{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T02:55:27Z","timestamp":1789268127033,"version":"build-2803163510"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>\n                    Over the last six decades, the extensive use of antibiotics as growth promoters in animal nutrition has contributed to antimicrobial resistance and ultimately poses a risk to public and environmental health. Therefore, there is a growing interest in alternative strategies, such as plant extracts and essential oils, to address this issue. The aim of this study was to evaluate the effect of\n                    <jats:italic>Morinda citrifolia<\/jats:italic>\n                    leaf ethanolic extract (MCEE) on the intestinal health and performance of broiler chickens. A total of 360 Cobb 500 broilers were randomly distributed into groups C1, C2, S1, S2, and S3, with six replicates of 12 chickens each. C1 was fed the base diet (BD), and C2 was fed BD\u202f+\u202f50\u202fppm zinc bacitracin (ZB). S1, S2, and S3 were supplemented with MCEE in daily doses of 5.62, 11.0, and 16.3\u202fmg\/kg BW, respectively, from 1 to 21\u202fdays of age. Hematological profiles and gut histology were assessed at 7, 14, and 21\u202fdays of age, while the abundance of microbiota in the ileum was measured at 21 and 28\u202fdays of age. Performance indices, including weight gain, feed intake, and feed conversion rate, were evaluated at 7, 21, and 33\u202fdays of age. Data were analyzed using a general factorial arrangement. The abundance of\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    and\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    log (CFU\/g) decreased in the three supplemented groups by 21\u202fdays of age, and these levels were maintained until 28\u202fdays of age. Additionally, in the three supplemented groups, the abundance of\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    sp. decreased by 21\u202fdays of age; however, it was re-established by 28\u202fdays of age. Villus height and crypt depth increased with age in the S2 group by 21\u202fdays of age. Performance indices improved during the fattening phase overall in chickens in group S2. In conclusion, a daily dose of 11.0\u202fmg\/kg BW MCEE in the diet improved performance indices by modulating gut microbiota and histology at 21\u202fdays in broiler chickens.\n                  <\/jats:p>","DOI":"10.3389\/fvets.2025.1686136","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T14:58:27Z","timestamp":1769612307000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Ethanolic extract of Morinda citrifolia improves gut microbiota, intestinal morphology, and performance without adverse effects on hematological profiles in broiler chickens"],"prefix":"10.3389","volume":"12","author":[{"given":"Daniel Marco","family":"Paredes-L\u00f3pez","sequence":"first","affiliation":[{"name":"Department of Animal Science, Universidad Nacional Agraria de la Selva","place":["Tingo Mar\u00eda, Peru"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rizal","family":"Robles-Huaynate","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Universidad Nacional Agraria de la Selva","place":["Tingo Mar\u00eda, Peru"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Amelia","family":"Perales-Camacho","sequence":"additional","affiliation":[{"name":"Department of Animal Health and Public Health, Faculty of Veterinary Medicine, Universidad Nacional Mayor de San Marcos","place":["Lima, Peru"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy Vanessa","family":"Alania-Santiago","sequence":"additional","affiliation":[{"name":"Posgraduate School, Universidad Nacional Agraria de la Selva","place":["Tingo Mar\u00eda, Peru"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uriel","family":"Aldava-Pardave","sequence":"additional","affiliation":[{"name":"Posgraduate School, Universidad Nacional Agraria La Molina","place":["Lima, Peru"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3389\/fvets.2015.00021","article-title":"Phytogenic feed additives as an alternative to antibiotic growth promoters in broiler chickens","volume":"2","author":"Murugesan","year":"2015","journal-title":"Front Vet Sci"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1286152","DOI":"10.3389\/fvets.2024.1286152","article-title":"Modulation of gut microbiota and morphometry, blood profiles, and performance of broiler chickens supplemented with Piper aduncum, Morinda citrifolia, and Artocarpus altilis leaves ethanolic extracts","volume":"11","author":"Paredes-L\u00f3pez","year":"2024","journal-title":"Front Vet Sci"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1597948","DOI":"10.3389\/fvets.2025.1597948","article-title":"Piper aduncum polyphenols and flavonoids enhance gut health, immune and anti-inflammatory activity and performance indices of broiler chickens","volume":"12","author":"Paredes-L\u00f3pez","year":"2025","journal-title":"Front Vet Sci"},{"key":"ref4","first-page":"227","article-title":"Chapter 13. 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