{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:44:08Z","timestamp":1791233048652,"version":"4.1.0"},"reference-count":106,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>\n                    <jats:italic>Lonicera japonica<\/jats:italic>\n                    (honeysuckle) is a traditional Chinese medicinal herb known for its properties of clearing heat, detoxifying, cooling blood, dispersing wind, and exerting anti-inflammatory and antibacterial effects. Research conducted on domestic animals, the bioactive constituents found in\n                    <jats:italic>Lonicera japonica<\/jats:italic>\n                    have been demonstrated to potentiate the immune response, thereby augmenting the animal\u2019s disease resistance capabilities. The antioxidant ingredients effectively diminish free radicals within the animal, thereby slowing down cellular aging and enhancing the quality of animal-derived products. The antibacterial and anti-inflammatory properties of its constituents can effectively harmonize the animal\u2019s intestinal microbiota and refine the gastrointestinal milieu. This equilibrium aids in bolstering nutrient uptake and refining the efficiency of feed utilization. Its antiviral components can minimize the presence of drug residues in animal-derived products, thereby enhancing product safety and bolstering market competitiveness. The attributes highlighted demonstrate that the application of\n                    <jats:italic>Lonicera japonica<\/jats:italic>\n                    aligns with the principles of green, eco-friendly, and sustainable development. Its usage promotes the advancement of ecological agriculture and the circular economy, fostering a more harmonious and sustainable approach to farming. This paper primarily reviews the key active constituents, therapeutic potential, biological functions of\n                    <jats:italic>Lonicera japonica<\/jats:italic>\n                    , and its contemporary applications in livestock and poultry farming. The objective is to offer a comprehensive reference for optimizing the production efficiency and enhancing the product quality of livestock and poultry, as well as for substituting antibiotics with\n                    <jats:italic>Lonicera japonica<\/jats:italic>\n                    in animal husbandry.\n                  <\/jats:p>","DOI":"10.3389\/fvets.2025.1622768","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T05:31:27Z","timestamp":1767591087000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["The biological functions of Lonicera japonica in animal husbandry and its application in green breeding"],"prefix":"10.3389","volume":"12","author":[{"given":"Xia","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuhua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunze","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haizhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlong","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.toxicon.2017.02.020","article-title":"Insects, arachnids and centipedes venom: a powerful weapon against bacteria. A literature review","volume":"130","author":"Fratini","year":"2017","journal-title":"Toxicon"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"5924","DOI":"10.2174\/0929867325666180713125314","article-title":"Antimicrobial Peptides: Amphibian Host Defense Peptides","volume":"26","author":"Patocka","year":"2019","journal-title":"Curr Med Chem"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"723","DOI":"10.3390\/ph7060723","article-title":"Antimicrobial peptides in reptiles","volume":"7","author":"van Hoek","year":"2014","journal-title":"Pharmaceuticals"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"99","DOI":"10.2174\/1568026615666150703121819","article-title":"Mammalian antimicrobial peptides: promising therapeutic targets against infection and chronic inflammation","volume":"16","author":"Dutta","year":"2016","journal-title":"Curr Top Med Chem"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1053\/j.spid.2004.02.001","article-title":"Penicillin: its discovery and early development","volume":"15","author":"Ligon","year":"2004","journal-title":"Semin Pediatr Infect Dis"},{"key":"ref6","first-page":"51","article-title":"History of antibiotics","volume":"2","author":"Kourkouta","year":"2018","journal-title":"Sumerian J Med Healthcare"},{"key":"ref7","first-page":"437","volume-title":"J Biol Chem","author":"Moore","year":"1946"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/485439a","article-title":"Antibiotics: recover the lost art of drug discovery","volume":"485","author":"Lewis","year":"2012","journal-title":"Nature"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1111\/j.1699-0463.1998.tb01391.x","article-title":"Surveillance