{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:37:51Z","timestamp":1793813871526,"version":"4.6.1"},"reference-count":76,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>A 10-year-old neutered male Ragdoll cat presented with symptoms of anorexia, nausea, vomiting, lethargy, and progressive weight loss. Laboratory parameters and clinical signs led to a diagnosis of International Renal Interest Society (IRIS) Chronic Kidney Disease (CKD) Stage III. Following basic supportive therapy, clinical symptoms subsided, and the patient was discharged for home management. Three months later, the cat\u2019s condition worsened, and upon reassessment, it met the diagnostic criteria for IRIS CKD Stage IV. After 4\u202fmonths of guideline-directed supportive care (in accordance with IRIS recommendations), there were no significant changes in clinical symptoms or laboratory markers, and the cat continued to exhibit a cachectic condition. Subsequently, allogeneic adipose-derived mesenchymal stem cell (AD-MSCs) therapy (2\u202f\u00d7\u202f10<jats:sup>6<\/jats:sup> cells\/kg) was initiated via intravenous (IV) infusion, administered weekly for three consecutive weeks. No adverse events, such as fever or vomiting, were observed during or after therapy. Prior to AD-MSCs therapy, the cat\u2019s serum creatinine (SCr), blood urea nitrogen (BUN), and phosphorus (P) levels were all above the normal reference ranges. Three weeks after the final of the three AD-MSC treatments, the SCr level had returned to the reference range for CKD Stage II, while BUN and P levels showed an improving trend. The cat\u2019s mental status and appetite also improved. Reevaluation according to IRIS CKD staging criteria confirmed functional enhancement from Stage IV to Stage II. During the subsequent follow-up period, the cat\u2019s physical condition improved, as shown by an increase in body weight, an improved Body Condition Score (BCS), and the normalization of mucous membrane color. Concurrently, laboratory results revealed a decrease in key renal biomarkers (SCr, BUN, and P) and an amelioration of the non-regenerative anemia. This case report suggests that allogeneic AD-MSCs have potential therapeutic efficacy in felines with end-stage CKD, offering a new possibility for the treatment of terminal chronic kidney disease.<\/jats:p>","DOI":"10.3389\/fvets.2025.1632324","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T14:47:16Z","timestamp":1753282036000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Case Report: Allogeneic adipose-derived mesenchymal stem cells for severe feline chronic kidney disease"],"prefix":"10.3389","volume":"12","author":[{"given":"Yizhe","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunpeng","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanting","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.cvsm.2012.04.008","article-title":"Chronic kidney disease in dogs and cats","volume":"42","author":"Bartges","year":"2012","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1177\/0300985815622975","article-title":"Chronic kidney disease in aged cats: clinical features, morphology, and proposed pathogeneses","volume":"53","author":"Brown","year":"2016","journal-title":"Vet Pathol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1177\/1098612x13477415","article-title":"Prospective evaluation of healthy ragdoll cats for chronic kidney disease by routine laboratory parameters and ultrasonography","volume":"15","author":"Paepe","year":"2013","journal-title":"J Feline Med Surg"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1177\/1098612x13511446","article-title":"Prevalence and classification of chronic kidney disease in cats randomly selected from four age groups and in cats recruited for degenerative joint disease studies","volume":"16","author":"Marino","year":"2013","journal-title":"J Feline Med Surg"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1177\/1098612x14536176","article-title":"Longevity and mortality of cats attending primary care veterinary practices in England","volume":"17","author":"O'Neill","year":"2015","journal-title":"J Feline Med Surg"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.tvjl.2014.10.009","article-title":"Renal fibrosis in feline chronic kidney disease: known mediators and mechanisms of injury","volume":"203","author":"Lawson","year":"2015","journal-title":"Vet J"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1002\/jemt.22955","article-title":"Morphological characterization of CKD in cats: insights of fibrogenesis to be recognized","volume":"81","author":"Morais","year":"2018","journal-title":"Microsc Res Tech"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1177\/1098612x13495235","article-title":"Feline CKD diagnosis, staging and screening - what is recommended?","volume":"15","author":"Paepe","year":"2013","journal-title":"J Feline Med Surg"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1177\/0300985814561095","article-title":"A comparison of biochemical and histopathologic staging in cats with chronic kidney disease","volume":"52","author":"McLeland","year":"2015","journal-title":"Vet Pathol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.jfms.2009.01.004","article-title":"Therapies for feline chronic kidney disease. 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