{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:11:04Z","timestamp":1792606264133,"version":"4.5.0"},"reference-count":236,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>Hair follicle development and cycling are governed by intricate genetic and molecular networks, with microRNAs (miRNAs) playing essential roles as post-transcriptional regulators. In cashmere goats, valued for their fine fiber, miRNAs have emerged as key modulators influencing hair follicle morphogenesis, regeneration, and fiber traits such as fineness and pigmentation. This review highlights recent discoveries in miRNA-mediated regulation of hair follicles, focusing on their dynamic expression patterns and cell-specific functions in keratinocytes, dermal papilla cells, and follicular stem cells. Key miRNAs, including miR-31, miR-22, and miR-214, are explored for their effects on follicle growth, hair shaft formation, and pigment regulation. We discuss advances in single-cell RNA sequencing and spatial transcriptomics, revealing new insights into cellular heterogeneity and lineage specification. Integrative multi-omics approaches, combining transcriptomics, proteomics, and epigenomics uncover complex regulatory networks in which miRNAs interact with other non-coding RNAs and signaling pathways. Artificial Intelligence (AI) -driven analytics enhance the discovery of biomarkers and therapeutic targets, offering precision strategies for clinical and livestock applications. miRNA profiling now informs breeding strategies to improve cashmere fiber quality and is a minimally invasive diagnostic tool for hair disorders. We outline future directions, including improved miRNA delivery methods, systems biology integration, and AI-powered multi-omics approaches to deepen our understanding of hair follicle biology and facilitate practical applications in medicine and agriculture.<\/jats:p>","DOI":"10.3389\/fvets.2025.1635202","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T05:45:45Z","timestamp":1752126345000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Multi-omics and AI-driven advances in miRNA-mediated hair follicle regulation in cashmere goats"],"prefix":"10.3389","volume":"12","author":[{"given":"Zhang","family":"Chunhua","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Shengli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Sachula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Antonini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun","family":"Haizhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s43042-024-00553-y","article-title":"A brief review of noncoding RNA","volume":"25","author":"George","year":"2024","journal-title":"Egypt J Med Hum Genet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"3869","DOI":"10.3390\/ani13243869","article-title":"Identification of potential miRNA\u2013mRNA regulatory network associated with growth and development of hair follicles in Forest musk deer","volume":"13","author":"Qi","year":"2023","journal-title":"Animals"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1007\/s13577-021-00540-0","article-title":"Current insight into the functions of microRNAs in common human hair loss disorders: a mini review","volume":"34","author":"Paul","year":"2021","journal-title":"Hum Cell"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"100565","DOI":"10.1016\/j.animal.2022.100565","article-title":"Cashmere production, skin characteristics, and mutated genes in crimped cashmere fibre goats","volume":"16","author":"Duan","year":"2022","journal-title":"Animal"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1111\/dpr.12074","article-title":"The Chinese cashmere industry: a global value chain analysis","volume":"32","author":"Waldron","year":"2014","journal-title":"Dev Policy Rev"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"65741","DOI":"10.1007\/s11356-024-35569-9","article-title":"Sustainable cashmere production in Mongolia: a practical framework approach under uncertainties","volume":"31","author":"Bui","year":"2024","journal-title":"Environ Sci Pollut Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/978-981-33-4343-6_3","article-title":"Goat and sheep farming","volume-title":"Sustainability in ruminant livestock: Management and marketing","author":"Rout","year":"2021"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1186\/s12864-023-09531-x","article-title":"Regulation of cashmere fineness traits by noncoding RNA in Jiangnan cashmere goats","volume":"24","author":"Wu","year":"2023","journal-title":"BMC Genomics"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.3390\/ijms24021063","article-title":"Discovery and functional analysis of secondary hair follicle miRNAs during annual cashmere growth","volume":"24","author":"Wang","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"585","DOI":"10.12688\/f1000research.6401.1","article-title":"Androgenetic alopecia: new insights into the pathogenesis and mechanism of hair loss","volume":"4","author":"Sinclair","year":"2015","journal-title":"F1000Res"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.procbio.2022.01.016","article-title":"The regulatory role of microRNAs in the development, cyclic changes, and cell differentiation of the hair follicle","volume":"114","author":"Mokabber","year":"2022","journal-title":"Process Biochem"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"486","DOI":"10.4103\/ijd.ijd_568_23","article-title":"miRNA: the next frontier in dermatology research and therapeutics","volume":"69","author":"Sil","year":"2024","journal-title":"Indian J Dermatol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1007\/s00335-025-10109-z","article-title":"Deciphering the molecular drivers for cashmere\/pashmina fiber production in goats: a comprehensive review","volume":"36","author":"Vasu","year":"2025","journal-title":"Mamm Genome"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1080\/15384101.2020.1867789","article-title":"Expression of miRNA-203 and its target gene in hair follicle cycle development of cashmere goat","volume":"20","author":"Ma","year":"2021","journal-title":"Cell Cycle"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s12864-025-11264-y","article-title":"Whole-transcriptome analysis reveals the profiles and roles of coding and non-coding RNAs during hair follicle cycling in rex rabbits","volume":"26","author":"Wu","year":"2025","journal-title":"BMC Genomics"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/978-3-030-64830-5_3","volume-title":"Biology of hair. Ethnic skin and hair and other cultural considerations","author":"Dawson","year":"2021"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jdermsci.2020.11.002","article-title":"Defining microRNA signatures of hair follicular stem and progenitor cells in healthy and androgenic alopecia patients","volume":"101","author":"Mohammadi","year":"2021","journal-title":"J Dermatol Sci"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"342","DOI":"10.3390\/genes13020342","article-title":"Integrated hair follicle profiles of microRNAs and mRNAs to reveal the pattern formation of Hu sheep lambskin","volume":"13","author":"Lv","year":"2022","journal-title":"Genes (Basel)"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1080\/10495398.2015.1105240","article-title":"Differential expression of microRNAs and their regulatory networks in skin tissue of Liaoning cashmere goat during hair follicle cycles","volume":"27","author":"Bai","year":"2016","journal-title":"Anim Biotechnol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s12861-020-00213-5","article-title":"The functions of ocu-miR-205 in regulating hair follicle development in rex rabbits","volume":"20","author":"Liu","year":"2020","journal-title":"BMC Dev Biol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"4519","DOI":"10.1038\/s41598-020-60351-5","article-title":"Inner Mongolian cashmere goat secondary follicle development regulation research based on mRNA-miRNA co-analysis","volume":"10","author":"Han","year":"2020","journal-title":"Sci Rep"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1016\/j.sjbs.2017.12.009","article-title":"High-throughput sequencing of hair follicle development-related micrornas in cashmere goat at various fetal periods","volume":"25","author":"Liu","year":"2018","journal-title":"Saudi J Biol Sci"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"409","DOI":"10.3390\/ani12182409","article-title":"Understanding mammalian hair follicle ecosystems by single-cell RNA sequencing","volume":"12","author":"Zheng","year":"2022","journal-title":"Animals (Basel)"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"7581","DOI":"10.7150\/thno.44306","article-title":"Single-cell transcriptome profiling reveals dermal and epithelial cell fate decisions during embryonic hair