of antimicrobial resistance in bacteria isolated from food animals to antimicrobial growth promoters and related therapeutic agents in Denmark","volume":"106","author":"Aarestrup","year":"1998","journal-title":"APMIS"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3389\/fmicb.2014.00033","article-title":"Antibiotic growth promoters enhance animal production by targeting intestinal bile salt hydrolase and its producers","volume":"5","author":"Lin","year":"2014","journal-title":"Front Microbiol"},{"key":"ref11","doi-asserted-by":"crossref","DOI":"10.1016\/B978-0-12-801214-7.00006-5","article-title":"Antimicrobial resistance in Vibrio species","volume-title":"Antimicrobial resistance and food safety","author":"Baker-Austin","year":"2015"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.36877\/pmmb.a0000019","article-title":"Determination of antibiotic resistance patterns of Vibrio parahaemolyticus from shrimp and shellfish in Selangor, Malaysia","volume":"2","author":"Letchumanan","year":"2019","journal-title":"Prog Microbes Mol Biol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"122","DOI":"10.14202\/IJOH.2021.122-127","article-title":"Antibiotic use in animal husbandry: a mixed-methods study among general community in Boyolali, Indonesia","volume":"1","author":"Karuniawati","year":"2021","journal-title":"Int J One Health"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"20211819","DOI":"10.1098\/rspb.2021.1819","article-title":"Antibiotics accelerate growth at the expense of immunity","volume":"288","author":"Galarza","year":"2021","journal-title":"Proc Biol Sci"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1186\/s12879-016-1810-x","article-title":"What are the factors driving antimicrobial resistance? Perspectives from a public event in London, England","volume":"16","author":"Castro-S\u00e1nchez","year":"2016","journal-title":"BMC Infect Dis"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"3300","DOI":"10.1093\/jac\/dkw300","article-title":"Understanding the culture of antimicrobial prescribing in agriculture: a qualitative study of UK pig veterinary surgeons","volume":"71","author":"Coyne","year":"2016","journal-title":"J Antimicrob Chemother"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"356","DOI":"10.2174\/1381612829666221219093450","article-title":"Antibiotic resistance and microbiota response","volume":"29","author":"Santacroce","year":"2023","journal-title":"Curr Pharm Des"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"6152","DOI":"10.1002\/fsn3.2568","article-title":"Antibiotic residues in cattle and sheep meat and human exposure assessment in southern Xinjiang, China","volume":"9","author":"Zhang","year":"2021","journal-title":"Food Sci Nutr"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"5649","DOI":"10.1073\/pnas.1503141112","article-title":"Global trends in antimicrobial use in food animals","volume":"112","author":"Van Boeckel","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"578","DOI":"10.3390\/antibiotics10050578","article-title":"Unveiling the impact of antibiotics and alternative methods for animal husbandry: a review","volume":"10","author":"Low","year":"2021","journal-title":"Antibiotics"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.fct.2019.01.033","article-title":"Importance of antibiotic residues in animal food","volume":"125","author":"Bacanl\u0131","year":"2019","journal-title":"Food Chem Toxicol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1017\/S146625232300004X","article-title":"Alternatives to antibiotics in veterinary medicine: considerations for the management of Johne's disease","volume":"24","author":"O'Connell","year":"2023","journal-title":"Anim Health Res Rev"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"471","DOI":"10.3390\/antibiotics10050471","article-title":"Alternatives to antibiotics: a symposium on the challenges and solutions for animal health and production","volume":"10","author":"Callaway","year":"2021","journal-title":"Antibiotics"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1080\/1040841X.2017.1373062","article-title":"Alternatives to antibiotics in poultry feed: molecular perspectives","volume":"44","author":"Suresh","year":"2018","journal-title":"Crit Rev Microbiol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"54","DOI":"10.2174\/1389200219666180523102920","article-title":"Application of traditional Chinese herbal medicine by-products as dietary feed supplements and antibiotic replacements in animal production","volume":"20","author":"Abdallah","year":"2019","journal-title":"Curr Drug Metab"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"879","DOI":"10.3390\/antiox12040879","article-title":"Advances in the application of