":"A mutation in the ribosomal protein uS12 reveals novel functions of its universally conserved PNSA loop","volume":"115","author":"Datta","year":"2021","journal-title":"Mol Microbiol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.bbaexp.2007.04.004","article-title":"Modulation of 16S rRNA function by ribosomal protein S12","volume":"1769","author":"Vila-Sanjurjo","year":"2007","journal-title":"Gene Struct Expres."},{"key":"B60","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3389\/fgene.2014.00171","article-title":"TRNAs as regulators of biological processes","author":"Raina","year":"2014","journal-title":"Front Genet."},{"key":"B61","unstructured":"Bowie, MD\n          CDCB\n          Haplotypes & Genetic conditions\n          \n          2024"},{"key":"B62","doi-asserted-by":"publisher","first-page":"7274","DOI":"10.3168\/jds.2015-10777","article-title":"Phenotypic and genetic effects of recessive haplotypes on yield, longevity, and fertility","volume":"99","author":"Cole","year":"2016","journal-title":"J Dairy Sci."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1002\/vms3.525","article-title":"Prevalence of nine genetic defects in Chinese Holstein cattle","volume":"7","author":"Khan","year":"2021","journal-title":"Vet Med Sci."},{"key":"B64","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1093\/aje\/kwj035","article-title":"Genetic variation in the sodium-dependent vitamin C transporters, SLC23A1, and SLC23A2 and risk for preterm delivery","volume":"163","author":"Erichsen","year":"2005","journal-title":"Am J Epidemiol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1053\/j.gastro.2005.03.051","article-title":"The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer","volume":"129","author":"Akino","year":"2005","journal-title":"Gastroenterology."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/2164897","article-title":"GTPBP4: a new therapeutic target gene promotes tumor progression in non-small cell lung cancer via EMT","volume":"2022","author":"Wu","year":"2022","journal-title":"J Oncol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"765","DOI":"10.3390\/genes15060765","article-title":"Identifying regions of the genome associated with conception rate to the first service in holstein heifers bred by artificial insemination and as embryo transfer recipients","volume":"15","author":"Kelson","year":"2024","journal-title":"Genes."},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1093\/jas\/skac045","author":"Tanner","year":"2022","journal-title":"J Animal Sci."},{"key":"B69","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.theriogenology.2016.04.037","article-title":"Pivotal periods for pregnancy loss during the first trimester of gestation in lactating dairy cows","volume":"86","author":"Wiltbank","year":"2016","journal-title":"Theriogenology."},{"key":"B70","unstructured":"Bozeman MT\n          Golden Helix, INC\n          SNP and Variation Suite (Version 9.1) [SVS]."},{"key":"B71","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.ajhg.2010.11.011","article-title":"GCTA: a tool for genome-wide complex trait analysis","volume":"88","author":"Yang","year":"2011","journal-title":"Am J Human Genet."},{"key":"B72","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1038\/ng.2314","article-title":"An efficient multi-locus mixed-model approach for genome-wide association studies in structured populations","volume":"44","author":"Segura","year":"2012","journal-title":"Nat. Genet."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nrg3382","article-title":"The nature of confounding in genome-wide association studies","volume":"14","author":"Vilhjalmsson","year":"2013","journal-title":"Nat. Rev. Genet."}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2025.1599401\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T06:28:45Z","timestamp":1748586525000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2025.1599401\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,30]]},"references-count":73,"alternative-id":["10.3389\/fvets.2025.1599401"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2025.1599401","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,30]]},"article-number":"1599401"}}