follicle development","volume":"10","author":"Ge","year":"2020","journal-title":"Theranostics"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"832813","DOI":"10.3389\/fnmol.2022.832813","article-title":"Pseudo-temporal analysis of single-cell RNA sequencing reveals trans-differentiation potential of greater epithelial ridge cells into hair cells during postnatal development of cochlea in rats","volume":"15","author":"Chen","year":"2022","journal-title":"Front Mol Neurosci"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"85","DOI":"10.4103\/npmj.npmj_47_24","article-title":"Androgenetic Alopecia: A Review","volume":"31","author":"Oiwoh","year":"2024","journal-title":"Niger Postgrad Med J"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"2623","DOI":"10.1016\/j.csbj.2024.06.026","article-title":"Application of multi-omics techniques to androgenetic alopecia: current status and perspectives","volume":"23","author":"Li","year":"2024","journal-title":"Comput Struct Biotechnol J"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"102041","DOI":"10.1016\/j.arr.2023.102041","article-title":"Recent omics advances in hair aging biology and hair biomarkers analysis","volume":"91","author":"Adav","year":"2023","journal-title":"Ageing Res Rev"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"101657","DOI":"10.1016\/j.genrep.2022.101657","article-title":"Prospects of integrated multi-omics-driven biomarkers for efficient hair loss therapy from systems biology perspective","volume":"28","author":"Yilmaz","year":"2022","journal-title":"Gene Rep"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"899095","DOI":"10.3389\/fcell.2022.899095","article-title":"Morphogenesis, growth cycle and molecular regulation of hair follicles","volume":"10","author":"Lin","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1111\/exd.13913","article-title":"An updated classification of hair follicle morphogenesis","volume":"28","author":"Saxena","year":"2019","journal-title":"Exp Dermatol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1972","DOI":"10.1684\/ejd.2013.1972","article-title":"Early stages of hair follicle development: a step by step microarray identity","volume":"1","author":"Cadau","year":"2013","journal-title":"Eur J Dermatol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1177\/03009858231176561","article-title":"Basic principles of hair follicle structure, morphogenesis, and regeneration","volume":"60","author":"Welle","year":"2023","journal-title":"Vet Pathol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"3076","DOI":"10.3390\/ani13193076","article-title":"Developmental mapping of hair follicles in the embryonic stages of cashmere goats using proteomic and metabolomic construction","volume":"13","author":"Gao","year":"2023","journal-title":"Animals"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1095\/biolreprod.113.107730","article-title":"Expression patterns and regulatory functions of microRNAs during the initiation of primordial follicle development in the neonatal mouse ovary","volume":"89","author":"Yang","year":"2013","journal-title":"Biol Reprod"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1111\/exd.12785","article-title":"MicroRNAs (miRNAs) in the control of HF development and cycling: the next frontiers in hair research","volume":"24","author":"Andl","year":"2015","journal-title":"Exp Dermatol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1016\/j.jid.2017.02.983","article-title":"Compartmentation of mitochondrial and oxidative metabolism in growing hair follicles: a ring of fire","volume":"137","author":"Lemasters","year":"2017","journal-title":"J Invest Dermatol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-3-031-62731-6_1","article-title":"MYB: a key transcription factor in the hematopoietic system subject to many levels of control","volume":"1459","author":"Lemma","year":"2024","journal-title":"Adv Exp Med Biol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"959952","DOI":"10.3389\/fvets.2022.959952","article-title":"Construction and functional analysis of ceRNA regulatory network related to the development of secondary hair follicles in Inner Mongolia cashmere goats","volume":"9","author":"Shang","year":"2022","journal-title":"Front Vet Sci"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"893","DOI":"10.3390\/jcm12030893","article-title":"Integrative and mechanistic approach to the hair growth cycle and hair loss","volume":"12","author":"Natarelli","year":"2023","journal-title":"J Clin Med"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/978-981-10-8195-8_2","article-title":"The follicle cycle in brief","volume":"1054","author":"Plowman","year":"2018","journal-title":"Adv Exp Med Biol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"553","DOI":"10.3390\/ijms21124553","article-title":"A Humanin analogue, promotes hair growth by inhibiting Anagen-to-Catagen transition","volume":"21","author":"Kim","year":"2020","journal-title":"Int J Mol Sci"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1111\/exd.13799","article-title":"Sequential cyclic changes of hair roots revealed by dermoscopy demonstrate a progressive mechanism of diffuse alopecia areata over time","volume":"29","author":"Zhang","year":"2020","journal-title":"Exp Dermatol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"e70001","DOI":"10.1111\/exd.70001","article-title":"The proportion of Catagen and Telogen hair follicles in occipital scalp of male androgenetic alopecia patients: challenging the established dogma","volume":"33","author":"Jimenez","year":"2024","journal-title":"Exp Dermatol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1186\/s12864-020-06870-x","article-title":"Shedding light on cashmere goat hair follicle biology: from morphology analyses to transcriptomic landascape","volume":"21","author":"Nocelli","year":"2020","journal-title":"BMC Genomics"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1007\/s00418-017-1540-1","article-title":"Hair follicle stem cell proliferation, Akt and Wnt signaling activation in TPA-induced hair regeneration","volume":"147","author":"Qiu","year":"2017","journal-title":"Histochem Cell Biol"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1016\/j.jid.2016.04.014","article-title":"STAT5 activation in the dermal papilla is important for hair follicle growth phase induction","volume":"136","author":"Legrand","year":"2016","journal-title":"J Invest Dermatol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1242\/dev.198671","article-title":"Cyclic growth of dermal papilla and regeneration of follicular mesenchymal components during feather cycling","volume":"148","author":"Wu","year":"2021","journal-title":"Development"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/j.bbrc.2019.06.146","article-title":"Characterization of human dermal sheath cells reveals CD36-expressing perivascular cells associated with capillary blood vessel formation in hair follicles","volume":"516","author":"Yoshida","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1007\/s00403-018-1843-7","article-title":"Expression and localization of VEGFR-2 in hair follicles during induced hair growth in mice","volume":"310","author":"Wu","year":"2018","journal-title":"Arch Dermatol Res"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1159\/000460300","article-title":"Exogen hairs in women with and without hair loss","volume":"3","author":"Guarrera","year":"2017","journal-title":"Skin Appendage Disord"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1159\/000488782","article-title":"Quantification of hair follicles in the scalp in Mexican mestizo population","volume":"5","author":"Mart\u00ednez-Luna","year":"2018","journal-title":"Skin Appendage Disord"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1016\/j.jid.2023.04.015","article-title":"Studying hair growth cycle and its effects on mouse skin","volume":"143","author":"Wang","year":"2023","journal-title":"J Invest Dermatol"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"e15327","DOI":"10.7717\/peerj.15327","article-title":"Transcriptome analysis reveals genes associated with wool fineness in merinos","volume":"11","author":"Ma","year":"2023","journal-title":"PeerJ"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"3869","DOI":"10.1096\/fj.10-160663","article-title":"Micro-RNA-31 controls hair cycle-associated changes in gene expression programs of the skin and hair follicle","volume":"24","author":"Mardaryev","year":"2010","journal-title":"FASEB J"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"e1005253","DOI":"10.1371\/journal.pgen.1005253","article-title":"Post-transcriptional regulation of keratinocyte progenitor cell expansion, differentiation and hair follicle regression by miR-22","volume":"11","author":"Yuan","year":"2015","journal-title":"PLoS