phytogenic extracts as antioxidants and their potential mechanisms in ruminants","volume":"12","author":"Piao","year":"2023","journal-title":"Antioxidants"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"2228","DOI":"10.3390\/ani12172228","article-title":"Effect of Chinese herbs on serum biochemical parameters, immunity indices, antioxidant capacity and metabolomics in early weaned yak calves","volume":"12","author":"Jiang","year":"2022","journal-title":"Animals"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1111\/jpn.13847","article-title":"Application potential of Humulus Scandens in livestock husbandry","volume":"107","author":"Dang","year":"2023","journal-title":"J Anim Physiol Anim Nutr"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/s0165-6147(00)89019-7","article-title":"Progress in traditional Chinese medicine","volume":"16","author":"Chan","year":"1995","journal-title":"Trends Pharmacol Sci"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"223","DOI":"10.4141\/cjas2013-144","article-title":"Chinese herbs as alternatives to antibiotics in feed for swine and poultry production: potential and challenges in application","volume":"2","author":"Gong","year":"2014","journal-title":"Can J Anim Sci"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.chmed.2021.09.010","article-title":"Future development of good agricultural practice in China under globalization of traditional herbal medicine trade","volume":"13","author":"Zhang","year":"2021","journal-title":"Chin Herb Med"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11101-019-09655-7","article-title":"Lonicerae japonicae flos and Lonicerae flos: a systematic review of ethnopharmacology, phytochemistry and pharmacology","volume":"19","author":"Li","year":"2020","journal-title":"Phytochem Rev"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1080691","DOI":"10.3389\/fpls.2023.1080691","article-title":"Construction of SNP fingerprint and population genetic analysis of honeysuckle germplasm resources in China","volume":"14","author":"Li","year":"2023","journal-title":"Front Plant Sci"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1397939","DOI":"10.3389\/fpls.2024.1397939","article-title":"Evaluating the impact of ecological factors on the quality and habitat distribution of Lonicera japonica Flos using HPLC and the MaxEnt model","volume":"15","author":"Cheng","year":"2024","journal-title":"Front Plant Sci"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1013992","DOI":"10.3389\/fphar.2022.1013992","article-title":"Systematic review of Lonicerae Japonicae Flos: a significant food and traditional Chinese medicine","volume":"13","author":"Zheng","year":"2022","journal-title":"Front Pharmacol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"405","DOI":"10.3390\/molecules22030405","article-title":"Iridoids, phenolic compounds and antioxidant activity of edible honeysuckle berries (Lonicera caerulea var. kamtschatica Sevast.)","volume":"22","author":"Kucharska","year":"2017","journal-title":"Molecules"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1038\/nbt966","article-title":"Engineering plants with increased levels of the antioxidant chlorogenic acid","volume":"22","author":"Niggeweg","year":"2004","journal-title":"Nat Biotechnol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1021\/jf504176r","article-title":"Production of chlorogenic acid and its derivatives in hairy root cultures of Stevia rebaudiana","volume":"63","author":"Fu","year":"2015","journal-title":"J Agric Food Chem"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3390\/nu8010016","article-title":"Role of chlorogenic acids in controlling oxidative and inflammatory stress conditions","volume":"8","author":"Liang","year":"2015","journal-title":"Nutrients"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.biopha.2017.10.064","article-title":"Chlorogenic acid (CGA): a pharmacological review and call for further research","volume":"97","author":"Naveed","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jep.2015.05.011","article-title":"Study on the anaphylactoid of three phenolic acids in honeysuckle","volume":"170","author":"Wang","year":"2015","journal-title":"J Ethnopharmacol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"5821","DOI":"10.1007\/s11694-023-02095-0","article-title":"Rapid determination of quercetin and caffeic acid in honeysuckle tea by high efficiency electrochemical sensor","volume":"17","author":"Dou","year":"2023","journal-title":"J Food Meas Charact"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1017\/jns.2016.41","article-title":"Flavonoids: an overview","volume":"5","author":"Panche","year":"2016","journal-title":"J Nutr Sci"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"31","DOI":"10.2174\/138955709787001712","article-title":"Distribution