{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T16:58:47Z","timestamp":1758041927468,"version":"3.44.0"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>A 22-week-old Staffordshire bull terrier presented with acute onset of bilateral mucopurulent nasal discharge and lethargy. Clinical examination revealed pyrexia and pain upon palpation of the head, accompanied by marked asymmetrical swelling. Computed tomography (CT) of the head showed severe thickening of multiple calvarial bones with periosteal reaction, with small defined areas of fluid accumulation and contrast enhancement of the osteopenic areas. There was mild thickening of the mucosa of the frontal sinuses suggestive of sinusitis, fluid in the left nasal passage, choanae, and nasopharynx. Histological examination of biopsies of the bone revealed periosteal reaction with fibrosis, neutrophilic and histiocytic inflammation, and necrosis. Culture yielded negative results. The dog was diagnosed with idiopathic calvarial hyperostosis and medically managed with methadone, paracetamol, and meloxicam. At recheck 10\u202fdays later, all clinical signs had resolved except for mild persistence of skull asymmetry. To the authors\u2019 knowledge, this is the first report of idiopathic calvarial hyperostosis in a Staffordshire bull terrier. The presence of bilateral purulent nasal discharge represents a novel clinical sign not previously reported.<\/jats:p>","DOI":"10.3389\/fvets.2025.1616797","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T13:22:26Z","timestamp":1757596946000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Idiopathic calvarial hyperostosis and concurrent nasal discharge in a 22-week-old Staffordshire bull terrier"],"prefix":"10.3389","volume":"12","author":[{"given":"Victoria","family":"Travail","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Moreno-Aguado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Motta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darren","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"439","DOI":"10.5326\/15473317-36-5-439","article-title":"Idiopathic hyperostosis of the calvaria in five young bullmastiffs","volume":"36","author":"Pastor","year":"2000","journal-title":"J Am Anim Hosp Assoc"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/j.1740-8261.2005.00108.x","article-title":"Calvarial hyperostosis syndrome in two bullmastiffs","volume":"47","author":"McConnell","year":"2006","journal-title":"Vet Radiol Ultrasound"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1111\/j.1463-5224.2011.00969.x","article-title":"Calvarial hyperostosis presenting as unilateral exophthalmos in a female English springer spaniel","volume":"15","author":"Mathes","year":"2012","journal-title":"Vet Ophthalmol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1080\/00480169.2011.579556","article-title":"Idiopathic canine juvenile cranial hyperostosis in a pit bull terrier","volume":"59","author":"Thompson","year":"2011","journal-title":"N Z Vet J"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"154","DOI":"10.21825\/vdt.v84i3.16604","article-title":"Calvarial hyperostosis syndrome in a young Weimaraner dog","volume":"84","author":"De Heer","year":"2015","journal-title":"Vlaams Diergeneeskd Tijdschr"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"49","DOI":"10.5152\/actavet.2018.009","article-title":"Calvarial hyperostosis syndrome in an American pit bull terrier","volume":"44","author":"Haktanir","year":"2018","journal-title":"Acta Vet Eurasia"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e7596","DOI":"10.1002\/ccr3.7596","article-title":"Calvarial hyperostosis syndrome in a Dalmatian dog","volume":"11","author":"Planas","year":"2023","journal-title":"Clin Case Rep"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/vop.70007","article-title":"Suspected calvarial hyperostosis syndrome causing different ophthalmological signs in two young Labrador retrievers-case report","author":"Steinmetz","year":"2025","journal-title":"Vet Ophthalmol"},{"key":"ref9","first-page":"143","article-title":"Hypertrophic osteodystrophy and calvarial hyperostosis","volume":"18","author":"Muir","year":"1996","journal-title":"Compend Contin Educ Pract Vet"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1172\/jci22760","article-title":"A novel COL1A1 mutation in infantile cortical hyperostosis (Caffey disease) expands the spectrum of collagen-related disorders","volume":"115","author":"Gensure","year":"2005","journal-title":"J Clin Invest"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1016\/j.joms.2013.01.027","article-title":"Infantile cortical hyperostosis (Caffey disease): a case report and review","volume":"71","author":"Shandilya","year":"2013","journal-title":"J Oral Maxillofac Surg"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"211","DOI":"10.2460\/javma.229.2.211","article-title":"What is your diagnosis? 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