Genet"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"595178","DOI":"10.3389\/fcell.2020.595178","article-title":"An intrinsic oscillation of gene networks inside hair follicle stem cells: an additional layer that can modulate hair stem cell activities","volume":"8","author":"Daszczuk","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"682","DOI":"10.3389\/fvets.2025.1542682","article-title":"Comparative proteomic analysis of the telogen-to-anagen transition in cashmere goat secondary hair follicles. Frontiers in veterinary","volume":"12","author":"Han","year":"2025","journal-title":"Science"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12864-017-4145-0","article-title":"Integrated analysis of coding genes and non-coding RNAs during hair follicle cycle of cashmere goat (Capra hircus)","volume":"18","author":"Wang","year":"2017","journal-title":"BMC Genomics"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/s12917-022-03253-0","article-title":"Integrated analysis of lncRNAs and mRNAs by RNA-Seq in secondary hair follicle development and cycling (anagen, catagen and telogen) of Jiangnan cashmere goat (Capra hircus)","volume":"18","author":"Wu","year":"2022","journal-title":"BMC Vet Res"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s10735-015-9616-5","article-title":"Expression of Wnt\/\u03b2-catenin signaling, stem-cell markers and proliferating cell markers in rat whisker hair follicles","volume":"46","author":"Lin","year":"2015","journal-title":"J Mol Histol"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1111\/odi.12931","article-title":"Genetic analysis: Wnt and other pathways in nonsyndromic tooth agenesis","volume":"25","author":"Yu","year":"2019","journal-title":"Oral Dis"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"461","DOI":"10.5194\/aab-63-461-2020","article-title":"EDA and EDAR expression at different stages of hair follicle development in cashmere goats and effects on expression of related genes","volume":"63","author":"Wu","year":"2020","journal-title":"Arch Anim Breed"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"646","DOI":"10.3390\/genes14081646","article-title":"Molecular regulatory mechanisms in chicken feather follicle morphogenesis","volume":"14","author":"Ji","year":"2023","journal-title":"Genes (Basel)"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"69316","DOI":"10.18632\/oncotarget.20613","article-title":"Wnt\/\u03b2-catenin signaling promotes aging-associated hair graying in mice","volume":"8","author":"Zhang","year":"2017","journal-title":"Oncotarget"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1002\/cbin.11797","article-title":"Wnt signaling pathway: a comprehensive review","volume":"46","author":"Hayat","year":"2022","journal-title":"Cell Biol Int"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41392-021-00762-6","article-title":"Wnt\/\u03b2-catenin signalling: function, biological mechanisms, and therapeutic opportunities","volume":"7","author":"Liu","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1111\/bjd.18356","article-title":"Deciphering the molecular morphology of the human hair cycle: Wnt signalling during the telogen-anagen transformation","volume":"182","author":"Hawkshaw","year":"2020","journal-title":"Br J Dermatol"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1186\/s13287-024-04051-1","article-title":"Restoration of follicular \u03b2-catenin signaling by mesenchymal stem cells promotes hair growth in mice with androgenetic alopecia","volume":"15","author":"Yan","year":"2024","journal-title":"Stem Cell Res Ther"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1093\/genetics\/iyad200","article-title":"Bone morphogenetic protein signaling: the pathway and its regulation","volume":"226","author":"Akiyama","year":"2024","journal-title":"Genetics"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"7769","DOI":"10.3390\/cimb46070460","article-title":"Roles of SMAD and SMAD-associated signaling pathways in nerve regeneration following peripheral nerve injury: a narrative literature review","volume":"46","author":"Lee","year":"2024","journal-title":"Curr Issues Mol Biol"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1007\/s00109-019-01772-2","article-title":"Regenerative potential of adipocytes in hypertrophic scars is mediated by myofibroblast reprogramming","volume":"97","author":"Hoerst","year":"2019","journal-title":"J Mol Med (Berl)"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"739","DOI":"10.3389\/fgene.2018.00739","article-title":"Defining key genes regulating morphogenesis of apocrine sweat gland in sheepskin","volume":"9","author":"Li","year":"2018","journal-title":"Front Genet"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.3390\/genes12091389","article-title":"Gene mutations of the three Ectodysplasin pathway key players (EDA, EDAR, and EDARADD) account for more than 60% of Egyptian ectodermal dysplasia: a report of seven novel mutations","volume":"12","author":"Ahmed","year":"2021","journal-title":"Genes (Basel)"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.bbrc.2019.10.031","article-title":"Ectodysplasin-A2 induces apoptosis in cultured human hair follicle cells and promotes regression of hair follicles in mice","volume":"520","author":"Kwack","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1111\/1346-8138.14983","article-title":"Functional studies for a dominant mutation in the EDAR gene responsible for hypohidrotic ectodermal dysplasia","volume":"46","author":"Okita","year":"2019","journal-title":"J Dermatol"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"788411","DOI":"10.3389\/fphys.2021.788411","article-title":"Ectodysplasin a\/Ectodysplasin a receptor system and their roles in multiple diseases","volume":"12","author":"Cai","year":"2021","journal-title":"Front Physiol"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"557","DOI":"10.3390\/cells13060557","article-title":"MiR-23b and miR-133 Cotarget TGF\u03b22\/NOTCH1 in sheep dermal fibroblasts, affecting hair follicle development","volume":"13","author":"He","year":"2024","journal-title":"Cells"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.1016\/j.celrep.2019.10.062","article-title":"miR-29a\/b1 inhibits hair follicle stem cell lineage progression by spatiotemporally suppressing WNT and BMP signaling","volume":"29","author":"Ge","year":"2019","journal-title":"Cell Rep"},{"key":"ref80","first-page":"4777","article-title":"MiR-214 inhibits human mesenchymal stem cells differentiating into osteoblasts through targeting \u03b2-catenin","volume":"21","author":"Li","year":"2017","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"9301","DOI":"10.3892\/mmr.2017.7821","article-title":"miR-214 promotes periodontal ligament stem cell osteoblastic differentiation by modulating Wnt\/\u03b2-catenin signaling","volume":"16","author":"Cao","year":"2017","journal-title":"Mol Med Rep"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1186\/s12864-018-4603-3","article-title":"Integrative analysis reveals ncRNA-mediated molecular regulatory network driving secondary hair follicle regression in cashmere goats","volume":"19","author":"Zhou","year":"2018","journal-title":"BMC Genomics"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1093\/jas\/skad314","article-title":"Regulation of secondary hair follicle cycle in cashmere goats by miR-877-3p targeting IGFBP5 gene","volume":"101","author":"Wu","year":"2023","journal-title":"J Anim Sci"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"266","DOI":"10.3390\/genes10040266","article-title":"An integrated analysis of cashmere fineness lncRNAs in cashmere goats","volume":"10","author":"Zheng","year":"2019","journal-title":"Genes (Basel)"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"6190","DOI":"10.3390\/ijms25116190","article-title":"Exploring the regulatory landscape of dementia: insights from non-coding RNAs","volume":"25","author":"Kim","year":"2024","journal-title":"Int J Mol Sci"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.neuroscience.2022.07.028","article-title":"Exosome-transported Long non-coding ribonucleic acid H19 induces blood-brain barrier disruption in cerebral ischemic stroke via the H19\/micro ribonucleic acid-18a\/vascular endothelial growth factor Axis","volume":"500","author":"Wang","year":"2022","journal-title":"Neuroscience"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3390\/ijms231710006","article-title":"Comprehensive transcriptome analysis of hair follicle morphogenesis reveals that lncRNA-H19 promotes dermal papilla cell proliferation through the chi-miR-214-3p\/\u03b2-catenin Axis in cashmere goats","volume":"23","author":"Zhang","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"e7167","DOI":"10.7717\/peerj.7167","article-title":"Identification