and biological activities of the flavonoid luteolin","volume":"9","author":"L\u00f3pez-L\u00e1zaro","year":"2009","journal-title":"Mini Rev Med Chem"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.plaphy.2021.05.023","article-title":"The role of quercetin in plants","volume":"166","author":"Singh","year":"2021","journal-title":"Plant Physiol Biochem"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"59","DOI":"10.17179\/excli2014-663","article-title":"An up-to-date review of rutin and its biological and pharmacological activities","volume":"14","author":"Al-Dhabi","year":"2015","journal-title":"EXCLI J"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"3773","DOI":"10.3390\/molecules25173773","article-title":"A review: the triterpenoid Saponins and biological activities of Lonicera Linn","volume":"25","author":"Fang","year":"2020","journal-title":"Molecules"},{"key":"ref48","first-page":"194","article-title":"Volatile constituents from the flowers of two species of honeysuckle (Lonicera japonica and Lonicera caprifolium)","volume":"1","author":"Ilie","year":"2014","journal-title":"Farmacia"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1177\/1934578X0800300727","article-title":"Linalool\u2013a review of a biologically active compound of commercial importance","volume":"7","author":"Kamatou","year":"2008","journal-title":"Nat Prod Commun"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"104","DOI":"10.4103\/jrptps.JRPTPS_25_19","article-title":"Antibacterial effect of combination of cinnamon essential oil and thymol, carvacrol, eugenol, or geraniol","volume":"9","author":"El Atki","year":"2020","journal-title":"J Rep Pharm Sci"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"820695","DOI":"10.1155\/2013\/820695","article-title":"The cardioprotective effects of citric acid and L-malic acid on myocardial ischemia\/reperfusion injury","volume":"2013","author":"Tang","year":"2013","journal-title":"Evid Based Complement Alternat Med"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"4828","DOI":"10.3390\/molecules28124828","article-title":"Extraction, purification, structural characteristics, health benefits, and application of the polysaccharides from Lonicera japonica Thunb.: a review","volume":"28","author":"Yang","year":"2023","journal-title":"Molecules"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0023-6438(03)00121-X","article-title":"Effects of gamma irradiation on color characteristics and biological activities of extracts of Lonicera japonica (Japanese honeysuckle) with methanol and acetone","volume":"37","author":"Byun","year":"2004","journal-title":"LWT-Food Sci Technol"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"100237","DOI":"10.1016\/j.hermed.2018.10.002","article-title":"Phytochemical characteristics and potential therapeutic properties of blue honeysuckle Lonicera caerulea L. (Caprifoliaceae)","volume":"16","author":"Becker","year":"2019","journal-title":"J Herbal Med"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"212","DOI":"10.3159\/08-RA-109.1","article-title":"Leaf phenology and freeze tolerance of the invasive shrub Amur honeysuckle and potential native competitors","volume":"136","author":"McEwan","year":"2009","journal-title":"J Torrey Bot Soc"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.plaphy.2017.01.020","article-title":"Saline stress enhanced accumulation of leaf phenolics in honeysuckle (Lonicera japonica Thunb.) without induction of oxidative stress","volume":"112","author":"Yan","year":"2017","journal-title":"Plant Physiol Biochem"},{"key":"ref57","first-page":"3","volume-title":"J Am Pomol Soc","author":"Hummer","year":"2006"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.seppur.2008.02.013","article-title":"Microwave-assisted extraction of chlorogenic acid from flower buds of Lonicera japonica Thunb","volume":"2","author":"Zhang","year":"2008","journal-title":"Sep Purif Technol"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/j.foodchem.2009.03.014","article-title":"In vitro control of food-borne and food spoilage bacteria by essential oil and ethanol extracts of Lonicera japonica Thunb","volume":"116","author":"Rahman","year":"2009","journal-title":"Food Chem"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"2238","DOI":"10.1080\/14786419.2017.1371153","article-title":"Two thymol derivatives from the flower buds of Lonicera japonica and their antibacterial activity","volume":"32","author":"Yang","year":"2018","journal-title":"Nat Prod Res"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.foodchem.2012.10.127","article-title":"Screening and identification of the antibacterial bioactive compounds from Lonicera japonica