{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T08:40:47Z","timestamp":1768207247260,"version":"3.49.0"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Two routes of administration for electrolyte solutions are commonly used in horses with fluid, electrolyte, and acid\u2013base imbalances: intravenous and nasogastric. Despite the frequent use of these routes, there are situations in which they cannot be applied. In such cases, intracecal fluid therapy represents a viable alternative, as this route enables the administration of enteral electrolyte solutions even in animals lacking normal anterior gastrointestinal function. This study aimed to evaluate the effects of a neutral hypotonic enteral electrolyte solution administered intracecally at two different infusion rates in horses experimentally subjected to a 24-h fasting period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study employed a crossover design in which six experimentally dehydrated horses underwent two treatments: Treat10 (10\u202fmL\u202fkg\n                      <jats:sup>\u22121<\/jats:sup>\n                      h\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) and Treat15 (15\u202fmL\u202fkg\n                      <jats:sup>\u22121<\/jats:sup>\n                      h\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) with a single neutral solution. Horses were subjected to cecal cannulation via video laparoscopy using a modified Hasson technique to insert a Foley catheter for solution administration. Samples were collected at T-24\u202fh (baseline, at the start of the water and food deprivation phase), T0h (at the end of the deprivation phase and the beginning of the fluid therapy), T4h (4\u202fh after the start of fluid therapy), T8h (8\u202fh after the start of fluid therapy), T12h (twelve hours after the start of fluid therapy), and T24h (twelve hours after the end of fluid therapy). Blood gas analysis and measurements of serum osmolarity, sodium, potassium, chloride, calcium, magnesium, phosphorus, fibrinogen, urea, creatinine, total protein, lactate, and glucose concentrations were performed. Urine samples were analyzed for concentrations of urea, creatinine, sodium, potassium, chloride, calcium, magnesium, and phosphorus.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the fluid therapy phase in animals from both groups, a progressive decrease in serum urea and potassium concentrations was recorded. A decrease in urinary specific gravity, urea and creatinine was also detected during the same period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Intracecal administration of electrolyte solutions at rates of 10\u202fmL (Treat10) and 15\u202fmL (Treat15) over 12\u202fh was effective and safe. The electrolyte solution used did not cause significant alterations in electrolyte or acid\u2013base balance, suggesting that its composition is appropriate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fvets.2025.1637033","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T05:43:13Z","timestamp":1768196593000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and laboratory evaluation in horses submitted to intracecal fluid therapy administered in two different rates"],"prefix":"10.3389","volume":"12","author":[{"given":"Brenda","family":"Ventura Lopes Carvalho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Carolina","family":"Neves de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadyne","family":"Souza Moreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Parisi Marliere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Victor","family":"Mesquita Mota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Drumond Bento","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana\u00efs","family":"de Castro Benitez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel Ferreira Bastos","family":"Avanza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella","family":"Bertoni Cavalcanti Teixeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Ricardo","family":"Barboza Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rinaldo Batista","family":"Viana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Moura Monteiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Paulo","family":"Maia Teixeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramiro","family":"Toribio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9lio Cordeiro","family":"Manso Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Dantas Ribeiro Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"ref1","first-page":"63","article-title":"Hidrata\u00e7\u00e3o Enteral em Ruminantes e Equ\u00eddeos. 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