{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:07:01Z","timestamp":1787242021991,"version":"build-2736575974"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>\n                    Notoedric mange (also known as feline scabies) is a highly contagious and intensely pruritic dermatologic condition of cats caused by infestation with\n                    <jats:italic>Notoedres cati<\/jats:italic>\n                    mites. Previous publications provide evidence that topical selamectin, and more recently, topical selamectin + sarolaner is efficacious in the treatment of notoedric mange in cats. The study reported here was conducted to confirm the efficacy of a topically applied combination of selamectin and sarolaner (Stronghold\n                    <jats:sup>\u00ae<\/jats:sup>\n                    Plus) in the treatment of notoedric mange in cats naturally infested with\n                    <jats:italic>N. cati.<\/jats:italic>\n                    Client-owned cats with clinical signs of notoedric mange and positive for live\n                    <jats:italic>N. cati<\/jats:italic>\n                    mites were enrolled and allocated randomly to treatment with either placebo (\n                    <jats:italic>n<\/jats:italic>\n                    \u202f=\u202f10) or Stronghold Plus (\n                    <jats:italic>n<\/jats:italic>\n                    \u202f=\u202f10). Treatment was administered on Days 0 and 30, and skin scrapings to detect live mites and assessment of the clinical signs of notoedric mange were conducted on Days 0, 30, and 60. The primary efficacy evaluation was based on the percent reduction in live mite counts in Stronghold Plus-treated cats compared to placebo-treated cats on Day 30. The parasitological cure (i.e., no live mites found) on Days 30 and 60 was also calculated for both treatment groups, as well as the improvement in clinical signs of notoedric mange. A single topical administration of Stronghold Plus provided a significant (\n                    <jats:italic>p\u202f&amp;lt;<\/jats:italic>\n                    0.0001) and 100% reduction in live\n                    <jats:italic>N. cati<\/jats:italic>\n                    mites relative to placebo within 30\u202fdays. All placebo-treated cats harbored mites on Days 30 and 60, while none of the Stronghold Plus-treated cats had any live mites. Parasitological cure on Days 30 and 60 was thus 100% and significantly different than placebo (\n                    <jats:italic>p\u202f&amp;lt;<\/jats:italic>\n                    0.0001). Clinical signs of notoedric mange improved in the Stronghold Plus-treated cats by Day 30, and no signs of notoedric mange were observed by Day 60. This study confirms that Stronghold Plus is highly effective in the treatment of notoedric mange in cats naturally infested with\n                    <jats:italic>N. cati.<\/jats:italic>\n                  <\/jats:p>","DOI":"10.3389\/fvets.2025.1652148","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T15:35:42Z","timestamp":1755790542000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of a spot-on combination product containing selamectin and sarolaner (Stronghold\u00ae Plus) in the treatment of naturally occurring Notoedres cati infestations in cats"],"prefix":"10.3389","volume":"12","author":[{"given":"Stasia","family":"Borowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Berlamont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Geurden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"D\u2019Hanis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhimiter","family":"Rapti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejan","family":"Cveji\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Suckstorff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"Simovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vickie L.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"ref1","first-page":"298","article-title":"Parasitic skin disease","volume-title":"Muller and Kirk\u2019s small animal dermatology","author":"Miller","year":"2013"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/978-3-030-29836-4_19","article-title":"Ectoparasitic diseases","volume-title":"Feline Dermatology","author":"Leone","year":"2020"},{"key":"ref3","first-page":"89","article-title":"Ectoparasites: Otodectes cynotis, Felicola subrostratus, and Notoedres cati in the ear of cats","volume":"41","author":"Rataj","year":"2004","journal-title":"Slov Vet Res"},{"key":"ref4","first-page":"115","article-title":"Notoedric mange (feline scabies)","volume-title":"Manual of skin diseases of the dog and