Thunb. leaves","volume":"138","author":"Xiong","year":"2013","journal-title":"Food Chem"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/0166-3542(95)00020-m","article-title":"Differential inhibition of reverse transcriptase and cellular DNA polymerase-alpha activities by lignans isolated from Chinese herbs, Phyllanthus myrtifolius moon, and tannins from Lonicera japonica Thunb and Castanopsis hystrix","volume":"27","author":"Chang","year":"1995","journal-title":"Antivir Res"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1007\/s12250-020-00302-6","article-title":"Inhibitory activity of honeysuckle extracts against influenza a virus in vitro and in vivo","volume":"36","author":"Li","year":"2021","journal-title":"Virol Sin"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"308","DOI":"10.3390\/v13020308","article-title":"Honeysuckle aqueous extracts induced let-7a suppress EV71 replication and pathogenesis in vitro and in vivo and is predicted to inhibit SARS-CoV-2","volume":"2","author":"Lee","year":"2021","journal-title":"Viruses"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.jep.2008.03.025","article-title":"Anti-inflammatory effect of SQC-beta-CD on lipopolysaccharide-induced acute lung injury","volume":"118","author":"Feng","year":"2008","journal-title":"J Ethnopharmacol"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"117776","DOI":"10.1016\/j.jep.2024.117776","article-title":"Study on the ameliorative effect of honeysuckle on DSS-induced ulcerative colitis in mice","volume":"325","author":"Zang","year":"2024","journal-title":"J Ethnopharmacol"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.jep.2015.03.012","article-title":"Protective and immunomodulatory effect of flos Lonicerae japonicae by augmenting IL-10 expression in a murine model of acute lung inflammation","volume":"168","author":"Kao","year":"2015","journal-title":"J Ethnopharmacol"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1089\/jmf.2014.3341","article-title":"Lonicera japonica Thunb Extract inhibits lipopolysaccharide-stimulated inflammatory responses by suppressing NF-\u03baB signaling in BV-2 microglial cells","volume":"18","author":"Kwon","year":"2015","journal-title":"J Med Food"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1080\/00071668.2015.1022711","article-title":"Effect of Lonicera japonica extract on Mycoplasma gallisepticum in naturally infected broiler flocks","volume":"56","author":"M\u00fc\u015ftak","year":"2015","journal-title":"Br Poult Sci"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1089\/jmf.2018.4231","article-title":"BST-104, a water extract of Lonicera japonica, has a gastroprotective effect via antioxidant and anti-inflammatory activities","volume":"22","author":"Bang","year":"2019","journal-title":"J Med Food"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.fsi.2018.08.035","article-title":"The ethanol extract of honeysuckle stem modulates the innate immunity of Chinese mitten crab Eriocheir sinensis against Aeromonas hydrophila","volume":"82","author":"Zhao","year":"2018","journal-title":"Fish Shellfish Immunol"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"120053","DOI":"10.1016\/j.carbpol.2022.120053","article-title":"Water-extracted Lonicera japonica polysaccharide attenuates allergic rhinitis by regulating NLRP3-IL-17 signaling axis","volume":"297","author":"Bai","year":"2022","journal-title":"Carbohydr Polym"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"121","DOI":"10.3390\/metabo12020121","article-title":"Mechanism assay of honeysuckle for heat-clearing based on metabolites and metabolomics","volume":"12","author":"Wang","year":"2022","journal-title":"Meta"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jep.2011.08.016","article-title":"Lonicera japonica Thunb.: ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine","volume":"138","author":"Shang","year":"2011","journal-title":"J Ethnopharmacol"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"4025","DOI":"10.3390\/nu15184025","article-title":"Lonicera Caerulea juice alleviates alcoholic liver disease by regulating intestinal Flora and the FXR-FGF15 signaling pathway","volume":"15","author":"Zhang","year":"2023","journal-title":"Nutrients"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s13020-021-00453-y","article-title":"Honeysuckle-derived microRNA2911 inhibits tumor growth by targeting TGF-\u03b21","volume":"16","author":"Liu","year":"2021","journal-title":"Chin Med"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"385","DOI":"10.3390\/molecules15010385","article-title":"Luteolin isolated from the flowers of Lonicera japonica suppresses inflammatory mediator release by blocking NF-kappaB and MAPKs activation pathways in HMC-1 