of microRNA-21 target genes associated with hair follicle development in sheep","volume":"7","author":"Zhai","year":"2019","journal-title":"PeerJ"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"110961","DOI":"10.1016\/j.ygeno.2024.110961","article-title":"Melatonin promotes the proliferation of dermal papilla cells in cashmere goats via activation of chi-let-7d-5p\/WNT2 axis","volume":"116","author":"Liu","year":"2024","journal-title":"Genomics"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/s41419-024-06554-4","article-title":"miR-184 represses \u03b2-catenin and behaves as a skin tumor suppressor","volume":"15","author":"Turovsky","year":"2024","journal-title":"Cell Death Dis"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.jbiosc.2022.03.010","article-title":"Effects of the PI3K\/Akt signaling pathway on the hair inductivity of human dermal papilla cells in hair beads","volume":"134","author":"Yamane","year":"2022","journal-title":"J Biosci Bioeng"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"e2201949","DOI":"10.1002\/advs.202201949","article-title":"SCD1 sustains homeostasis of bulge niche via maintaining Hemidesmosomes in basal keratinocytes","volume":"10","author":"Xue","year":"2023","journal-title":"Adv Sci (Weinh)"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1093\/g3journal\/jkab091","article-title":"Chi-miR-370-3p regulates hair follicle morphogenesis of inner Mongolian cashmere goats","volume":"11","author":"Hai","year":"2021","journal-title":"G3 (Bethesda)"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"e0231376","DOI":"10.1371\/journal.pone.0231376","article-title":"Exploring differentially expressed genes between anagen and telogen secondary hair follicle stem cells from the cashmere goat (Capra hircus) by RNA-Seq","volume":"15","author":"He","year":"2020","journal-title":"PLoS One"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"969","DOI":"10.3390\/cells9040969","article-title":"Integrative analysis of Methylome and transcriptome reveals the regulatory mechanisms of hair follicle morphogenesis in cashmere goat","volume":"9","author":"Wang","year":"2020","journal-title":"Cells"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1007\/s10142-022-00842-y","article-title":"Screening of microRNA and mRNA related to secondary hair follicle morphogenesis and development and functional analysis in cashmere goats","volume":"22","author":"Shang","year":"2022","journal-title":"Funct Integr Genomics"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1186\/s13287-019-1504-6","article-title":"Pre-aggregation of scalp progenitor dermal and epidermal stem cells activates the WNT pathway and promotes hair follicle formation in in vitro and in vivo systems","volume":"10","author":"Su","year":"2019","journal-title":"Stem Cell Res Ther"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1007\/s10142-018-0616-x","article-title":"Differential expression of miR-let7a in hair follicle cycle of Liaoning cashmere goats and identification of its targets","volume":"18","author":"Ma","year":"2018","journal-title":"Funct Integr Genomics"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1111\/jcmm.14046","article-title":"CXXC5: a novel regulator and coordinator of TGF-\u03b2, BMP and Wnt signaling","volume":"23","author":"Xiong","year":"2019","journal-title":"J Cell Mol Med"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"660","DOI":"10.3892\/ol.2021.12921","article-title":"MicroRNA-1298-5p inhibits the tumorigenesis of breast cancer by targeting E2F1","volume":"22","author":"Zhang","year":"2021","journal-title":"Oncol Lett"},{"key":"ref101","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1080\/10495398.2022.2058519","article-title":"Expression of miRNA-1-3p and its target gene in hair follicle cycle development of Liaoning cashmere goat","volume":"34","author":"Zhang","year":"2023","journal-title":"Anim Biotechnol"},{"key":"ref102","doi-asserted-by":"publisher","first-page":"402","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of MicroRNA biogenesis, mechanisms of actions, and circulation","volume":"9","author":"O'Brien","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref103","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.3390\/biom10091285","article-title":"MicroRNAs: diverse mechanisms of action and their potential applications as Cancer epi-therapeutics","volume":"10","author":"Sadakierska-Chudy","year":"2020","journal-title":"Biomol Ther"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"818668","DOI":"10.3389\/fgene.2021.818668","article-title":"The role of alternative polyadenylation in the regulation of subcellular RNA localization","volume":"12","author":"Arora","year":"2021","journal-title":"Front Genet"},{"key":"ref105","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1080\/10495398.2020.1730392","article-title":"The expression of miR-129-5p and its target genes in the skin of goats","volume":"32","author":"Li","year":"2021","journal-title":"Anim Biotechnol"},{"key":"ref106","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1080\/10495398.2021.1998089","article-title":"MiR-19 3b regulated the formation of coat colors by targeting WNT10A and GNAI2 in cashmere goats","volume":"34","author":"Xiang","year":"2023","journal-title":"Anim Biotechnol"},{"key":"ref107","doi-asserted-by":"publisher","first-page":"2863","DOI":"10.1080\/10495398.2022.2124165","article-title":"CeRNA regulates network and expression and SNP effect on NFKBIA of cashmere fineness","volume":"34","author":"Zheng","year":"2023","journal-title":"Anim Biotechnol"},{"key":"ref108","doi-asserted-by":"publisher","first-page":"137511","DOI":"10.1016\/j.ijbiomac.2024.137511","article-title":"An anti-sense lncRNA of the A-FABP gene regulates the proliferation of hair follicle stem cells via the chi-miR-335-5p\/DKK1\/\u03b2-catenin axis","volume":"283","author":"Zhang","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"ref109","doi-asserted-by":"publisher","first-page":"3498","DOI":"10.7150\/ijms.60728","article-title":"Expression and localization of Sox10 during hair follicle morphogenesis and induced hair cycle","volume":"18","author":"Jing","year":"2021","journal-title":"Int J Med Sci"},{"key":"ref110","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1007\/s10529-018-2532-5","article-title":"Establishment of dermal sheath cell line from cashmere goat and characterizing cytokeratin 13 as its novel biomarker","volume":"40","author":"Zhu","year":"2018","journal-title":"Biotechnol Lett"},{"key":"ref111","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.3390\/ani14142049","article-title":"Shh gene regulates the proliferation and apoptosis of dermal papilla cells to affect its differential expression in secondary hair follicle growth cycle of cashmere goats","volume":"14","author":"Zhang","year":"2024","journal-title":"Animals (Basel)"},{"key":"ref112","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1111\/exd.14204","article-title":"The dermal sheath: an emerging component of the hair follicle stem cell niche","volume":"30","author":"Martino","year":"2021","journal-title":"Exp Dermatol"},{"key":"ref113","doi-asserted-by":"publisher","first-page":"18470","DOI":"10.1038\/srep18470","article-title":"Genome-wide analysis of microRNAs identifies the lipid metabolism pathway to be a defining factor in adipose tissue from different sheep","volume":"5","author":"Miao","year":"2015","journal-title":"Sci Rep"},{"key":"ref114","doi-asserted-by":"publisher","first-page":"590","DOI":"10.3389\/fgene.2020.00590","article-title":"Transcriptomic analysis reveals the involvement of lncRNA-miRNA-mRNA networks in hair follicle induction in Aohan fine wool sheep skin","volume":"11","author":"Zhao","year":"2020","journal-title":"Front Genet"},{"key":"ref115","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s10142-024-01444-6","article-title":"lncRNA HOTAIR and cardiovascular diseases","volume":"24","author":"Taghvimi","year":"2024","journal-title":"Funct Integr Genomics"},{"key":"ref116","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1186\/s12864-022-08954-2","article-title":"Integrated analysis of miRNAs and mRNA profiling reveals the potential roles of miRNAs in sheep hair follicle development","volume":"23","author":"He","year":"2022","journal-title":"BMC Genomics"},{"key":"ref117","doi-asserted-by":"publisher","first-page":"16449","DOI":"10.1021\/acs.jafc.4c02508","article-title":"Bta-miR-200a regulates Milk fat biosynthesis by targeting IRS2 to inhibit the PI3K\/Akt signal pathway in bovine mammary epithelial cells","volume":"72","author":"Tan","year":"2024","journal-title":"J Agric Food Chem"},{"key":"ref118","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1038\/s41598-024-52716-x","article-title":"miRNA