{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:24:15Z","timestamp":1759335855850,"version":"3.41.2"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>The study assessed the kidney, liver, and spleen of adult male rabbits (<jats:italic>n<\/jats:italic>\u202f=\u202f10\/group) in relation to fumonisin B series exposure (10 and 20\u202fmg FB<jats:sub>1<\/jats:sub>\u202f+\u202fFB<jats:sub>2<\/jats:sub>\u202f+\u202fFB<jats:sub>3<\/jats:sub>\/kg feed) over a period of 65\u202fdays. The rabbit growth and feed intake remained unaffected; meanwhile, kidney and liver weights increased. The highest dose provided greater alterations in total phospholipid fatty acid profiles, particularly in the kidney (C20:5n3 and C18:0) and spleen (C18:1n7, C22:0, C20:4n6, and C20:5n3) than in the liver. Neither the kidneys nor the spleens demonstrated modifications in their antioxidant (glutathione and glutathione peroxidase) and lipid peroxidation (malondialdehyde) markers; however, there was a marked drop in the liver glutathione concentration and glutathione peroxidase of the group that administered 20\u202fmg FBs\/kg diet, while liver malondialdehyde levels remained unchanged. Serum clinical measures revealed elevated creatinine, total cholesterol, high-density lipoproteins, and gamma-glutamyl transferase activity at the highest FBs dose. Histological scores revealed mild nephrotoxicity and hepatotoxicity in the 20\u202fmg FBs\/kg group, accompanied by a mild to moderate lesion score in the spleen. Overall, FBs exposure elicited diverse organ-specific adverse effects, with severity increasing at higher doses. Despite these alterations, rabbits demonstrated adaptability to FBs over the study period, as indicated by steady growth performance.<\/jats:p>","DOI":"10.3389\/fvets.2025.1599805","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T04:10:50Z","timestamp":1749528650000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Differential organ responses to fumonisins in rabbits: kidney, liver, and spleen membrane fatty acid composition, oxidation markers, and 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