cells","volume":"15","author":"Kang","year":"2010","journal-title":"Molecules"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"828521","DOI":"10.1155\/2012\/828521","article-title":"Regulation of Proinflammatory mediators via NF-\u03baB and p38 MAPK-dependent mechanisms in RAW 264.7 macrophages by polyphenol components isolated from Korea Lonicera japonica THUNB","volume":"2012","author":"Park","year":"2012","journal-title":"Evid Based Complement Alternat Med"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1111\/asj.13259","article-title":"Effects of Lonicera japonica extract supplementation on in vitro ruminal fermentation, methane emission, and microbial population","volume":"90","author":"Yejun","year":"2019","journal-title":"Anim Sci J"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1080\/1828051X.2016.1202736","article-title":"Effects of Scutellaria baicalensis and Lonicera japonica extract mixture supplementation on growth performance, nutrient digestibility, blood profiles and meat quality in finishing pigs","volume":"15","author":"Liu","year":"2016","journal-title":"Ital J Anim Sci"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1139\/cjas-2023-0008","article-title":"Effects of Chinese herbal plant extracts on diarrhea rate, intestinal morphology, nutrient digestibility, and immunity of weaned piglets","volume":"103","author":"Li","year":"2023","journal-title":"Can J Anim Sci"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"650084","DOI":"10.3389\/fphys.2021.650084","article-title":"Dietary supplementation with chlorogenic acid derived from Lonicera macranthoides hand-Mazz improves meat quality and muscle fiber characteristics of finishing pigs via enhancement of antioxidant capacity","volume":"12","author":"Wang","year":"2021","journal-title":"Front Physiol"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.aninu.2016.08.006","article-title":"Dietary supplementation of Lonicera macranthoides leaf powder improves amino acid profiles in serum and longissimus thoracis muscle of growing-finishing pigs","volume":"2","author":"Long","year":"2016","journal-title":"Anim Nutr"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/1927348","article-title":"Epidermal growth factor and intestinal barrier function","volume":"2016","author":"Tang","year":"2016","journal-title":"Mediat Inflamm"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"719877","DOI":"10.3389\/fmicb.2021.719877","article-title":"Potential application of Lonicera japonica extracts in animal production: from the perspective of intestinal health","volume":"12","author":"Tang","year":"2021","journal-title":"Front Microbiol"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/2049-1891-4-19","article-title":"The biological stress of early weaned piglets","volume":"4","author":"Campbell","year":"2013","journal-title":"J Anim Sci Biotechnol"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"612","DOI":"10.2527\/jas.2013-6986","article-title":"Development of an antioxidant system after early weaning in piglets","volume":"92","author":"Yin","year":"2014","journal-title":"J Anim Sci"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"e1700814","DOI":"10.1002\/mnfr.201700814","article-title":"Flaxseed oil attenuates intestinal damage and inflammation by regulating necroptosis and TLR4\/NOD signaling pathways following lipopolysaccharide challenge in a piglet model","volume":"62","author":"Zhu","year":"2018","journal-title":"Mol Nutr Food Res"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.3390\/ani12162109","article-title":"Influence of Lonicera japonica and Radix Puerariae crude extracts on the fecal microbiome and nutrient apparent digestibility of finishing pigs","volume":"12","author":"Liu","year":"2022","journal-title":"Animals"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"4968","DOI":"10.1039\/C8FO01126E","article-title":"Dietary chlorogenic acid supplementation affects gut morphology, antioxidant capacity and intestinal selected bacterial populations in weaned piglets","volume":"9","author":"Zhang","year":"2018","journal-title":"Food Funct"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1111\/jpn.13422","article-title":"Effects of dietary supplementation with herbal extract mixture on growth performance, organ weight and intestinal morphology in weaning piglets","volume":"104","author":"Wang","year":"2020","journal-title":"J Anim Physiol Anim Nutr"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"421","DOI":"10.5713\/ajas.2009.80334","article-title":"Effect of dietary inclusion of medicinal herb extract mix in a poultry ration on the physico-chemical quality and oxidative stability of eggs","volume":"22","author":"Liu","year":"2009","journal-title":"Asian Australas J Anim