profiling of chicken follicles during follicular development","volume":"14","author":"Xu","year":"2024","journal-title":"Sci Rep"},{"key":"ref119","doi-asserted-by":"publisher","first-page":"e1189","DOI":"10.1002\/mgg3.1189","article-title":"MicroRNA-150 serves as a diagnostic biomarker and is involved in the inflammatory pathogenesis of Parkinson's disease","volume":"8","author":"Li","year":"2020","journal-title":"Mol Genet Genomic Med"},{"key":"ref120","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1093\/pcmedi\/pbac020","article-title":"JAM-A facilitates hair follicle regeneration in alopecia areata through functioning as ceRNA to protect VCAN expression in dermal papilla cells. Precis","volume":"5","author":"Wu","year":"2022","journal-title":"Clin Med"},{"key":"ref121","doi-asserted-by":"publisher","first-page":"5645","DOI":"10.1038\/s41467-020-19485-3","article-title":"Tp63-expressing adult epithelial stem cells cross lineages boundaries revealing latent hairy skin competence","volume":"11","author":"Claudinot","year":"2020","journal-title":"Nat Commun"},{"key":"ref122","doi-asserted-by":"publisher","first-page":"988","DOI":"10.3389\/fgene.2019.00988","article-title":"mRNA and miRNA transcriptome profiling of granulosa and Theca layers from geese ovarian follicles reveals the crucial pathways and interaction networks for regulation of follicle selection","volume":"10","author":"Li","year":"2019","journal-title":"Front Genet"},{"key":"ref123","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1186\/s12864-024-10427-7","article-title":"Comprehensive analysis of the expression profiles of mRNA, lncRNA, circRNA, and miRNA in primary hair follicles of coarse sheep fetal skin","volume":"25","author":"Tian","year":"2024","journal-title":"BMC Genomics"},{"key":"ref124","doi-asserted-by":"publisher","first-page":"1374843","DOI":"10.3389\/fmolb.2024.1374843","article-title":"Regulatory role of RNA-binding proteins in microRNA biogenesis","volume":"11","author":"Hynes","year":"2024","journal-title":"Front Mol Biosci"},{"key":"ref125","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1515\/jib-2016-305","article-title":"Dynamics of miRNA biogenesis and nuclear transport","volume":"13","author":"Kotipalli","year":"2017","journal-title":"J Integr Bioinform"},{"key":"ref126","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1002\/stem.3117","article-title":"Hes1 regulates anagen initiation and hair follicle regeneration through modulation of hedgehog signaling","volume":"38","author":"Suen","year":"2020","journal-title":"Stem Cells"},{"key":"ref127","doi-asserted-by":"publisher","first-page":"117664","DOI":"10.1016\/j.lfs.2020.117664","article-title":"MicroRNA-374a-5p inhibits neuroinflammation in neonatal hypoxic-ischemic encephalopathy via regulating NLRP3 inflammasome targeted Smad6","volume":"252","author":"Chen","year":"2020","journal-title":"Life Sci"},{"key":"ref128","doi-asserted-by":"publisher","first-page":"7821","DOI":"10.3892\/mmr.2018.8829","article-title":"MicroRNA-92a overexpression promotes the osteogenic differentiation of bone mesenchymal stem cells by impeding Smad6-mediated runt-related transcription factor 2 degradation","volume":"17","author":"Yan","year":"2018","journal-title":"Mol Med Rep"},{"key":"ref129","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.jmb.2017.12.006","article-title":"Transcriptome-wide identification and validation of interactions between the miRNA machinery and HuR on mRNA targets","volume":"430","author":"Li","year":"2018","journal-title":"J Mol Biol"},{"key":"ref130","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1002\/2211-5463.13126","article-title":"De novo filament formation by human hair keratins K85 and K35 follows a filament development pattern distinct from cytokeratin filament networks","volume":"11","author":"Yamamoto","year":"2021","journal-title":"FEBS Open Bio"},{"key":"ref131","doi-asserted-by":"publisher","first-page":"931797","DOI":"10.3389\/fgene.2022.931797","article-title":"An integrative analysis of the lncRNA-miRNA-mRNA competitive endogenous RNA network reveals potential mechanisms in the murine hair follicle cycle","volume":"13","author":"Ding","year":"2022","journal-title":"Front Genet"},{"key":"ref132","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1182\/bloodadvances.2018023804","article-title":"microRNA-22 promotes megakaryocyte differentiation through repression of its target, GFI1","volume":"3","author":"Weiss","year":"2019","journal-title":"Blood Adv"},{"key":"ref133","first-page":"2159","article-title":"MiR-22 regulated T cell differentiation and hepatocellular carcinoma growth by directly targeting Jarid2","volume":"11","author":"Zhang","year":"2021","journal-title":"Am J Cancer Res"},{"key":"ref134","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1080\/15476286.2016.1269994","article-title":"Knockout of miR-221 and miR-222 reveals common and specific targets for paralogous miRNAs","volume":"14","author":"Jeong","year":"2017","journal-title":"RNA Biol"},{"key":"ref135","doi-asserted-by":"publisher","first-page":"3288","DOI":"10.1038\/s41388-018-0670-9","article-title":"Wnt5a and ROR1 activate non-canonical Wnt signaling via RhoA in TCF3-PBX1 acute lymphoblastic leukemia and highlight new treatment strategies via Bcl-2 co-targeting","volume":"38","author":"Karvonen","year":"2019","journal-title":"Oncogene"},{"key":"ref136","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.7150\/ijbs.33233","article-title":"Exosomal Micro RNAs derived from dermal papilla cells mediate hair follicle stem cell proliferation and differentiation","volume":"15","author":"Yan","year":"2019","journal-title":"Int J Biol Sci"},{"key":"ref137","doi-asserted-by":"publisher","first-page":"12726","DOI":"10.18632\/aging.103165","article-title":"EZH2-mediated inhibition of microRNA-22 promotes differentiation of hair follicle stem cells by elevating STK40 expression","volume":"12","author":"Cai","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"ref138","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s43141-023-00480-2","article-title":"The potential role of the KFG and KITLG proteins in preventing granulosa cell apoptosis in Bubalus bubalis","volume":"21","author":"Panwar","year":"2023","journal-title":"J Genet Eng Biotechnol"},{"key":"ref139","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1111\/exd.12488","article-title":"Epigenetic control of skin and hair regeneration after wounding","volume":"24","author":"Plikus","year":"2015","journal-title":"Exp Dermatol"},{"key":"ref140","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1101\/gr.257576.119","article-title":"Distinct contributions of DNA methylation and histone acetylation to the genomic occupancy of transcription factors","volume":"30","author":"Cusack","year":"2020","journal-title":"Genome Res"},{"key":"ref141","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/s00294-021-01167-2","article-title":"Fng1 is involved in crosstalk between histone acetylation and methylation","volume":"67","author":"Ye","year":"2021","journal-title":"Curr Genet"},{"key":"ref142","doi-asserted-by":"publisher","first-page":"931","DOI":"10.3791\/53931","article-title":"Isolating hair follicle stem cells and epidermal keratinocytes from dorsal mouse skin","volume":"110","author":"Soteriou","year":"2016","journal-title":"J Vis Exp"},{"key":"ref143","doi-asserted-by":"publisher","first-page":"8","DOI":"10.7554\/eLife.45977","article-title":"Skin vasculature and hair follicle cross-talking associated with stem cell activation and tissue homeostasis","volume":"8","author":"Li","year":"2019","journal-title":"eLife"},{"key":"ref144","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1186\/s12864-020-06799-1","article-title":"Chi-miR-30b-5p inhibits dermal papilla cells proliferation by targeting CaMKII\u03b4 gene in cashmere goat","volume":"21","author":"Zhang","year":"2020","journal-title":"BMC Genomics"},{"key":"ref145","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.ejcb.2017.03.011","article-title":"Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: lessons from the human hair follicle matrix","volume":"96","author":"Purba","year":"2017","journal-title":"Eur J Cell Biol"},{"key":"ref146","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/s41419-021-04464-3","article-title":"CircMTO1 suppresses hepatocellular carcinoma progression via the miR-541-5p\/ZIC1 axis by regulating Wnt\/\u03b2-catenin signaling pathway and epithelial-to-mesenchymal transition","volume":"13","author":"Li","year":"2021","journal-title":"Cell Death Dis"},{"key":"ref147","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.3892\/ijmm.2018.3675","article-title":"BMP-6 protects retinal pigment epithelial