cat","author":"Paterson","year":"2008"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1017\/S0031182016001505","article-title":"A synthetic review of Notoedres species mites and mange","volume":"143","author":"Foley","year":"2016","journal-title":"Parasitology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/9780470376805","volume-title":"Feline Clinical Parasitology","author":"Bowman","year":"2002"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S0195-5616(87)50609-X","article-title":"Zoonotic dermatoses of dogs and cats","volume":"17","author":"Scott","year":"1987","journal-title":"Vet Clin N Am Small Anim Pract"},{"key":"ref8","first-page":"36","article-title":"Parasites relevant to feline skin disease","author":"Colombo","year":"2020","journal-title":"British Veterinary Dermatology"},{"key":"ref9","first-page":"421","article-title":"Feline notoedric mange: a report of 22 cases","volume":"38","author":"Leone","year":"2003","journal-title":"Prat M\u00e9d Chir Anim Comp"},{"key":"ref10","first-page":"154","article-title":"Treatment of Notoedres cati infestation in cats with selamectin","volume":"154","author":"Itoh","year":"2004","journal-title":"Vet Rec"},{"key":"ref11","first-page":"87","article-title":"Effect of selamectin in feline sarcoptic mange of Wayanad district, Kerala","volume":"9","author":"Xavier","year":"2020","journal-title":"Pharma Innovation"},{"key":"ref12","first-page":"15","article-title":"Efficacy of selamectin spot on in the treatment of Notoedres cati in a Persian kitten","volume":"3","author":"Balamurugan","year":"2022","journal-title":"J Res Chem"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"849525","DOI":"10.3389\/fvets.2022.849525","article-title":"Case report: Notoedric mange and aelurostrongylidosis in two domestic cats from rural environment in Romania","volume":"9","author":"Gyorke","year":"2022","journal-title":"Front Vet Sci"},{"key":"ref14","first-page":"41","article-title":"Therapeutic efficacy of topical treatment with selamectin and sarolaner against notoedric mange in a domestic cat: case report","volume":"31","author":"Deak","year":"2021","journal-title":"Rev Rom Med Vet"},{"key":"ref15","year":"2016"},{"key":"ref16","year":"2016"},{"key":"ref17","year":"2016"},{"key":"ref18","year":"2016"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/jvp.12959","article-title":"Current review of isoxazoline ectoparasiticides used in veterinary medicine","volume":"45","author":"Zhou","year":"2021","journal-title":"J Vet Pharmacol Ther"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ph13080196","article-title":"Avermectin deravitives, pharmacokinetics, therapeutic and toxic dosages, mechanisms of action, and their biological effects","volume":"13","author":"Batiha El-Saber","year":"2020","journal-title":"Pharmaceuticals"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.vetpar.2016.02.019","article-title":"Discovery of sarolaner: a novel, orally administered, broad-spectrum, isoxazoline ectoparasiticide for dogs","volume":"222","author":"McTier","year":"2016","journal-title":"Vet Parasitol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/S0304-4017(00)00300-9","article-title":"Efficacy and safety of selamectin against Sarcoptes scabiei on dogs and Otodectes cynotis on dogs and cats presented as veterinary patients","volume":"91","author":"Six","year":"2000","journal-title":"Vet Parasitol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.vetpar.2016.02.017","article-title":"Efficacy and safety of a novel oral isoxazoline, sarolaner (Simparica\u2122), for the treatment of sarcoptic mange in dogs","volume":"222","author":"Becskei","year":"2016","journal-title":"Vet Parasitol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"21","DOI":"10.5324\/fn.v35i0.1652","article-title":"The taxonomy, life cycle and pathology of Sarcoptes scabiei and Notoedres cati (Acarina, Sarcoptidae): a review in a Fennosscandian wildlife perspective","volume":"35","author":"Kraabol","year":"2015","journal-title":"Fauna Norvegica"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.cvsm.2005.09.002","article-title":"Feline facial dermatoses","volume":"36","author":"Friberg","year":"2006","journal-title":"Vet Clin N Am Small Anim Pract"}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2025.1652148\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T15:35:44Z","timestamp":1755790544000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2025.1652148\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,21]]},"references-count":25,"alternative-id":["10.3389\/fvets.2025.1652148"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2025.1652148","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,21]]},"article-number":"1652148"}}