Sci"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1080\/1828051X.2024.2448164","article-title":"Impact of Lonicera hypoglauca leaf inclusion on immune and antioxidant responses in geese","volume":"1","author":"Lv","year":"2025","journal-title":"Ital J Anim Sci"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"1006318","DOI":"10.3389\/fvets.2022.1006318","article-title":"Supplementation with honeysuckle extract improves growth performance, immune performance, gut morphology, and cecal microbes in geese","volume":"9","author":"Li","year":"2022","journal-title":"Front Vet Sci"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.3969\/j.issn.1006-267x.2020.05.030","article-title":"Effects of Lonicera japonica extract on performance, serum biochemical indexes and immune function of heat-stressed dairy cows","volume":"33","author":"Ma","year":"2020","journal-title":"Asian Australas J Anim Sci"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"10074","DOI":"10.3168\/jds.2020-18504","article-title":"Effect of Lonicera japonica extract on lactation performance, antioxidant status, and endocrine and immune function in heat-stressed mid-lactation dairy cows","volume":"103","author":"Ma","year":"2020","journal-title":"J Dairy Sci"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.5713\/ajas.19.0388","article-title":"Effects of Lonicera japonica extract on performance, blood biomarkers of inflammation and oxidative stress during perinatal period in dairy cows","volume":"33","author":"Zhao","year":"2020","journal-title":"Asian Australas J Anim Sci"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.3390\/molecules21091157","article-title":"Identification of Iridoids in edible honeysuckle berries (Lonicera caerulea L. var. kamtschatica Sevast.) by UPLC-ESI-qTOF-MS\/MS","volume":"21","author":"Kucharska","year":"2016","journal-title":"Molecules"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"8968940","DOI":"10.1155\/2016\/8968940","article-title":"Research Progress on chemical constituents of Lonicerae japonicae flos","volume":"2016","author":"Wang","year":"2016","journal-title":"Biomed Res Int"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1248\/bpb.34.1330","article-title":"Allergy-preventive effects of chlorogenic acid and iridoid derivatives from flower buds of Lonicera japonica","volume":"34","author":"Oku","year":"2011","journal-title":"Biol Pharm Bull"},{"key":"ref101","doi-asserted-by":"publisher","first-page":"1442879","DOI":"10.3389\/fpls.2024.1442879","article-title":"Exploring stachydrine: from natural occurrence to biological activities and metabolic pathways","volume":"15","author":"He","year":"2024","journal-title":"Front Plant Sci"},{"key":"ref102","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.16438\/j.0513-4870.2016-0208","article-title":"Chemical constituents of Lonicera japonica roots and their anti-inflammatory effects","volume":"51","author":"Yu","year":"2016","journal-title":"Yao Xue Xue Bao"},{"key":"ref103","doi-asserted-by":"publisher","first-page":"7303","DOI":"10.3390\/cimb46070433","article-title":"Lonicera japonica Thunb. ethanol extract exerts a protective effect on normal human gastric epithelial cells by modulating the activity of tumor-necrosis-factor-\u03b1-induced inflammatory cyclooxygenase 2\/prostaglandin E2 and matrix metalloproteinase 9","volume":"46","author":"Hsieh","year":"2024","journal-title":"Curr Issues Mol Biol"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"BSR20190673","DOI":"10.1042\/BSR20190673","article-title":"Honeysuckle extract relieves ovalbumin-induced allergic rhinitis by inhibiting AR-induced inflammation and autoimmunity","volume":"39","author":"Lin","year":"2019","journal-title":"Biosci Rep"},{"key":"ref105","doi-asserted-by":"publisher","first-page":"8670","DOI":"10.3390\/nu7105423","article-title":"The ethanol extract from Lonicera japonica Thunb. Regresses nonalcoholic Steatohepatitis in a methionine- and choline-deficient diet-fed animal model","volume":"7","author":"Tzeng","year":"2015","journal-title":"Nutrients"},{"key":"ref106","doi-asserted-by":"publisher","first-page":"S227","DOI":"10.1016\/jaci.2003.12.570","article-title":"Anaphylaxis to honeysuckle","volume":"113","author":"Leung","year":"2004","journal-title":"J Allergy Clin Immunol"}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2025.1622768\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T05:31:29Z","timestamp":1767591089000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2025.1622768\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,5]]},"references-count":106,"alternative-id":["10.3389\/fvets.2025.1622768"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2025.1622768","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,5]]},"article-number":"1622768"}}