cells from oxidative stress-induced injury by inhibiting the MAPK signaling pathways","volume":"42","author":"Chen","year":"2018","journal-title":"Int J Mol Med"},{"key":"ref148","doi-asserted-by":"publisher","first-page":"3661","DOI":"10.1002\/jcp.27135","article-title":"Downregulated miR-187 contributes to the keratinocytes hyperproliferation in psoriasis","volume":"234","author":"Tang","year":"2019","journal-title":"J Cell Physiol"},{"key":"ref149","doi-asserted-by":"publisher","first-page":"3669","DOI":"10.1007\/s10620-015-3798-2","article-title":"Proper BMP signaling levels are essential for 3D assembly of hepatic cords from Hepatoblasts and mesenchymal cells","volume":"60","author":"Tsai","year":"2015","journal-title":"Dig Dis Sci"},{"key":"ref150","doi-asserted-by":"publisher","first-page":"686805","DOI":"10.3389\/fcell.2021.686805","article-title":"Roles of melatonin in goat hair follicle stem cell proliferation and pluripotency through regulating the Wnt signaling pathway","volume":"9","author":"Zhang","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"ref151","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1093\/jmcb\/mjy032","article-title":"\u0392-Catenin activation in hair follicle dermal stem cells induces ectopic hair outgrowth and skin fibrosis","volume":"11","author":"Tao","year":"2019","journal-title":"J Mol Cell Biol"},{"key":"ref152","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1046\/j.0022-202x.2001.01670.x","article-title":"Molecular mechanisms regulating hair follicle development","volume":"118","author":"Millar","year":"2002","journal-title":"J Invest Dermatol"},{"key":"ref153","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1111\/j.1600-0625.2006.00512.x","article-title":"Biology of the wool follicle: an excursion into a unique tissue interaction system waiting to be re-discovered","volume":"15","author":"Rogers","year":"2006","journal-title":"Exp Dermatol"},{"key":"ref154","doi-asserted-by":"publisher","first-page":"3145","DOI":"10.1093\/hmg\/ddaa188","article-title":"Integrative analysis of scRNA-seq and GWAS data pinpoints periportal hepatocytes as the relevant liver cell types for blood lipids","volume":"29","author":"Hao","year":"2020","journal-title":"Hum Mol Genet"},{"key":"ref155","doi-asserted-by":"publisher","first-page":"800157","DOI":"10.3389\/fcell.2021.800157","article-title":"Single-cell transcriptomics reveals the molecular anatomy of sheep hair follicle heterogeneity and wool curvature","volume":"9","author":"Wang","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"ref156","doi-asserted-by":"publisher","first-page":"2176","DOI":"10.1111\/exd.14917","article-title":"Genetic lineage tracing in skin reveals predominant expression of HEY2 in dermal papilla during telogen and that HEY2(+) cells contribute to the regeneration of dermal cells during wound healing","volume":"32","author":"Wang","year":"2023","journal-title":"Exp Dermatol"},{"key":"ref157","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.molcel.2017.01.023","article-title":"Comparative analysis of single-cell RNA sequencing methods","volume":"65","author":"Ziegenhain","year":"2017","journal-title":"Mol Cell"},{"key":"ref158","doi-asserted-by":"publisher","first-page":"95","DOI":"10.12688\/f1000research.3928.2","article-title":"edgeR: a versatile tool for the analysis of shRNA-seq and CRISPR-Cas9 genetic screens","volume":"3","author":"Dai","year":"2014","journal-title":"F1000Res"},{"key":"ref159","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1038\/s41576-025-00845-y","article-title":"Cell-type deconvolution methods for spatial transcriptomics","volume":"1","author":"Gaspard-Boulinc","year":"2025","journal-title":"Nat Rev Genet"},{"key":"ref160","doi-asserted-by":"publisher","first-page":"1424077","DOI":"10.3389\/fphys.2024.1424077","article-title":"The overexpression of R-spondin 3 affects hair morphogenesis and hair development along with the formation and maturation of the hair follicle stem cells","volume":"15","author":"Olczak","year":"2024","journal-title":"Front Physiol"},{"key":"ref161","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.cels.2016.08.010","article-title":"Single-cell transcriptomics reveals that differentiation and spatial signatures shape epidermal and hair follicle heterogeneity","volume":"3","author":"Joost","year":"2016","journal-title":"Cell Syst"},{"key":"ref162","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1016\/j.stem.2021.05.007","article-title":"Lgr6 marks epidermal stem cells with a nerve-dependent role in wound re-epithelialization","volume":"28","author":"Huang","year":"2021","journal-title":"Cell Stem Cell"},{"key":"ref163","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/s41592-019-0667-5","article-title":"NicheNet: modeling intercellular communication by linking ligands to target genes","volume":"17","author":"Browaeys","year":"2020","journal-title":"Nat Methods"},{"key":"ref164","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1101\/gad.1614408","article-title":"BMP signaling in dermal papilla cells is required for their hair follicle-inductive properties","volume":"22","author":"Rendl","year":"2008","journal-title":"Genes Dev"},{"key":"ref165","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1038\/s41588-023-01445-4","article-title":"Integrated single-cell chromatin and transcriptomic analyses of human scalp identify gene-regulatory programs and critical cell types for hair and skin diseases","volume":"55","author":"Ober-Reynolds","year":"2023","journal-title":"Nat Genet"},{"key":"ref166","doi-asserted-by":"publisher","first-page":"4395","DOI":"10.1126\/science.aad4395","article-title":"Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis","volume":"351","author":"Matsumura","year":"2016","journal-title":"Science"},{"key":"ref167","doi-asserted-by":"publisher","first-page":"961","DOI":"10.3390\/ijms24043961","article-title":"Dermal PapillaCell-derived exosomes regulate hair follicle stem cell proliferation via LEF1","volume":"24","author":"Li","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref168","doi-asserted-by":"publisher","first-page":"2288","DOI":"10.3390\/molecules29102288","article-title":"Can plant extracts help prevent hair loss or promote hair growth? A review comparing their therapeutic efficacies, phytochemical components, and modulatory targets","volume":"29","author":"Choi","year":"2024","journal-title":"Molecules"},{"key":"ref169","doi-asserted-by":"publisher","first-page":"e0147124","DOI":"10.1371\/journal.pone.0147124","article-title":"A microarray-based analysis reveals that a short photoperiod promotes hair growth in the Arbas cashmere goat","volume":"11","author":"Liu","year":"2016","journal-title":"PLoS One"},{"key":"ref170","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1016\/S2095-3119(12)60110-5","article-title":"Hoxc13\/\u03b2-catenin correlation with hair follicle activity in cashmere goat","volume":"11","author":"Wu","year":"2012","journal-title":"J Integr Agric"},{"key":"ref171","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1002\/aro2.41","article-title":"Comprehensive analysis of the circular RNA expression profile and circRNA\u2013miRNA\u2013mRNA network in the goat skin with divergent wool curvature","volume":"1","author":"Su","year":"2023","journal-title":"Anim Res One Health"},{"key":"ref172","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.devcel.2010.01.016","article-title":"beta-catenin activity in the dermal papilla regulates morphogenesis and regeneration of hair","volume":"18","author":"Enshell-Seijffers","year":"2010","journal-title":"Dev Cell"},{"key":"ref173","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1111\/exd.14155","article-title":"Hair follicle immune privilege and its collapse in alopecia areata","volume":"29","author":"Bertolini","year":"2020","journal-title":"Exp Dermatol"},{"key":"ref174","doi-asserted-by":"publisher","first-page":"985","DOI":"10.3390\/cells11243985","article-title":"Comparative analysis of mRNA and miRNA expression between dermal papilla cells and hair matrix cells of hair follicles in yak","volume":"11","author":"Zhang","year":"2022","journal-title":"Cells"},{"key":"ref175","doi-asserted-by":"publisher","first-page":"678825","DOI":"10.3389\/fgene.2021.678825","article-title":"Expression profiling and functional analysis of circular RNAs in inner Mongolian cashmere goat hair follicles","volume":"12","author":"Shang","year":"2021","journal-title":"Front Genet"},{"key":"ref176","doi-asserted-by":"publisher","first-page":"9028","DOI":"10.12659\/MSM.917925","article-title":"Integrative analysis of expression profiles of MicroRNAs and mRNAs in treatment of acute myocardial infarction with compound Longmaining decoction","volume":"25","author":"Bu","year":"2019","journal-title":"Med Sci Monit"},{"key":"ref177","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1186\/s12864-022-08552-2","article-title":"Gene network analysis reveals candidate genes related with the hair follicle development in sheep","volume":"23","author":"He","year":"2022","journal-title":"BMC Genomics"},{"key":"ref178","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.tins.2019.03.006","article-title":"Mechanisms of hair cell damage and repair","volume":"42","author":"Wagner","year":"2019","journal-title":"Trends Neurosci"},{"key":"ref179","doi-asserted-by":"publisher","first-page":"e12415","DOI":"10.1111\/dth.12415","article-title":"Prevalence of hair shedding among women","volume":"30","author":"Kovacevic","year":"2017","journal-title":"Dermatol Ther"},{"key":"ref180","author":"Pavan","year":"2023"},{"key":"ref181","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1097\/JD9.0000000000000404","article-title":"Artificial intelligence in dermatology: a systematized review. International journal of","volume":"8","author":"Biswas","year":"2025","journal-title":"Dermatol Venereol"},{"key":"ref182","doi-asserted-by":"publisher","first-page":"100150","DOI":"10.1016\/j.xjidi.2022.100150","article-title":"Deep learning in dermatology: a systematic review of current approaches, outcomes, and limitations","volume":"3","author":"Jeong","year":"2023","journal-title":"JID Innov"},{"key":"ref183","doi-asserted-by":"publisher","first-page":"490","DOI":"10.2139\/ssrn.4054490","article-title":"Deep study on alopecia Areata diagnosis for hair loss related autoimmune disorder problem using machine learning techniques","volume":"1","author":"Sayyad","year":"2022","journal-title":"SSRN Electron J"},{"key":"ref184","doi-asserted-by":"publisher","first-page":"283","DOI":"10.3390\/jimaging8100283","article-title":"Hair follicle classification and hair loss severity estimation using mask R-CNN","volume":"8","author":"Kim","year":"2022","journal-title":"J Imaging"},{"key":"ref185","doi-asserted-by":"publisher","first-page":"650","DOI":"10.3390\/s22020650","article-title":"Evaluation of automated measurement of hair density using deep neural networks","volume":"22","author":"Kim","year":"2022","journal-title":"Sensors (Basel)"},{"key":"ref186","doi-asserted-by":"publisher","first-page":"7935346","DOI":"10.1155\/2022\/7935346","article-title":"A framework for interactive medical image segmentation using optimized swarm intelligence with convolutional neural networks","volume":"2022","author":"Kaushal","year":"2022","journal-title":"Comput Intell Neurosci"},{"key":"ref187","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1002\/jemt.23181","article-title":"Adaptive tuning piecewise cubic Hermite interpolation with wiener filter in wavelet domain for scanning electron microscope images","volume":"82","author":"Yeap","year":"2019","journal-title":"Microsc Res Tech"},{"key":"ref188","doi-asserted-by":"publisher","first-page":"1448538","DOI":"10.3389\/fnbot.2024.1448538","article-title":"Target detection and classification via EfficientDet and CNN over unmanned aerial vehicles","volume":"18","author":"Yusuf","year":"2024","journal-title":"Front Neurorobot"},{"key":"ref189","doi-asserted-by":"publisher","first-page":"100326","DOI":"10.1016\/j.health.2024.100326","article-title":"A hybrid grasshopper optimization algorithm for skin lesion segmentation and melanoma classification using deep learning","volume":"5","author":"Thapar","year":"2024","journal-title":"Healthc Anal"},{"key":"ref190","author":"Tiwari","year":"2023"},{"key":"ref191","doi-asserted-by":"publisher","first-page":"5870","DOI":"10.1364\/BOE.503312","article-title":"Non-invasive assessment of hair regeneration in androgenetic alopecia mice in vivo using two-photon and second harmonic generation imaging","volume":"14","author":"He","year":"2023","journal-title":"Biomed Opt Express"},{"key":"ref192","doi-asserted-by":"publisher","first-page":"582282","DOI":"10.3389\/fcell.2020.582282","article-title":"Increased expression of Zyxin and its potential function in androgenetic alopecia","volume":"8","author":"Liu","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"ref193","doi-asserted-by":"publisher","first-page":"20329","DOI":"10.1002\/jcp.28633","article-title":"miR-218-5p regulates skin and hair follicle development through Wnt\/\u03b2-catenin signaling pathway by targeting SFRP2","volume":"234","author":"Zhao","year":"2019","journal-title":"J Cell Physiol"},{"key":"ref194","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.3390\/cells10112957","article-title":"Perspectives on miRNAs targeting DKK1 for developing hair regeneration therapy","volume":"10","author":"Papukashvili","year":"2021","journal-title":"Cells"},{"key":"ref195","doi-asserted-by":"publisher","first-page":"4924356","DOI":"10.1155\/2018\/4924356","article-title":"miR-195-5p regulates hair follicle inductivity of dermal papilla cells by suppressing Wnt\/\u03b2-catenin activation","volume":"2018","author":"Zhu","year":"2018","journal-title":"Biomed Res Int"},{"key":"ref196","doi-asserted-by":"publisher","first-page":"104589","DOI":"10.1016\/j.yexmp.2020.104589","article-title":"miRNA microarray profiling in patients with androgenic alopecia and the effects of miR-133b on hair growth","volume":"118","author":"Deng","year":"2021","journal-title":"Exp Mol Pathol"},{"key":"ref197","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1111\/ijd.17406","article-title":"The efficacy of adipose stem cell-derived exosomes in hair regeneration based on a preclinical and clinical study","volume":"63","author":"Lee","year":"2024","journal-title":"Int J Dermatol"},{"key":"ref198","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.bbrc.2018.09.103","article-title":"Downregulated miR-1247-5p associates with poor prognosis and facilitates tumor cell growth via DVL1\/Wnt\/\u03b2-catenin signaling in breast cancer","volume":"505","author":"Zeng","year":"2018","journal-title":"Biochem Biophys res Commun"},{"key":"ref199","doi-asserted-by":"publisher","first-page":"465","DOI":"10.3390\/biomedicines11020465","article-title":"Micro ribonucleic acid-29a (miR-29a) antagonist normalizes bone metabolism in osteogenesis imperfecta (OI)","volume":"11","author":"Ko","year":"2023","journal-title":"Mice Model Biomedicines"},{"key":"ref200","doi-asserted-by":"publisher","first-page":"2088","DOI":"10.1016\/j.jid.2022.01.003","article-title":"Androgen receptor-mediated paracrine signaling induces regression of blood vessels in the dermal papilla in androgenetic alopecia","volume":"142","author":"Deng","year":"2022","journal-title":"J Invest Dermatol"},{"key":"ref201","doi-asserted-by":"publisher","first-page":"141","DOI":"10.5772\/67845","article-title":"Androgenic alopecia: cross-talk between cell signal transduction pathways","author":"Nesterova","year":"2017","journal-title":"Hair Scalp Disord"},{"key":"ref202","doi-asserted-by":"publisher","first-page":"473","DOI":"10.3390\/genes14020473","article-title":"The identification and characteristics of miRNAs related to cashmere fiber traits in skin tissue of cashmere goats","volume":"14","author":"Qiao","year":"2023","journal-title":"Genes"},{"key":"ref203","doi-asserted-by":"publisher","first-page":"e10217","DOI":"10.7717\/peerj.10217","article-title":"Integrated analysis of lncRNA and mRNA reveals novel insights into cashmere fineness in Tibetan cashmere goats","volume":"8","author":"Fu","year":"2020","journal-title":"PeerJ"},{"key":"ref204","doi-asserted-by":"publisher","first-page":"694","DOI":"10.3390\/ani12060694","article-title":"Identification and molecular analysis of m6A-circRNAs from cashmere goat reveal their integrated regulatory network and putative functions in secondary hair follicle during anagen stage","volume":"12","author":"Hui","year":"2022","journal-title":"Animals"},{"key":"ref205","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1089\/dna.2015.3161","article-title":"Transcriptome-wide comparative analysis of microRNA profiles in the telogen skins of Liaoning cashmere goats (Capra hircus) and fine-wool sheep (Ovis aries) by solexa deep sequencing","volume":"35","author":"Li","year":"2016","journal-title":"DNA Cell Biol"},{"key":"ref206","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12864-019-5861-4","article-title":"Synchronous profiling and analysis of mRNAs and ncRNAs in the dermal papilla cells from cashmere goats","volume":"20","author":"Ma","year":"2019","journal-title":"BMC Genomics"},{"key":"ref207","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.5713\/ab.24.0081","article-title":"N6-methyladenosine (m6A)-circHECA from secondary hair follicle of cashmere goats: identification, regulatory network and expression regulated potentially by methylation of its host gene promoter","volume":"37","author":"Shen","year":"2024","journal-title":"Anim Biosci"},{"key":"ref208","doi-asserted-by":"publisher","first-page":"18977","DOI":"10.1038\/s41598-025-01187-9","article-title":"Transcriptome sequencing reveals the expression profiles of lncRNAs and mRNAs in goat skin tissues with different types of wool coats","volume":"15","author":"Zhao","year":"2025","journal-title":"Sci Rep"},{"key":"ref209","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.3390\/ijms15011647","article-title":"Signaling involved in hair follicle morphogenesis and development","volume":"15","author":"Rishikaysh","year":"2014","journal-title":"Int J Mol Sci"},{"key":"ref210","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.3390\/genes12122017","article-title":"miR-143 targeting CUX1 to regulate proliferation of dermal papilla cells in Hu sheep","volume":"12","author":"Hu","year":"2021","journal-title":"Genes"},{"key":"ref211","doi-asserted-by":"publisher","first-page":"5098","DOI":"10.26355\/eurrev_201808_15703","article-title":"MiR-203 is involved in osteoporosis by regulating DKK1 and inhibiting osteogenic differentiation of MSCs","volume":"22","author":"Xia","year":"2018","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref212","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.jare.2023.11.014","article-title":"Activation of mitochondrial aldehyde dehydrogenase 2 promotes hair growth in human hair follicles","volume":"64","author":"Lee","year":"2024","journal-title":"J Adv Res"},{"key":"ref213","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.trsl.2011.01.007","article-title":"MicroRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseases","volume":"157","author":"Dai","year":"2011","journal-title":"Transl Res"},{"key":"ref214","doi-asserted-by":"publisher","first-page":"21","DOI":"10.32607\/20758251-2016-8-1-21-33","article-title":"MicroRNAs: the role in autoimmune inflammation","volume":"8","author":"Baulina","year":"2016","journal-title":"Acta Naturae"},{"key":"ref215","doi-asserted-by":"publisher","first-page":"397","DOI":"10.2147\/CCID.S53985","article-title":"Epidemiology and burden of alopecia areata: a systematic review","volume":"1","author":"Villasante Fricke","year":"2015","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"ref216","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/gene.2017.4","article-title":"Identification of differentially expressed miRNAs in alopecia areata that target immune-regulatory pathways","volume":"18","author":"Wang","year":"2017","journal-title":"Genes Immunity"},{"key":"ref217","doi-asserted-by":"publisher","first-page":"556","DOI":"10.2174\/1389201019666180730094046","article-title":"Changes in the expression profile of Jak\/Stat signaling pathway genes and miRNAs regulating their expression under the adalimumab therapy","volume":"19","author":"Grabarek","year":"2018","journal-title":"Curr Pharm Biotechnol"},{"key":"ref218","doi-asserted-by":"publisher","first-page":"e24791","DOI":"10.1002\/jcla.24791","article-title":"Application of lncRNA\u2013miRNA\u2013mRNA ceRNA network analysis in the treatment of androgenic alopecia","volume":"37","author":"Wei","year":"2023","journal-title":"J Clin Lab Anal"},{"key":"ref219","doi-asserted-by":"publisher","first-page":"587","DOI":"10.21608\/asmj.2024.299393.1282","article-title":"A review on androgenic alopecia: etiology, pathogenesis, pharmacological and non-pharmacological treatment approaches","volume":"75","author":"Elgobashy","year":"2024","journal-title":"Ain Shams Med J"},{"key":"ref220","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1186\/s13287-024-03801-5","article-title":"Clinical and preclinical approach in AGA treatment: a review of current and new therapies in the regenerative field","volume":"15","author":"Pozo-P\u00e9rez","year":"2024","journal-title":"Stem Cell Res Ther"},{"key":"ref221","volume-title":"The role of miRNA-486-5p in hair growth and the hair follicle immune privilege","author":"Broadley","year":"2020"},{"key":"ref222","doi-asserted-by":"publisher","first-page":"e70182","DOI":"10.1002\/mco2.70182","article-title":"Alopecia Areata: pathogenesis, diagnosis, and therapies","volume":"6","author":"Ma","year":"2025","journal-title":"MedComm"},{"key":"ref223","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1111\/jdv.14287","article-title":"Frontal fibrosing alopecia: clinical and prognostic classification","volume":"31","author":"Moreno-Arrones","year":"2017","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref224","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/j.jaad.2011.12.038","article-title":"Frontal fibrosing alopecia: a review of 60 cases","volume":"67","author":"MacDonald","year":"2012","journal-title":"J Am Acad Dermatol"},{"key":"ref225","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/978-3-319-22671-2_16","article-title":"Essential role of microRNA in skin physiology and disease","volume":"888","author":"Glava\u010d","year":"2015","journal-title":"Adv Exp Med Biol"},{"key":"ref226","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1755-8417-2-7","article-title":"microRNAs and genetic diseases","volume":"2","author":"Meola","year":"2009","journal-title":"PathoGenetics"},{"key":"ref227","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-662-47293-4","volume-title":"MicroRNA detection and pathological functions","author":"Zhang","year":"2015"},{"key":"ref228","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1083\/jcb.201708173","article-title":"The microRNA-200 family coordinately regulates cell adhesion and proliferation in hair morphogenesis","volume":"217","author":"Hoefert","year":"2018","journal-title":"J Cell Biol"},{"key":"ref229","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1080\/10495398.2021.1968884","article-title":"MiR-125b regulates the differentiation of hair follicles in fine-wool sheep and cashmere goats by targeting MXD4 and FGFR2","volume":"34","author":"Qu","year":"2023","journal-title":"Anim Biotechnol"},{"key":"ref230","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1002\/1873-3468.70051","article-title":"miRNA-29 regulates epidermal and mesenchymal functions in skin repair","volume":"599","author":"Thiagarajan","year":"2025","journal-title":"FEBS Lett"},{"key":"ref231","doi-asserted-by":"publisher","first-page":"5703","DOI":"10.3390\/ijms24065703","article-title":"Adipose mesenchymal stromal cell-derived exosomes carrying MiR-122-5p antagonize the inhibitory effect of dihydrotestosterone on hair follicles by targeting the TGF-\u03b21\/SMAD3 signaling pathway","volume":"24","author":"Liang","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref232","doi-asserted-by":"publisher","first-page":"2234","DOI":"10.3390\/ani13132234","article-title":"Effect of fibroblast growth factor 10 and an interacting non-coding RNA on secondary hair follicle dermal papilla cells in cashmere goats\u2019 follicle development assessed by whole-transcriptome sequencing technology","volume":"13","author":"Gao","year":"2023","journal-title":"Animals"},{"key":"ref233","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/s41421-018-0052-z","article-title":"HCV-associated exosomes promote myeloid-derived suppressor cell expansion via inhibiting miR-124 to regulate T follicular cell differentiation and function","volume":"4","author":"Wang","year":"2018","journal-title":"Cell Discov"},{"key":"ref234","doi-asserted-by":"publisher","first-page":"643362","DOI":"10.3389\/fonc.2021.643362","article-title":"Circular RNA TAF4B promotes bladder cancer progression by sponging miR-1298-5p and regulating TGFA expression","volume":"11","author":"Zhang","year":"2021","journal-title":"Front Oncol"},{"key":"ref235","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1080\/10495398.2019.1675683","article-title":"MiR-27a regulates WNT3A and KITLG expression in cashmere goats with different coat colors","volume":"32","author":"Wu","year":"2021","journal-title":"Anim Biotechnol"},{"key":"ref236","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/6832680","article-title":"Study on the mechanism of miR-125b-5p affecting melanocyte biological behavior and melanogenesis in vitiligo through regulation of MITF","volume":"2022","author":"Wang","year":"2022","journal-title":"Dis Markers"}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2025.1635202\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T12:13:43Z","timestamp":1752149623000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2025.1635202\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,9]]},"references-count":236,"alternative-id":["10.3389\/fvets.2025.1635202"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2025.1635202","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,9]]},"article-number":"1635202"}}